Tuna comes from the prickly pear cactus,which is grown in infertile soils and severely drought-stricken conditions.Its nutritional properties are little known and its cost is very affordable.Tamarind grows in warm,sem...Tuna comes from the prickly pear cactus,which is grown in infertile soils and severely drought-stricken conditions.Its nutritional properties are little known and its cost is very affordable.Tamarind grows in warm,semi-dry climates;it can withstand drought and seasonal flooding.The seeds,leaves,flowers,fruits,and even the wood can be harvested.It has nutritional properties.展开更多
This study took the teaching practice of food-related majors in Chengdu University,a representative applied institution in China,as an example.Aligning with the course characteristics and educational objectives of Fun...This study took the teaching practice of food-related majors in Chengdu University,a representative applied institution in China,as an example.Aligning with the course characteristics and educational objectives of Functional Foods,it introduced the features of the BOPPPS teaching model and its implementation in course design.By incorporating research cases and presenting teaching examples,the steps and methods of BOPPPS-based teaching reform were explored while incorporating ideological and political elements into specialized instruction.This study provides insights and references for reforming other food-related courses and contributes to cultivating more food professionals with practical awareness and critical thinking.展开更多
Long-term postprandial hyperglycemia is a primary risk factor for developing chronic metabolic diseases such as obesity,type 2 diabetes,and cardiovascular disease.Chronic hyperglycemia induces the glycation of protein...Long-term postprandial hyperglycemia is a primary risk factor for developing chronic metabolic diseases such as obesity,type 2 diabetes,and cardiovascular disease.Chronic hyperglycemia induces the glycation of proteins,oxidative stress,inflammation and increases plasma insulin and lipid concentrations.Insulin resistance is the primary cause of postprandial excursions of blood glucose and lipids.Hyperglycemia can be treated by lowering dietary carbohydrates intake,digestion,and absorption.Various functional foods improve glucose metabolism by increasing insulin sensitivity and inhibitingα-glucosidase in the small intestine.Natural phytochemicals,especially active phenolics are good antioxidants and show anti-inflammatory action and regulate blood glucose.This review aimed to report on hypoglycemic properties of active phenolics from functional foods and their proposed anti-diabetic mechanisms.Nevertheless,further clinical trials are required to confirm the bioavailability,safety,and efficacy of phenolics,especially the dosage and duration of treatment,to avoid adverse effects and give better dietary recommendations.展开更多
Hepatitis C virus(HCV)is a major cause of viral hepatitis and currently infects approximately 170 million people worldwide.An infection by HCV causes high rates of chronic hepatitis(】75%)and progresses to liver cirrh...Hepatitis C virus(HCV)is a major cause of viral hepatitis and currently infects approximately 170 million people worldwide.An infection by HCV causes high rates of chronic hepatitis(】75%)and progresses to liver cirrhosis and hepatocellular carcinoma ultimately.HCV can be eliminated by a combination of pegylatedα-interferon and the broad-spectrum antiviral drug ribavirin;however,this treatment is still associated with poor efficacy and tolerability and is often accompanied by serious side-effects.While some novel direct-actingantivirals against HCV have been developed recently,high medical costs limit the access to the therapy in cost-sensitive countries.To search for new natural anti-HCV agents,we screened local agricultural products for their suppressive activities against HCV replication using the HCV replicon cell system in vitro.We found a potent inhibitor of HCV RNA expression in the extracts of blueberry leaves and then identified oligomeric proanthocyanidin as the active ingredient.Further investigations into the action mechanism of oligomeric proanthocyanidin suggested that it is an inhibitor of heterogeneous nuclear ribonucleoproteins(hn RNPs)such as hn RNP A2/B1.In this review,we presented an overview of functional foods and ingredients efficient for HCV infection,the chemical structural characteristics of oligomeric proanthocyanidin,and its action mechanism.展开更多
This study aimed to compare the efficacy of four formulations of plant-based functional foods on the protection against salt-induced endothelial dysfunction.A randomized crossover design was employed.Ten healthy subje...This study aimed to compare the efficacy of four formulations of plant-based functional foods on the protection against salt-induced endothelial dysfunction.A randomized crossover design was employed.Ten healthy subjects were recruited,and on five separate occasions they received,in random sequence one of the following 5 treatments:250 mL of plain water(control)alone,and with beetroot powder,celery powder,green tea extract or beetroot powder with green tea extract prior to consuming 150 mL of high-salt chicken broth.Flow-mediated dilation(FMD),blood pressure(BP),heart rate(HR)and pulse-wave velocity(PWV)were measured at fasting and at 30,60,90 and 120 min postprandial.Comparing with control,beetroot supplementation led to a significantly increased HR at 30,60 and 90 min postprandially(P=0.025,0.004,<0.001,respectively).No significant difference was observed for FMD,BP and PWV between control and any of the treatments.Salt reduction may still be the most effective strategy to improve vascular health.展开更多
This study was to explore the immunity-promoting activity of porcine placenta as a potential raw material for functional foods.Porcine placenta was subjected to the analysis for its bioactive substances,and their immu...This study was to explore the immunity-promoting activity of porcine placenta as a potential raw material for functional foods.Porcine placenta was subjected to the analysis for its bioactive substances,and their immunity-promoting activity was determined in mice supplemented with porcine placenta extract(PPE)and freeze-dried porcine placenta powder at high(PPH)and low(PPL)dosage.Results showed that porcine placenta contained placental peptides and 15 free amino acids,and the amounts of estrogen and progesterone in products developed from porcine placenta were within the limit of national standard.Mice model experiment revealed that compared with the control,the PPH treatment significantly improved the spleen index(P<0.05)by increasing the phagocytic rate of macrophages from 20%to 60%and the conversion rate of T lymphocytes from 8%to 60%.The q PCR analysis disclosed that the porcine placenta powder enhanced mice immunity via promoting the expression of Th1 cytokines of interleukin-2(IL-2)and IFN-γ,especially the former,by almost 8 times in the spleens of male mice,while inhibited Th2 cytokines of IL-4 and IL-10.This investigation has provided a reference for the development of porcine placenta as a raw material applied in functional foods to improve human immunity.展开更多
