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To explore the mechanism of Fuyang Jiebiao granules against viral pneumonia based on network pharmacology and pharmacodynamics
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作者 TAN Dan-dan FENG Zhenyu +4 位作者 MENG Shuang WANG Xuyan WANG Xin-xin ZHAO Jie ZHAO Jian-ping 《Journal of Hainan Medical University》 CAS 2024年第4期37-46,共10页
Objective:To investigate the mechanism of Fuyang Jiebiao granule(FYJBKL)in the treatment of viral pneumonia.Methods:Firstly,a network model was constructed using network pharmacology to study the target expression sit... Objective:To investigate the mechanism of Fuyang Jiebiao granule(FYJBKL)in the treatment of viral pneumonia.Methods:Firstly,a network model was constructed using network pharmacology to study the target expression sites of FYJBKL viral pneumonia,so as to determine the main targets and important signal transduction pathways for the treatment of viral pneumonia.Secondly,the main components of the drug and the main target are docked.Then,the fever,sweating and inflammation rat models were established to explore the antipyretic,sweating and anti-inflammatory mechanisms of FYJBKL.Finally,the contents of IL-17,IL-1β,TNF-αand IL-6 in blood samples of rats were analyzed by ELISA method,and the morphological changes of lung tissue were observed by HE staining.Results:Quercetin,luteolin,kaempferol,etc.,and the main mechanism targets are IL-17,IL-1β,TNF-α,IL-6 and so on.Thirty signal pathways were identified by KEGG enrichment analysis,including interleukin-17 signaling pathway(IL-17 signaling pathway),human cytomegalovirus infection pathway(human cytomegalovirus infection),Kaposi's sarcoma associated herpesvirus infection pathway(Kaposi's sarcoma-as-sociated herpesvirus infection)and so on.After the study of molecular docking,we found that the contact efficiency between active substances and possible key targets is good.The high and middle concentration groups of FYJBKL significantly decreased the expression of IL-17,IL-1β,TNF-αand IL-6 in the blood of rats with inflammation(P<0.05).FYJBKL significantly reduced the foot swelling induced by egg white and inhibited the increase of body temperature induced by yeast in rats(P<0.05).HE staining showed that FYJBKL improved pulmonary fibrosis and inflammatory exudation to varying degrees.Conclusion:The effects of FuyangJiebiao granules on the related signal pathways of anti-virus,anti-immune and anti-inflammation as well as biological and cellular processes may be caused by the binding of quercetin,luteolin,kaempferol and other active ingredients to their shared targets.Fuyang Jiebiao granules can improve the related symptoms caused by viral pneumonia,and its mechanism may be related to the activities of TNF,IL-17,IL-6 and other related channels,which are multiple targets of inflammation regulation. 展开更多
关键词 FYJBKL granule Network pharmacology PHARMACODYNAMICS Viral pneumonia Molecular docking Jing-fang fuyang
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Application of Fuyang Paper Cutting Art in Cultural and Creative Design from the Perspective of Rural Revitalization
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作者 KANG Wenwen 《Journal of Landscape Research》 2024年第3期59-62,共4页
The application significance of Fuyang paper cutting art in cultural and creative design from the perspective of rural revitalization was discussed,and the implementation principles and specific practices of applying ... The application significance of Fuyang paper cutting art in cultural and creative design from the perspective of rural revitalization was discussed,and the implementation principles and specific practices of applying the elements and techniques of Fuyang traditional paper cutting art in cultural and creative products with local features were analyzed to provide reference for rural revitalization and development of cultural industry. 展开更多
