We conducted a systematic review of studies using non-invasive brain stimulation（NIBS： repetitive transcranial magnetic stimulation（r TMS） and transcranial direct current stimulation（t DCS）） as a research and c...We conducted a systematic review of studies using non-invasive brain stimulation（NIBS： repetitive transcranial magnetic stimulation（r TMS） and transcranial direct current stimulation（t DCS）） as a research and clinical tool aimed at improving motor and functional recovery or spasticity in patients following spinal cord injury（SCI） under the assumption that if the residual corticospinal circuits could be stimulated appropriately, the changes might be accompanied by functional recovery or an improvement in spasticity. This review summarizes the literature on the changes induced by NIBS in the motor and functional recovery and spasticity control of the upper and lower extremities following SCI.展开更多
In this study, we induced cerebral infarction in rats by occluding the right middle cerebral artery, and tested the effects of electroacupuncture at the Baihui acupoint （DU 20）. Motor and sensory function was tested...In this study, we induced cerebral infarction in rats by occluding the right middle cerebral artery, and tested the effects of electroacupuncture at the Baihui acupoint （DU 20）. Motor and sensory function was tested using Garcia’s scale and motor weakness grading, and the expression of vascular endothelial growth factor in the brain was quantified using immunoblotting and immunohistochemistry. We found that scalp electroacupuncture at DU 20 significantly improved motor performance and sensory function in rats with stroke, and this was accompanied by an increased expression of vascular endothelial growth factor in the ischemic brain tissue and peri-ischemic area. In addition, Pearson correlation analysis showed that the improvements in functional recovery were correlated with the increased expression of vascular endothelial growth factor.展开更多
This study proposed a new and more flexible S-shaped rock damage evolution model from a phenomenological perspective based on an improved Logistic function to describe the characteristics of the rock strain softening ...This study proposed a new and more flexible S-shaped rock damage evolution model from a phenomenological perspective based on an improved Logistic function to describe the characteristics of the rock strain softening and damage process.Simultaneously,it established a constitutive model capable of describing the entire process of rock pre-peak compaction and post-peak strain softening deformation,considering the nonlinear effects of the initial compaction stage of rocks,combined with damage mechanics theory and effective medium theory.In addition,this research verified the rationality of the constructed damage constitutive model using results from uniaxial and conventional triaxial compression tests on Miluo granite,yellow sandstone,mudstone,and glutenite.The results indicate that based on the improved Logistic function,the theoretical damage model accurately describes the entire evolution of damage characteristics during rock compression deformation,from maintenance through gradual onset,accelerated development to deceleration and termination,in a simple and unified expression.At the same time,the constructed constitutive model can accurately simulate the stress-strain process of different rock types under uniaxial and conventional triaxial compression,and the theoretical model curve closely aligns with experimental data.Compared to existing constitutive models,the proposed model has significant advantages.The damage model parameters a,r and β have clear physical meanings and interact competitively,where the three parameters collectively determine the shape of the theoretical stress−strain curve.展开更多
In this paper, a new theoretical expression of dissipation term is presented on the basis of statistical model of breaking wave, which is an improvement to LAGFD-WAM wave model. The computational results in three typi...In this paper, a new theoretical expression of dissipation term is presented on the basis of statistical model of breaking wave, which is an improvement to LAGFD-WAM wave model. The computational results in three typical wind fields show a good improvement to LAGFD-WAM model and a better accuracy in comparison with the observed data in the South China Sea.展开更多
BACKGROUND： Transplantation of fetal cell suspension or blocks of fetal tissue can ameliorate the nerve function after the injury or disease in the central nervous system, and it has been used to treat neurodegenerat...BACKGROUND： Transplantation of fetal cell suspension or blocks of fetal tissue can ameliorate the nerve function after the injury or disease in the central nervous system, and it has been used to treat neurodegenerative disorders induced by Parkinson disease. OBJECTIVE： To observe the effects of the transplantation of neuron-like cells derived from bone marrow stromal cells （rMSCs） into the brain in restoring the dysfunctions of muscle strength and balance as well as learning and memory in rat models of cerebral infarction. DESIGN ： A randomized controlled experiment.SETTING ： Department of Pathophysiology, Zhongshan Medical College of Sun Yat-sen University.MATERIALS ： Twenty-four male SD rats （3-4 weeks of age, weighing 200-220 g） were used in this study （Certification number：2001A027）. METHODS： The experiments were carried out in Zhongshan Medical College of Sun Yat-sen University between December 2003 and December 2004. ① Twenty-four male SD rats randomized into three groups with 8 rats in each： experimental group, control group and sham-operated group. Rats in the experiment al group and control group were induced into models of middle cerebral artery occlusion （MCAO）. After in vitro cultured, purified and identified with digestion, the Fischer344 rMSCs were induced to differentiate by tanshinone IIA, which was locally injected into the striate cortex （18 area） of rats in the experimental group, and the rats in the control group were injected by L-DMEM basic culture media （without serum） of the same volume to the corresponding brain area. In