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From Wave Energy to Electricity:Functional Design and Performance Analysis of Triboelectric Nanogenerators
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作者 Ying Lou Mengfan Li +2 位作者 Aifang Yu Junyi Zhai Zhong Lin Wang 《Nano-Micro Letters》 2025年第12期33-73,共41页
Triboelectric nanogenerators(TENGs)offer a selfsustaining power solution for marine regions abundant in resources but constrained by energy availability.Since their pioneering use in wave energy harvesting in 2014,nea... Triboelectric nanogenerators(TENGs)offer a selfsustaining power solution for marine regions abundant in resources but constrained by energy availability.Since their pioneering use in wave energy harvesting in 2014,nearly a decade of advancements has yielded nearly thousands of research articles in this domain.Researchers have developed various TENG device structures with diverse functionalities to facilitate their commercial deployment.Nonetheless,there is a gap in comprehensive summaries and performance evaluations of TENG structural designs.This paper delineates six innovative structural designs,focusing on enhancing internal device output and adapting to external environments:high space utilization,hybrid generator,mechanical gain,broadband response,multi-directional operation,and hybrid energy-harvesting systems.We summarize the prevailing trends in device structure design identified by the research community.Furthermore,we conduct a meticulous comparison of the electrical performance of these devices under motorized,simulated wave,and real marine conditions,while also assessing their sustainability in terms of device durability and mechanical robustness.In conclusion,the paper outlines future research avenues and discusses the obstacles encountered in the TENG field.This review aims to offer valuable perspectives for ongoing research and to advance the progress and application of TENG technology. 展开更多
关键词 Triboelectric nanogenerator functional design Blue energy Electrical performance Sustainability analysis
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Variable reward function-driven strategies for impulsive orbital attack-defense games under multiple constraints and victory conditions
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作者 Liran Zhao Sihan Xu +1 位作者 Qinbo Sun Zhaohui Dang 《Defence Technology(防务技术)》 2025年第9期159-183,共25页
This paper investigates impulsive orbital attack-defense(AD)games under multiple constraints and victory conditions,involving three spacecraft:attacker,target,and defender.In the AD scenario,the attacker aims to breac... This paper investigates impulsive orbital attack-defense(AD)games under multiple constraints and victory conditions,involving three spacecraft:attacker,target,and defender.In the AD scenario,the attacker aims to breach the defender's interception to rendezvous with the target,while the defender seeks to protect the target by blocking or actively pursuing the attacker.Four different maneuvering constraints and five potential game outcomes are incorporated to more accurately model AD game problems and increase complexity,thereby reducing the effectiveness of traditional methods such as differential games and game-tree searches.To address these challenges,this study proposes a multiagent deep reinforcement learning solution with variable reward functions.Two attack strategies,Direct attack(DA)and Bypass attack(BA),are developed for the attacker,each focusing on different mission priorities.Similarly,two defense strategies,Direct interdiction(DI)and Collinear interdiction(CI),are designed for the defender,each optimizing specific defensive actions through tailored reward functions.Each reward function incorporates both process rewards(e.g.,distance and angle)and outcome rewards,derived from physical principles and validated via geometric analysis.Extensive simulations of four strategy confrontations demonstrate average defensive success rates of 75%for DI vs.DA,40%for DI vs.BA,80%for CI vs.DA,and 70%for CI vs.BA.Results indicate that CI outperforms DI for defenders,while BA outperforms DA for attackers.Moreover,defenders achieve their objectives more effectively under identical maneuvering capabilities.Trajectory evolution analyses further illustrate the effectiveness of the proposed variable reward function-driven strategies.These strategies and analyses offer valuable guidance for practical orbital defense scenarios and lay a foundation for future multi-agent game research. 展开更多
关键词 Orbital attack-defense game Impulsive maneuver Multi-agent deep reinforcement learning Reward function design