Older people may have more difficulties in acquiring the nutrients they need from diet and they are at greater risk of chronic diseases. Hence, functional foods based on algae, might have a role in improving very impo...Older people may have more difficulties in acquiring the nutrients they need from diet and they are at greater risk of chronic diseases. Hence, functional foods based on algae, might have a role in improving very important nutrients intake without an increase in calories. This is crucial for middle age people that become less active and will not dispend as much energy as they use to, which will contribute for certain diseases associated with age. Algae produce a great variety of biological active compounds which cannot be found in other organisms. Moreover, they have been reported for their potential medicinal uses. Therefore, they have high potential as a source of functional ingredients. In this review, we will give relevant information about the issue, explain above, pointing out the information related to the compounds that could be responsible for the improvement in quality of life during elderly. It will be also referred that seaweeds can be a source of new compounds for drug discovery.展开更多
Background: Functional foods have been proposed as vehicles to prevent diseases in response to disease increase throughout the world. Methods: Descriptive cross-sectional study. The nutritional labeling of processed f...Background: Functional foods have been proposed as vehicles to prevent diseases in response to disease increase throughout the world. Methods: Descriptive cross-sectional study. The nutritional labeling of processed functional foods (PFF) commercially available in Honduras was examined to consider health benefits based on functionality according to the Central American Technical Regulation (CATR) and critical nutrient content according to the profile of the Panamerican Health Organization (PAHO). Results: Out of a national sample of 631 commercial processed foods (CPF), 144 were defined as functional;sweetened and flavored yogurts and cereal bars reached the highest proportions (70% and 66%) of products available in their respective categories. None of the categories was on average “low in calories” according to criteria of CATR;sweetened breakfast cereals were the most caloric (180 kcal) and only sweetened juices had “calorie free” products (15%). Prepared meat did not meet the criterion of “low cholesterol” even though all the products in this category were the reduced fat version of the original CPF. All categories of cereal-based products met the “source of dietary fiber” criteria and 64% of baked products were “high in dietary fiber”. More than 70% of PFF exceeded the sugar recommendation of the PAHO profile, mainly sweetened breakfast cereals (100%) and sweetened juices (93%). 49% of the products exceeded the sodium recommendation, particularly baked products (100%) and cheeses (86%);100% of the later exceeded the recommendation of total fats. More than 60% of products simultaneously exceeded between 2 and 3 of PAHO profile criteria;5% exceeded all the criteria and 4% met all the PAHO profile criteria. The average price of PFF was $2.34, while that of conventional products was $1.87;sweetened breakfast cereals were the most expensive ($3.49 and $3.28) and sweetened juices were the cheapest ($1.79 and $1.89) for both CPF and PFF. Conclusions: PFF marketed in Honduras have an excessive content of critical nutrients. These results demonstrate the need for a rigorous and mandatory regulation in the production, advertising and sale of functional and conventional processed foods.展开更多
Technological advances in biotechnology are transforming food production and redefining the link between nutrition,health,and sustainability.From traditional fermentation to genome editing,these tools enable the creat...Technological advances in biotechnology are transforming food production and redefining the link between nutrition,health,and sustainability.From traditional fermentation to genome editing,these tools enable the creation of functional foods that enhance well-being and reduce environmental impact.Historically,low-energy fermentation methods improved the nutritional quality and preservation of foods while supporting gut and metabolic health.Today,emerging fields such as synthetic biology,precision fermentation,microbiome engineering,and artificial intelligence are accelerating innovation in personalised and nutritional approaches that complement conventional diets.These approaches can upcycle agricultural by-products,generate bioactive compounds,and mitigate chronic diseases through targeted microbial or molecular interventions.The purpose of this narrative review is to evaluate the role of biotechnology in developing functional foods that promote health and sustainability.Specifically,it examines how fermentation,biofortification,waste valorisation,and genome editing contribute to metabolic,immune,and cognitive health while supporting environmentally responsible food systems.By integrating traditional food wisdom with modern biosciences,this review highlights biotechnology’s potential to bridge health promotion,sustainability,and innovation in the next generation of functional foods.展开更多
Collagen,an abundant extracellular matrix protein in food-producing animals,is widely integrated into food systems for its unique physicochemical properties.Oral collagen-based supplements have received increasing att...Collagen,an abundant extracellular matrix protein in food-producing animals,is widely integrated into food systems for its unique physicochemical properties.Oral collagen-based supplements have received increasing attention for their potential to enhance overall well-being.This review aims to provide valuable insights into the application of oral collagen supplements in food systems,promoting their broader use in food processing,preservation,and the development of functional foods.Specifically,the applications of oral collagen-based supplements in functional foods,focusing on their biological activities,health benefits,and functional properties are summarized.Importantly,their molecular mechanisms of biological activities are critically discussed,including antioxidant,angiotensin-converting enzyme inhibitory,and dipeptidyl peptidase IV inhibitory activities.The health benefits of oral collagen-based supplements,particularly in improving skin,immune,and gastrointestinal health are also explored.Additionally,various functional properties of collagen-based supplements are evaluated,including their stability,bioavailability,taste masking,and sensory attributes.展开更多