关键词 Rural revitalization fuyang paper cutting Cultural and creative design
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Constructing a New Fuyang─An Interview with Wang Huaizhong, Secretary of the CPC Fuyang Municipal Committee
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《China Today》 1997年第3期14-16,共3页
关键词 CPC An Interview with Wang Huaizhong Constructing a New fuyang Secretary of the CPC fuyang Municipal Committee
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Application of Multi-agent Models to Urban Expansion in Medium and Small Cities: A Case Study in Fuyang City,Zhejiang Province,China 被引量:5
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作者 ZHANG Jing WANG Ke +3 位作者 SONG Gengxin ZHANG Zhongchu CHEN Xinming YU Zhoulu 《Chinese Geographical Science》 SCIE CSCD 2013年第6期754-764,共11页
In this study, three-phase satellite images were used to define rules for the allocation of time and space in construction land resources based on a complex adaptive system and game theory. The decision behavior and r... In this study, three-phase satellite images were used to define rules for the allocation of time and space in construction land resources based on a complex adaptive system and game theory. The decision behavior and rules of government agent, enterprise agent and resident agent in construction land growth were explored. A distinctive and dynamic simulation model of construction land growth was built, which integrated multi-agent, GIS technology and RS data and described the interaction among influencing agents, Taking Fuyang City in the Changjiang River Delta as an example, an assessment process for the remote sensing data in construction land and scenario planning was constructed. Repast and ArcGIS were used as simulation platforms. A simulation of the spatial pattern in land-use planning and the setting of scenario planning were conducted by using the incomplete active game, which was based on different natural, social and economic levels. Through this model, a simulation of urban planning space and decision-making for Fuyang City was created. Relevant non-structured problems arising from urban planning management could be identified, and the process and logic of urban planning spatial decision-making could thus be improved. Cell-by-cell comparison showed that the simulation accuracy was over 72%. This model has great potential for use by government and town planners in decision support and technique support in the policy-making process. 展开更多
关键词 multi-agent system medium and small cities urban expansion game theory fuyang City
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Difference analysis of Doppler ultrasound blood flow of Cunkou(radial artery)pulse,Renying(carotid artery)pulse,and Fuyang(anterior tibial artery)pulse 被引量:1
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作者 WANG Chao WU Qiong +2 位作者 WANG Zhigang WEI Yun XU Shijie 《Journal of Traditional Chinese Medicine》 SCIE CSCD 2023年第1期168-174,共7页
OBJECTIVE:To analyze the Doppler ultrasound blood flow of Renying(carotid artery)pulse,Cunkou(radial artery)pulse,and Fuyang(anterior tibial artery)pulse in the normal group and the functional constipation with gastro... OBJECTIVE:To analyze the Doppler ultrasound blood flow of Renying(carotid artery)pulse,Cunkou(radial artery)pulse,and Fuyang(anterior tibial artery)pulse in the normal group and the functional constipation with gastrointestinal heat(FCGH)group,and to compare and explore the differences of Renying,Cunkou and Fuyang pulses.METHODS:Sixty normal subjects and 60 patients