Alkali-soluble associative latex thickeners modified with hydrophobic long chain alkyl groups were prepared using common acrylics and varying amount of a functional monomer,ethoxylated behenyl methacrylate(BEM),throug...Alkali-soluble associative latex thickeners modified with hydrophobic long chain alkyl groups were prepared using common acrylics and varying amount of a functional monomer,ethoxylated behenyl methacrylate(BEM),through emulsion polymerization.It was found that the size of the emulsion particle became larger with addition of BEM.The light transmittance of the thickener latex sharply increased with pH varied from 6 to 7.The associative latex thickener manifested a higher viscosity when solids in the latex thickeners were kept at 0.5 wt%or higher,and the optimal amount of BEM was found to be around 2.5 wt%,or 0.16 mol%.All thickener latexes modified with BEM have better shearing resistance than the BEM-free thickener.展开更多
A molecular modeling approach was used to elucidate template-monomer interaction and the effect of solvent on the recognition of molecularly imprinted polymers （MIPs）. Ciprofloxacin （CIP） was taken as the template...A molecular modeling approach was used to elucidate template-monomer interaction and the effect of solvent on the recognition of molecularly imprinted polymers （MIPs）. Ciprofloxacin （CIP） was taken as the template molecule. The methacrylic acid （MAA）, 4-vinyl pyridine （4-Vpy）, acrylamide （AAM）, and 2-（trifluoromethyl） acrylic acid （TFMAA） were taken as the functional monomers, respectively. Density functional theory （DFT） at the LC-WPBE/6-31g（d,p） level has been adopted to investigate the geometry optimization. The NBO charge and the binding energies of CIP with the monomers were carried out. The molecular imprinting mechanism of CIP and the monomers as well as the influence of solvent was also discussed. Results indicate that CIP and the monomers are matchable in steric structure and chemical groups lead to ordered compounds. The interaction between CIP and TFMAA is the strongest, and when the ratio of CIP-TFMA_A is 1：6, the polymer has the lowest energy in toluene. The computational approach has been applied to provide details of interactions between CIP and the monomers. This research will hopefully shed light on the future study of CIP-MIPs.展开更多
Polystyrene microspheres with sulfo- or aldehyde- surface were synthesized through dispersion polymerization. Functional polystyrene fluorescent microspheres were prepared by the way of adding 2, 5-diphenyloxazole (P...Polystyrene microspheres with sulfo- or aldehyde- surface were synthesized through dispersion polymerization. Functional polystyrene fluorescent microspheres were prepared by the way of adding 2, 5-diphenyloxazole (PPO) into the reaction system directly and dying the blank microspheres in the ethanol solution of PPO. The influence of preparing matters on the encapsulating rate of PPO, and the influence of functional groups on the adsorbability to human serum albumin (HSA) were investigated.展开更多
Functional monomer (MP)_2PT having tertiary aromatic amino group was systhesized from the reaction of N, N-di (2-hydroxypropyl)-p-toluidine with 2-methyl acryloyl chloride. In the presence of organic peroxide, the rad...Functional monomer (MP)_2PT having tertiary aromatic amino group was systhesized from the reaction of N, N-di (2-hydroxypropyl)-p-toluidine with 2-methyl acryloyl chloride. In the presence of organic peroxide, the radical polymerization of (MP)_2PT in toluene took place. The kinetics of (MP)_2PT polymerization and the ESR spectra of LPO-(MP)2PT-MNP systems were determined respectively.展开更多
A new molecularly imprinted polymer was synthesized with malachite green (MG) as molecular template, methacrylic acid (MAA) as functional monomer, ethylene dimethacrylate (EDMA) as crosslinker, and azobisisobutyronitr...A new molecularly imprinted polymer was synthesized with malachite green (MG) as molecular template, methacrylic acid (MAA) as functional monomer, ethylene dimethacrylate (EDMA) as crosslinker, and azobisisobutyronitrile (AIBN) as initiator. Recognition properties of the MG imprinted polymer were studied by equilibrium adsorption and HPLC. The results showed that the imprinted polymer had good affinity and marked selectivity for MG, and can separate MG with its analogue commendably. The new polymer can be used for the enrichment of MG in complex sample, and can work as separation media to separate and detect MG by HPLC.展开更多
In order to investigate the association of fibrin monomer polymerization function (FMPF) with traditional cerebrovascular risk factors and ischemic cerebrovascular disease in old people. 1∶1 paired case-control compa...In order to investigate the association of fibrin monomer polymerization function (FMPF) with traditional cerebrovascular risk factors and ischemic cerebrovascular disease in old people. 1∶1 paired case-control comparative study was performed for FMPF and traditional cerebrovascular risk factors on 110 cases of old ischemic cerebrovascular disease and 110 controls matched on age, sex and living condition. The results showed that cerebrovascular risk factors were more prevalent in case group than in control group. In the case group, FMPF was significantly higher than in control group. There was a significant positive correlation between hypertension and fibrin monomer polymerization velocity (FMPV), hypertension and fibrinogen (Fbg), alcohol consumption and Fbg, but no significant correlation between diabetic mellitus, smoking and FMPF was found. Among the parameters of blood lipids, there were significant positive correlations between total cholesterol (TC) and parameters of FMPF to varying degrees, triglycerides (TG) and FMPV, TG and Fbg. Our results also showed there were significant linear trends between TC and FMPV (P<0. 001), TC and Fbg (P=0. 0087), TG and FMPV/Amax (maximum absorbance)(P=0. 0143) respectively. Multiple logistic regression analysis revealed that FMPF in case group remained significantly higher than control group after adjustment of all risk factors that were significant in univariate analysis. It was concluded that there is a possible pathophysiological link between FMPF and cerebrovascular risk factors. An elevated FMPF is associated with ischemic cerebrovascular disease and an independent risk factor of this disease. In old people, detection of FMPF might be a useful screening to identify individuals at increased cerebrothrombotic risk.展开更多
