BACKGROUND Glycated hemoglobin(HbA1c),the gold standard for assessing glycemic control,has limited ability to reflect the risks of hypoglycemia and glycemic variability,raising great concerns,especially in patients wi...BACKGROUND Glycated hemoglobin(HbA1c),the gold standard for assessing glycemic control,has limited ability to reflect the risks of hypoglycemia and glycemic variability,raising great concerns,especially in patients with type 1 diabetes(T1D).The glycemia risk index(GRI),a composite metric derived from continuous glucose monitoring(CGM),has emerged as a potential solution by systematically in-tegrating both hypoglycemia and hyperglycemia risks into a single interpretable score.The GRI exhibited linear correlations with HbA1c(r=0.53),time in range(r=-0.90),time above range(r=0.63),time below range(TBR)(r=0.37),and co-efficient of variation(CV)(r=0.71).It correlated strongly with TBR and CV than HbA1c.The association between HbA1c levels and GRI was influenced by TBR and CV.At a given HbA1c,each 1%increase in TBR or CV raised GRI by 1.87[95%confidence interval(CI):1.72-2.01]and 1.94(95%CI:1.80-2.10),respectively(P<0.001).Clustering of the CGM data identified four subgroups:Moderate-risk glycemic fluctuations,high-risk hypoglycemia,optimal glycemic control,and high-risk hyperglycemia.The GRI and its components for hypoglycemia and hyperglycemia could distinguish between these subgroups.CONCLUSION The GRI offers a comprehensive view of glycemic control in T1D.Combining HbA1c with the GRI enables accurate assessment for managing glycemic control in patients with T1D.展开更多
Aeropropulsion System Test Facility (ASTF) is required to accurately control the pressure and temperature of the airflow to test the performance of the aero-engine. However, the control accuracy of ASTF is significant...Aeropropulsion System Test Facility (ASTF) is required to accurately control the pressure and temperature of the airflow to test the performance of the aero-engine. However, the control accuracy of ASTF is significantly affected by the flow disturbance caused by aero-engine acceleration and deceleration. This would reduce the credibility of ASTF’s test results for the aero-engine. Therefore, first, this paper proposes a feedforward compensation-based L1 adaptive control method for ASTF to address this problem. The baseline controller is first designed based on ideal uncoupled closed-loop dynamics to achieve dynamic decoupling. Then, L1 adaptive control is adopted to deal with various uncertainties and ensure good control performance. To further enhance the anti-disturbance performance, a feedforward strategy based on disturbance prediction is designed in the L1 adaptive control framework to compensate for the unmatched flow disturbance, which cannot be measured directly. In addition, this strategy takes into account the effects of actuator dynamics. With this method, the feedforward term can be determined from the nominal model parameters despite uncertainties. Finally, to demonstrate the effectiveness of the proposed method, various comparative experiments are performed on a hardware-in-the-loop system of ASTF. The experimental results show that the proposed method possesses excellent tracking performance, anti-disturbance performance and robustness.展开更多
With validamycin A.（0.2 billion spores/ml） Paenibacillus polymyxa DN-1 3% AS as the test agent, the effects of different dosage and different application time on the control efficacy for＇ rich sheath blight were in...With validamycin A.（0.2 billion spores/ml） Paenibacillus polymyxa DN-1 3% AS as the test agent, the effects of different dosage and different application time on the control efficacy for＇ rich sheath blight were investigated. The results of two- year test showed that when the application amount was in the range of 45-90 g.a.i/ hm^2, the field efficacy of validamycin A-（0.2 billion spores/ml） P. polymyxa DN-1 3% AS in the initial infection stage of rich sheath blight （Le., the diseased plant rate was below 5%） reached 80.38%-89.06%, and that in the peak infection stage （i.e., the diseased plant rate was higher than 10%） reached only 41.12%-53.26%. The field efficacy of validamycin A.（0.2 billion spores/ml） P. polymyxa DN-1 3% AS at the early onset of rich sheath blight was significantly better than that at the onset, so that the application time of validamycin A .（0.2 billion spores/ml） P. polymyxa DN-1 3% AS should be appropriately brought forward in the prevention and control of rice sheath blight.展开更多
AIM:To evaluate the long-term effect of aerobic and/or anaerobic exercise on glycemic control in youths with type 1 diabetes.METHODS:Literature review was performed in spring and summer 2014 using Pub Med/MEDLINE,Goog...AIM:To evaluate the long-term effect of aerobic and/or anaerobic exercise on glycemic control in youths with type 1 diabetes.METHODS:Literature review was performed in spring and summer 2014 using Pub Med/MEDLINE,Google Scholar,Scopus,and Science Direct with the following terms:aerobic,anaerobic,high-intensity,resistance,exercise/training,combined with glycemic/metabolic control,glycated haemoglobin A1c(Hb A1c) and type 1diabetes.Only peer-reviewed articles in English were included published in the last 15 years.It was selected from 1999 to 2014.Glycemic control was measured with Hb A1 c.Studies with an intervention lasting at least 12 wk were included if the Hb A1 c was measured before and after the intervention.RESULTS:A total of nine articles were found,and they were published between the years of 2002-2011.The