Food-grade biopolymers and nanotechnology have been increasingly used to revolutionize the delivery of bioactive compounds by enhancing stability,bioavailability,and controlled release.Within the scope of nanoencapsul...Food-grade biopolymers and nanotechnology have been increasingly used to revolutionize the delivery of bioactive compounds by enhancing stability,bioavailability,and controlled release.Within the scope of nanoencapsulation systems,this review explores food-derived polymers such as vicilin,zein,gluten,cruciferin,inulin,and others.These biopolymers are ideal since they encapsulate numerous functional compounds,such as vitamins,probiotics,essential oils,and polyphenols,because they are biocompatible,amphiphilic,and biodegradable.The specific physical and chemical properties of each polymer,extraction procedures,and nanoencapsulation techniques applied therein(e.g.,ionic gelation and spray drying)are described.The review highlights advanced targeting systems like pH-sensitive,magnetic delivery.Additional applications include those in synergistic nutraceutical systems,oral administration of vaccination,and intelligent food packaging.All these findings demonstrate that food polymers are increasingly more viable as functional nanocarriers by way of increasing bioactive delivery and the shifting requirements of personalized and health-based dietary regimes.展开更多
Sumac(Rhus coriaria)is a flowering plant that is widely consumed for its promoting health benefits and used in food preparations as a spice in the Mediterranean region.It is a high shrub or small tree with imparipinna...Sumac(Rhus coriaria)is a flowering plant that is widely consumed for its promoting health benefits and used in food preparations as a spice in the Mediterranean region.It is a high shrub or small tree with imparipinnate leaves,villus and red fruits with one-seeded drupe,and small greenish-white flowers.The nutraceutical and pharmaceutical potential of sumac makes it a remarkable functional food.In this review,the phytochemical and nutritional properties of sumac as an under valorized functional food have been discussed.Flavonoids,anthocyanins,phenolic acids,and organic acids have been reported as dominant phytochemicals in sumac,which are well known for their pharmacological properties that attract many consumers to commonly choose sumac in their diet as well as food preparations.The remarkable volatile compounds present in sumac give it a unique aroma that increases its acceptance by consumers and potential use in the food industry.Sumac has been evaluated for a broad range of nutritional and pharmacological activities such as antioxidant,antinociceptive,anti-inflammatory,anti-diabetic,hepatoprotective,cardioprotective,anticancer,anti-infertility,and neuroprotective potential.This review has also briefly outlined the safety concerns concerning the use of sumac in terms of toxicology and interactions.展开更多
Morocco's oat sector is shifting from forage to food,creating demand for varieties with proven processing performance.We profiled nine Moroccan oats(four parental lines,four interspecific derivatives,and one hull-...Morocco's oat sector is shifting from forage to food,creating demand for varieties with proven processing performance.We profiled nine Moroccan oats(four parental lines,four interspecific derivatives,and one hull-less diploid check)against the key drivers of functionality:β-glucan,hydration metrics(WAI,WSI,swelling power),interfacial metrics(foam capacity/stability,emulsion capacity/stability),and kernel geometry(thousand-kernel weight/width),using SEM to interpret microstructure.Varietal differences were pronounced and actionable.The A.sativa×A.magna derivative Hamdali showed fast wetting(low WAI),strong foaming(highest FS),and high emulsion capacity.These traits make it suitable for oat drinks and large,crack-free flakes.The A.sativa×A.murphyi descendants Al Fawze and Abtah exhibited restrained swelling(lower SP)and moderate WAI/WSI,favoring crisp snacks,biscuits,and pasta;Abtah additionally delivered high emulsion stability suitable for shelf-stable beverages.Amlal and Nezha offered balanced,steerable profiles.Linkingβ-glucan,hydration,and interfacial behavior to kernel traits provides a variety-to-application map for Moroccan oats.We recommend Hamdali/Niema for foamed beverages/flakes;Tissir/Soualem for porridges and thick beverages;Abtah for pasta and stable emulsions;Al Fawze for crisp snacks/biscuits.展开更多
Liver diseases remain a global health crisis,with limited safe therapeutic options.Cornus officinalis,a traditional medicinal-edible plant,has demonstrated significant hepatoprotective potential.This review systematic...Liver diseases remain a global health crisis,with limited safe therapeutic options.Cornus officinalis,a traditional medicinal-edible plant,has demonstrated significant hepatoprotective potential.This review systematically summarizes its liver-protective mechanisms and explores its potential as a functional food.Data were collected from scientific databases such as Pub Med,Science Direct,Elsevier,Google Scholar,and relevant literature.Key bioactive compounds—including iridoids,polyphenols,and polysaccharides—contribute to hepatoprotection by mitigating oxidative stress,inflammation,steatosis,apoptosis,and by regulating gut microbiota.As critical quality markers,iridoids exhibit suboptimal bioavailability,necessitating targeted technological interventions—nanoencapsulation for liver-specific delivery and microbial fermentation for controlled aglycone conversion are proposed to enhance their pharmacokinetic properties and bioactivity.Future research could adopt encapsulation and fermentation technologies for C.officinalis processing,aiming to develop targeted functional food products with enhanced bioactivity of its active components.This review,for the first time,establishes a“component-pathway-integration”model,providing a theoretical framework for evidence-based CO-derived functional food development and highlighting the need for further research on iridoid metabolic transformation to advance liver health management.展开更多
Selenium(Se),one of the indispensable nutrients for both human health and animal growth,participates in various physiological functions,such as antioxidant and immune responses and metabolism.The role of dietary Se,in...Selenium(Se),one of the indispensable nutrients for both human health and animal growth,participates in various physiological functions,such as antioxidant and immune responses and metabolism.The role of dietary Se,in its organic and inorganic forms,has been well documented in domestic animals.Furthermore,many feeding strategies for different animals have been developed to increase the Se concentration in animal products to address Se deficiency and even as a potential nutritional strategy to treat free radical-associated diseases.Nevertheless,studies on investigating the optimum addition of Se in feed,the long-term consequences of Se usage in food for animal nutrition,the mechanism of metallic Se nanoparticle(SeNP)transformation in vivo,and the nutritional effects of SeNPs on feed workers and the environment are urgently needed.Starting from the absorption and metabolism mechanism of Se,this review discusses the antioxidant role of Se in detail.Based on this characteristic,we further investigated the application of Se in animal health and described some unresolved issues and unanswered questions warranting further investigation.This review is expected to provide a theoretical reference for improving the quality of food animal meat as well as for the development of Se-based biological nutrition enhancement technology.展开更多
