In recent years,modification of texture distribution has been considered a valid approach to improve the room-temperature(RT)formability of magnesium(Mg)alloys.In this study,a novel Mgsingle bond2Znsingle bond3Lisingl...In recent years,modification of texture distribution has been considered a valid approach to improve the room-temperature(RT)formability of magnesium(Mg)alloys.In this study,a novel Mgsingle bond2Znsingle bond3Lisingle bond1Gd alloy sheet with weak elliptical-texture was fabricated by cold rolling and subsequent annealing,and it showed an excellent Erichsen(IE)value near 7.1 mm.Both quasi-in-situ electron backscatter diffraction(EBSD)and transmission electron microscopy(TEM)analysis indicate that considerable basal and pyramidal dislocations can be activated in the cold rolling process.During annealing,these dislocations can induce nucleation and then cause preferential misorientation relationships around〈uvt0〉concerning the nuclei and parent grains,which can facilitate the formation of elliptical texture.Furthermore,the particle-stimulated nucleation(PSN)mechanism and the co-segregation of Zn and Gd at grain boundaries(GB)further weak texture intensity.Finally,the mechanical properties of the Mgsingle bond2Znsingle bond3Lisingle bond1Gd alloy sheet are significantly improved.展开更多
Gangliosides,sialic acid-containing sphingolipids,are major constituents of neuronal membranes.According to the number of sialic acids and the structure of the oligosaccharide chain,gangliosides can be classified as s...Gangliosides,sialic acid-containing sphingolipids,are major constituents of neuronal membranes.According to the number of sialic acids and the structure of the oligosaccharide chain,gangliosides can be classified as simple or complex and grouped in different ganglio-series.Hundreds of gangliosides have been identified in vertebrate cells,with different expression patterns during development and related to several physiological processes,especially in the nervous system.While GD3 and its O-acetylated form,9acGD3,are highly expressed in early developmental stages,GM1,GD1a,GD1b,and GT1b are the most abundant ganglioside species in the mature nervous system.Mutations in enzymes involved in ganglioside metabolism can lead to the accumulation of specific species,a condition termed gangliosidosis and usually marked by severe neurological impairment.Changes in ganglioside levels have also been described in several neurodegenerative diseases,such as Alzheimer’s and Parkinson’s.In this review,we summarized recent information about the roles of GD3,9acGD3,GM1,GD1a,GD1b,GT1b,and other ganglioside species in nervous system development and regeneration,as well as clinical trials evaluating possible therapeutic applications of these molecules.展开更多
基金supports from the National Natural Science Foundation of China(51901204,52161023,52271249)Science and Technology project of Yunnan Precious Metal Laboratory(YPML-2023050208)+1 种基金Yunnan Science and Technology Planning Project(202201AU070010,202301AT070276,202302AB080008,202303AA080001)supported by Yunnan Key Laboratory of Electromagnetic Materials and Devices.
文摘In recent years,modification of texture distribution has been considered a valid approach to improve the room-temperature(RT)formability of magnesium(Mg)alloys.In this study,a novel Mgsingle bond2Znsingle bond3Lisingle bond1Gd alloy sheet with weak elliptical-texture was fabricated by cold rolling and subsequent annealing,and it showed an excellent Erichsen(IE)value near 7.1 mm.Both quasi-in-situ electron backscatter diffraction(EBSD)and transmission electron microscopy(TEM)analysis indicate that considerable basal and pyramidal dislocations can be activated in the cold rolling process.During annealing,these dislocations can induce nucleation and then cause preferential misorientation relationships around〈uvt0〉concerning the nuclei and parent grains,which can facilitate the formation of elliptical texture.Furthermore,the particle-stimulated nucleation(PSN)mechanism and the co-segregation of Zn and Gd at grain boundaries(GB)further weak texture intensity.Finally,the mechanical properties of the Mgsingle bond2Znsingle bond3Lisingle bond1Gd alloy sheet are significantly improved.
基金supported by grants and fellowships from the Departamento de Ciência e Tecnologia(DECIT/MS)do Ministério da Saúde,Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa,Fundação de AmparoàPesquisa do Estado do Rio de Janeiro(FAPERJ)(to RMO).
文摘Gangliosides,sialic acid-containing sphingolipids,are major constituents of neuronal membranes.According to the number of sialic acids and the structure of the oligosaccharide chain,gangliosides can be classified as simple or complex and grouped in different ganglio-series.Hundreds of gangliosides have been identified in vertebrate cells,with different expression patterns during development and related to several physiological processes,especially in the nervous system.While GD3 and its O-acetylated form,9acGD3,are highly expressed in early developmental stages,GM1,GD1a,GD1b,and GT1b are the most abundant ganglioside species in the mature nervous system.Mutations in enzymes involved in ganglioside metabolism can lead to the accumulation of specific species,a condition termed gangliosidosis and usually marked by severe neurological impairment.Changes in ganglioside levels have also been described in several neurodegenerative diseases,such as Alzheimer’s and Parkinson’s.In this review,we summarized recent information about the roles of GD3,9acGD3,GM1,GD1a,GD1b,GT1b,and other ganglioside species in nervous system development and regeneration,as well as clinical trials evaluating possible therapeutic applications of these molecules.
