Primary liver cancer(PLC) is the third major cause of cancer related death, which seriously affects the survival period and quality of life of patients. However, there is currently no evidence to prove which treatment...Primary liver cancer(PLC) is the third major cause of cancer related death, which seriously affects the survival period and quality of life of patients. However, there is currently no evidence to prove which treatment method is most effective. Traditional Chinese Medicine(TCM) has shown certain advantages in the treatment of PLC, especially in the side effects of Western Medicine. Therefore, we designed a clinical trial protocol for the treatment of PLC using TCM granules. Our purpose is to explore the efficacy and safety of Yangxiao Fukang granule(YXFKG, 养消复康颗粒) in the treatment of stage Ⅲ hepatitis B related PLC. A total of 216 patients from three hospitals in Henan Province will be enrolled and randomly divided into a trial group and a control group in a 1 ∶ 1 ratio. The trial group will be treated with conventional western medicine plus YXFKG, while the control group will receive conventional western medicine plus a placebo for YXFKG. All patients will receive a daily dose of either YXFKG or a placebo for six months, followed by a six-month follow-up period. The main observation outcome includes 1-year survival rate, while secondary outcomes include conversion rate to remission, objective response rate, progression free survival, overall survival, quality of life score, and TCM clinical symptom score. Blood routine, urine routine, stool routine, electrocardiogram, liver and kidney function, coagulation function test, and D-dimer are safety indicators. Collect data before treatment and during the 3rd, 6th, 9th, and 12th months of treatment, and conduct statistical analysis. This study will preliminarily verify the effectiveness and safety of YXFKG in the treatment of stage Ⅲ hepatitis B related PLC, which may provide a new choice for clinical treatment of PLC.展开更多
Soil salinity is the most important factor affecting vegetation distribution,and the secondary salinization has affected the development of oasis agriculture.In arid areas the spatial variation of soil moisture and sa...Soil salinity is the most important factor affecting vegetation distribution,and the secondary salinization has affected the development of oasis agriculture.In arid areas the spatial variation of soil moisture and sa lt content is marked-ly affected by groundwater,irratio nal irrigation in artificial oasis.By analyzing the soil moisture,salt content and groundwa-ter table in different areas of old oasis,new oasis and desert in Fukang Oa sis,it is shown that topography and l and use are main factors affecting the change of groundwater table,the redistribution of soil moisture and salt cont ent.When undis-turbed by human,the groundwater tab le rises from mountain to belt of grou nd water spillage,the groundwater t able rises mightily in plain because of the artificial irrigation,and the secondary salinization of soil is very seriou s.In oasis the ground-water table raises compared with that in the natural desert at the same latitude.In old oasis of upper reaches o f river salt has not been concentrated too much in rhizosphere because this area is the belt of groundwater drainage,soil t exture is coarse,the groundwater table is very low,and the salt in soil is drained i nto the groundwater.The new oasis has been the areas of salt accumulation becau se of the artificial irrigation,the salt content in soil is higher than th at in old oasis,so some cultivated fields here had to be thrown out because of the serious s econdary salinization.展开更多
The origin and source of the petroleum in the Jurassic reservoirs within the eastern Fukang sub-depression were geochemically investigated.They show thermal maturities matching the peak generation stage,while the cond...The origin and source of the petroleum in the Jurassic reservoirs within the eastern Fukang sub-depression were geochemically investigated.They show thermal maturities matching the peak generation stage,while the condensates are at the early stage of intense cracking.Oils and condensates may have experienced mild evaporative fractionation,while mixing of severely biodegraded with non-biodegraded oils has occurred.Using biomarkers and isotopes,petroleums were classified into GroupⅠ,ⅡandⅢgenetic groups,with GroupⅢfurther divided intoⅢa andⅢb subgroups.GroupⅠpetroleum displays heavy carbon isotopes,a strong predominance of pristine over phytane,high C_(19)and C_(20)tricyclic and C_(24)tetracyclic terpanes,low gammacerane,and dominant C_(29)steranes,while GroupⅡshows light carbon isotopes,a predominance of phytane over pristine,high C_(21)and C_(23)tricyclic with low C_(24)tetracyclic terpanes,high gammacerane and dominant C_(27)steranes.GroupⅢa petroleum shows mixing compositions of GroupⅠandⅡ,while GroupⅢb displays similar compositions to Group I,but with significantly higher Ts,C_(29)Ts and C_(30)diahopane proportions.Oil-source rock correlation suggests GroupⅠandⅡpetroleums originate from Jurassic and Permian source rocks,respectively,while GroupⅢa are mixtures sourced from these rocks andⅢb are mixtures from Jurassic and Triassic source rocks.展开更多
