GPR126也称ADGRG6,是研究较为深入的黏附类G蛋白偶联受体(adhesion G protein-coupled receptors,aGPCRs)成员之一。最初,GPR126被认为是一种与肌肉发育相关的受体,主要在肌肉和骨骼系统中表达;随着研究的深入,人们发现GPR126在哺乳动...GPR126也称ADGRG6,是研究较为深入的黏附类G蛋白偶联受体(adhesion G protein-coupled receptors,aGPCRs)成员之一。最初,GPR126被认为是一种与肌肉发育相关的受体,主要在肌肉和骨骼系统中表达;随着研究的深入,人们发现GPR126在哺乳动物多个组织和器官中表达,并参与胚胎发育、神经系统发育和细胞外基质相互作用等多种生物学过程。GPR126具有典型的aGPCRs的七次跨膜螺旋结构,可介导跨膜信号转导,参与调控细胞增殖、分化和迁移等多种细胞过程。近年来,GPR126新配体的发现为探索其生理功能提供了有价值的工具。然而,目前GPR126在各类疾病中的生物学功能及其作为治疗靶点的潜力仍待进一步研究。该文重点描述GPR126的结构、物种间差异性与保守性、信号转导及其生物学功能,为未来GPR126的研究提供思路和参考。展开更多
In this paper, we establish the following limiting weak-type behaviors of Littlewood-Paley g-function g_φ: for nonnegative function f∈ L^1(R^n),■and ■where f_t(x) =t^(-n)f(t^(-1) x) for t > 0. Meanwhile, the co...In this paper, we establish the following limiting weak-type behaviors of Littlewood-Paley g-function g_φ: for nonnegative function f∈ L^1(R^n),■and ■where f_t(x) =t^(-n)f(t^(-1) x) for t > 0. Meanwhile, the corresponding results for Marcinkiewicz integral and its fractional version with kernels satisfying L_α~q-Dini condition are also given.展开更多
Membrane technology has been used for H_2 purification. In this paper, the systematic density functional simulations are conducted to study the separation of H_2 from the impurity gases(H_2, N_2, H_2 O, CO, Cl_2, and ...Membrane technology has been used for H_2 purification. In this paper, the systematic density functional simulations are conducted to study the separation of H_2 from the impurity gases(H_2, N_2, H_2 O, CO, Cl_2, and CH_4) by the bilayer porous graphitic carbon nitride(g-C_3 N_4) membrane. Theoretically, the bilayer g-C3 N4 membrane with a diameter of about3.25 A? should be a perfect candidate for H_2 purification from these mixed gases, which is verified by the high selectivity(S) for H_2 over other kinds of gases(3.43 × 1028 for H_2/N2; 1.40 × 1028 for H_262/H_2 O; 1.60 × 10 for H_2/CO; 4.30 × 10^(14) for H_2/Cl_2; 2.50 × 10^(55) for H_2/CH_4), and the permeance(P) of H_2(13 mol/m^2·s·Pa) across the bilayer g-C_3 N_4 membrane at 300 K, which should be of great potential in energy and environmental research. Our studies highlight a new approach towards the final goal of high P and high S molecular-sieving membranes used in simple structural engineering.展开更多
Since the room-temperature detector CdZnTe(CZT) has advantages in terms of detection efficiency,energy resolution, and size, it has been extensively used to detect X-rays and gamma-rays. So far, nuclear radiation dete...Since the room-temperature detector CdZnTe(CZT) has advantages in terms of detection efficiency,energy resolution, and size, it has been extensively used to detect X-rays and gamma-rays. So far, nuclear radiation detectors such as cerium chloride doped with lanthanum bromide(LaBr_3(Ce)), thallium doped with cesium iodide(sI(Tl)), thallium doped with sodium iodide(NaI(Tl)),and high-purity germanium(HPGe) primarily use the spectroscopy-dose rate function(G(E)) to achieve the accurate measurement of air kerma rate(K_a) and ambient dose equivalent rate(H*(10)). However, the spectroscopy-dose rate function has been rarely measured for a CZT detector. In this study, we performed spectrum measurement using a hemispherical CZT detector in a radiation protection standards laboratory. The spectroscopy-dose rate function G(E) of the CZT detector was calculated using the least-squares method combined with the standard dose rate at the measurement position. The results showed that the hemispherical CZT detector could complete the measurement of air kerma rate(K_a) and ambient dose equivalent rate(H*(10)) by using the G(E) function at energies between 48 keV and 1.25 MeV, and the relative intrinsic errors were, respectively, controlled within ± 2. 3 and ± 2. 1%.展开更多