the sham-operated group, only muscle and vessel of neck were separated. ② At 2 and 8 weeks after the transplantation, the rats were given the screen test, prehensile-traction test, balance beam test and Morris water-maze test. ③ The survival and distribution of the induced cells in corresponding brain area were observed with Nissl stained with toluidine blue and hematoxylin and eosin （HE） staining in the groups.MAIN OUTCOME MEASURES ： ① Results of the behavioral tests （time of the Morris water-maze test screen test, prehensile-traction test, balance beam test）; ② Survival and distribution of the induced cells.RESULTS： All the 24 rats were involved in the analysis of results. ① Two weeks after transplantation, rats with neuron-like cells grafts in the experimental group had significant improvement on their general muscle strength than those in the control group [screen test： （9.4±1.7）, （4.7±1.0） s, P 〈 0.01]; forelimb muscle strength [prehensile-traction test： （7.6±1.4）, （5.2±1.2） s, P 〈 0.01], ability to keep balance [balance beam test： （7.9±0.74）, （6.1±0.91） s, P 〈 0.01] and abilities of learning and memory [latency to find the platform： （35.8±5.9）, （117.5±11.6） s, P 〈 0.01; distance： （623.1±43.4）, （1 902.3±98.6） cm, P 〈 0.01] as compared with those in the control group. The functional performances in the experimental group at 8 weeks were better than those at two weeks, which were still obviously different from those in the sham-operated group （P 〈 0.05）. ② The HE and Nissl stained brain tissue section showed that there was nerve cell proliferation at the infarcted cortex in the experiment group, the density was higher than that in the control group, plenty of aggregative or scattered cells could be observed at the site where needle was inserted for transplantation, the cells migrated directively towards the area around them, the cerebral vascular walls were wrapped by plenty of cells; In the control group, most of the cortices were destroyed, karyopyknosis and necrosis of neurons were observed, normal nervous tissue structure disappeared induced by edema, only some nerve fibers and glial cells remained.CONCLUSION： The rMSCs transplantation can obviously enhance the motor function and the abilities of learning and memory in rat models of cerebral infarction.展开更多
In this paper the definitions of generalized transfer functios of control system and itscontinuity are presented.Using generalized transfer function as a tool,a set of theorems fordeciding movement stability have been...In this paper the definitions of generalized transfer functios of control system and itscontinuity are presented.Using generalized transfer function as a tool,a set of theorems fordeciding movement stability have been constructed.Thus basing understanding of thecharacteristics of a control dynamics system on its measured procedure will simplify thedecision method of movement stability problems.展开更多
The study examined the nexus between operations improvement function (dimensioned by contingency planning, benchmarking and continuous improvement processes) and organisational adaptability of Petroleum tank farms in ...The study examined the nexus between operations improvement function (dimensioned by contingency planning, benchmarking and continuous improvement processes) and organisational adaptability of Petroleum tank farms in South-South, Nigeria. The contingency theory and the theory of routine dynamics underpinned the study, and positivism was the underlying philosophy. The study adopted the cross-sectional survey through the use of questionnaire. 820 middle and top-level managers constituted the elements of the population, and the Krejcie & Morgan’s formula was used to determine the sample size of 262 respondents. Structural Equation Modeling was deployed to test the hypotheses at a 0.05 significance level. The results showed that contingency planning;benchmarking and continuous improvement processes all have a significant positive relationship with organisational adaptability of Petroleum tank farms in South-South, Nigeria. The study concludes that Petroleum tank farms’ operations should focus on the adoption of contingency planning, benchmarking and continuous improvement processes to enhance organisational adaptability. Therefore, it is recommended that the management of Petroleum tank farms should put in place mechanisms to advance continuous improvement processes by allocating the necessary amount of resources, such as energy, time and money, in order to promote the continuous development of the continuous improvement systems. Furthermore, managers of Petroleum tank farms should make better the adoption of contingency planning, ensuring that there is as much necessary training and information for employees on how to act during a crises situation, in order to evaluate safety and prepare in advance for recovery from disasters.展开更多
Objective To study the effect and mechanism of neurological function recovery in rats with spinal cord injury ( SCI) rats after transplantation of neural stem cells which are directly differentiated from bone marrow m...Objective To study the effect and mechanism of neurological function recovery in rats with spinal cord injury ( SCI) rats after transplantation of neural stem cells which are directly differentiated from bone marrow mesenchymal stem cells ( BMSC ) ,and to investigate the suitable engraftment time. Methods BMSC at 3rd passage were differentiated into neural stem cells ( NSC) , and immunofluorescence staining was used to展开更多