Bacteria have been employed widely in the food and beverage industry,with evolving dimensions in recent years.Proteases derived from lactic acid bacteria(LAB)are useful in the production of fermented functional bevera...Bacteria have been employed widely in the food and beverage industry,with evolving dimensions in recent years.Proteases derived from lactic acid bacteria(LAB)are useful in the production of fermented functional beverages and are of particular use in conditioning their shelf life,nutritional content,flavour,and texture quality,thus making fermented foods and beverages functional and therapeutic.This review focuses on bacteria,especially protease-producing LAB used in food processing,and their usefulness in the production of functional foods and beverages.A case study of oat beverages was briefly explored due to its popularity.The safety and quality importance of the food products were also considered with a few recommendations.展开更多
The well-known relation between food and bioactives explores the great prospective of innovative and novel food to maintain or improve health,increasing the demand investigating advance products with medicinal effect....The well-known relation between food and bioactives explores the great prospective of innovative and novel food to maintain or improve health,increasing the demand investigating advance products with medicinal effect.Withania somnifera also known as‘Ashwagandha’in India,is one of the most utilized plants in different ancient medicine systems.The present work is an effort to develop a knowledge-based concept and a quality control approach for the development of functional foods.The study took into account the standardization criteria and examined how different geographies or different field sites(of India)would influence the phytoconstituents and their distribution in the different samples of W.somnifera.Phytoconstituents level were strongly influenced by soil quality,cultivar,and growing season.An increase in phenolic content,flavonoid content,antioxidants and the quality yield,were all correlated with increased phytoconstituent concentrations.The highest hydro-methanolic extract yield(by reflux(Soxhlet),sonication(20 min)and maceration(16 h)was from the sample collected from Rajasthan(18.61%,m/m)followed by West Bengal(11.21%)and Madhya Pradesh(12.67%)respectively.The methanolic extract of Rajasthan sample(produced by the reflux(Soxhlet)extraction method)had the highest concentrations of flavonoids(65.32 mg quercetin equivalent(QE)/g)and the total phenols(60.35 mg gallic acid equivalent(GAE)/g),while Madhya Pradesh sample(distilled water reflux(Soxhlet))extract had the highest antioxidant content(74.13%).High performance thin layer chromatography(HPTLC)method was also utilized for identification of withanolides A.Chromatographic separations were carried out using V(ethyl acetate):V(toluene):V(acetic acid)=9.1:1:0.6 as the mobile phase.The gas chromatograph-mass spectrometer(GC-MS)study of hydro-methanolic Soxhlet extract of W.somnifera from 3 different regions of India was done and the total phytochemical substances identified were 132 in sample from Rajasthan,107 in sample from West Bengal,and 164 in sample from Madhya Pradesh respectively.To conclude,the present study demonstrates how,within a framework of integrated agricultural practices,yield and phytochemicals merge into a new paradigm of functional foods.展开更多
Consumption of insects as food has a long history and has been documented by many researches.Globally,it is extensively practiced in Africa,Asia,Australia,and Latin America as traditional food providing nutritional,ec...Consumption of insects as food has a long history and has been documented by many researches.Globally,it is extensively practiced in Africa,Asia,Australia,and Latin America as traditional food providing nutritional,economic and ecological benefit for rural communities.In today’s world,edible insects are limelight by many researchers and industrialist due to the presence of enormous nutrient potential as well as bioactive compounds.This review mainly focuses on the potential of edible insect for its diverse nutraceutical properties,production and processing as a functional food and its acceptance and boost in the market trends in global scenario.The consumption of edible insects is purely based on ethnic traditional knowledge of the local communities.Previous studies on edible insects have shown their potential as source of nutraceuticals with promote health benefit and can be an alternative source of protein.Most of the edible insects are rich source of protein,energy,vitamins,essential fatty acids and minerals.Beyond these insects can be a source of bioactive compounds especially peptides,which can be applied in functional food industry.In many countries,the traditional knowledge of entomophagy is being applied for production of value-added products using modern technology.展开更多
The consumption of marine macroalgae has been linked with health benefits,albeit some actions,including genoprotection,remain underexplored.Hence,we evaluated the genoprotective potential of a mixture of Ulva rigida,F...The consumption of marine macroalgae has been linked with health benefits,albeit some actions,including genoprotection,remain underexplored.Hence,we evaluated the genoprotective potential of a mixture of Ulva rigida,Fucus vesiculosus and Gracilaria gracilis,through direct consumption or via indirect intake using fish(Sparus aurata)as a vector of algal phytocompounds.Mice(Mus musculus)were subjected to a 1-month dietary supplementation with 5%of macroalgae mix or 10%of fillet of fish previously fed with an algae-supplemented aquafeed(for comparison purposes,10%supplementation with fillet of fish standardly fed was also considered).Thereafter,mice were challenged by the genotoxicant methyl methanesulfonate(MMS),and the genetic damage was evaluated through the micronuclei test.Complementarily,a wider evaluation was carried out encompassing the assessment of energy metabolism,haematological and histological parameters,as well as growth performance.Macroalgae unequivocally protected against MMS-induced genotoxicity.The activity profile of hepatic lactate and isocitrate dehydrogenases promoted by the supplemented diets reflected an improved energy balance.Genoprotection properties were not transferred via fish fed with the algae-supplemented aquafeed,though the transference of phytocomponents with beneficial properties(viz.energy balance improvement)should not be disregarded.Overall,these findings highlighted the genoprotection afforded by marine macroalgae,likely promoted by desmutagenic factors,reinforcing their definition as functional food.The possibility of using fish as an indirect source of algae-borne phytocomponents proved to be plausible and worthy of further investigations.展开更多
文摘Tuna comes from the prickly pear cactus,which is grown in infertile soils and severely drought-stricken conditions.Its nutritional properties are little known and its cost is very affordable.Tamarind grows in warm,semi-dry climates;it can withstand drought and seasonal flooding.The seeds,leaves,flowers,fruits,and even the wood can be harvested.It has nutritional properties.