sample size was 401 diabetic youths(166 males and 235 females) with an age range of 10-19 years except one study,in which the age range was 13-30 years.Study participants were from Australia,Tunisia,Lithuania,Taiwan,Turkey,Brazilia,Belgium,Egypt and France.Four studies were aerobic-based,four were combined aerobic and anaerobic programs,and one compared aerobic exercise to anaerobic one.Available studies had insufficient evidence that any type of exercise or combined training would clearly improve the glycemic control in type 1 diabetic youth.Only three(two aerobic-based and one combined) studies could provide a significant positive change in glycemic control.CONCLUSION:The regular physical exercise has several other valuable physiological and health benefits that justify the inclusion of exercise in pediatric diabetes treatment and care.展开更多
Type 1 diabetes mellitus is associated with celiac disease,with a prevalence that varies between 0.6% and 16.4%,according to different studies.After a diagnosis of celiac disease is confirmed by small bowel biopsy,pat...Type 1 diabetes mellitus is associated with celiac disease,with a prevalence that varies between 0.6% and 16.4%,according to different studies.After a diagnosis of celiac disease is confirmed by small bowel biopsy,patients are advised to commence a gluten-free diet(GFD).This dietary restriction may be particularly difficult for the child with diabetes,but in Europe(and in Italy) many food stores have targeted this section of the market with better labeling of products and more availability of specific GFD products.Treatment with a GFD in symptomatic patients has been shown to improve the symptoms,signs and complications of celiac disease.However,the effects of a GFD on diabetic control are less well established.Initial reports of improved hypoglycemic control were based on children who were diagnosed with celiac disease associated with malabsorption,but there have subsequently been reports of improvement in patients with type 1 diabetes with subclinical celiac disease.There are other studies reporting no effect,improved control and an improvement of hypoglycemic episodes.Moreover,in this review we wish to focus on low glycemic index foods,often suggested in people with type 1 diabetes,since they might reduce postprandial glycemic excursion and enhance longterm glycemic control.In contrast,GFD may be rich in high glycemic index foods that can increase the risk of obesity,insulin resistance and cardiovascular disease,worsening the metabolic control of the child with diabetes.Hence,it is important to evaluate the impact of a GFD on metabolic control,growth and nutritional status in children with type 1 diabetes.展开更多
An iterative optimization strategy is proposed and applied to the steady state optimizing control of the bio-dissimilation process of glycerol to 1,3-propanediol in the presence of model-plant mismatch and input const...An iterative optimization strategy is proposed and applied to the steady state optimizing control of the bio-dissimilation process of glycerol to 1,3-propanediol in the presence of model-plant mismatch and input constraints. The scheme is based on the Augmented Integrated System Optimization and Parameter Estimation （AI- SOPE） technique, but a linearization of some performance function in the modified model-based optimization problem of AISOPE is introduced to overcome the difficulty of determining an appropriate penalty parameter. When carrying out the iterative optimization, the penalty coefficient is set to a larger value at the current iteration than at the previous iteration, which can promote the evolution rate of the iterative optimization. Simulation studies illustrate the potential ofthe approach presented for the optimizing control of the bioTdissimilation process of glycerol to 1,3-propanediol. The effects of measurement noise, measured and unmeasured disturbances on the proposed algorithm are also investigated.展开更多
BACKGROUND Type 1 diabetes is one of the most common chronic diseases in childhood.The number of type 1 diabetes patients in China still ranks fourth in the world.Therefore,children with type 1 diabetes in China are a...BACKGROUND Type 1 diabetes is one of the most common chronic diseases in childhood.The number of type 1 diabetes patients in China still ranks fourth in the world.Therefore,children with type 1 diabetes in China are a group that needs attention.The management of type 1 diabetes mellitus(T1DM)involves many aspects of daily life.It is extremely challenging for children and their families.T1DM children have complex medical care needs.Despite the continuous development of therapeutic medicine and treatment technologies,blood glucose control in children with T1DM is still not ideal.They and their parents need to acquire more knowledge and skills before being discharged.AIM To explore the influence of hospital discharge plan based on parental care needs of children with T1DM on discharge readiness,quality of discharge education and blood glucose control level.METHODS In total,102 parents of children with type 1 diabetes were divided into control group and intervention group according to admission time.Fifty cases from February to June 2019 were selected as the control group,and 52 cases from July to October 2019 were selected as the intervention group to implement the discharge plan.The Readiness for Hospital Discharge Scale,Hospital Discharged Education Quality Scale and children's blood glucose metabolism indicators were used to compare the differences in discharge