This paper investigates the path-following control problem with obstacle avoidance of autonomous surface vehicles in the presence of actuator faults,uncertainty and external disturbances.Autonomous surface vehicles in...This paper investigates the path-following control problem with obstacle avoidance of autonomous surface vehicles in the presence of actuator faults,uncertainty and external disturbances.Autonomous surface vehicles inevitably suffer from actuator faults in complex sea environments,which may cause existing obstacle avoidance strategies to fail.To reduce the influence of actuator faults,an improved artificial potential function is constructed by introducing the lower bound of actuator efficiency factors.The nonlinear state observer,which only depends on measurable position information of the autonomous surface vehicle,is used to address uncertainties and external disturbances.By using a backstepping technique and adaptive mechanism,a path-following control strategy with obstacle avoidance and fault tolerance is designed which can ensure that the tracking errors converge to a small neighborhood of zero.Compared with existing results,the proposed control strategy has the capability of obstacle avoidance and fault tolerance simultaneously.Finally,the comparison results through simulations are given to verify the effectiveness of the proposed method.展开更多
As an active ingredient extracted from Salvia miltiorrhiza,the neuroprotective effects of salvianolic acid B in Parkinson's disease include antioxidation,improvement of mitochondrial function,modulation of neuroin...As an active ingredient extracted from Salvia miltiorrhiza,the neuroprotective effects of salvianolic acid B in Parkinson's disease include antioxidation,improvement of mitochondrial function,modulation of neuroinflammation,inhibition of apoptosis,promotion of neuronal differentiation and proliferation,and influence on intestinal flora.As an adjuvant drug,salbutamol B can be used in combination with conventional therapeutic drugs to enhance the efficacy and minimize the side effects,which provides a method and basis for the early diagnosis and treatment of Parkinson's disease in clinical practice.展开更多
Background:Scar contractions caused by trauma or burns can cause secondary physical dysfunction and disfigurement.Many minimally invasive methods for scar contraction have shown limited applicability and efficacy.This...Background:Scar contractions caused by trauma or burns can cause secondary physical dysfunction and disfigurement.Many minimally invasive methods for scar contraction have shown limited applicability and efficacy.This study investigated the feasibility and efficacy of intralesional collagenase injections for scar contraction treatment.Methods:Patients with contracted scars who had limited joint movement and physical disfiguration for>1 year were enrolled in this single-blind,randomized clinical trial from July 2017 to February 2018 at Shanghai Ninth People’s Hospital.Collagenase was injected into the firm-contracted scar(15 U/cm^(2))three times at 4-week intervals in the multiple treatment group and once in the single treatment group,and a placebo injection was performed in the control group.Scar length and skin texture were documented at the 4-and 12-week follow-ups.The safety of the collagenase treatment was also evaluated.Results:The contracted scar was significantly elongated after both single and multiple collagenase treatments.The results showed that,compared to a one-time treatment,repeated injections were more effective at 12 weeks,with an average improvement of 26.83(15.79%).At 12 weeks,78.9% of the patients in the multiple group and 52.9%in the single group achieved significant improvement at 12 weeks.No severe adverse events were observed.Conclusion:Intralesional collagenase injection showed promising results in improving scar contraction and provides an alternative treatment for patients.展开更多
Objective: to investigate the effect of proximal femoral nail (PFNA) in the treatment of elderly patients with interfemoral fracture. Methods: the 64 patients were elderly patients with interfemoral fracture in the ho...Objective: to investigate the effect of proximal femoral nail (PFNA) in the treatment of elderly patients with interfemoral fracture. Methods: the 64 patients were elderly patients with interfemoral fracture in the hospital, with admission time: February 2019 to February 2021. The observation group (32 cases) and the control group (32 cases) were generated with a random digital table as a tool to perform PFNA treatment regimen and dynamic hip screw system (DHS) respectively. Differences between groups were analyzed for clinical indicators, Harris scores, complications and other indicators. Results: operation time, postoperative pain, fracture healing and first loading time were less bleeding (P <0.05), Harris scores at 2 weeks, 3 months and half months and higher quality of life (P <0.05) and lower complications (6.25%) (P <0.05). Conclusion: PFNA treatment of interfemoral fracture, rapid healing, better hip function recovery, and guaranteed safety.展开更多
The Amendment(Ⅺ)to the Criminal Law of the People’s Republic of China responds to the institutional needs of civic education,and supplements the clause of the Criminal Law on protection of citizens’right to educati...The Amendment(Ⅺ)to the Criminal Law of the People’s Republic of China responds to the institutional needs of civic education,and supplements the clause of the Criminal Law on protection of citizens’right to education nuy means of Article 32.Imposing legal responsibility in the form of internal punishments,administrative punishments,and economic compensation have failed to prevent infringements on citizens’right to education.Its role as a"secondary protection law"is the conceptual obstacle that hinders the Criminal Law from effectively intervening in the field of citizens’right to education.The equivalence between the legal interests of people to the right to education and the rights protected by the existing charges in the Criminal Law is the legitimate basis for it to intervene in disputes over the right to education.Based on Article 32 of the Amendment(Ⅺ)to the Criminal Law of the People’s Republic of China,it is suggested to further clarify the prepositional law,improve the liability provisions for the right to education,change the modest and restrained view of the Criminal Law regarding protection of the right to education,and expand the behavior types of Article 32 provided in the Amendment(Ⅺ)in due time.展开更多
