2-Amino-3-nitrile-chromenes with potential antitumor activity were constructed by a novel catalytic system. In combination with a-naphthol, quinine could effectively promote the Michael-cyclization process of malononi...2-Amino-3-nitrile-chromenes with potential antitumor activity were constructed by a novel catalytic system. In combination with a-naphthol, quinine could effectively promote the Michael-cyclization process of malononitrile with functionalized chalcones in high yields and moderate to good enantioselectivity（up to 84% ee）. It is notable that the enantioselectivity could be greatly improved when a-naphthol was employed as additive.展开更多
基金financially supported by the National Natural Science Foundation of China(No.21402163)the Science and Technology Department of Sichuan Province(No.2013JY0135)the Graduate Innovation Project of Southwest University for Nationalities(No.CX2015SZ064)
文摘2-Amino-3-nitrile-chromenes with potential antitumor activity were constructed by a novel catalytic system. In combination with a-naphthol, quinine could effectively promote the Michael-cyclization process of malononitrile with functionalized chalcones in high yields and moderate to good enantioselectivity（up to 84% ee）. It is notable that the enantioselectivity could be greatly improved when a-naphthol was employed as additive.