with gastrointestinal heat constipation were collected in the department of ultrasound,Beijing Anzhen Hospital,Capital Medical University.Doppler ultrasound was used to observe the blood flow indexes including maximum systolic velocity(Vp),maximum diastolic velocity(Vd),mean velocity(Vm),pulse index(PI),resistance index(RI),vascular diameter(D),and circulation blood flow cycle(ET)of Renying pulse,Cunkou pulse and Fuyang pulse in the normal group and patients with gastrointestinal heat constipation.The differences of these three pulses were compared between the normal group and the FCGH group.RESULTS:The PI,Vp,Vm,RI,and D of the three pulses in the normal group were statistically significant different(P<0.01).In the comparison of Doppler flow diagram of three pulses in the FCGH group,there were significant differences in PI,Vd,Vp,Vm,RI,and D(P<0.01).CONCLUSION:Under normal conditions,the indexes of Renying pulse Doppler flow diagram,Cunkou pulse Doppler flow diagram,and Fuyang pulse Doppler flow diagram are significantly different.In the FCGH group,most of the indexes of Renying pulse Doppler flow diagram,Cunkou pulse Doppler flow diagram,and Fuyang pulse Doppler flow diagram are different.This result verified the necessity of simultaneous examinations of all Renying,Cunkou,and Fuyang pulses in modern Chinese medicine. 展开更多
关键词 Cunkou pulse Renying pulse fuyang pulse Doppler flow diagram functional constipation gastrointestinal heat type pulse index resistance index
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Seismic identification of channel sandbodies in the Fuyang oil layer in North Songliao Basin, China
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作者 Liu Jinping Wang Yunqing +3 位作者 Yang Maoxin Xie Chunlai Zhao Xiuhong Chen Shumei 《Applied Geophysics》 SCIE CSCD 2007年第2期127-132,共6页
The Fuyang oil-layer in North Songliao Basin is characterized by thin interbedded sands and shales, strong lateral variation, strong reservoir heterogeniety, and so on. The thickness of individual sand layers is gener... The Fuyang oil-layer in North Songliao Basin is characterized by thin interbedded sands and shales, strong lateral variation, strong reservoir heterogeniety, and so on. The thickness of individual sand layers is generally 3 - 5 m. Identifying the channel sand-bodies of the Fuyang oil layer using seismic techniques is very difficult due to the low seismic resolution. Taking the GTZ area as an example, we discuss the genetic characteristics of the channel sand-bodies and point out the real difficulty in using seismic techniques to predict the channel sand-bodies. Two methods for the identification of channels are presented: frequency spectrum imaging and pre-stack azimuthal anisotropy. Identifying the channel sand-bodies in Fuyu oil-layer using the two seismic methods results in a success rate up to 80% compared with well data. 展开更多
关键词 Seismic technique fuyang oil layer channel sand frequency spectrum imaging azimuthal anisotropy
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Inheritance and Development of Fuyang Folk Paper-cut Art: A Case Study of “Cheng’s Paper-cut” Art
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作者 YU Wenshan CHENG Xinghong PAN Jie 《Journal of Landscape Research》 2019年第6期91-96,共6页
Intangible cultural heritage plays a prominent role in local cultural construction and tourism brand building. This paper took Fuyang as an example to expound the origin and development of Fuyang folk paper-cut art, a... Intangible cultural heritage plays a prominent role in local cultural construction and tourism brand building. This paper took Fuyang as an example to expound the origin and development of Fuyang folk paper-cut art, analyzed its characteristics, and put forward some countermeasures and ways of inheritance and development, so as to promote the inheritance, protection and development of intangible cultural heritage. 展开更多