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Functional design of wind turbine airfoils based on roughness sensitivity characteristics 被引量:4
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作者 王旭东 Xia Hongjun 《High Technology Letters》 EI CAS 2014年第4期442-445,共4页
To improve aerodynamic performance of wind turbine airfoils,the shape profile characteristic of the airfoil is investigated.Application of conformal transformation,one functional and integrated expression of wind turb... To improve aerodynamic performance of wind turbine airfoils,the shape profile characteristic of the airfoil is investigated.Application of conformal transformation,one functional and integrated expression of wind turbine airfoils is presented.Using the boundary layer theory,the aerodynamic model with roughness of wind turbine airfoils is introduced by studying flow separation around the airfoil.Based on the shape expression and aerodynamic performance of airfoils,the function design of wind turbine airfoils is carried out that the maximum lift-drag ratio and low roughness sensitivity are designed objects.Three wind turbines airfoils with different thickness are gained which are used at tip part of blades.As an example,the aerodynamic performance of one designed airfoil with relative thickness of 15%is simulated in different conditions of clean surface,rough surface,laminar flow and turbulent flow.The comparison of aerodynamic performance between the designed airfoil and one popular NACA airfoil is completed which can verify the better performance of the designed airfoil and reliability of the designed method. 展开更多
关键词 wind turbine airfoils integrated expression lift-drag ratio roughness sensitivity function design
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Method for Functional Design of Axiomatic Design Based on Connections 被引量:3
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作者 DENG Jianxin SHAO Ming 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2011年第3期364-371,共8页
Axiomatic design(AD) is a popular design method,and satisfying the independence axiom is the basis of AD.However,AD doesn't provide methods to decompose functions then keep them independent and to handle coupled de... Axiomatic design(AD) is a popular design method,and satisfying the independence axiom is the basis of AD.However,AD doesn't provide methods to decompose functions then keep them independent and to handle coupled design.A few of ways of handling coupled design are mainly passive resolutions when coupled design exists,but not efficient to each product design.Hence,this paper presents an innovative approach to design and decompose functions of complex products based on functional connections,aiming at actively avoiding functional coupling.By contrasting with component networks,four kinds of relations among functions are identified,including spatial,energy,material,and information connection.Then the definitions of these relations and the dominant connection are given.Based on the definitions,the principles of functional decomposition and design are developed,in which each non-leaf function is broken into sub functions centered on its dominant connection with avoidance of functional cross and coupling,and sequentially satisfies the independence axiom.Then the operational flow of the proposed approach is constructed.Determining the dominant connection of a function,decomposing the function into sub functions in terms of the dominant connection and reverse examination and optimization are planed as the core steps in each zigzagging.Input process output(IPO) analysis is introduced to obtain the dominant connection of a function,some rules for examining and optimizing the decomposition results reversely according to oriented object theory are presented as well.An illustrative example about the pouring function of squeeze casting equipments presented demonstrates how to use the proposed approach,and indicates its effectiveness.The proposed approach expands the principles of AD,constructs a guidance policy for independent functional design of complex products based on AD,and can help decrease or actively avoid coupled design and improve design efficiency. 展开更多
关键词 axiomatic design functional design complex product functional decomposition CONNECTIONS squeeze casting equipment
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Aircraft robust multidisciplinary design optimization methodology based on fuzzy preference function 被引量:4
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作者 Ali Reza BABAEI Mohammad Reza SETAYANDEH Hamid FARROKHFAL 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2018年第12期2248-2259,共12页
