Article continues and complements our previous articles on the HM16 ether (ETH) model. Here, we describe the mechanism of occurrence of the submicroparticle (SMP). A general hypothesis, HFVI, is introduced for the mod...Article continues and complements our previous articles on the HM16 ether (ETH) model. Here, we describe the mechanism of occurrence of the submicroparticle (SMP). A general hypothesis, HFVI, is introduced for the modalities of interaction between two SMPs, based on periodic mechanical percussion forces, produced by fundamental vibrations FVs. A mechanism for describing the interaction between a SMPs and the ETH is presented. Positive and negative particles are defined by their membrane types of movement, such as +, <span style="white-space:nowrap;">−</span><em>u</em>/+, <span style="white-space:nowrap;">−</span><em>v</em> vibrations, and rotations at speeds +<span style="white-space:nowrap;">Ω</span>/<span style="white-space:nowrap;">−</span><span style="white-space:nowrap;">Ω</span>. The process of creating a pair of SMPs is discussed. Applying HFVI to the interaction between pairs of SMPs immobile in ETH, and considering longitudinal FVL, was obtained the forces of attraction/repulsion +<em>F</em><sub><em>L</em>21</sub>/–<em>F<sub>L</sub></em><sub>21</sub>, which correspond to the completed Coulomb force<em> F<sub>CC</sub></em> including gravitation. The resultant <em>F</em><sub>RL21</sub> will form an oriented field of forces, which is a quasielectric field <em>QE</em>, equivalent to actual <em>E</em> electric field. Considering transversal FVT, was obtained the vibratory forces +, <span style="white-space:nowrap;">−</span><em>F<sub>T</sub></em><sub>21</sub>, whose resultant forms an vibrating field of forces, <em>QHs</em>, a quasimagnetic special field, which may explain some of the quantum properties of SMPs. Considering a mobile SMP, two new<em> <span style="white-space:nowrap;">γ</span></em> strains in ETH appear. Strains <em><span style="white-space:nowrap;">γ</span><sub>L</sub></em> are created by the displacement of SMP with velocity<em> V</em>, whose force +, <span style="white-space:nowrap;">−</span><em>F<sub>T</sub></em><sub>12</sub> is the support of a component of the magnetic field <em>H</em> (quasimagnetic field <em>QH</em>), giving the <em>QH<sub>L</sub></em> component. Strains <em>γ</em><sub>R</sub> are created by the rotation of SMP with speed <span style="white-space:nowrap;">Ω</span>, whose force +, <span style="white-space:nowrap;">−</span><em>F</em><sub>R12</sub> constitutes physical support of the component <em>QH<sub>R</sub></em> of magnetic field <em>H </em>(<em>i.e. QH)</em><em></em>. The creation of a photon PH is modelled as a special ESMP containing two zones of opposed rotations, and a mechanism is presented for its movement in the ETH with speed <em>c</em> based on the HS hypothesis of screwing in ETH, with frequency <em>ν</em>.展开更多
Background:A novel data-driven Boolean model,namely,the fundamental Boolean model(FBM),has been proposed to draw genetic regulatory insights into gene activation,inhibition,and protein decay,published in 2018.This nov...Background:A novel data-driven Boolean model,namely,the fundamental Boolean model(FBM),has been proposed to draw genetic regulatory insights into gene activation,inhibition,and protein decay,published in 2018.This novel Boolean model facilitates the analysis of the activation and inhibition pathways.However,the novel model does not handle the situation well,where genetic regulation might require more time steps to complete.Methods:Here,we propose extending the fundamental Boolean modelling to address the issue that some gene regulations might require more time steps to complete than others.We denoted this extension model as the temporal fundamental Boolean model(TFBM)and related networks as the temporal fundamental Boolean networks(TFBNs).The leukaemia microarray datasets downloaded from the National Centre for Biotechnology Information have been adopted to demonstrate the utility of the proposed TFBM and TFBNs.Results:We developed the TFBNs that contain 285 components and 2775 Boolean rules based on TFBM on the leukaemia microarray datasets,which are in the form of short-time series.The data contain gene expression measurements for 13 GC-sensitive children under therapy for acute lymphoblastic leukaemia,and each sample has three time points:0 hour(before GC treatment),6/8 hours(after GC treatment)and 24 hours(after GC treatment).Conclusion:We conclude that the proposed TFBM unlocks their predecessor’s limitation,Le.,FBM,that could help pharmaceutical agents identify any side effects on clinic-related data.New hypotheses could be identified by analysing the extracted fundamental Boolean networks and analysing their up-regulatory and down-regulatory pathways.展开更多