关键词 FOLK PAPER-CUT HERITAGE PROTECTION fuyang
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Quality Standard of Fuyang Wenshen Granules
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作者 Wei CHEN Jing FU +3 位作者 Xiaoxia LI Jinhua LIU Jiabao MA Yueqiang HU 《Medicinal Plant》 CAS 2023年第2期43-45,共3页
[Objectives]To establish the quality standard of Fuyang Wenshen Granules and carry out the routine examination of granule type.[Methods]The particle size,water content,solubility,loading difference and microbial limit... [Objectives]To establish the quality standard of Fuyang Wenshen Granules and carry out the routine examination of granule type.[Methods]The particle size,water content,solubility,loading difference and microbial limit of Fuyang Wenshen Granules were examined,and TLC was used for qualitative identification of Astmgali Radix and Notoginseng Radix Et Rhizoma.[Results]The particle size,water content,solubility,loading difference,and microbial limit of Fuyang Wenshen Granules complied with the relevant provisions of the Pharmacopoeia of the People's Republic of China(2020).The TLC spots of Astmgali Radix and Notoginseng Radix Et Rhizoma were clearly colored,and negative had no interference.[Conclusions]The method was simple,accurate,reliable,specific and reproducible,and can effectively control the quality of Fuyang Wenshen Granules. 展开更多
关键词 fuyang Wenshen Granules Quality control TLC
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Mechanism and Research Progress of Fuyang Huoxue Jiedu Formula against Recurrence of Ulcerative Colitis
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作者 Yi LI Changan ZHOU +2 位作者 Rongrong LI Jiaojiao ZHANG Xingxing YU 《Medicinal Plant》 CAS 2022年第6期95-98,共4页
By introducing the composition and modern pharmacology of Fuyang Huoxue Jiedu Formula,the paper further explored the mechanism and research progress of Fuyang Huoxue Jiedu Formula against recurrence of ulcerative coli... By introducing the composition and modern pharmacology of Fuyang Huoxue Jiedu Formula,the paper further explored the mechanism and research progress of Fuyang Huoxue Jiedu Formula against recurrence of ulcerative colitis(UC).The formula can effectively improve the TCM syndromes of UC patients,reduce the recurrence rate,and improve clinical efficacy and patients’quality of life. 展开更多
关键词 fuyang Huoxue Jiedu Formula Ulcerative colitis(UC) Traditional Chinese medicine(TCM) RECURRENCE Research progress
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Clinical Effect of Fuyang Prescription in Treatment of Ischemic Stroke during the Convalescent Stage:An Analysis of 25 Cases
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作者 Menghua WEI Xiaoping MEI +5 位作者 Xueni MO Kaihua WANG Ying CHEN Min ZOU Jianlong SHU Yang ZHAI 《Medicinal Plant》 CAS 2022年第5期70-73,共4页
[Objectives]The paper was to investigate the clinical effect of Fuyang prescription in the treatment of yang deficiency syndrome in the convalescent stage of ischemic stroke(IS)and its mechanism of action.[Methods]A t... [Objectives]The paper was to investigate the clinical effect of Fuyang prescription in the treatment of yang deficiency syndrome in the convalescent stage of ischemic stroke(IS)and its mechanism of action.