This paper presents a Fuzzy Preference Function-based Robust Multidisciplinary Design Optimization(FPF-RMDO) methodology. This method is an effective approach to multidisciplinary systems, which can be used to designe... This paper presents a Fuzzy Preference Function-based Robust Multidisciplinary Design Optimization(FPF-RMDO) methodology. This method is an effective approach to multidisciplinary systems, which can be used to designer experiences during the design optimization process by fuzzy preference functions. In this study, two optimizations are done for Predator MQ-1 Unmanned Aerial Vehicle(UAV):(A) deterministic optimization and(B) robust optimization. In both problems, minimization of takeoff weight and drag is considered as objective functions, which have been optimized using Non-dominated Sorting Genetic Algorithm(NSGA). In the robust design optimization, cruise altitude and velocity are considered as uncertainties that are modeled by the Monte Carlo Simulation(MCS) method. Aerodynamics, stability and control, mass properties, performance, and center of gravity are used for multidisciplinary analysis. Robust design optimization results show 46% and 42% robustness improvement for takeoff weight and cruise drag relative to optimal design respectively. 展开更多
关键词 Fuzzy logic Multidisciplinary design optimization Preference function Robust design Unmanned Aerial Vehicle(UAV)
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Reliable Space Pursuing for Reliability-based Design Optimization with Black-box Performance Functions 被引量:2
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作者 SHAN Songqing WANG G Gary 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2009年第1期27-35,共9页
Reliability-based design optimization (RBDO) is intrinsically a double-loop procedure since it involves an overall optimization and an iterative reliability assessment at each search point. Due to the double-loop pr... Reliability-based design optimization (RBDO) is intrinsically a double-loop procedure since it involves an overall optimization and an iterative reliability assessment at each search point. Due to the double-loop procedure, the computational expense of RBDO is normally very high. Current RBDO research focuses on problems with explicitly expressed performance functions and readily available gradients. This paper addresses a more challenging type of RBDO problem in which the performance functions are computation intensive. These computation intensive functions are often considered as a "black-box" and their gradients are not available or not reliable. On the basis of the reliable design space (RDS) concept proposed earlier by the authors, this paper proposes a Reliable Space Pursuing (RSP) approach, in which RDS is first identified and then gradually refined while optimization is performed. It fundamentally avoids the nested optimization and probabilistic assessment loop. Three well known RBDO problems from the literature are used for testing and demonstrating the effectiveness of the proposed RSP method. 展开更多
关键词 Reliability based design optimization black-box function reliable design space
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Structural analysis and design of frost resistance function for subgrade of high-speed railway ballasted track in cold regions 被引量:1
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作者 Qiang Luo WenQiang Lv +1 位作者 QingZhi Ye RuiGuo Zhang 《Research in Cold and Arid Regions》 CSCD 2015年第5期594-604,共11页
According to the technical characteristics of short fixed wheelbase of a high-speed carriage, a subgrade-track integrated space mechanical response analysis model is proposed for trains under the action ofbiaxial load... According to the technical characteristics of short fixed wheelbase of a high-speed carriage, a subgrade-track integrated space mechanical response analysis model is proposed for trains under the action ofbiaxial load after the comparison of the stress distribution characteristics of the ballast track subgrade bed structures for high-speed railway under the action of uniaxial load and biaxial load. The loading threshold value (high-cycle long-term dynamic strength) under the circum- stance where the cumulative deformation of subgrade structure gradually develops and finally reaches the convergent state, and its relationship with the foundation coefficient K30 were deduced, based on the characteristics of cumulative defor- mation evolution obtained from the unit structure filling model test under the action of cyclic loading. In view of structure stability and frost resistance requirements of the railway subgrade in cold regions, technical conditions to maintain good service performance of subgrade structure of high-speed railway ballasted track are discussed and analyzed. Study