preparation,discharge education quality and blood glucose control between the two groups of children and their parents.RESULTS On the day of discharge,the two groups of children had the following scores of readiness for discharge:The intervention group score was 225.34±32.47,and the control group score was 208.68±29.31.The P value was 0.007,and the difference was statistically significant.The discharge education quality scores were as follows:The intervention group score was 135.11±19.86,the control group score was 124.13±15.56,the P value was 0.002 and the difference was statistically significant.Three months after discharge,the blood glucose metabolism indicator showed that the glycosylated hemoglobin value of the two groups was(7.45%±1.04%),and that of the control group was(8.04%±1.27%),P=0.012.Therefore,the improvement of parents'readiness for discharge,quality of discharge education and blood glucose metabolism indicators(glycosylated hemoglobin,fasting blood glucose and postprandial blood glucose)in the intervention group were better than those in the control group(P<0.05),and the difference was statistically significant.CONCLUSION The discharge plan for children with T1DM can help the children and their families realize the transition from hospital care to home self-management and improve the parents'readiness for discharge,thereby improving children’s blood glucose control levels.展开更多
The genomes of eukaryotic cells are under continuous assault by environmental agents and endogenous metabolic byproducts. Damage induced in DNA usually leads to a cascade of cellular events, the DNA damage response. F...The genomes of eukaryotic cells are under continuous assault by environmental agents and endogenous metabolic byproducts. Damage induced in DNA usually leads to a cascade of cellular events, the DNA damage response. Failure of the DNA damage response can lead to development of malignancy by reducing the efficiency and fidelity of DNA repair. The NBS1 protein is a component of the MRE11/RAD50/NBS 1 complex （MRN） that plays a critical role in the cellular response to DNA damage and the maintenance of chromosomal integrity. Mutations in the NBS1 gene are responsible for Nijmegen breakage syndrome （NBS）, a hereditary disorder that imparts an increased predisposition to development of malignancy. The phenotypic characteristics of cells isolated from NBS patients point to a deficiency in the repair of DNA double strand breaks. Here, we review the current knowledge of the role of NBS1 in the DNA damage response. Emphasis is placed on the role of NBS1 in the DNA double strand repair, modulation of the DNA damage sensing and signaling, cell cycle checkpoint control and maintenance oftelomere stability.展开更多
This paper presents an adaptive control scheme with an integration of sliding mode control into the L1 adaptive control architecture, which provides good tracking performance as well as robustness against matched unce...This paper presents an adaptive control scheme with an integration of sliding mode control into the L1 adaptive control architecture, which provides good tracking performance as well as robustness against matched uncertainties. Sliding mode control is used as an adaptive law in the L1 adaptive control architecture, which is considered as a virtual control of error dynamics between estimated states and real states. Low-pass filtering mechanism in the control law design prevents a discontinuous signal in the adaptive law from appearing in actual control signal while maintaining control accuracy. By using sliding mode control as a virtual control of error dynamics and introducing the low-pass filtered control signal, the chattering effect is eliminated. The performance bounds between the close-loop adaptive system and the closed-loop reference system are characterized in this paper. Numerical simulation is provided to demonstrate the performance of the presented adaptive control scheme.展开更多
Angiogenesis in ischemic tissue is a complex and multi-gene event. In the study, we constructed hypoxic re-sponse elements （HRE） and the Tet-On advanced double-controlled systems and investigated their effects on th...Angiogenesis in ischemic tissue is a complex and multi-gene event. In the study, we constructed hypoxic re-sponse elements （HRE） and the Tet-On advanced double-controlled systems and investigated their effects on the expression of hVEGF165 and angiopoietin-1 （Ang-1） genes in rat cardiomyocytes exposed to hypoxia and pharma-cologic induction. We infected neonatal rat cardiomyocytes with recombinant rAAV-rtTA-Rs-M2/rAAV-TRE-Tight-Ang-1 and rAAV-9HRE- hVEGF165. Our results indicated that the viral titer was 1×1012 vg /mL and the viral purity exceeded 98%. hVEGF165 expression was induced by hypoxia, but not by normoxia （P 0.001）. Ang-1 expression was evident under doxycycline induction, but undetectable without doxycycline induction （P 0.001）. Immunofluorescence staining showed that positively stained hVEGF165 and Ang-1 protein appeared only under both hypoxia and doxycycline induction. We demonstrate here that HRE and the recombinant Tet-On advanced double gene-controlled systems sensitively regulate the expression of hVEGF165 and Ang-1 genes in an altered oxygen environment and under pharmacological induction in vitro.展开更多