In this paper, the spectral element method(SEM)is improved to solve the moving load problem. In this method, a structure with uniform geometry and material properties is considered as a spectral element, which means t...In this paper, the spectral element method(SEM)is improved to solve the moving load problem. In this method, a structure with uniform geometry and material properties is considered as a spectral element, which means that the element number and the degree of freedom can be reduced significantly. Based on the variational method and the Laplace transform theory, the spectral stiffness matrix and the equivalent nodal force of the beam-column element are established. The static Green function is employed to deduce the improved function. The proposed method is applied to two typical engineering practices—the one-span bridge and the horizontal jib of the tower crane. The results have revealed the following. First, the new method can yield extremely high-precision results of the dynamic deflection, the bending moment and the shear force in the moving load problem.In most cases, the relative errors are smaller than 1%. Second, by comparing with the finite element method, one can obtain the highly accurate results using the improved SEM with smaller element numbers. Moreover, the method can be widely used for statically determinate as well as statically indeterminate structures. Third, the dynamic deflection of the twin-lift jib decreases with the increase in the moving load speed, whereas the curvature of the deflection increases.Finally, the dynamic deflection, the bending moment and the shear force of the jib will all increase as the magnitude of the moving load increases.展开更多
The paper presents the improved element-free Galerkin （IEFG） method for three-dimensional wave propa- gation. The improved moving least-squares （IMLS） approx- imation is employed to construct the shape function, w...The paper presents the improved element-free Galerkin （IEFG） method for three-dimensional wave propa- gation. The improved moving least-squares （IMLS） approx- imation is employed to construct the shape function, which uses an orthogonal function system with a weight function as the basis function. Compared with the conventional moving least-squares （MLS） approximation, the algebraic equation system in the IMLS approximation is not ill-conditioned, and can be solved directly without deriving the inverse matrix. Because there are fewer coefficients in the IMLS than in the MLS approximation, fewer nodes are selected in the IEFG method than in the element-free Galerkin method. Thus, the IEFG method has a higher computing speed. In the IEFG method, the Galerkin weak form is employed to obtain a dis- cretized system equation, and the penalty method is applied to impose the essential boundary condition. The traditional difference method for two-point boundary value problems is selected for the time discretization. As the wave equations and the boundary-initial conditions depend on time, the scal- ing parameter, number of nodes and the time step length are considered for the convergence study.展开更多
In this paper,a hybrid Lattice Boltzmann Flux Solver(LBFS)with an improved switch function is proposed for simulation of integrated hypersonic fluid-thermal-structural problems.In the solver,the macroscopic Navier–St...In this paper,a hybrid Lattice Boltzmann Flux Solver(LBFS)with an improved switch function is proposed for simulation of integrated hypersonic fluid-thermal-structural problems.In the solver,the macroscopic Navier–Stokes equations and structural heat transfer equation are discretized by the finite volume method,and the numerical fluxes at the cell interface are reconstructed by the local solution of the Boltzmann equation.To compute the numerical fluxes,two equilibrium distribution functions are introduced.One is the D1Q4 discrete velocity model for calculating the inviscid flux across the cell interface of Navier–Stokes equations,and the other is the D2Q4 model for evaluating the flux of structural energy equation.In this work,a new dual thermal resistance model is proposed to calculate the thermal properties at the fluid–solid interface.The accuracy and stability of the present hybrid solver are validated by simulating several numerical examples,including the fluid-thermal-structural problem of cylindrical leading edge.Numerical results show that the present solver can accurately predict the thermal properties of hypersonic fluid-thermalstructural problems and has the great potential for solving fluid-thermal-structural problems of long-endurance high-speed vehicles.展开更多
The improved tanh function method [Commun. Theor. Phys. （Beijing, China） 43 （2005） 585] is further improved by generalizing the ansatz solution of the considered equation. As its application, the （2＋1）-dimensio...The improved tanh function method [Commun. Theor. Phys. （Beijing, China） 43 （2005） 585] is further improved by generalizing the ansatz solution of the considered equation. As its application, the （2＋1）-dimensional Broer-Kaup equations are considered and abundant new exact non-travelling wave solutions are obtained.展开更多
With the help of an improved mapping approach and a linear-variable-separation approach, a new family of exact solutions with arbitrary functions of the （2＋1）-dimensional Nizhnik-Novikov-Veselov system （NNV） is d...With the help of an improved mapping approach and a linear-variable-separation approach, a new family of exact solutions with arbitrary functions of the （2＋1）-dimensional Nizhnik-Novikov-Veselov system （NNV） is derived. Based on the derived solutions and using some multi-valued functions, we find a few new folded solitary wave excitations for the （2＋1）-dimensional NNV system.展开更多
文摘We conducted a systematic review of studies using non-invasive brain stimulation（NIBS： repetitive transcranial magnetic stimulation（r TMS） and transcranial direct current stimulation（t DCS）） as a research and clinical tool aimed at improving motor and functional recovery or spasticity in patients following spinal cord injury（SCI） under the assumption that if the residual corticospinal circuits could be stimulated appropriately, the changes might be accompanied by functional recovery or an improvement in spasticity. This review summarizes the literature on the changes induced by NIBS in the motor and functional recovery and spasticity control of the upper and lower extremities following SCI.