文摘This study took the teaching practice of food-related majors in Chengdu University,a representative applied institution in China,as an example.Aligning with the course characteristics and educational objectives of Functional Foods,it introduced the features of the BOPPPS teaching model and its implementation in course design.By incorporating research cases and presenting teaching examples,the steps and methods of BOPPPS-based teaching reform were explored while incorporating ideological and political elements into specialized instruction.This study provides insights and references for reforming other food-related courses and contributes to cultivating more food professionals with practical awareness and critical thinking.
文摘Long-term postprandial hyperglycemia is a primary risk factor for developing chronic metabolic diseases such as obesity,type 2 diabetes,and cardiovascular disease.Chronic hyperglycemia induces the glycation of proteins,oxidative stress,inflammation and increases plasma insulin and lipid concentrations.Insulin resistance is the primary cause of postprandial excursions of blood glucose and lipids.Hyperglycemia can be treated by lowering dietary carbohydrates intake,digestion,and absorption.Various functional foods improve glucose metabolism by increasing insulin sensitivity and inhibitingα-glucosidase in the small intestine.Natural phytochemicals,especially active phenolics are good antioxidants and show anti-inflammatory action and regulate blood glucose.This review aimed to report on hypoglycemic properties of active phenolics from functional foods and their proposed anti-diabetic mechanisms.Nevertheless,further clinical trials are required to confirm the bioavailability,safety,and efficacy of phenolics,especially the dosage and duration of treatment,to avoid adverse effects and give better dietary recommendations.
基金Supported by The Collaboration of Regional Entities for the Advancement of Technological Excellence from Japan Science and Technology Agency
文摘Hepatitis C virus(HCV)is a major cause of viral hepatitis and currently infects approximately 170 million people worldwide.An infection by HCV causes high rates of chronic hepatitis(】75%)and progresses to liver cirrhosis and hepatocellular carcinoma ultimately.HCV can be eliminated by a combination of pegylatedα-interferon and the broad-spectrum antiviral drug ribavirin;however,this treatment is still associated with poor efficacy and tolerability and is often accompanied by serious side-effects.While some novel direct-actingantivirals against HCV have been developed recently,high medical costs limit the access to the therapy in cost-sensitive countries.To search for new natural anti-HCV agents,we screened local agricultural products for their suppressive activities against HCV replication using the HCV replicon cell system in vitro.We found a potent inhibitor of HCV RNA expression in the extracts of blueberry leaves and then identified oligomeric proanthocyanidin as the active ingredient.Further investigations into the action mechanism of oligomeric proanthocyanidin suggested that it is an inhibitor of heterogeneous nuclear ribonucleoproteins(hn RNPs)such as hn RNP A2/B1.In this review,we presented an overview of functional foods and ingredients efficient for HCV infection,the chemical structural characteristics of oligomeric proanthocyanidin,and its action mechanism.
基金funded by the Seed Funding for Translational and Applied Research,University Grants Council,The University of Hong Kong(Ref:201611160038)。
文摘This study aimed to compare the efficacy of four formulations of plant-based functional foods on the protection against salt-induced endothelial dysfunction.A randomized crossover design was employed.Ten healthy subjects were recruited,and on five separate occasions they received,in random sequence one of the following 5 treatments:250 mL of plain water(control)alone,and with beetroot powder,celery powder,green tea extract or beetroot powder with green tea extract prior to consuming 150 mL of high-salt chicken broth.Flow-mediated dilation(FMD),blood pressure(BP),heart rate(HR)and pulse-wave velocity(PWV)were measured at fasting and at 30,60,90 and 120 min postprandial.Comparing with control,beetroot supplementation led to a significantly increased HR at 30,60 and 90 min postprandially(P=0.025,0.004,<0.001,respectively).No significant difference was observed for FMD,BP and PWV between control and any of the treatments.Salt reduction may still be the most effective strategy to improve vascular health.
基金supported by grants from the National Key Research and Development Projects(2019YFE0103800)Scientific Research Project of Sichuan Provincial Health Department(No.18PJ586)Research and Innovation Team Project of Chengdu Medical College(No.CYTD16-04)。
文摘This study was to explore the immunity-promoting activity of porcine placenta as a potential raw material for functional foods.Porcine placenta was subjected to the analysis for its bioactive substances,and their immunity-promoting activity was determined in mice supplemented with porcine placenta extract(PPE)and freeze-dried porcine placenta powder at high(PPH)and low(PPL)dosage.Results showed that porcine placenta contained placental peptides and 15 free amino acids,and the amounts of estrogen and progesterone in products developed from porcine placenta were within the limit of national standard.Mice model experiment revealed that compared with the control,the PPH treatment significantly improved the spleen index(P<0.05)by increasing the phagocytic rate of macrophages from 20%to 60%and the conversion rate of T lymphocytes from 8%to 60%.The q PCR analysis disclosed that the porcine placenta powder enhanced mice immunity via promoting the expression of Th1 cytokines of interleukin-2(IL-2)and IFN-γ,especially the former,by almost 8 times in the spleens of male mice,while inhibited Th2 cytokines of IL-4 and IL-10.This investigation has provided a reference for the development of porcine placenta as a raw material applied in functional foods to improve human immunity.