results show that the additive effect manifests itself obviously for railway train bogies under the action of biaxial load than uni- axial load, which has a significant dynamic effect on the subgrade bed bottom and a slight effect on the surface layer. Thus, the adoption of a biaxial load model in the design of a high-speed railway subgrade accurately reflects the vehicle load. Pursuant to the structure design principle, the design method of the subgrade structure of high-speed railway ballasted track is proposed to meet the technical requirements such as structural strength, bearing stiffness and high-cyclic and long-term stability. Technical indicators are obtained for the variation of thickness of the surface layer of reinforced sub- grade bed in the double-layer subgrade mode along with the change of K30 at the subgrade bed bottom. The double-layer structure mode of "closure on the upper layer and drainage on the lower layer" was proposed in order to meet the water- proofing and drainage requirements of the upper layer of the subgrade bed in cold regions. A dense-framework graded gravel filler with weak water permeability at a coefficient of 10 4 cm/s is used on the upper layer and the void-framework graded gravel filler at the water permeability coefficient of 10 2 cm/s is adopted on the lower layer. 展开更多
关键词 high-speed railway in cold regions subgrade structure biaxial load mode structural analysis design of frostresistance function
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Optimum Weight Design of Functionally Graded Material Gears 被引量:7
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作者 JING Shikai ZHANG He +1 位作者 ZHOU Jingtao SONG Guohua 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2015年第6期1186-1193,共8页
Traditional gear weight optimization methods consider gear tooth number, module, face width or other dimension parameters of gear as design variables. However, due to the complicated form and geometric features peculi... Traditional gear weight optimization methods consider gear tooth number, module, face width or other dimension parameters of gear as design variables. However, due to the complicated form and geometric features peculiar to the gear, there will be large amounts of design parameters in gear design, and the influences of gear parameters changing on gear trains, transmission system and the whole equipment have to be taken into account, which increases the complexity of optimization problem. This paper puts forward to apply functionally graded materials(FGMs) to gears and then conduct the optimization. According to the force situation of gears, the material distribution form of FGM gears is determined. Then based on the performance parameters analysis of FGMs and the practical working demands for gears, a multi-objective optimization model is formed. Finally by using the goal driven optimization(GDO) method, the optimal material distribution is achieved, which makes gear weight and the maximum deformation be minimum and the maximum bending stress do not exceed the allowable stress. As an example, the applying of FGM to automotive transmission gear is conducted to illustrate the optimization design process and the result shows that under the condition of keeping the normal working performance of gear, the method achieves in greatly reducing the gear weight. This research proposes a FGM gears design method that is able to largely reduce the weight of gears by optimizing the microscopic material parameters instead of changing the macroscopic dimension parameters of gears, which reduces the complexity of gear weight optimization problem. 展开更多
关键词 GEARS optimum weight design functionally graded materials material distribution additive manufacturing
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TOPOLOGY DESCRIPTION FUNCTION BASED METHOD FOR MATERIAL DESIGN 被引量:1
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作者 Cao Xianfan Liu Shutian 《Acta Mechanica Solida Sinica》 SCIE EI 2006年第2期95-102,共8页