基金the Incheon St. Mary’s Hospital of the Catholic University of Korea, through the Clinical Research Laboratory Foundation Program, Korea Health 21 R&D Project, No. A092058, and WCU Neurocytomics
文摘In this study, we induced cerebral infarction in rats by occluding the right middle cerebral artery, and tested the effects of electroacupuncture at the Baihui acupoint （DU 20）. Motor and sensory function was tested using Garcia’s scale and motor weakness grading, and the expression of vascular endothelial growth factor in the brain was quantified using immunoblotting and immunohistochemistry. We found that scalp electroacupuncture at DU 20 significantly improved motor performance and sensory function in rats with stroke, and this was accompanied by an increased expression of vascular endothelial growth factor in the ischemic brain tissue and peri-ischemic area. In addition, Pearson correlation analysis showed that the improvements in functional recovery were correlated with the increased expression of vascular endothelial growth factor.
基金Project(52074299)supported by the National Natural Science Foundation of ChinaProjects(2023JCCXSB02,BBJ2024083)supported by the Fundamental Research Funds for the Central Universities,China。
文摘This study proposed a new and more flexible S-shaped rock damage evolution model from a phenomenological perspective based on an improved Logistic function to describe the characteristics of the rock strain softening and damage process.Simultaneously,it established a constitutive model capable of describing the entire process of rock pre-peak compaction and post-peak strain softening deformation,considering the nonlinear effects of the initial compaction stage of rocks,combined with damage mechanics theory and effective medium theory.In addition,this research verified the rationality of the constructed damage constitutive model using results from uniaxial and conventional triaxial compression tests on Miluo granite,yellow sandstone,mudstone,and glutenite.The results indicate that based on the improved Logistic function,the theoretical damage model accurately describes the entire evolution of damage characteristics during rock compression deformation,from maintenance through gradual onset,accelerated development to deceleration and termination,in a simple and unified expression.At the same time,the constructed constitutive model can accurately simulate the stress-strain process of different rock types under uniaxial and conventional triaxial compression,and the theoretical model curve closely aligns with experimental data.Compared to existing constitutive models,the proposed model has significant advantages.The damage model parameters a,r and β have clear physical meanings and interact competitively,where the three parameters collectively determine the shape of the theoretical stress−strain curve.
文摘In this paper, a new theoretical expression of dissipation term is presented on the basis of statistical model of breaking wave, which is an improvement to LAGFD-WAM wave model. The computational results in three typical wind fields show a good improvement to LAGFD-WAM model and a better accuracy in comparison with the observed data in the South China Sea.
基金the National Natural Science Foundation of China, No. 03030307 the Great Special Fund of Guangdong Province, No. 2004A30201002
文摘BACKGROUND： Transplantation of fetal cell suspension or blocks of fetal tissue can ameliorate the nerve function after the injury or disease in the central nervous system, and it has been used to treat neurodegenerative disorders induced by Parkinson disease. OBJECTIVE： To observe the effects of the transplantation of neuron-like cells derived from bone marrow stromal cells （rMSCs） into the brain in restoring the dysfunctions of muscle strength and balance as well as learning and memory in rat models of cerebral infarction. DESIGN ： A randomized controlled experiment.SETTING ： Department of Pathophysiology, Zhongshan Medical College of Sun Yat-sen University.MATERIALS ： Twenty-four male SD rats （3-4 weeks of age, weighing 200-220 g） were used in this study （Certification number：2001A027）. METHODS： The experiments were carried out in Zhongshan Medical College of Sun Yat-sen University between December 2003 and December 2004. ① Twenty-four male SD rats randomized into three groups with 8 rats in each： experimental group, control group and sham-operated group. Rats in the experiment al group and control group were induced into models of middle cerebral artery occlusion （MCAO）. After in vitro cultured, purified and identified with digestion, the Fischer344 rMSCs were induced to differentiate by tanshinone IIA, which was locally injected into the striate cortex （18 area） of rats in the experimental group, and the rats in the control group were injected by L-DMEM basic culture media （without serum） of the same volume to the corresponding brain area. In the sham-operated group, only muscle and vessel of neck were separated. ② At 2 and 8 weeks after the transplantation, the rats were given the screen test, prehensile-traction test, balance beam test and Morris water-maze test. ③ The survival and distribution of the induced cells in corresponding brain area were observed with Nissl stained with toluidine blue and hematoxylin and eosin （HE） staining in the groups.MAIN OUTCOME MEASURES ： ① Results of the behavioral tests （time of the Morris water-maze test screen test, prehensile-traction test, balance beam test）; ② Survival and distribution of the induced cells.RESULTS： All the 24 rats were involved in the analysis of results. ① Two