文摘Older people may have more difficulties in acquiring the nutrients they need from diet and they are at greater risk of chronic diseases. Hence, functional foods based on algae, might have a role in improving very important nutrients intake without an increase in calories. This is crucial for middle age people that become less active and will not dispend as much energy as they use to, which will contribute for certain diseases associated with age. Algae produce a great variety of biological active compounds which cannot be found in other organisms. Moreover, they have been reported for their potential medicinal uses. Therefore, they have high potential as a source of functional ingredients. In this review, we will give relevant information about the issue, explain above, pointing out the information related to the compounds that could be responsible for the improvement in quality of life during elderly. It will be also referred that seaweeds can be a source of new compounds for drug discovery.
基金the Institute for Technology in Health Care(ITHC),which agreed to finance this study.
文摘Background: Functional foods have been proposed as vehicles to prevent diseases in response to disease increase throughout the world. Methods: Descriptive cross-sectional study. The nutritional labeling of processed functional foods (PFF) commercially available in Honduras was examined to consider health benefits based on functionality according to the Central American Technical Regulation (CATR) and critical nutrient content according to the profile of the Panamerican Health Organization (PAHO). Results: Out of a national sample of 631 commercial processed foods (CPF), 144 were defined as functional;sweetened and flavored yogurts and cereal bars reached the highest proportions (70% and 66%) of products available in their respective categories. None of the categories was on average “low in calories” according to criteria of CATR;sweetened breakfast cereals were the most caloric (180 kcal) and only sweetened juices had “calorie free” products (15%). Prepared meat did not meet the criterion of “low cholesterol” even though all the products in this category were the reduced fat version of the original CPF. All categories of cereal-based products met the “source of dietary fiber” criteria and 64% of baked products were “high in dietary fiber”. More than 70% of PFF exceeded the sugar recommendation of the PAHO profile, mainly sweetened breakfast cereals (100%) and sweetened juices (93%). 49% of the products exceeded the sodium recommendation, particularly baked products (100%) and cheeses (86%);100% of the later exceeded the recommendation of total fats. More than 60% of products simultaneously exceeded between 2 and 3 of PAHO profile criteria;5% exceeded all the criteria and 4% met all the PAHO profile criteria. The average price of PFF was $2.34, while that of conventional products was $1.87;sweetened breakfast cereals were the most expensive ($3.49 and $3.28) and sweetened juices were the cheapest ($1.79 and $1.89) for both CPF and PFF. Conclusions: PFF marketed in Honduras have an excessive content of critical nutrients. These results demonstrate the need for a rigorous and mandatory regulation in the production, advertising and sale of functional and conventional processed foods.
文摘Technological advances in biotechnology are transforming food production and redefining the link between nutrition,health,and sustainability.From traditional fermentation to genome editing,these tools enable the creation of functional foods that enhance well-being and reduce environmental impact.Historically,low-energy fermentation methods improved the nutritional quality and preservation of foods while supporting gut and metabolic health.Today,emerging fields such as synthetic biology,precision fermentation,microbiome engineering,and artificial intelligence are accelerating innovation in personalised and nutritional approaches that complement conventional diets.These approaches can upcycle agricultural by-products,generate bioactive compounds,and mitigate chronic diseases through targeted microbial or molecular interventions.The purpose of this narrative review is to evaluate the role of biotechnology in developing functional foods that promote health and sustainability.Specifically,it examines how fermentation,biofortification,waste valorisation,and genome editing contribute to metabolic,immune,and cognitive health while supporting environmentally responsible food systems.By integrating traditional food wisdom with modern biosciences,this review highlights biotechnology’s potential to bridge health promotion,sustainability,and innovation in the next generation of functional foods.
基金support from the National Key R&D Program of China(2022YFA0912800)National Excellent Young Scientists Fund(00308054 A1045)+5 种基金National Natural Science Foundation of China(22178233)Talents Program of Sichuan Province,Double First-Class University Plan of Sichuan University,State Key Laboratory of Polymer Materials Engineering(sklpme 2020-03-01)Tianfu Emei Program of Sichuan Province(2022-EC02-00073-CG)Postdoctoral Special Funding of Sichuan Province(TB2022063)Postdoctoral Funding of Sichuan University(2022SCU12099)Ministry of Education Key Laboratory of Leather Chemistry and Engineering,and National Engineering Research Center of Clean Technology in Leather Industry.
文摘Collagen,an abundant extracellular matrix protein in food-producing animals,is widely integrated into food systems for its unique physicochemical properties.Oral collagen-based supplements have received increasing attention for their potential to enhance overall well-being.This review aims to provide valuable insights into the application of oral collagen supplements in food systems,promoting their broader use in food processing,preservation,and the development of functional foods.Specifically,the applications of oral collagen-based supplements in functional foods,focusing on their biological activities,health benefits,and functional properties are summarized.Importantly,their molecular mechanisms of biological activities are critically discussed,including antioxidant,angiotensin-converting enzyme inhibitory,and dipeptidyl peptidase IV inhibitory activities.The health benefits of oral collagen-based supplements,particularly in improving skin,immune,and gastrointestinal health are also explored.Additionally,various functional properties of collagen-based supplements are evaluated,including their stability,bioavailability,taste masking,and sensory attributes.