The purpose of this paper is to investigate the application of topology description function (TDF) in material design. Using TDF to describe the topology of the microstructure, the formulation and the solving techni... The purpose of this paper is to investigate the application of topology description function (TDF) in material design. Using TDF to describe the topology of the microstructure, the formulation and the solving technique of the design problem of materials with prescribed mechanical properties are presented. By presenting the TDF as the sum of a series of basis functions determined by parameters, the topology optimization of material microstructure is formulated as a size optimization problem whose design variables are parameters of TDF basis functions and independent of the mesh of the design domain. By this method, high quality topologies for describing the distribution of constituent material in design domain can be obtained and checkerboard problem often met in the variable density method is avoided. Compared with the conventional level set method, the optimization problem can be solved simply by existing optimization techniques without the process to solve the 'Hamilton-Jacobi-type' equation by the difference method. The method proposed is illustrated with two 2D examples. One gives the unit cell with positive Poisson's ratio, the other with negative Poisson's ratio. The examples show the method based on TDF is effective for material design. 展开更多
关键词 topology optimization topology description function material design
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Modular Design of Complex Product Based on the Triple Fusion of Function/Feature/Knowledge 被引量:1
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作者 李宝童 洪军 +2 位作者 李婷 邱志惠 陈玉宝 《Journal of Shanghai Jiaotong university(Science)》 EI 2010年第5期563-570,共8页
The modular design technology is of importance increasingly,as product structure is more and more complex.Modular design systems face challenging problems as the design information tends to be dynamic,redundant,and ve... The modular design technology is of importance increasingly,as product structure is more and more complex.Modular design systems face challenging problems as the design information tends to be dynamic,redundant,and very large.This paper describes a novel approach for handling them.In this approach,a partition is firstly performed for the complex structural components by mapping functions to the structures layer by layer.Based on this partition,a comprehensive design matrix is then developed to identify the key design mode which is driven by a special function.The design process is also programmed by analyzing the coupled information on both the functional and structural hierarchies.Then,the integrated knowledge model based on object-oriented method and hybrid inference method is constructed.In this model,knowledge can be organized at hierarchical classification and expressed with different forms.Finally,the methodology developed has been applied to a real application in automobile cylinder block design and the results are presented. 展开更多
关键词 modular design functional feature partition comprehensive design matrix knowledge model
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DESIGN AND PROPERTIES OF A FUNCTIONALLY GRADIENT CERAMIC TOOL MATERIAL 被引量:15
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作者 J. Zhao,X. Ai, J.H. Zhang, J.X. Deng and C.Z. Huang Department of Mechanical Engineering, Shandong University of Technology, Jinan 250061,China 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 1999年第5期1054-1058,共5页
Based on the analyses of the severity of cutting process as well as the failure mechanisms of ceramic tools, a model for designing functionally gradient ceramic tool materials with symmetrical distribution is presente... Based on the analyses of the severity of cutting process as well as the failure mechanisms of ceramic tools, a model for designing functionally gradient ceramic tool materials with symmetrical distribution is presented, by which a Al 2O 3/(W,Ti)C ceramic tool material FG 2 was developed. Multi objective optimization method was employed in designing the compositional distribution of this ceramic tool material. The results of both continuous and intermittent cutting tests are indicative of the much better cutting behavior of the functionally gradient ceramic tool FG 2 than that of the common ceramic tool SG 4. 展开更多
关键词 functionally gradient materials materials design compositional distribution ceramic tool
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Design of Co-sedimentation Experiments Used to Fabricate Functionally Graded Materials with a Continuous Change of Composition 被引量:1
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作者 杨中民 《Journal of Wuhan University of Technology(Materials Science)》 SCIE EI CAS 2004年第2期11-13,共3页
In the process of particle settling in a dilute,a density graded distribution of the liquid below the suspension needs to be designed according to the gravity of the suspension prior to sedimentation.In the present pa... In the process of particle settling in a dilute,a density graded distribution of the liquid below the suspension needs to be designed according to the gravity of the suspension prior to sedimentation.In the present paper a compositionally graded W-Mo composite was formed via the settling of the W and Mo particles,with a density gradient distributed in the initial clear liquid along the settling direction. 展开更多