文摘Article continues and complements our previous articles on the HM16 ether (ETH) model. Here, we describe the mechanism of occurrence of the submicroparticle (SMP). A general hypothesis, HFVI, is introduced for the modalities of interaction between two SMPs, based on periodic mechanical percussion forces, produced by fundamental vibrations FVs. A mechanism for describing the interaction between a SMPs and the ETH is presented. Positive and negative particles are defined by their membrane types of movement, such as +, <span style="white-space:nowrap;">−</span><em>u</em>/+, <span style="white-space:nowrap;">−</span><em>v</em> vibrations, and rotations at speeds +<span style="white-space:nowrap;">Ω</span>/<span style="white-space:nowrap;">−</span><span style="white-space:nowrap;">Ω</span>. The process of creating a pair of SMPs is discussed. Applying HFVI to the interaction between pairs of SMPs immobile in ETH, and considering longitudinal FVL, was obtained the forces of attraction/repulsion +<em>F</em><sub><em>L</em>21</sub>/–<em>F<sub>L</sub></em><sub>21</sub>, which correspond to the completed Coulomb force<em> F<sub>CC</sub></em> including gravitation. The resultant <em>F</em><sub>RL21</sub> will form an oriented field of forces, which is a quasielectric field <em>QE</em>, equivalent to actual <em>E</em> electric field. Considering transversal FVT, was obtained the vibratory forces +, <span style="white-space:nowrap;">−</span><em>F<sub>T</sub></em><sub>21</sub>, whose resultant forms an vibrating field of forces, <em>QHs</em>, a quasimagnetic special field, which may explain some of the quantum properties of SMPs. Considering a mobile SMP, two new<em> <span style="white-space:nowrap;">γ</span></em> strains in ETH appear. Strains <em><span style="white-space:nowrap;">γ</span><sub>L</sub></em> are created by the displacement of SMP with velocity<em> V</em>, whose force +, <span style="white-space:nowrap;">−</span><em>F<sub>T</sub></em><sub>12</sub> is the support of a component of the magnetic field <em>H</em> (quasimagnetic field <em>QH</em>), giving the <em>QH<sub>L</sub></em> component. Strains <em>γ</em><sub>R</sub> are created by the rotation of SMP with speed <span style="white-space:nowrap;">Ω</span>, whose force +, <span style="white-space:nowrap;">−</span><em>F</em><sub>R12</sub> constitutes physical support of the component <em>QH<sub>R</sub></em> of magnetic field <em>H </em>(<em>i.e. QH)</em><em></em>. The creation of a photon PH is modelled as a special ESMP containing two zones of opposed rotations, and a mechanism is presented for its movement in the ETH with speed <em>c</em> based on the HS hypothesis of screwing in ETH, with frequency <em>ν</em>.
文摘Background:A novel data-driven Boolean model,namely,the fundamental Boolean model(FBM),has been proposed to draw genetic regulatory insights into gene activation,inhibition,and protein decay,published in 2018.This novel Boolean model facilitates the analysis of the activation and inhibition pathways.However,the novel model does not handle the situation well,where genetic regulation might require more time steps to complete.Methods:Here,we propose extending the fundamental Boolean modelling to address the issue that some gene regulations might require more time steps to complete than others.We denoted this extension model as the temporal fundamental Boolean model(TFBM)and related networks as the temporal fundamental Boolean networks(TFBNs).The leukaemia microarray datasets downloaded from the National Centre for Biotechnology Information have been adopted to demonstrate the utility of the proposed TFBM and TFBNs.Results:We developed the TFBNs that contain 285 components and 2775 Boolean rules based on TFBM on the leukaemia microarray datasets,which are in the form of short-time series.The data contain gene expression measurements for 13 GC-sensitive children under therapy for acute lymphoblastic leukaemia,and each sample has three time points:0 hour(before GC treatment),6/8 hours(after GC treatment)and 24 hours(after GC treatment).Conclusion:We conclude that the proposed TFBM unlocks their predecessor’s limitation,Le.,FBM,that could help pharmaceutical agents identify any side effects on clinic-related data.New hypotheses could be identified by analysing the extracted fundamental Boolean networks and analysing their up-regulatory and down-regulatory pathways.