[Methods]A total of 50 patients with yang deficiency syndrome in the convalescent stage of IS were randomly divided into treatment group and control group,with 25 patients in each group.The patients in the treatment group were given basic treatment combined with Fuyang prescription,and those in the control group were given basic treatment combined with Buyang Huanwu decoction;the course of treatment was 28 d for both groups.The activities of daily living(ADL)score,National Institutes of Health Stroke Scale(NIHSS)score,quality of life score,TCM syndrome score,and safety in both groups were observed before treatment and at 14 and 28 d post treatment,and their clinical outcome was evaluated.[Results]There was a significant difference in overall response rate between the treatment group and the control group[92.00%(23/25)vs 76.00%(19/25),P<0.05].After treatment,both groups had significant changes in ADL score,NIHSS score,quality of life score,and TCM syndrome score,and there were significant differences in these indices between the two groups at the same time point after treatment(P<0.05 or P<0.01).There were no significant changes in routine blood,routine stool,routine urine,and liver/renal function in either group after treatment.[Conclusions]Fuyang prescription has a marked clinical effect in the treatment of yang deficiency syndrome in the convalescent stage of IS,with significantly better clinical effect than Buyang Huanwu decoction,and it provides clinical evidence for the traditional Chinese medicine theory of yang supporting in the treatment of IS in the convalescent stage. 展开更多
关键词 Convalescent stage of ischemic stroke fuyang prescription Buyang Huanwu decoction
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Fuyang Welcomes Investors From Abroad
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作者 Wang Huaizhong,Secretary of CPCLuyang Municipal CommitteeLi Hezhong,Mayor of Fuyang 《China's Foreign Trade》 1996年第8期50-51,共2页
Fuyang is located in the northwesternpart of Anhui Province,bordering theHuai River to the south and adjoiningCentral China to the north.With a populationof 13.33 million,the city covers and area of18,169 square km an... Fuyang is located in the northwesternpart of Anhui Province,bordering theHuai River to the south and adjoiningCentral China to the north.With a populationof 13.33 million,the city covers and area of18,169 square km and has jurisdiction overseven counties and three districts.It is one ofthe largest cities in the country,with itspopulation,area of farmland and output ofgrains all accounting for one percent of thenation’s total respectively. The Beijing-Kowloon railway runsfor 192 km long through the city’s area.Oneof the country’s six largest hubs of rail traffic,the Fuyang railway hub boasts an array of244 parallel tracks laid in its marshallingyard with a daily handling capacity of morethan 10,000 trains and cars.Its 展开更多
关键词 THAN MORE fuyang Welcomes Investors From Abroad
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Anhui Fuyang Pharmaceutical Works
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《China's Foreign Trade》 1996年第8期56-56,共1页
Established in 1970,the Fuyang PharmaceuticalWorks is a large pharmaceutical and chemicalenterprise with complete category of products,including citric acid,infusion fluid,tablets,capsules,lotion and health products;i... Established in 1970,the Fuyang PharmaceuticalWorks is a large pharmaceutical and chemicalenterprise with complete category of products,including citric acid,infusion fluid,tablets,capsules,lotion and health products;it is also one of China’s top100 pharmaceutical enterprises,one of Anhui’s top100 best enterprises,Anhui’s new high-tech enterpriseand Anhui’s important export enterprise withautonomous import and export rights. The factory has a staff of 1168,including 展开更多
关键词 HIGH ACID Anhui fuyang Pharmaceutical Works
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Anhui Fuyang Economic and Technological Development Area
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《China's Foreign Trade》 1996年第8期51-51,共1页