weeks after transplantation, rats with neuron-like cells grafts in the experimental group had significant improvement on their general muscle strength than those in the control group [screen test： （9.4±1.7）, （4.7±1.0） s, P 〈 0.01]; forelimb muscle strength [prehensile-traction test： （7.6±1.4）, （5.2±1.2） s, P 〈 0.01], ability to keep balance [balance beam test： （7.9±0.74）, （6.1±0.91） s, P 〈 0.01] and abilities of learning and memory [latency to find the platform： （35.8±5.9）, （117.5±11.6） s, P 〈 0.01; distance： （623.1±43.4）, （1 902.3±98.6） cm, P 〈 0.01] as compared with those in the control group. The functional performances in the experimental group at 8 weeks were better than those at two weeks, which were still obviously different from those in the sham-operated group （P 〈 0.05）. ② The HE and Nissl stained brain tissue section showed that there was nerve cell proliferation at the infarcted cortex in the experiment group, the density was higher than that in the control group, plenty of aggregative or scattered cells could be observed at the site where needle was inserted for transplantation, the cells migrated directively towards the area around them, the cerebral vascular walls were wrapped by plenty of cells; In the control group, most of the cortices were destroyed, karyopyknosis and necrosis of neurons were observed, normal nervous tissue structure disappeared induced by edema, only some nerve fibers and glial cells remained.CONCLUSION： The rMSCs transplantation can obviously enhance the motor function and the abilities of learning and memory in rat models of cerebral infarction.
文摘In this paper the definitions of generalized transfer functios of control system and itscontinuity are presented.Using generalized transfer function as a tool,a set of theorems fordeciding movement stability have been constructed.Thus basing understanding of thecharacteristics of a control dynamics system on its measured procedure will simplify thedecision method of movement stability problems.
文摘The study examined the nexus between operations improvement function (dimensioned by contingency planning, benchmarking and continuous improvement processes) and organisational adaptability of Petroleum tank farms in South-South, Nigeria. The contingency theory and the theory of routine dynamics underpinned the study, and positivism was the underlying philosophy. The study adopted the cross-sectional survey through the use of questionnaire. 820 middle and top-level managers constituted the elements of the population, and the Krejcie & Morgan’s formula was used to determine the sample size of 262 respondents. Structural Equation Modeling was deployed to test the hypotheses at a 0.05 significance level. The results showed that contingency planning;benchmarking and continuous improvement processes all have a significant positive relationship with organisational adaptability of Petroleum tank farms in South-South, Nigeria. The study concludes that Petroleum tank farms’ operations should focus on the adoption of contingency planning, benchmarking and continuous improvement processes to enhance organisational adaptability. Therefore, it is recommended that the management of Petroleum tank farms should put in place mechanisms to advance continuous improvement processes by allocating the necessary amount of resources, such as energy, time and money, in order to promote the continuous development of the continuous improvement systems. Furthermore, managers of Petroleum tank farms should make better the adoption of contingency planning, ensuring that there is as much necessary training and information for employees on how to act during a crises situation, in order to evaluate safety and prepare in advance for recovery from disasters.
文摘Objective To study the effect and mechanism of neurological function recovery in rats with spinal cord injury ( SCI) rats after transplantation of neural stem cells which are directly differentiated from bone marrow mesenchymal stem cells ( BMSC ) ,and to investigate the suitable engraftment time. Methods BMSC at 3rd passage were differentiated into neural stem cells ( NSC) , and immunofluorescence staining was used to
基金the National Natural Science Foundation of China(51939001,52171292,51979020,61976033)Dalian Outstanding Young Talents Program(2022RJ05)+1 种基金the Topnotch Young Talents Program of China(36261402)the Liaoning Revitalization Talents Program(XLYC20-07188)。
文摘This paper investigates the path-following control problem with obstacle avoidance of autonomous surface vehicles in the presence of actuator faults,uncertainty and external disturbances.Autonomous surface vehicles inevitably suffer from actuator faults in complex sea environments,which may cause existing obstacle avoidance strategies to fail.To reduce the influence of actuator faults,an improved artificial potential function is constructed by introducing the lower bound of actuator efficiency factors.The nonlinear state observer,which only depends on measurable position information of the autonomous surface vehicle,is used to address uncertainties and external disturbances.By using a backstepping technique and adaptive mechanism,a path-following control strategy with obstacle avoidance and fault tolerance is designed which can ensure that the tracking errors converge to a small neighborhood of zero.Compared with existing results,the proposed control strategy has the capability of obstacle avoidance and fault tolerance simultaneously.Finally,the comparison results through simulations are given to verify the effectiveness of the proposed method.