文摘Food-grade biopolymers and nanotechnology have been increasingly used to revolutionize the delivery of bioactive compounds by enhancing stability,bioavailability,and controlled release.Within the scope of nanoencapsulation systems,this review explores food-derived polymers such as vicilin,zein,gluten,cruciferin,inulin,and others.These biopolymers are ideal since they encapsulate numerous functional compounds,such as vitamins,probiotics,essential oils,and polyphenols,because they are biocompatible,amphiphilic,and biodegradable.The specific physical and chemical properties of each polymer,extraction procedures,and nanoencapsulation techniques applied therein(e.g.,ionic gelation and spray drying)are described.The review highlights advanced targeting systems like pH-sensitive,magnetic delivery.Additional applications include those in synergistic nutraceutical systems,oral administration of vaccination,and intelligent food packaging.All these findings demonstrate that food polymers are increasingly more viable as functional nanocarriers by way of increasing bioactive delivery and the shifting requirements of personalized and health-based dietary regimes.
文摘Sumac(Rhus coriaria)is a flowering plant that is widely consumed for its promoting health benefits and used in food preparations as a spice in the Mediterranean region.It is a high shrub or small tree with imparipinnate leaves,villus and red fruits with one-seeded drupe,and small greenish-white flowers.The nutraceutical and pharmaceutical potential of sumac makes it a remarkable functional food.In this review,the phytochemical and nutritional properties of sumac as an under valorized functional food have been discussed.Flavonoids,anthocyanins,phenolic acids,and organic acids have been reported as dominant phytochemicals in sumac,which are well known for their pharmacological properties that attract many consumers to commonly choose sumac in their diet as well as food preparations.The remarkable volatile compounds present in sumac give it a unique aroma that increases its acceptance by consumers and potential use in the food industry.Sumac has been evaluated for a broad range of nutritional and pharmacological activities such as antioxidant,antinociceptive,anti-inflammatory,anti-diabetic,hepatoprotective,cardioprotective,anticancer,anti-infertility,and neuroprotective potential.This review has also briefly outlined the safety concerns concerning the use of sumac in terms of toxicology and interactions.
文摘Morocco's oat sector is shifting from forage to food,creating demand for varieties with proven processing performance.We profiled nine Moroccan oats(four parental lines,four interspecific derivatives,and one hull-less diploid check)against the key drivers of functionality:β-glucan,hydration metrics(WAI,WSI,swelling power),interfacial metrics(foam capacity/stability,emulsion capacity/stability),and kernel geometry(thousand-kernel weight/width),using SEM to interpret microstructure.Varietal differences were pronounced and actionable.The A.sativa×A.magna derivative Hamdali showed fast wetting(low WAI),strong foaming(highest FS),and high emulsion capacity.These traits make it suitable for oat drinks and large,crack-free flakes.The A.sativa×A.murphyi descendants Al Fawze and Abtah exhibited restrained swelling(lower SP)and moderate WAI/WSI,favoring crisp snacks,biscuits,and pasta;Abtah additionally delivered high emulsion stability suitable for shelf-stable beverages.Amlal and Nezha offered balanced,steerable profiles.Linkingβ-glucan,hydration,and interfacial behavior to kernel traits provides a variety-to-application map for Moroccan oats.We recommend Hamdali/Niema for foamed beverages/flakes;Tissir/Soualem for porridges and thick beverages;Abtah for pasta and stable emulsions;Al Fawze for crisp snacks/biscuits.
基金funded by the Major Science and Technology Project of Henan Province(231100310200)the National Key Research and Development Program(2023YFF1103804).
文摘Liver diseases remain a global health crisis,with limited safe therapeutic options.Cornus officinalis,a traditional medicinal-edible plant,has demonstrated significant hepatoprotective potential.This review systematically summarizes its liver-protective mechanisms and explores its potential as a functional food.Data were collected from scientific databases such as Pub Med,Science Direct,Elsevier,Google Scholar,and relevant literature.Key bioactive compounds—including iridoids,polyphenols,and polysaccharides—contribute to hepatoprotection by mitigating oxidative stress,inflammation,steatosis,apoptosis,and by regulating gut microbiota.As critical quality markers,iridoids exhibit suboptimal bioavailability,necessitating targeted technological interventions—nanoencapsulation for liver-specific delivery and microbial fermentation for controlled aglycone conversion are proposed to enhance their pharmacokinetic properties and bioactivity.Future research could adopt encapsulation and fermentation technologies for C.officinalis processing,aiming to develop targeted functional food products with enhanced bioactivity of its active components.This review,for the first time,establishes a“component-pathway-integration”model,providing a theoretical framework for evidence-based CO-derived functional food development and highlighting the need for further research on iridoid metabolic transformation to advance liver health management.
基金supported by grants from the National Natural Science Foundation of China(31972585)the Guangdong Basic and Applied Basic Research Foundation(2019B1515210001)the Technical System of Poultry Industry of Guangdong Province,China(2021KJ128)。
文摘Selenium(Se),one of the indispensable nutrients for both human health and animal growth,participates in various physiological functions,such as antioxidant and immune responses and metabolism.The role of dietary Se,in its organic and inorganic forms,has been well documented in domestic animals.Furthermore,many feeding strategies for different animals have been developed to increase the Se concentration in animal products to address Se deficiency and even as a potential nutritional strategy to treat free radical-associated diseases.Nevertheless,studies on investigating the optimum addition of Se in feed,the long-term consequences of Se usage in food for animal nutrition,the mechanism of metallic Se nanoparticle(SeNP)transformation in vivo,and the nutritional effects of SeNPs on feed workers and the environment are urgently needed.Starting from the absorption and metabolism mechanism of Se,this review discusses the antioxidant role of Se in detail.Based on this characteristic,we further investigated the application of Se in animal health and described some unresolved issues and unanswered questions warranting further investigation.This review is expected to provide a theoretical reference for improving the quality of food animal meat as well as for the development of Se-based biological nutrition enhancement technology.