In this paper a controlled quantum teleportation scheme of an N-particle unknown state is proposed when N groups of three-particle W1 states are utilized as quantum channels. The quantum information of N-particle unkn...In this paper a controlled quantum teleportation scheme of an N-particle unknown state is proposed when N groups of three-particle W1 states are utilized as quantum channels. The quantum information of N-particle unknown state is transmitted from the sender to the recipient under the control of all supervisors. It can be realized with a certain probability. After the sender makes Bell-state measurements and the supervisors perform the computational basis measurements, the recipient will introduce auxiliary particles and carry out unitary transformations depending on classical information from the sender and the supervisors. Finally, the computational basis measurement will be performed by the recipient to confirm whether the teleportation succeeds or not. The successful completion of the scheme relies on all supervisors＇ cooperation. In addition, the fidelity and security of the scheme are discussed.展开更多
A series of LaAl 1-xFe xO 3 catalysts prepared with lanthanum nitrate, aluminium nitrate and iron nitrate was investigated in catalytical syntheses of carbon nanotubes with high yields and purity. The properties ...A series of LaAl 1-xFe xO 3 catalysts prepared with lanthanum nitrate, aluminium nitrate and iron nitrate was investigated in catalytical syntheses of carbon nanotubes with high yields and purity. The properties of carbon nanotubes prepared by the method of CVD(chemical vapor deposition) with n-hexane as the carbon resource were studied and it was shown that the diameter of carbon nanotubes can be controlled by the molar ratio of iron to aluminum in the catalysts and that the diameter of carbon nanotubes changes a little with the decrease of the iron content in the catalysts. From the TEM pictures of carbon nanotubes, it can be found that the LaAl 1-xFe xO 3 catalysts have a significant influence on the wall thickness of the carbon nanotubes, whereas they have little influence on the inner diameter of the carbon nanotubes.展开更多
Objective: Octreotide three times daily is re-ported to reduce daily insulin by 50% in patients with Type 1 DM. Therefore, we assessed the impact of long acting Octreotide (Sandostatin LAR) monthly Intramuscular admin...Objective: Octreotide three times daily is re-ported to reduce daily insulin by 50% in patients with Type 1 DM. Therefore, we assessed the impact of long acting Octreotide (Sandostatin LAR) monthly Intramuscular administration in a subject with Type 1 DM. Methods: A 32-year-old man with Type 1 DM of 16 years participated after obtaining informed consent. He had no microvascular or macrovascular complications. He continued the present insulin regimen for four weeks. IM Sandostatin LAR 20 mg was initiated and increased at four weeks to 30 mg. He was followed every four weeks for six months. Insulin regimen was adjusted every two weeks based on blood glucose before meals, bedtime and on onset of hypoglycemic symptoms. He continued other medications, previous diet and activity Assessment of HbA1c, serum electrolytes, urea nitrogen, creatinine, TSH, free T4, liver enzymes, complete blood cell counts, vitamin B12, lipids and insulin regimen were performed at the initiation and end of the study. Results: HbA1c declined from 9 to 8% with reduction in daily insulin dose from 55 to 43 units, with a major reduction in insulin Glargine, 50 to 40 units. Body weight remained unaltered. Other laboratory tests including gallbladder examina-tion remained unchanged Conclusion: Monthly Sandostatin LAR administration may improve glycemic control with less insulin in Type 1 DM.展开更多
The main task of this work is to design a control system for a small tail-sitter Unmanned Aerial Vehicle(UAV)during the transition process.Although reasonable control performance can be obtained through a well-tuned s...The main task of this work is to design a control system for a small tail-sitter Unmanned Aerial Vehicle(UAV)during the transition process.Although reasonable control performance can be obtained through a well-tuned single PID or cascade PID control architecture under nominal conditions,large or fast time-varying disturbances and a wide range of changes in the equilibrium point bring nonlinear characteristics to the transition control during the transition process,which leads to control precision degradation.Meanwhile,the PID controller’s tuning method relies on engineering experiences to a certain extent and the controller parameters need to be retuned under different working conditions,which limits the rapid deployment and preliminary validation.Based on the above issues,a novel control architecture of L1 neural network adaptive control associated with PID control is proposed to improve the compensation ability during the transition process and guarantee the security transition.The L1 neural network adaptive control is revised to solve the multi-input and multi-output problem of the tail-sitter UAV system in this study.Finally,the transition characteristics of the time setting difference between the desired transition speed and the desired transition pitch angle are analyzed.展开更多
基金Supported by the Noncommunicable Chronic Diseases-National Science and Technology Major Project,No.2023ZD0508201the National Key R and D Program of China,No.2022YFC2010100+3 种基金the National Natural Science Foundation of China,No.82070812the Natural Science Foundation of Hunan Province,No.2024JJ9049,No.2023JJ30762 and No.2021JC0003Sinocare Diabetes Foundation,No.2020SD08the National Clinical Research Center for Metabolic Diseases Clinical Diagnosis and Treatment Capacity Enhancement Program,No.2023ZLNL003.
