China's Northern and Southern Dynasties period(3rd–6th centuries AD)marked a significant era of ethnic integration in northern China.However,previous ancient DNA studies have primarily focused on northern ethnic ...China's Northern and Southern Dynasties period(3rd–6th centuries AD)marked a significant era of ethnic integration in northern China.However,previous ancient DNA studies have primarily focused on northern ethnic groups,with limited research on the genetic formation of the hereditary elite family,especially considering their abundant archaeological record and clear material identity.In this study,we obtain the ancient genome of a hereditary elite family,Gao Bin(高宾,503 AD–572 AD),at 0.6473-fold coverage with 475,132 single-nucleotide polymorphisms(SNPs)on the 1240k panel.His mitochondrial haplogroup belongs to Z4 and Y-haplogroup to O1a1a2b-F2444∗.The genetic profile of Gao Bin is most similar to that of the northern Han Chinese.He can be modeled as deriving all his ancestry from Late Neolithic to Iron Age Yellow River farmers without influence from Northeast Asia,Korea,or the Mongolian Plateau.Our study sheds light on the genetic formation of hereditary elite families in the context of the Southern and Northern Dynasties ethnic integration.展开更多
The spleen and stomach are the foundation of acquired constitution, and the source of qi and blood production. Therefore, harmonizing the spleen and stomach is of great importance in treatment of diseases. In this pap...The spleen and stomach are the foundation of acquired constitution, and the source of qi and blood production. Therefore, harmonizing the spleen and stomach is of great importance in treatment of diseases. In this paper, based on GAO＇s academic ideas of acupuncture and moxibustion, the different rules of harmonizing the spleen and stomach for internal miscellaneous diseases and carefully supplementing spleen and stomach for externally-contracted diseases were elaborated by starting with the acupoint selection prescriptions and harmonizing the spleen and stomach. In addition, time acupuncture and pattern differentiation moxibustion application and other treatment characteristics were put forward. The experience of professor GAO Yu-chun in acupuncture manipulation of ＂harmonizing the spleen and stomach＂ was summarized in detail from five aspects for learning and reference.展开更多
基金funded by the National Natural Science Foundation of China(32070576,31801040,and 32270667)Lantai Young Scholars Program of Chinese History Institute(2022LTQN602)+11 种基金the National Social Science Fund of China(19VJX074 and 21CKG022)Priority Research Program of the Chinese Academy of Sciences:Pan-Third Pole Environment Study for a Green Silk Road(Pan-TPE)(XDA2004010101)the National Key Research and Development Program(2023YFC3303701-02)the Natural Science Foundation of Fujian Province of China(2023J06013)the Science and Technology Commission of Shanghai Municipality(18490750300)the National Key Research and Development Program(2020YFE0201600)Shanghai Municipal Science and Technology Major Project(2017SHZDZX01)the Major Project of National Social Science Foundation of China granted to C.C.W.(21&ZD285),S.W.(20&ZD212),and D.L.(21&ZD237)Major Special Project of Philosophy and Social Sciences Research of the Ministry of Education(2022JZDZ023)Open Research Fund of State Key Laboratory of Genetic Engineering at Fudan University(SKLGE-2310)Open Research Fund of Forensic Genetics Key Laboratory of the Ministry of Public Security(2023FGKFKT07)European Research Council(ERC)grant(ERC-2019-ADG-883700-TRAM).
文摘China's Northern and Southern Dynasties period(3rd–6th centuries AD)marked a significant era of ethnic integration in northern China.However,previous ancient DNA studies have primarily focused on northern ethnic groups,with limited research on the genetic formation of the hereditary elite family,especially considering their abundant archaeological record and clear material identity.In this study,we obtain the ancient genome of a hereditary elite family,Gao Bin(高宾,503 AD–572 AD),at 0.6473-fold coverage with 475,132 single-nucleotide polymorphisms(SNPs)on the 1240k panel.His mitochondrial haplogroup belongs to Z4 and Y-haplogroup to O1a1a2b-F2444∗.The genetic profile of Gao Bin is most similar to that of the northern Han Chinese.He can be modeled as deriving all his ancestry from Late Neolithic to Iron Age Yellow River farmers without influence from Northeast Asia,Korea,or the Mongolian Plateau.Our study sheds light on the genetic formation of hereditary elite families in the context of the Southern and Northern Dynasties ethnic integration.
基金Supported by Project of Hebei Provincial Science and Technology Department:“Clinical study of the acupuncture manipulation of regulating governor vessel and unblocking brain in treatment of dominant diseases of acupuncture-moxibustion”:14277706D2014 project of scientific research on traditional Chinese medicine of Hebei Provincial Administration of Traditional Chinese Medicine“Study of GAO’s academic ideas of acupuncture and moxibustion”:2014038
文摘The spleen and stomach are the foundation of acquired constitution, and the source of qi and blood production. Therefore, harmonizing the spleen and stomach is of great importance in treatment of diseases. In this paper, based on GAO＇s academic ideas of acupuncture and moxibustion, the different rules of harmonizing the spleen and stomach for internal miscellaneous diseases and carefully supplementing spleen and stomach for externally-contracted diseases were elaborated by starting with the acupoint selection prescriptions and harmonizing the spleen and stomach. In addition, time acupuncture and pattern differentiation moxibustion application and other treatment characteristics were put forward. The experience of professor GAO Yu-chun in acupuncture manipulation of ＂harmonizing the spleen and stomach＂ was summarized in detail from five aspects for learning and reference.