关键词 co-sedimentation design functionally graded material
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QUALITY FUNCTION DEPLOYMENT IN BOTTOM-UP PROCESS FOR DESIGN REUSE 被引量:4
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作者 Tan Runhua, Duan Guolin, Liang Yanhong, Yuan Caiyun (School of Mechanical Engineering,Hebei University of Technology) 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2001年第4期381-384,共4页
To deal with a bottom up process model for design reuses a specific extended house of quality(EHOQ)is proposed Two kinds of supported functions,basic supported functions and new supported functions,are defined.Two ... To deal with a bottom up process model for design reuses a specific extended house of quality(EHOQ)is proposed Two kinds of supported functions,basic supported functions and new supported functions,are defined.Two processes to determine two kinds of functions are presented A kind of EHOQ matrix for a company is given and its management steps are studied. 展开更多
关键词 Quality function deployment BOTTOM up process design reuse
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Function and Design Idea of UHVDC Test Base
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作者 Yu Yongqing, Li Guangfan, Sun Lin, Su Zhiyi and Lu Jiayu China Electric Power Research Institute Zhao Fang 《Electricity》 2009年第1期38-43,共6页
The function of the UHVDC test base of the State Grid Corporation of China (SGCC) is oriented to serve UHVDC power transmission and substation projects, especially power transmission from West China to East China, and... The function of the UHVDC test base of the State Grid Corporation of China (SGCC) is oriented to serve UHVDC power transmission and substation projects, especially power transmission from West China to East China, and to promote localization of UHVDC transmission and substation equipment. In essentials, this test base consists of UHVDC test transmission line, corona cage, outdoor test site, UHV test hall, pollution and environment laboratory, electromagnetic environment simulation test site, insulator laboratory, arrester laboratory and live equipment test field. This paper introduces the function and design idea of the test base, presents the main performance parameters of the above-mentioned test facilities, and summarizes the matters of concern when siting and planning. 展开更多
关键词 UHVDC TEST function and design Idea of UHVDC Test Base design TEST
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Product design on the basis of fuzzy quality function deployment 被引量:2
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作者 Li Zhaoling Gao Qisheng Zhang Dongling 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2008年第6期1165-1170,共6页
In the implementation of quality function deployment (QFD), the determination of the target values of engineering characteristics is a complex decision process with multiple variables and multiple objectives that sh... In the implementation of quality function deployment (QFD), the determination of the target values of engineering characteristics is a complex decision process with multiple variables and multiple objectives that should trade off, and optimize all kinds of conflicts and constraints. A fuzzy linear programming model (FLP) is proposed. On the basis of the inherent fuzziness of QFD system, triangular fuzzy numbers are used to represent all the relationships and correlations, and then, the functional relationships between the customer needs and engineering characteristics and the functional correlations among the engineering characteristics are determined with the information in the house of quality (HoQ) fully used. The fuzzy linear programming (FLP) model aims to find the optimal target values of the engineering characteristics to maximize the customer satisfaction. Finally, the proposed method is illustrated by a numerical example. 展开更多
关键词 quality function deployment house of quality product design fuzzy optimization customer satisfaction
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Path Analysis of Agricultural Project Design Based on Function Expansion: A Case Study of Naya Mountain Villa 被引量:2
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作者 Yuehong SUN Yongsheng WU +1 位作者 Rui CHEN Xue YANG 《Asian Agricultural Research》 2018年第2期22-31,共10页