The Fuyang Economic and TechnologicalDevelopment area(FETDA) is aprovincial development area approvedby the Anhui provincial government.Situatedin the south of the city,the area is close to theold town in the north an... The Fuyang Economic and TechnologicalDevelopment area(FETDA) is aprovincial development area approvedby the Anhui provincial government.Situatedin the south of the city,the area is close to theold town in the north and bordering to thesouth the outer ring road,and the Beijing-Kowloon railway in the east.To the southeastis the large freight terminal of the railway.And the Xiqinghe River runs along its westernborder.It is four km away from Fuyangairport and national highway 105 and theFuyang-Yingzhou highway run through thearea,which covers a total area of eight sqkm. With all kinds of public facilities,thearea will be operated in line with 展开更多
关键词 Anhui fuyang Economic and Technological Development Area
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Fuyang,a Land for Investment
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《China Today》 1997年第3期17-18,共2页
关键词 fuyang a Land for Investment
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Land subsidence analysis of Fuyang sluice in Ying river
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《Global Geology》 1998年第1期13-13,共1页
关键词 Land subsidence analysis of fuyang sluice in Ying river
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Development Characteristics,Problems and Recommendations of Sweet Potato Industry in Fuyang City
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作者 Zemin FAN Xinliang LIU +3 位作者 Yuling ZHU Xiumei WANG Xiaolu JIANG Fengwu XING 《Asian Agricultural Research》 2013年第12期45-48,共4页
The development of sweet potato industry in Fuyang City takes on following characteristics:increase in planting area of specialized households and professional cooperatives;increase in production input and yield;const... The development of sweet potato industry in Fuyang City takes on following characteristics:increase in planting area of specialized households and professional cooperatives;increase in production input and yield;constant optimization of planting varieties;diversified planting modes.Sweet potato industry has made significant contribution to Fuyang City:(1)enriching types of agricultural products and promoting healthy diet;(2)driving development of agricultural product processing industry and increasing the employment rate of rural labor;(3)increasing financial revenue and rate of export-making foreign exchange of agricultural products;(4)increasing farmers'income and promoting new socialist countryside construction.In line with comparative advantages and existing problems of sweet potato industry in Fuyang City,it presents corresponding industrial development recommendations. 展开更多
关键词 SWEET POTATO INDUSTRIAL development RECOMMENDATION
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Efficacy and mechanism of Fuyang Yiyin method in pulmonary fibrosis based on the theory of“Yang transforming into Qi,Yin constituting form”
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作者 Zihan Wang Yuejie Bai +5 位作者 Shuang Li Meng Dong Shengjun Sun Yuxiao Gou Wenjie Chen Xinyue Zhang 《Journal of Clinical Technology and Theory》 2024年第1期6-12,共7页