The deformation pattern and Holocene slip rate along the Fukang fault in Eastern Tianshan, China are analyzed and studied using the data obtained in field investigation. The result indicates that the Fukang fault cons...The deformation pattern and Holocene slip rate along the Fukang fault in Eastern Tianshan, China are analyzed and studied using the data obtained in field investigation. The result indicates that the Fukang fault consists of 4 low-angle south-dipping thrust faults with stepover, displaying recent tectonic activity. The movement along the termination parts of the fault is weaker, with an average vertical slip rate of 0 13～0 33 mm/a in Holocene, and along the middle part of the fault is stronger, with an average vertical slip rate larger than 1.42 mm/a in Holocene. The Holocene deformation pattern along the fault displays generally steady slip, multi-phase intermittent movement along its western segment, and persistent movement along its middle and eastern segments, which have caused rapid dislocation up to the surface in an earlier phase.展开更多
The characteristics and formation mechanism of clastic reservoirs have a significant impact on petroleum accumulation in the deep-seated strata of sedimentary basins.Newly drill data indicate that the tight reservoirs...The characteristics and formation mechanism of clastic reservoirs have a significant impact on petroleum accumulation in the deep-seated strata of sedimentary basins.Newly drill data indicate that the tight reservoirs in the lower slop of Fukang Sag in the Junggar Basin produce a lot of oil despite being buried extremely deep and with low porosity.By using lithological and geochemical studies,we investigated the formation of these deep-seated reservoirs through the comparison between upper and lower slopes.The results suggest that the reservoir of lower slop is highly compacted and has weaker dissolution than the reservoir in the upper slope.Dissolution and micro fractures are the key factors in determining the formation of deep-seated reservoirs.The fluids that caused the dissolution of reservoir can be divided into three stages and sourced from the mixture of deep and basin fluids.A model of reservoir formation and evolution has been set up.Our research could provide an insight for the formation of deep-seated reservoirs in similar geological conditions worldwide.展开更多
基金Supported by Henan Provincial Department of Science and Technology Project:Clinical Study on Yangxiao Fukang granule in the Treatment of StageⅢhepatitis B related Liver Cancer(232102310188)Henan Province Characteristic Backbone Discipline Construction Project:Guidelines for Traditional Chinese Medicine Diagnosis and Treatment of Hepatocellular Carcinoma after Hepatic Arterial Chemotherapy and Embolization(STG-ZYX03-202126)。
文摘Primary liver cancer(PLC) is the third major cause of cancer related death, which seriously affects the survival period and quality of life of patients. However, there is currently no evidence to prove which treatment method is most effective. Traditional Chinese Medicine(TCM) has shown certain advantages in the treatment of PLC, especially in the side effects of Western Medicine. Therefore, we designed a clinical trial protocol for the treatment of PLC using TCM granules. Our purpose is to explore the efficacy and safety of Yangxiao Fukang granule(YXFKG, 养消复康颗粒) in the treatment of stage Ⅲ hepatitis B related PLC. A total of 216 patients from three hospitals in Henan Province will be enrolled and randomly divided into a trial group and a control group in a 1 ∶ 1 ratio. The trial group will be treated with conventional western medicine plus YXFKG, while the control group will receive conventional western medicine plus a placebo for YXFKG. All patients will receive a daily dose of either YXFKG or a placebo for six months, followed by a six-month follow-up period. The main observation outcome includes 1-year survival rate, while secondary outcomes include conversion rate to remission, objective response rate, progression free survival, overall survival, quality of life score, and TCM clinical symptom score. Blood routine, urine routine, stool routine, electrocardiogram, liver and kidney function, coagulation function test, and D-dimer are safety indicators. Collect data before treatment and during the 3rd, 6th, 9th, and 12th months of treatment, and conduct statistical analysis. This study will preliminarily verify the effectiveness and safety of YXFKG in the treatment of stage Ⅲ hepatitis B related PLC, which may provide a new choice for clinical treatment of PLC.