文摘BACKGROUND Glycated hemoglobin(HbA1c),the gold standard for assessing glycemic control,has limited ability to reflect the risks of hypoglycemia and glycemic variability,raising great concerns,especially in patients with type 1 diabetes(T1D).The glycemia risk index(GRI),a composite metric derived from continuous glucose monitoring(CGM),has emerged as a potential solution by systematically in-tegrating both hypoglycemia and hyperglycemia risks into a single interpretable score.The GRI exhibited linear correlations with HbA1c(r=0.53),time in range(r=-0.90),time above range(r=0.63),time below range(TBR)(r=0.37),and co-efficient of variation(CV)(r=0.71).It correlated strongly with TBR and CV than HbA1c.The association between HbA1c levels and GRI was influenced by TBR and CV.At a given HbA1c,each 1%increase in TBR or CV raised GRI by 1.87[95%confidence interval(CI):1.72-2.01]and 1.94(95%CI:1.80-2.10),respectively(P<0.001).Clustering of the CGM data identified four subgroups:Moderate-risk glycemic fluctuations,high-risk hypoglycemia,optimal glycemic control,and high-risk hyperglycemia.The GRI and its components for hypoglycemia and hyperglycemia could distinguish between these subgroups.CONCLUSION The GRI offers a comprehensive view of glycemic control in T1D.Combining HbA1c with the GRI enables accurate assessment for managing glycemic control in patients with T1D.
基金supported by the“Shuimu Tsinghua Scholar”Project,China(No.2024SM223)the National Science and Technology Major Project,China(No.Y2022-V-0002-0028).
文摘Aeropropulsion System Test Facility (ASTF) is required to accurately control the pressure and temperature of the airflow to test the performance of the aero-engine. However, the control accuracy of ASTF is significantly affected by the flow disturbance caused by aero-engine acceleration and deceleration. This would reduce the credibility of ASTF’s test results for the aero-engine. Therefore, first, this paper proposes a feedforward compensation-based L1 adaptive control method for ASTF to address this problem. The baseline controller is first designed based on ideal uncoupled closed-loop dynamics to achieve dynamic decoupling. Then, L1 adaptive control is adopted to deal with various uncertainties and ensure good control performance. To further enhance the anti-disturbance performance, a feedforward strategy based on disturbance prediction is designed in the L1 adaptive control framework to compensate for the unmatched flow disturbance, which cannot be measured directly. In addition, this strategy takes into account the effects of actuator dynamics. With this method, the feedforward term can be determined from the nominal model parameters despite uncertainties. Finally, to demonstrate the effectiveness of the proposed method, various comparative experiments are performed on a hardware-in-the-loop system of ASTF. The experimental results show that the proposed method possesses excellent tracking performance, anti-disturbance performance and robustness.
基金Supported by National Agricultural Science and Technology Achievement Transformation Fund of China(2010GB2C300196)Modern Agricultural Production Development Fund(Rice Industry)Project of Anhui Academy of Agricultural SciencesIntegration and Demonstration of Chemical Fertilizer and Agrochemical Reduction and Efficiency Increasing Technology for Rice in Rice-wheat(rape)Rotation Areas in Anhui(2016YFD0200806)~~
文摘With validamycin A.（0.2 billion spores/ml） Paenibacillus polymyxa DN-1 3% AS as the test agent, the effects of different dosage and different application time on the control efficacy for＇ rich sheath blight were investigated. The results of two- year test showed that when the application amount was in the range of 45-90 g.a.i/ hm^2, the field efficacy of validamycin A-（0.2 billion spores/ml） P. polymyxa DN-1 3% AS in the initial infection stage of rich sheath blight （Le., the diseased plant rate was below 5%） reached 80.38%-89.06%, and that in the peak infection stage （i.e., the diseased plant rate was higher than 10%） reached only 41.12%-53.26%. The field efficacy of validamycin A.（0.2 billion spores/ml） P. polymyxa DN-1 3% AS at the early onset of rich sheath blight was significantly better than that at the onset, so that the application time of validamycin A .（0.2 billion spores/ml） P. polymyxa DN-1 3% AS should be appropriately brought forward in the prevention and control of rice sheath blight.