Creating artificial receptors that can recognize sulfonated anions in water is a difficult task,and employing these receptors to extract sulfonated surfactants and pollutants from water is extremely challenging.We rep...Creating artificial receptors that can recognize sulfonated anions in water is a difficult task,and employing these receptors to extract sulfonated surfactants and pollutants from water is extremely challenging.We report the synthesis of molecularly imprinted polymers(MIPs)using a stoichiometric sub-structure imprinting approach.The binding pocket of the receptor was generated by the polymerization of a complex of phenylsulfonic acid(PSA)and tweezer-type functional monomers featuring parallel two imidazolium sites.The complexation and stoichiometry of the bisimidazolium monomer with PSA was evaluated by UV and ^(1)H NMR titrations in the pre-polymerization solvents supported by modeling.Further,we studied the solubility and affinity of the imidazolium monomers with PSA easily tuned by counter anions.We report that the large number of comonomers containing hydroxyl groups around the binding pocket improve the water compatibility and capacity of the imprinted receptors.Finally,we have demonstrated the potential applications of PSA imprinted material by rebinding larger molecules with PSA substructure such as benzyl orange,methyl orange,and linear alkylbenzene sulfonates(LAS).The PSA MIP showed binding capacity around 60μmol g^(−1) and affinity with an imprinted factor of two in the solvents containing≥50%water for benzyl orange dye.The developed MIP-based receptors bind sulfonated dyes within 10 min in aqueous environments.Further we demonstrated an MIP-based receptor able to capture LAS from commercial grade sodium dodecyl sulfate and confirmed this by MS measurements.展开更多
Two molecularly imprinted polymers binding to analgesic acetanilide were prepared using either dual functional monomers of calix[4]arene derivative and acrylamide or single monomer acrylamide, respectively. The polyme...Two molecularly imprinted polymers binding to analgesic acetanilide were prepared using either dual functional monomers of calix[4]arene derivative and acrylamide or single monomer acrylamide, respectively. The polymers were ground, sieved and investigated by equilibrium binding experiment to evaluate their recognition properties for the template and other substrates. Scatchard analysis showed that homogeneous recognition sites were formed in the imprinted polymer matrix. Our results demonstrated that the polymer using two functional monomers exhibited better selectivity for the template. This study may open new frontiers for the development and application of imprinted polymers, such as drug separation and purification.展开更多
文摘Alkali-soluble associative latex thickeners modified with hydrophobic long chain alkyl groups were prepared using common acrylics and varying amount of a functional monomer,ethoxylated behenyl methacrylate(BEM),through emulsion polymerization.It was found that the size of the emulsion particle became larger with addition of BEM.The light transmittance of the thickener latex sharply increased with pH varied from 6 to 7.The associative latex thickener manifested a higher viscosity when solids in the latex thickeners were kept at 0.5 wt%or higher,and the optimal amount of BEM was found to be around 2.5 wt%,or 0.16 mol%.All thickener latexes modified with BEM have better shearing resistance than the BEM-free thickener.
基金Supported by the Natural Science Foundation of Jilin Province (No. 201215180)the Science and Technology Research Projects for Education Department of Jilin Province (No. 201359)Science and Technology Development Plan of Jilin Province (No. 20130206099sf)
文摘A molecular modeling approach was used to elucidate template-monomer interaction and the effect of solvent on the recognition of molecularly imprinted polymers （MIPs）. Ciprofloxacin （CIP） was taken as the template molecule. The methacrylic acid （MAA）, 4-vinyl pyridine （4-Vpy）, acrylamide （AAM）, and 2-（trifluoromethyl） acrylic acid （TFMAA） were taken as the functional monomers, respectively. Density functional theory （DFT） at the LC-WPBE/6-31g（d,p） level has been adopted to investigate the geometry optimization. The NBO charge and the binding energies of CIP with the monomers were carried out. The molecular imprinting mechanism of CIP and the monomers as well as the influence of solvent was also discussed. Results indicate that CIP and the monomers are matchable in steric structure and chemical groups lead to ordered compounds. The interaction between CIP and TFMAA is the strongest, and when the ratio of CIP-TFMA_A is 1：6, the polymer has the lowest energy in toluene. The computational approach has been applied to provide details of interactions between CIP and the monomers. This research will hopefully shed light on the future study of CIP-MIPs.
