GAME15, a scaffold protein, orchestrates the biosynthesis of steroidal glycoalkaloids (a class of compounds with known defensive properties) and steroidal saponins (which contribute to plant defense) in Solanaceae pla...GAME15, a scaffold protein, orchestrates the biosynthesis of steroidal glycoalkaloids (a class of compounds with known defensive properties) and steroidal saponins (which contribute to plant defense) in Solanaceae plants, essential for their defense mechanisms. By assembling key enzymes at the endoplasmic reticulum, GAME15 ensures efficient metabolite production, preventing toxic intermediate diffusion. This breakthrough in plant defense biosynthesis opens opportunities for metabolic engineering, enabling the production of valuable metabolites in non-native hosts and offering potential strategies for crop protection, reducing the need for chemical pesticides.展开更多
基金supported by the National Natural Science Foundation of China(31971314)the Open Fund of State Key Laboratory of Tea Plant Biology and Utilization(SKLTOF20210122).
文摘GAME15, a scaffold protein, orchestrates the biosynthesis of steroidal glycoalkaloids (a class of compounds with known defensive properties) and steroidal saponins (which contribute to plant defense) in Solanaceae plants, essential for their defense mechanisms. By assembling key enzymes at the endoplasmic reticulum, GAME15 ensures efficient metabolite production, preventing toxic intermediate diffusion. This breakthrough in plant defense biosynthesis opens opportunities for metabolic engineering, enabling the production of valuable metabolites in non-native hosts and offering potential strategies for crop protection, reducing the need for chemical pesticides.