文摘Soil salinity is the most important factor affecting vegetation distribution,and the secondary salinization has affected the development of oasis agriculture.In arid areas the spatial variation of soil moisture and sa lt content is marked-ly affected by groundwater,irratio nal irrigation in artificial oasis.By analyzing the soil moisture,salt content and groundwa-ter table in different areas of old oasis,new oasis and desert in Fukang Oa sis,it is shown that topography and l and use are main factors affecting the change of groundwater table,the redistribution of soil moisture and salt cont ent.When undis-turbed by human,the groundwater tab le rises from mountain to belt of grou nd water spillage,the groundwater t able rises mightily in plain because of the artificial irrigation,and the secondary salinization of soil is very seriou s.In oasis the ground-water table raises compared with that in the natural desert at the same latitude.In old oasis of upper reaches o f river salt has not been concentrated too much in rhizosphere because this area is the belt of groundwater drainage,soil t exture is coarse,the groundwater table is very low,and the salt in soil is drained i nto the groundwater.The new oasis has been the areas of salt accumulation becau se of the artificial irrigation,the salt content in soil is higher than th at in old oasis,so some cultivated fields here had to be thrown out because of the serious s econdary salinization.
基金supported by the Fundamental Research Funds for the Central Universities(Grant No.20CX02108A)the Development Fund of the Key Laboratory of Deep Oil&Gas,China University of Petroleum(East China)。
文摘The origin and source of the petroleum in the Jurassic reservoirs within the eastern Fukang sub-depression were geochemically investigated.They show thermal maturities matching the peak generation stage,while the condensates are at the early stage of intense cracking.Oils and condensates may have experienced mild evaporative fractionation,while mixing of severely biodegraded with non-biodegraded oils has occurred.Using biomarkers and isotopes,petroleums were classified into GroupⅠ,ⅡandⅢgenetic groups,with GroupⅢfurther divided intoⅢa andⅢb subgroups.GroupⅠpetroleum displays heavy carbon isotopes,a strong predominance of pristine over phytane,high C_(19)and C_(20)tricyclic and C_(24)tetracyclic terpanes,low gammacerane,and dominant C_(29)steranes,while GroupⅡshows light carbon isotopes,a predominance of phytane over pristine,high C_(21)and C_(23)tricyclic with low C_(24)tetracyclic terpanes,high gammacerane and dominant C_(27)steranes.GroupⅢa petroleum shows mixing compositions of GroupⅠandⅡ,while GroupⅢb displays similar compositions to Group I,but with significantly higher Ts,C_(29)Ts and C_(30)diahopane proportions.Oil-source rock correlation suggests GroupⅠandⅡpetroleums originate from Jurassic and Permian source rocks,respectively,while GroupⅢa are mixtures sourced from these rocks andⅢb are mixtures from Jurassic and Triassic source rocks.
文摘The deformation pattern and Holocene slip rate along the Fukang fault in Eastern Tianshan, China are analyzed and studied using the data obtained in field investigation. The result indicates that the Fukang fault consists of 4 low-angle south-dipping thrust faults with stepover, displaying recent tectonic activity. The movement along the termination parts of the fault is weaker, with an average vertical slip rate of 0 13～0 33 mm/a in Holocene, and along the middle part of the fault is stronger, with an average vertical slip rate larger than 1.42 mm/a in Holocene. The Holocene deformation pattern along the fault displays generally steady slip, multi-phase intermittent movement along its western segment, and persistent movement along its middle and eastern segments, which have caused rapid dislocation up to the surface in an earlier phase.
基金supported by the PetroChina Science and Technology Major Project(No.2023ZZ0205)the Scientific research and technology development project of CNPC(Nos.2021DJ04 and 2021DJ0401)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDA14010301)the National Natural Science Foundation of China(Grant No.41702138).
文摘The characteristics and formation mechanism of clastic reservoirs have a significant impact on petroleum accumulation in the deep-seated strata of sedimentary basins.Newly drill data indicate that the tight reservoirs in the lower slop of Fukang Sag in the Junggar Basin produce a lot of oil despite being buried extremely deep and with low porosity.By using lithological and geochemical studies,we investigated the formation of these deep-seated reservoirs through the comparison between upper and lower slopes.The results suggest that the reservoir of lower slop is highly compacted and has weaker dissolution than the reservoir in the upper slope.Dissolution and micro fractures are the key factors in determining the formation of deep-seated reservoirs.The fluids that caused the dissolution of reservoir can be divided into three stages and sourced from the mixture of deep and basin fluids.A model of reservoir formation and evolution has been set up.Our research could provide an insight for the formation of deep-seated reservoirs in similar geological conditions worldwide.