文摘AIM:To evaluate the long-term effect of aerobic and/or anaerobic exercise on glycemic control in youths with type 1 diabetes.METHODS:Literature review was performed in spring and summer 2014 using Pub Med/MEDLINE,Google Scholar,Scopus,and Science Direct with the following terms:aerobic,anaerobic,high-intensity,resistance,exercise/training,combined with glycemic/metabolic control,glycated haemoglobin A1c(Hb A1c) and type 1diabetes.Only peer-reviewed articles in English were included published in the last 15 years.It was selected from 1999 to 2014.Glycemic control was measured with Hb A1 c.Studies with an intervention lasting at least 12 wk were included if the Hb A1 c was measured before and after the intervention.RESULTS:A total of nine articles were found,and they were published between the years of 2002-2011.The sample size was 401 diabetic youths(166 males and 235 females) with an age range of 10-19 years except one study,in which the age range was 13-30 years.Study participants were from Australia,Tunisia,Lithuania,Taiwan,Turkey,Brazilia,Belgium,Egypt and France.Four studies were aerobic-based,four were combined aerobic and anaerobic programs,and one compared aerobic exercise to anaerobic one.Available studies had insufficient evidence that any type of exercise or combined training would clearly improve the glycemic control in type 1 diabetic youth.Only three(two aerobic-based and one combined) studies could provide a significant positive change in glycemic control.CONCLUSION:The regular physical exercise has several other valuable physiological and health benefits that justify the inclusion of exercise in pediatric diabetes treatment and care.
文摘Type 1 diabetes mellitus is associated with celiac disease,with a prevalence that varies between 0.6% and 16.4%,according to different studies.After a diagnosis of celiac disease is confirmed by small bowel biopsy,patients are advised to commence a gluten-free diet(GFD).This dietary restriction may be particularly difficult for the child with diabetes,but in Europe(and in Italy) many food stores have targeted this section of the market with better labeling of products and more availability of specific GFD products.Treatment with a GFD in symptomatic patients has been shown to improve the symptoms,signs and complications of celiac disease.However,the effects of a GFD on diabetic control are less well established.Initial reports of improved hypoglycemic control were based on children who were diagnosed with celiac disease associated with malabsorption,but there have subsequently been reports of improvement in patients with type 1 diabetes with subclinical celiac disease.There are other studies reporting no effect,improved control and an improvement of hypoglycemic episodes.Moreover,in this review we wish to focus on low glycemic index foods,often suggested in people with type 1 diabetes,since they might reduce postprandial glycemic excursion and enhance longterm glycemic control.In contrast,GFD may be rich in high glycemic index foods that can increase the risk of obesity,insulin resistance and cardiovascular disease,worsening the metabolic control of the child with diabetes.Hence,it is important to evaluate the impact of a GFD on metabolic control,growth and nutritional status in children with type 1 diabetes.
基金the State Science and Technology Project of China (No.2001BA204B01).
文摘An iterative optimization strategy is proposed and applied to the steady state optimizing control of the bio-dissimilation process of glycerol to 1,3-propanediol in the presence of model-plant mismatch and input constraints. The scheme is based on the Augmented Integrated System Optimization and Parameter Estimation （AI- SOPE） technique, but a linearization of some performance function in the modified model-based optimization problem of AISOPE is introduced to overcome the difficulty of determining an appropriate penalty parameter. When carrying out the iterative optimization, the penalty coefficient is set to a larger value at the current iteration than at the previous iteration, which can promote the evolution rate of the iterative optimization. Simulation studies illustrate the potential ofthe approach presented for the optimizing control of the bioTdissimilation process of glycerol to 1,3-propanediol. The effects of measurement noise, measured and unmeasured disturbances on the proposed algorithm are also investigated.