基金Research on the Neuroprotective Mechanism of Salvianolic Acid B on Parkinson's DiseaseFunded Project of Gansu Province Health Industry Scientific Research Program(GSWSKY2018-43)+3 种基金Mechanism Research on the Regulation of Antioxidant Dysregulation in Parkinson's Disease Model by Salvianolic Acid B through Nrf2-ARE Signaling PathwayHospital Graduate Student Supervisor Special Project(Hospital Health[2022]yxky011)Mechanism and Clinical Efficacy Study on Treatment of Parkinson's Disease by Exenatide Combined with Deep Brain Electrical StimulationScience and Technology Plan Project of Lanzhou Science and Technology Bureau(2023-ZD-167).
文摘As an active ingredient extracted from Salvia miltiorrhiza,the neuroprotective effects of salvianolic acid B in Parkinson's disease include antioxidation,improvement of mitochondrial function,modulation of neuroinflammation,inhibition of apoptosis,promotion of neuronal differentiation and proliferation,and influence on intestinal flora.As an adjuvant drug,salbutamol B can be used in combination with conventional therapeutic drugs to enhance the efficacy and minimize the side effects,which provides a method and basis for the early diagnosis and treatment of Parkinson's disease in clinical practice.
基金supported by the National Natural Science Foundation of China(grant nos.81501678,81971848,and 82272287)Clinical Research Plan of Shanghai Hospital Development Center(grant nos.SHDC2020CR1019B and SHDC2020CR4029)+1 种基金Shanghai Municipal Key Clinical Specialty(grant no.shslczdzk00901)Innovative Research Team of High-Level Local University in Shanghai(grant no.SSMUZDCX20180700).
文摘Background:Scar contractions caused by trauma or burns can cause secondary physical dysfunction and disfigurement.Many minimally invasive methods for scar contraction have shown limited applicability and efficacy.This study investigated the feasibility and efficacy of intralesional collagenase injections for scar contraction treatment.Methods:Patients with contracted scars who had limited joint movement and physical disfiguration for>1 year were enrolled in this single-blind,randomized clinical trial from July 2017 to February 2018 at Shanghai Ninth People’s Hospital.Collagenase was injected into the firm-contracted scar(15 U/cm^(2))three times at 4-week intervals in the multiple treatment group and once in the single treatment group,and a placebo injection was performed in the control group.Scar length and skin texture were documented at the 4-and 12-week follow-ups.The safety of the collagenase treatment was also evaluated.Results:The contracted scar was significantly elongated after both single and multiple collagenase treatments.The results showed that,compared to a one-time treatment,repeated injections were more effective at 12 weeks,with an average improvement of 26.83(15.79%).At 12 weeks,78.9% of the patients in the multiple group and 52.9%in the single group achieved significant improvement at 12 weeks.No severe adverse events were observed.Conclusion:Intralesional collagenase injection showed promising results in improving scar contraction and provides an alternative treatment for patients.
文摘Objective: to investigate the effect of proximal femoral nail (PFNA) in the treatment of elderly patients with interfemoral fracture. Methods: the 64 patients were elderly patients with interfemoral fracture in the hospital, with admission time: February 2019 to February 2021. The observation group (32 cases) and the control group (32 cases) were generated with a random digital table as a tool to perform PFNA treatment regimen and dynamic hip screw system (DHS) respectively. Differences between groups were analyzed for clinical indicators, Harris scores, complications and other indicators. Results: operation time, postoperative pain, fracture healing and first loading time were less bleeding (P <0.05), Harris scores at 2 weeks, 3 months and half months and higher quality of life (P <0.05) and lower complications (6.25%) (P <0.05). Conclusion: PFNA treatment of interfemoral fracture, rapid healing, better hip function recovery, and guaranteed safety.
基金the Key Project supported by the National Social Science Fund,“Study on the Relationship between the Rule of Law and the Rule of Morality”(14AZD135)The Key Project of Philosophy and Social Science Research of Ministry of Education,“Study on Promoting the National Inspection and Supervision Covering all Sectors”(18JZD037)the Postgraduate Scientific Research Innovation Project of Southwest University of Political Science and Law,“Research on the Issue of Criminal Law Protection of Citizens’Right to Education”(2019XZXS-066)
文摘The Amendment(Ⅺ)to the Criminal Law of the People’s Republic of China responds to the institutional needs of civic education,and supplements the clause of the Criminal Law on protection of citizens’right to education nuy means of Article 32.Imposing legal responsibility in the form of internal punishments,administrative punishments,and economic compensation have failed to prevent infringements on citizens’right to education.Its role as a"secondary protection law"is the conceptual obstacle that hinders the Criminal Law from effectively intervening in the field of citizens’right to education.The equivalence between the legal interests of people to the right to education and the rights protected by the existing charges in the Criminal Law is the legitimate basis for it to intervene in disputes over the right to education.Based on Article 32 of the Amendment(Ⅺ)to the Criminal Law of the People’s Republic of China,it is suggested to further clarify the prepositional law,improve the liability provisions for the right to education,change the modest and restrained view of the Criminal Law regarding protection of the right to education,and expand the behavior types of Article 32 provided in the Amendment(Ⅺ)in due time.