文摘Polystyrene microspheres with sulfo- or aldehyde- surface were synthesized through dispersion polymerization. Functional polystyrene fluorescent microspheres were prepared by the way of adding 2, 5-diphenyloxazole (PPO) into the reaction system directly and dying the blank microspheres in the ethanol solution of PPO. The influence of preparing matters on the encapsulating rate of PPO, and the influence of functional groups on the adsorbability to human serum albumin (HSA) were investigated.
文摘Functional monomer (MP)_2PT having tertiary aromatic amino group was systhesized from the reaction of N, N-di (2-hydroxypropyl)-p-toluidine with 2-methyl acryloyl chloride. In the presence of organic peroxide, the radical polymerization of (MP)_2PT in toluene took place. The kinetics of (MP)_2PT polymerization and the ESR spectra of LPO-(MP)2PT-MNP systems were determined respectively.
文摘A new molecularly imprinted polymer was synthesized with malachite green (MG) as molecular template, methacrylic acid (MAA) as functional monomer, ethylene dimethacrylate (EDMA) as crosslinker, and azobisisobutyronitrile (AIBN) as initiator. Recognition properties of the MG imprinted polymer were studied by equilibrium adsorption and HPLC. The results showed that the imprinted polymer had good affinity and marked selectivity for MG, and can separate MG with its analogue commendably. The new polymer can be used for the enrichment of MG in complex sample, and can work as separation media to separate and detect MG by HPLC.
文摘In order to investigate the association of fibrin monomer polymerization function (FMPF) with traditional cerebrovascular risk factors and ischemic cerebrovascular disease in old people. 1∶1 paired case-control comparative study was performed for FMPF and traditional cerebrovascular risk factors on 110 cases of old ischemic cerebrovascular disease and 110 controls matched on age, sex and living condition. The results showed that cerebrovascular risk factors were more prevalent in case group than in control group. In the case group, FMPF was significantly higher than in control group. There was a significant positive correlation between hypertension and fibrin monomer polymerization velocity (FMPV), hypertension and fibrinogen (Fbg), alcohol consumption and Fbg, but no significant correlation between diabetic mellitus, smoking and FMPF was found. Among the parameters of blood lipids, there were significant positive correlations between total cholesterol (TC) and parameters of FMPF to varying degrees, triglycerides (TG) and FMPV, TG and Fbg. Our results also showed there were significant linear trends between TC and FMPV (P<0. 001), TC and Fbg (P=0. 0087), TG and FMPV/Amax (maximum absorbance)(P=0. 0143) respectively. Multiple logistic regression analysis revealed that FMPF in case group remained significantly higher than control group after adjustment of all risk factors that were significant in univariate analysis. It was concluded that there is a possible pathophysiological link between FMPF and cerebrovascular risk factors. An elevated FMPF is associated with ischemic cerebrovascular disease and an independent risk factor of this disease. In old people, detection of FMPF might be a useful screening to identify individuals at increased cerebrothrombotic risk.
文摘Creating artificial receptors that can recognize sulfonated anions in water is a difficult task,and employing these receptors to extract sulfonated surfactants and pollutants from water is extremely challenging.We report the synthesis of molecularly imprinted polymers(MIPs)using a stoichiometric sub-structure imprinting approach.The binding pocket of the receptor was generated by the polymerization of a complex of phenylsulfonic acid(PSA)and tweezer-type functional monomers featuring parallel two imidazolium sites.The complexation and stoichiometry of the bisimidazolium monomer with PSA was evaluated by UV and ^(1)H NMR titrations in the pre-polymerization solvents supported by modeling.Further,we studied the solubility and affinity of the imidazolium monomers with PSA easily tuned by counter anions.We report that the large number of comonomers containing hydroxyl groups around the binding pocket improve the water compatibility and capacity of the imprinted receptors.Finally,we have demonstrated the potential applications of PSA imprinted material by rebinding larger molecules with PSA substructure such as benzyl orange,methyl orange,and linear alkylbenzene sulfonates(LAS).The PSA MIP showed binding capacity around 60μmol g^(−1) and affinity with an imprinted factor of two in the solvents containing≥50%water for benzyl orange dye.The developed MIP-based receptors bind sulfonated dyes within 10 min in aqueous environments.Further we demonstrated an MIP-based receptor able to capture LAS from commercial grade sodium dodecyl sulfate and confirmed this by MS measurements.
基金Project supported by the National Natural Science Foundation of China (Nos. 20175009 and 20375017) the Doctoral Foundation of Education Ministry of China (No. 2002055002) and Tianjin Natural Science Foundation (No. 033603511).
文摘Two molecularly imprinted polymers binding to analgesic acetanilide were prepared using either dual functional monomers of calix[4]arene derivative and acrylamide or single monomer acrylamide, respectively. The polymers were ground, sieved and investigated by equilibrium binding experiment to evaluate their recognition properties for the template and other substrates. Scatchard analysis showed that homogeneous recognition sites were formed in the imprinted polymer matrix. Our results demonstrated that the polymer using two functional monomers exhibited better selectivity for the template. This study may open new frontiers for the development and application of imprinted polymers, such as drug separation and purification.