文摘BACKGROUND Type 1 diabetes is one of the most common chronic diseases in childhood.The number of type 1 diabetes patients in China still ranks fourth in the world.Therefore,children with type 1 diabetes in China are a group that needs attention.The management of type 1 diabetes mellitus(T1DM)involves many aspects of daily life.It is extremely challenging for children and their families.T1DM children have complex medical care needs.Despite the continuous development of therapeutic medicine and treatment technologies,blood glucose control in children with T1DM is still not ideal.They and their parents need to acquire more knowledge and skills before being discharged.AIM To explore the influence of hospital discharge plan based on parental care needs of children with T1DM on discharge readiness,quality of discharge education and blood glucose control level.METHODS In total,102 parents of children with type 1 diabetes were divided into control group and intervention group according to admission time.Fifty cases from February to June 2019 were selected as the control group,and 52 cases from July to October 2019 were selected as the intervention group to implement the discharge plan.The Readiness for Hospital Discharge Scale,Hospital Discharged Education Quality Scale and children's blood glucose metabolism indicators were used to compare the differences in discharge preparation,discharge education quality and blood glucose control between the two groups of children and their parents.RESULTS On the day of discharge,the two groups of children had the following scores of readiness for discharge:The intervention group score was 225.34±32.47,and the control group score was 208.68±29.31.The P value was 0.007,and the difference was statistically significant.The discharge education quality scores were as follows:The intervention group score was 135.11±19.86,the control group score was 124.13±15.56,the P value was 0.002 and the difference was statistically significant.Three months after discharge,the blood glucose metabolism indicator showed that the glycosylated hemoglobin value of the two groups was(7.45%±1.04%),and that of the control group was(8.04%±1.27%),P=0.012.Therefore,the improvement of parents'readiness for discharge,quality of discharge education and blood glucose metabolism indicators(glycosylated hemoglobin,fasting blood glucose and postprandial blood glucose)in the intervention group were better than those in the control group(P<0.05),and the difference was statistically significant.CONCLUSION The discharge plan for children with T1DM can help the children and their families realize the transition from hospital care to home self-management and improve the parents'readiness for discharge,thereby improving children’s blood glucose control levels.
文摘The genomes of eukaryotic cells are under continuous assault by environmental agents and endogenous metabolic byproducts. Damage induced in DNA usually leads to a cascade of cellular events, the DNA damage response. Failure of the DNA damage response can lead to development of malignancy by reducing the efficiency and fidelity of DNA repair. The NBS1 protein is a component of the MRE11/RAD50/NBS 1 complex （MRN） that plays a critical role in the cellular response to DNA damage and the maintenance of chromosomal integrity. Mutations in the NBS1 gene are responsible for Nijmegen breakage syndrome （NBS）, a hereditary disorder that imparts an increased predisposition to development of malignancy. The phenotypic characteristics of cells isolated from NBS patients point to a deficiency in the repair of DNA double strand breaks. Here, we review the current knowledge of the role of NBS1 in the DNA damage response. Emphasis is placed on the role of NBS1 in the DNA double strand repair, modulation of the DNA damage sensing and signaling, cell cycle checkpoint control and maintenance oftelomere stability.
文摘This paper presents an adaptive control scheme with an integration of sliding mode control into the L1 adaptive control architecture, which provides good tracking performance as well as robustness against matched uncertainties. Sliding mode control is used as an adaptive law in the L1 adaptive control architecture, which is considered as a virtual control of error dynamics between estimated states and real states. Low-pass filtering mechanism in the control law design prevents a discontinuous signal in the adaptive law from appearing in actual control signal while maintaining control accuracy. By using sliding mode control as a virtual control of error dynamics and introducing the low-pass filtered control signal, the chattering effect is eliminated. The performance bounds between the close-loop adaptive system and the closed-loop reference system are characterized in this paper. Numerical simulation is provided to demonstrate the performance of the presented adaptive control scheme.
基金supported by a grant from the National Natural Science Foundation of China (No.30672081)
文摘Angiogenesis in ischemic tissue is a complex and multi-gene event. In the study, we constructed hypoxic re-sponse elements （HRE） and the Tet-On advanced double-controlled systems and investigated their effects on the expression of hVEGF165 and angiopoietin-1 （Ang-1） genes in rat cardiomyocytes exposed to hypoxia and pharma-cologic induction. We infected neonatal rat cardiomyocytes with recombinant rAAV-rtTA-Rs-M2/rAAV-TRE-Tight-Ang-1 and rAAV-9HRE- hVEGF165. Our results indicated that the viral titer was 1×1012 vg /mL and the viral purity exceeded 98%. hVEGF165 expression was induced by hypoxia, but not by normoxia （P 0.001）. Ang-1 expression was evident under doxycycline induction, but undetectable without doxycycline induction （P 0.001）. Immunofluorescence staining showed that positively stained hVEGF165 and Ang-1 protein appeared only under both hypoxia and doxycycline induction. We demonstrate here that HRE and the recombinant Tet-On advanced double gene-controlled systems sensitively regulate the expression of hVEGF165 and Ang-1 genes in an altered oxygen environment and under pharmacological induction in vitro.