文摘Bacteria have been employed widely in the food and beverage industry,with evolving dimensions in recent years.Proteases derived from lactic acid bacteria(LAB)are useful in the production of fermented functional beverages and are of particular use in conditioning their shelf life,nutritional content,flavour,and texture quality,thus making fermented foods and beverages functional and therapeutic.This review focuses on bacteria,especially protease-producing LAB used in food processing,and their usefulness in the production of functional foods and beverages.A case study of oat beverages was briefly explored due to its popularity.The safety and quality importance of the food products were also considered with a few recommendations.
文摘The well-known relation between food and bioactives explores the great prospective of innovative and novel food to maintain or improve health,increasing the demand investigating advance products with medicinal effect.Withania somnifera also known as‘Ashwagandha’in India,is one of the most utilized plants in different ancient medicine systems.The present work is an effort to develop a knowledge-based concept and a quality control approach for the development of functional foods.The study took into account the standardization criteria and examined how different geographies or different field sites(of India)would influence the phytoconstituents and their distribution in the different samples of W.somnifera.Phytoconstituents level were strongly influenced by soil quality,cultivar,and growing season.An increase in phenolic content,flavonoid content,antioxidants and the quality yield,were all correlated with increased phytoconstituent concentrations.The highest hydro-methanolic extract yield(by reflux(Soxhlet),sonication(20 min)and maceration(16 h)was from the sample collected from Rajasthan(18.61%,m/m)followed by West Bengal(11.21%)and Madhya Pradesh(12.67%)respectively.The methanolic extract of Rajasthan sample(produced by the reflux(Soxhlet)extraction method)had the highest concentrations of flavonoids(65.32 mg quercetin equivalent(QE)/g)and the total phenols(60.35 mg gallic acid equivalent(GAE)/g),while Madhya Pradesh sample(distilled water reflux(Soxhlet))extract had the highest antioxidant content(74.13%).High performance thin layer chromatography(HPTLC)method was also utilized for identification of withanolides A.Chromatographic separations were carried out using V(ethyl acetate):V(toluene):V(acetic acid)=9.1:1:0.6 as the mobile phase.The gas chromatograph-mass spectrometer(GC-MS)study of hydro-methanolic Soxhlet extract of W.somnifera from 3 different regions of India was done and the total phytochemical substances identified were 132 in sample from Rajasthan,107 in sample from West Bengal,and 164 in sample from Madhya Pradesh respectively.To conclude,the present study demonstrates how,within a framework of integrated agricultural practices,yield and phytochemicals merge into a new paradigm of functional foods.
文摘Consumption of insects as food has a long history and has been documented by many researches.Globally,it is extensively practiced in Africa,Asia,Australia,and Latin America as traditional food providing nutritional,economic and ecological benefit for rural communities.In today’s world,edible insects are limelight by many researchers and industrialist due to the presence of enormous nutrient potential as well as bioactive compounds.This review mainly focuses on the potential of edible insect for its diverse nutraceutical properties,production and processing as a functional food and its acceptance and boost in the market trends in global scenario.The consumption of edible insects is purely based on ethnic traditional knowledge of the local communities.Previous studies on edible insects have shown their potential as source of nutraceuticals with promote health benefit and can be an alternative source of protein.Most of the edible insects are rich source of protein,energy,vitamins,essential fatty acids and minerals.Beyond these insects can be a source of bioactive compounds especially peptides,which can be applied in functional food industry.In many countries,the traditional knowledge of entomophagy is being applied for production of value-added products using modern technology.
基金financial support to CESAM(UID/AMB/50017-POCI-01-0145-FEDER-007638)to FCT/MCTES through national funds(PIDDAC)+1 种基金the co-funding by the FEDER,within the PT2020 Partnership Agreement and Compete 2020 and to FCT/MCTES through the Ph.D.fellowship(SFRH/BD/102671/2014)funded by the projects UIDB/CVT/00772/2020 and UIDB/04033/2020 supported by FCT/MCTES.
文摘The consumption of marine macroalgae has been linked with health benefits,albeit some actions,including genoprotection,remain underexplored.Hence,we evaluated the genoprotective potential of a mixture of Ulva rigida,Fucus vesiculosus and Gracilaria gracilis,through direct consumption or via indirect intake using fish(Sparus aurata)as a vector of algal phytocompounds.Mice(Mus musculus)were subjected to a 1-month dietary supplementation with 5%of macroalgae mix or 10%of fillet of fish previously fed with an algae-supplemented aquafeed(for comparison purposes,10%supplementation with fillet of fish standardly fed was also considered).Thereafter,mice were challenged by the genotoxicant methyl methanesulfonate(MMS),and the genetic damage was evaluated through the micronuclei test.Complementarily,a wider evaluation was carried out encompassing the assessment of energy metabolism,haematological and histological parameters,as well as growth performance.Macroalgae unequivocally protected against MMS-induced genotoxicity.The activity profile of hepatic lactate and isocitrate dehydrogenases promoted by the supplemented diets reflected an improved energy balance.Genoprotection properties were not transferred via fish fed with the algae-supplemented aquafeed,though the transference of phytocomponents with beneficial properties(viz.energy balance improvement)should not be disregarded.Overall,these findings highlighted the genoprotection afforded by marine macroalgae,likely promoted by desmutagenic factors,reinforcing their definition as functional food.The possibility of using fish as an indirect source of algae-borne phytocomponents proved to be plausible and worthy of further investigations.