Idiopathic pulmonary fibrosis(IPF)is a common pathological manifestation of various pulmonary diseases,characterized by insidious onset and progression to irreversible organ failure.Currently,there are still inadequac... Idiopathic pulmonary fibrosis(IPF)is a common pathological manifestation of various pulmonary diseases,characterized by insidious onset and progression to irreversible organ failure.Currently,there are still inadequacies in the diagnosis and treatment of IPF.Traditional Chinese medicine(TCM)can intervene in IPF at multiple levels,targets,and pathways,possessing significant advantages in the treatment of IPF.The underlying mechanisms deserve further exploration.The theory of“Yang Transforming into Qi,Yin Constituting Form”in Huangdi Neijing embodies the specific meanings of yin and yang,containing profound views on life and disease.The pathological changes of IPF conform to the theory of yin and yang in“Yang Transforming into Qi,Yin Constituting Form”,where deficiency of yang transforming into qi and excessive formation of yin constitute the core pathogenesis of IPF.This paper proposes the principle of Fuyang Yiyin for IPF,aiming to nourish the source of fire and dispel yin turbidity,in order to broaden the clinical treatment strategies for IPF. 展开更多
关键词 Yang transforming into Qi Yin constituting form pulmonary fibrosis fuyang Yiyin
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扶阳及其学派时间轴线与空间尺度延拓考 被引量:1
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作者 刘立安 孙永章 +4 位作者 李海霞 孟月 王泽桐 王育林 周立群 《中医药导报》 2025年第1期208-212,236,共6页
从中医扶阳学派传承研究切入,在医文互鉴视域下,考证了中医学与中华文明中的扶阳及相关思想,将扶阳之说从清代郑钦安追溯至《后汉书》,并钩沉其先秦易道渊源。“扶”的本义是“辅佐”,辅佐阳气又包含着补阳、温阳、通阳、化阳、回阳、... 从中医扶阳学派传承研究切入,在医文互鉴视域下,考证了中医学与中华文明中的扶阳及相关思想,将扶阳之说从清代郑钦安追溯至《后汉书》,并钩沉其先秦易道渊源。“扶”的本义是“辅佐”,辅佐阳气又包含着补阳、温阳、通阳、化阳、回阳、潜阳等多元化方法之指向,梳理并延展了扶阳及其学派、学术传承的时间轴线,并窥得扁鹊学脉与命门学说为扶阳传承中的关键之处。进而在扶阳传承溯源基础上,参合易道传承,立足医道融通范畴,综合道家与道教的修行与辅行、医家的少火与壮火,重释所扶之“阳”的生理与病理内涵。扶阳之“阳”,既是修道之阳,也是为医之阳,既是生理之阳,又是病理之阳。勾勒出人体生命“火寄水中”的“阴平阳秘”平衡态与以“阳主阴从”为“角力”的恒动态。重新考察了灼艾、丹药、附子等扶阳干预方法的“阳气资源配置优化”“阳气资源补充再生”定位,拓展了中医扶阳的空间尺度。 展开更多
关键词 扶阳 扶阳学派 火神派 中医溯源 扁鹊学脉 命门学说 医道融通 文献考证
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扶阳罐联合复方大血藤液保留灌肠治疗SPID慢性盆腔痛的疗效观察
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作者 杨丹 易蓉 +3 位作者 全昆 戈维 屈赵 叶攀 《时珍国医国药》 北大核心 2025年第15期2906-2911,共6页
目的观察扶阳罐联合复方大血藤液保留灌肠治疗盆腔炎性疾病后遗症(SPID)慢性盆腔痛的临床疗效。方法选取2023年1月至2024年6月该院收治的SPID慢性盆腔痛患者110例。随机分入对照组和观察组,每组55例。两组均口服桂枝茯苓胶囊治疗,观察... 目的观察扶阳罐联合复方大血藤液保留灌肠治疗盆腔炎性疾病后遗症(SPID)慢性盆腔痛的临床疗效。方法选取2023年1月至2024年6月该院收治的SPID慢性盆腔痛患者110例。随机分入对照组和观察组,每组55例。两组均口服桂枝茯苓胶囊治疗,观察组加用扶阳罐联合复方大血藤液保留灌肠治疗。治疗3个月经周期后,评估两组患者的临床疗效、疼痛程度、中医证候积分、炎症因子水平、盆腔血流动力学指标和治疗安全性。结果观察组总有效率94.55%(52/55),对照组总有效率80.00%(44/55),观察组疗效优于对照组(P<0.05)。治疗后,两组患者下腹部VAS评分、腰骶部VAS评分和Mc Cormack量表评分降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,两组患者中医证候各项积分下降(P<0.05),且观察组低于对照组(P<0.05)。治疗后,两组患者血清IL-6、TNF-α、MCP-1水平降低(P<0.05),且观察组低于对照组(P<0.05)。治疗后,两组患者血清TGF-β1水平升高(P<0.05),且观察组高于对照组(P<0.05)。治疗后,两组患者PI和RI下降、PSV增加(P<0.05),且观察组PI和RI低于对照组、PSV高于对照组(P<0.05)。治疗期间,观察组、对照组患者不良反应发生率分别为3.64%(2/55)、5.45%(3/55),组间差异无统计学意义(P>0.05)。结论扶阳罐联合复方大血藤液保留灌肠治疗气滞血瘀型SPID慢性盆腔痛的临床效果良好,能有效缓解疼痛,减轻炎症,促进盆腔血流恢复,且具有较高的安全性。 展开更多
关键词 扶阳罐 复方大血藤液 保留灌肠 盆腔炎性疾病后遗症 慢性盆腔痛
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扶阳解毒颗粒对HIV感染者免疫细胞及炎症因子的影响分析
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作者 刘晶晶 杨欣怡 +3 位作者 苏琛 吴亚梅 张毅 彭鑫 《四川中医》 2025年第2期202-206,共5页
目的:观察扶阳解毒颗粒对艾滋病病毒(HIV)感染者免疫细胞及炎症因子的影响。方法:纳入104例患者随机分为治疗组(52例)和对照组(52例),治疗组给予扶阳解毒颗粒^(+)高效抗反转录病毒治疗,对照组给予扶阳解毒颗粒模拟剂^(+)高效抗反转录病... 目的:观察扶阳解毒颗粒对艾滋病病毒(HIV)感染者免疫细胞及炎症因子的影响。方法:纳入104例患者随机分为治疗组(52例)和对照组(52例),治疗组给予扶阳解毒颗粒^(+)高效抗反转录病毒治疗,对照组给予扶阳解毒颗粒模拟剂^(+)高效抗反转录病毒治疗,疗程48周,观察两组患者治疗前、48周后HIV患者病毒载量、免疫细胞及炎症因子的变化情况。结果:治疗48周,试验组CD8^(+)T细胞显著下降,CD4^(+)/CD8^(+)比值、IL-17、TNF-α、IFN-γ明显上升,差异有统计学意义;对照组IL-17、IFN-γ明显上升,差异有统计学意义;与对照组相比,试验组IL-17明显上升,差异有统计学意义(P<0.05)。相关性分析显示,试验组HIV病毒载量与CD4^(+)T细胞、CD4^(+)/CD8^(+)比值呈负相关,CD4^(+)/CD8^(+)比值与TNF-α呈正相关,与CD8^(+)T细胞呈负相关,IL-4与IL-17、TNF-α、IFN-γ呈正相关(P<0.05)。对照组HIV病毒载量与CD4^(+)T细胞、CD4/CD8比值呈负相关,CD4^(+)T细胞与CD8^(+)T细胞、CD4^(+)/CD8^(+)比值、NK细胞呈正相关,CD4^(+)/CD8^(+)比值与IL-4、TNF-α呈正相关;IL-4与IL-17、TNF-α、IFN-γ呈正相关(P<0.05)。结论:与单纯HAART相比,扶阳解毒颗粒联合HAART对HIV感染者的免疫调节作用更好,且呈现多靶点的特点。 展开更多
关键词 扶阳解毒颗粒 HIV 免疫细胞 炎症因子
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