基金Project supported by the National Natural Science Foundation of China （Grant No 10647101）.
文摘In this paper a controlled quantum teleportation scheme of an N-particle unknown state is proposed when N groups of three-particle W1 states are utilized as quantum channels. The quantum information of N-particle unknown state is transmitted from the sender to the recipient under the control of all supervisors. It can be realized with a certain probability. After the sender makes Bell-state measurements and the supervisors perform the computational basis measurements, the recipient will introduce auxiliary particles and carry out unitary transformations depending on classical information from the sender and the supervisors. Finally, the computational basis measurement will be performed by the recipient to confirm whether the teleportation succeeds or not. The successful completion of the scheme relies on all supervisors＇ cooperation. In addition, the fidelity and security of the scheme are discussed.
基金Supported by the Natural Science Foundation of Guangdong Province(No.0 314 2 0 ),the Guangzhou City Science andTechnology Project(No.2 0 0 3Z3- D2 0 71) and the Science and Technology Project of Guangdong Province(No.2 0 0 3C335 0 5
文摘A series of LaAl 1-xFe xO 3 catalysts prepared with lanthanum nitrate, aluminium nitrate and iron nitrate was investigated in catalytical syntheses of carbon nanotubes with high yields and purity. The properties of carbon nanotubes prepared by the method of CVD(chemical vapor deposition) with n-hexane as the carbon resource were studied and it was shown that the diameter of carbon nanotubes can be controlled by the molar ratio of iron to aluminum in the catalysts and that the diameter of carbon nanotubes changes a little with the decrease of the iron content in the catalysts. From the TEM pictures of carbon nanotubes, it can be found that the LaAl 1-xFe xO 3 catalysts have a significant influence on the wall thickness of the carbon nanotubes, whereas they have little influence on the inner diameter of the carbon nanotubes.
文摘Objective: Octreotide three times daily is re-ported to reduce daily insulin by 50% in patients with Type 1 DM. Therefore, we assessed the impact of long acting Octreotide (Sandostatin LAR) monthly Intramuscular administration in a subject with Type 1 DM. Methods: A 32-year-old man with Type 1 DM of 16 years participated after obtaining informed consent. He had no microvascular or macrovascular complications. He continued the present insulin regimen for four weeks. IM Sandostatin LAR 20 mg was initiated and increased at four weeks to 30 mg. He was followed every four weeks for six months. Insulin regimen was adjusted every two weeks based on blood glucose before meals, bedtime and on onset of hypoglycemic symptoms. He continued other medications, previous diet and activity Assessment of HbA1c, serum electrolytes, urea nitrogen, creatinine, TSH, free T4, liver enzymes, complete blood cell counts, vitamin B12, lipids and insulin regimen were performed at the initiation and end of the study. Results: HbA1c declined from 9 to 8% with reduction in daily insulin dose from 55 to 43 units, with a major reduction in insulin Glargine, 50 to 40 units. Body weight remained unaltered. Other laboratory tests including gallbladder examina-tion remained unchanged Conclusion: Monthly Sandostatin LAR administration may improve glycemic control with less insulin in Type 1 DM.
基金supported by the Natural Science Basic Research Plan in Shaanxi Province,China(No.2021JQ-214)the Fundamental Research Funds for the Central Universities,China(No.300102251101).
文摘The main task of this work is to design a control system for a small tail-sitter Unmanned Aerial Vehicle(UAV)during the transition process.Although reasonable control performance can be obtained through a well-tuned single PID or cascade PID control architecture under nominal conditions,large or fast time-varying disturbances and a wide range of changes in the equilibrium point bring nonlinear characteristics to the transition control during the transition process,which leads to control precision degradation.Meanwhile,the PID controller’s tuning method relies on engineering experiences to a certain extent and the controller parameters need to be retuned under different working conditions,which limits the rapid deployment and preliminary validation.Based on the above issues,a novel control architecture of L1 neural network adaptive control associated with PID control is proposed to improve the compensation ability during the transition process and guarantee the security transition.The L1 neural network adaptive control is revised to solve the multi-input and multi-output problem of the tail-sitter UAV system in this study.Finally,the transition characteristics of the time setting difference between the desired transition speed and the desired transition pitch angle are analyzed.