The expansion of agricultural function is one of the important means for modern agricultural projects to promote agricultural economic benefits. Successful modern agricultural projects require good creative ideas and ... The expansion of agricultural function is one of the important means for modern agricultural projects to promote agricultural economic benefits. Successful modern agricultural projects require good creative ideas and design programs. While developing high-efficient modern agricultural production activities,we should fully explore the intangible value of agricultural production activities,combine agriculture with agricultural products,natural conditions,cultural conception and other effective resources,to expand agricultural functions,and promote comprehensive benefits. In order to build a sustainable modern agricultural project operation system,Naya Mountain Villa project planning is taken as an example for analysis. Naya Mountain Villa began construction in 2011; the creative planning based on the agricultural expansion function was carried out in 2013; it had successful access to the capital market in 2015. The project realizes the effective integration of agricultural production system and agricultural function expansion,constructs a set of long-term stable profiting models,and lays an important foundation for entering the capital market. The project is a representative example of the function-expanding modern agricultural project. Through the analysis of the design ideas of the project,this paper discusses the function expansion elements of basic resources,public welfare and agricultural function expansion methods,the formation of general ideas,source and construction logic of creative thinking,and summarizes and abstracts some inspiring design methods of agricultural function expansion. Through the analysis of the key points in the design of the specific technical aspects of the project,this paper provides a reference for solving common difficult problems in the practical design. The summary and refinement of the thinking logic,thinking construction and specific design method of the project is inspiring and repeatable to some extent,which can provide reference for the relevant researchers. 展开更多
关键词 Modern agriculture design of Naya Mountain Villa function expansion
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生态美学与功能性植物空间设计的融合研究 被引量:2
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作者 张鹏 《分子植物育种》 北大核心 2025年第2期641-646,共6页
本研究探讨了生态美学与功能性植物空间设计的融合,提出了在景观设计中实现生态功能与美学价值双重目标的具体策略。随着全球生态环境恶化和城市化进程的加快,生态美学通过自然景观的美学体验提升人们的环保意识,而功能性植物设计则通... 本研究探讨了生态美学与功能性植物空间设计的融合,提出了在景观设计中实现生态功能与美学价值双重目标的具体策略。随着全球生态环境恶化和城市化进程的加快,生态美学通过自然景观的美学体验提升人们的环保意识,而功能性植物设计则通过空气净化和生物多样性提升等生态功能改善环境质量。研究提出了植物选择与配置、植物纹理与空间设计等关键设计原则,强调了现代技术与跨学科合作的重要性。研究结果显示,生态美学与功能性植物设计的结合不仅能提高景观的生态效益,还能增强美学体验,促进环境保护与可持续发展。本研究为城市景观设计提供了理论支持和实践指导,旨在提高公众对生态美学的认知,推动其在生态文明建设中的广泛应用。 展开更多
关键词 生态美学 功能性植物 景观设计 生态功能 美学价值
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生物大模型技术前沿与应用进展 被引量:1
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作者 石金龙 张哲 +2 位作者 戴安琳 林恺 何昆仑 《生理科学进展》 北大核心 2025年第3期235-242,共8页
以基因、转录、蛋白质等生命组学为主体的生物大数据快速积累和以深度学习为代表的人工智能技术迅猛发展,催生出各种类别的生物大模型(biological large models)。复杂的深度学习架构、巨大的参数量和算力需求、以及海量的预训练数据等... 以基因、转录、蛋白质等生命组学为主体的生物大数据快速积累和以深度学习为代表的人工智能技术迅猛发展,催生出各种类别的生物大模型(biological large models)。复杂的深度学习架构、巨大的参数量和算力需求、以及海量的预训练数据等是大模型技术的主要特征。预训练数据类别及参数量一定程度上决定了大模型所具备的能力强弱,而不同的模型架构则可支撑不同类别的下游任务。近两年,围绕DNA/RNA/蛋白质等生物序列与单细胞表达图谱等组学数据分析挖掘、大分子结构预测、新型药物设计和功能机制解析等多种应用场景,涌现了多种通用或专用大模型,展示出其在生物医学研究及转化应用等领域的巨大潜力。本文旨在结合不同类别的生物数据特点和研究应用需求,概述生物数据特征及其用于生物大模型训练的技术方法,并进一步综述现有大模型在生物医学研究及疾病诊疗中的应用进展,为提升生物大模型能力、拓展应用范围提供新的思路。 展开更多
关键词 生物大模型 注意力机制 序列分析 结构预测 功能解读 合成设计
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基于“肝主谋虑”探讨肝与执行功能衰退的关系 被引量:1
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作者 霍磊 邓亚南 +3 位作者 邓金钗 张妍 杜雪源 詹向红 《中医杂志》 北大核心 2025年第2期201-204,216,共5页
执行功能可被归为中医学“神”的范畴,与“肝主谋虑”密切相关。通过探讨肝与执行功能衰退的关系,认为肝郁日久,谋虑不决,为执行功能衰退发生的始动因素;肝血亏虚,谋虑难出,为执行功能衰退发展的重要基础;“肝-督脉-脑”通路阻滞,谋虑失... 执行功能可被归为中医学“神”的范畴,与“肝主谋虑”密切相关。通过探讨肝与执行功能衰退的关系,认为肝郁日久,谋虑不决,为执行功能衰退发生的始动因素;肝血亏虚,谋虑难出,为执行功能衰退发展的重要基础;“肝-督脉-脑”通路阻滞,谋虑失清,为执行功能衰退加速的重要因素。从中医学、现代医学与认知心理学角度探讨肝与执行功能衰退的关系,以期为从肝论治执行功能衰退提供思路。 展开更多
关键词 谋虑 执行功能 足厥阴肝经 痴呆
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防屈曲支撑-钢筋混凝土框架结构基于韧性的抗震设计方法研究 被引量:2
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作者 马恺泽 李兰欣 +1 位作者 邢国华 陈韵如 《振动与冲击》 北大核心 2025年第7期146-154,共9页
为实现防屈曲支撑-钢筋混凝土(buckling-restrained braced reinforced concrete,BRB-RC)框架结构基于韧性的抗震设计,引入韧性水平量化指标,建立建筑抗震韧性等级的分级,提出利用功能损失控制韧性指标的计算假定,并建立建筑多层级功能... 为实现防屈曲支撑-钢筋混凝土(buckling-restrained braced reinforced concrete,BRB-RC)框架结构基于韧性的抗震设计,引入韧性水平量化指标,建立建筑抗震韧性等级的分级,提出利用功能损失控制韧性指标的计算假定,并建立建筑多层级功能损失量化关系,提出根据建筑功能损失控制构件损伤及工程需求参数的方法。依据BRB-RC框架结构的受力机制,提出其基于韧性的抗震设计方法并建立设计流程。将设计方法应用于一幢5层的BRB-RC框架结构的抗震设计并进行罕遇地震作用下的弹塑性时程分析。分析结果表明,结构的层间位移角和层间剪力分布均满足设计要求,所提出的方法能实现预期的抗震韧性目标。 展开更多
关键词 建筑抗震韧性 防屈曲支撑(BRB) 钢筋混凝土(RC)框架结构 抗震设计 功能损失
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