文摘GPR126也称ADGRG6,是研究较为深入的黏附类G蛋白偶联受体(adhesion G protein-coupled receptors,aGPCRs)成员之一。最初,GPR126被认为是一种与肌肉发育相关的受体,主要在肌肉和骨骼系统中表达;随着研究的深入,人们发现GPR126在哺乳动物多个组织和器官中表达,并参与胚胎发育、神经系统发育和细胞外基质相互作用等多种生物学过程。GPR126具有典型的aGPCRs的七次跨膜螺旋结构,可介导跨膜信号转导,参与调控细胞增殖、分化和迁移等多种细胞过程。近年来,GPR126新配体的发现为探索其生理功能提供了有价值的工具。然而,目前GPR126在各类疾病中的生物学功能及其作为治疗靶点的潜力仍待进一步研究。该文重点描述GPR126的结构、物种间差异性与保守性、信号转导及其生物学功能,为未来GPR126的研究提供思路和参考。
文摘In this paper, we establish the following limiting weak-type behaviors of Littlewood-Paley g-function g_φ: for nonnegative function f∈ L^1(R^n),■and ■where f_t(x) =t^(-n)f(t^(-1) x) for t > 0. Meanwhile, the corresponding results for Marcinkiewicz integral and its fractional version with kernels satisfying L_α~q-Dini condition are also given.
基金Project supported by the Fundamental Research Funds for the Central Universities,China(Grant No.2018B19414)the Natural Science Foundation of Jiangsu Province,China(Grant No.BK20161501)+5 种基金the Six Talent Peaks Project in Jiangsu Province,China(Grant No.2015-XCL-010)the National Natural Science Foundation of China(Grant Nos.51776094 and 51406075)the Program of Henan Provincial Department of Education,China(Grant No.16A330004)the Special Fund of Nanyang Normal University,China(Grant No.ZX2016003)the Science and Technology Program of Henan Department of Science and Technology,China(Grant No.182102310609)the Scientific Research and Service Platform Fund of Henan Province,China(Grant No.2016151)
文摘Membrane technology has been used for H_2 purification. In this paper, the systematic density functional simulations are conducted to study the separation of H_2 from the impurity gases(H_2, N_2, H_2 O, CO, Cl_2, and CH_4) by the bilayer porous graphitic carbon nitride(g-C_3 N_4) membrane. Theoretically, the bilayer g-C3 N4 membrane with a diameter of about3.25 A? should be a perfect candidate for H_2 purification from these mixed gases, which is verified by the high selectivity(S) for H_2 over other kinds of gases(3.43 × 1028 for H_2/N2; 1.40 × 1028 for H_262/H_2 O; 1.60 × 10 for H_2/CO; 4.30 × 10^(14) for H_2/Cl_2; 2.50 × 10^(55) for H_2/CH_4), and the permeance(P) of H_2(13 mol/m^2·s·Pa) across the bilayer g-C_3 N_4 membrane at 300 K, which should be of great potential in energy and environmental research. Our studies highlight a new approach towards the final goal of high P and high S molecular-sieving membranes used in simple structural engineering.
基金supported by the National Key Scientific Instruments to Develop Dedicated(Nos.2013YQ090811 and 2016YFF0103800)
文摘Since the room-temperature detector CdZnTe(CZT) has advantages in terms of detection efficiency,energy resolution, and size, it has been extensively used to detect X-rays and gamma-rays. So far, nuclear radiation detectors such as cerium chloride doped with lanthanum bromide(LaBr_3(Ce)), thallium doped with cesium iodide(sI(Tl)), thallium doped with sodium iodide(NaI(Tl)),and high-purity germanium(HPGe) primarily use the spectroscopy-dose rate function(G(E)) to achieve the accurate measurement of air kerma rate(K_a) and ambient dose equivalent rate(H*(10)). However, the spectroscopy-dose rate function has been rarely measured for a CZT detector. In this study, we performed spectrum measurement using a hemispherical CZT detector in a radiation protection standards laboratory. The spectroscopy-dose rate function G(E) of the CZT detector was calculated using the least-squares method combined with the standard dose rate at the measurement position. The results showed that the hemispherical CZT detector could complete the measurement of air kerma rate(K_a) and ambient dose equivalent rate(H*(10)) by using the G(E) function at energies between 48 keV and 1.25 MeV, and the relative intrinsic errors were, respectively, controlled within ± 2. 3 and ± 2. 1%.