基金supported by the National Key Technology R&D Program (Grant 2011BAJ02B01-02)the National Natural Science Foundation of China (Grant 11602065)
文摘In this paper, the spectral element method(SEM)is improved to solve the moving load problem. In this method, a structure with uniform geometry and material properties is considered as a spectral element, which means that the element number and the degree of freedom can be reduced significantly. Based on the variational method and the Laplace transform theory, the spectral stiffness matrix and the equivalent nodal force of the beam-column element are established. The static Green function is employed to deduce the improved function. The proposed method is applied to two typical engineering practices—the one-span bridge and the horizontal jib of the tower crane. The results have revealed the following. First, the new method can yield extremely high-precision results of the dynamic deflection, the bending moment and the shear force in the moving load problem.In most cases, the relative errors are smaller than 1%. Second, by comparing with the finite element method, one can obtain the highly accurate results using the improved SEM with smaller element numbers. Moreover, the method can be widely used for statically determinate as well as statically indeterminate structures. Third, the dynamic deflection of the twin-lift jib decreases with the increase in the moving load speed, whereas the curvature of the deflection increases.Finally, the dynamic deflection, the bending moment and the shear force of the jib will all increase as the magnitude of the moving load increases.
基金supported by the National Natural Science Foundation of China (11171208)Shanghai Leading Academic Discipline Project (S30106)
文摘The paper presents the improved element-free Galerkin （IEFG） method for three-dimensional wave propa- gation. The improved moving least-squares （IMLS） approx- imation is employed to construct the shape function, which uses an orthogonal function system with a weight function as the basis function. Compared with the conventional moving least-squares （MLS） approximation, the algebraic equation system in the IMLS approximation is not ill-conditioned, and can be solved directly without deriving the inverse matrix. Because there are fewer coefficients in the IMLS than in the MLS approximation, fewer nodes are selected in the IEFG method than in the element-free Galerkin method. Thus, the IEFG method has a higher computing speed. In the IEFG method, the Galerkin weak form is employed to obtain a dis- cretized system equation, and the penalty method is applied to impose the essential boundary condition. The traditional difference method for two-point boundary value problems is selected for the time discretization. As the wave equations and the boundary-initial conditions depend on time, the scal- ing parameter, number of nodes and the time step length are considered for the convergence study.
基金co-supported by the Postgraduate Research&Practice Innovation Program of Jiangsu Province of China(No.KYCX17_0235)Nanjing University of Aeronautics and Astronautics Ph D Short-term Visiting Scholar Project(No.180602DF01)National Numerical Wind Tunnel Project(Nos.NNW2018-ZT3B08 and NNW2019-ZT7B30)。
文摘In this paper,a hybrid Lattice Boltzmann Flux Solver(LBFS)with an improved switch function is proposed for simulation of integrated hypersonic fluid-thermal-structural problems.In the solver,the macroscopic Navier–Stokes equations and structural heat transfer equation are discretized by the finite volume method,and the numerical fluxes at the cell interface are reconstructed by the local solution of the Boltzmann equation.To compute the numerical fluxes,two equilibrium distribution functions are introduced.One is the D1Q4 discrete velocity model for calculating the inviscid flux across the cell interface of Navier–Stokes equations,and the other is the D2Q4 model for evaluating the flux of structural energy equation.In this work,a new dual thermal resistance model is proposed to calculate the thermal properties at the fluid–solid interface.The accuracy and stability of the present hybrid solver are validated by simulating several numerical examples,including the fluid-thermal-structural problem of cylindrical leading edge.Numerical results show that the present solver can accurately predict the thermal properties of hypersonic fluid-thermalstructural problems and has the great potential for solving fluid-thermal-structural problems of long-endurance high-speed vehicles.
文摘The improved tanh function method [Commun. Theor. Phys. （Beijing, China） 43 （2005） 585] is further improved by generalizing the ansatz solution of the considered equation. As its application, the （2＋1）-dimensional Broer-Kaup equations are considered and abundant new exact non-travelling wave solutions are obtained.
基金supported by the Natural Science Foundation of Zhejiang Province under Grant No.Y604106the Scientific Research Foundation of Zhejiang Provincial Education Department under Grant No.20070568the Natural Science Foundation of Zhejiang Lishui University under Grant No.KZ08001
文摘With the help of an improved mapping approach and a linear-variable-separation approach, a new family of exact solutions with arbitrary functions of the （2＋1）-dimensional Nizhnik-Novikov-Veselov system （NNV） is derived. Based on the derived solutions and using some multi-valued functions, we find a few new folded solitary wave excitations for the （2＋1）-dimensional NNV system.
