This study investigated the therapeutic effects on metabolic syndrome(MetS)and the impact on the intestinal barrier and gut microbiota of Fu brick tea aqueous extracts(FTE)on MetS in rats fed with a high-fat diet(HFD)...This study investigated the therapeutic effects on metabolic syndrome(MetS)and the impact on the intestinal barrier and gut microbiota of Fu brick tea aqueous extracts(FTE)on MetS in rats fed with a high-fat diet(HFD).Here,the results showed that FTE supplement significantly reduced HFD-induced weight gain,adiposity,dyslipidemia,fasting blood glucose(FBG)increment,and non-alcoholic fatty liver disease(NAFLD).Moreover,FTE supplement resulted in a decline in lipopolysaccharide(LPS)level and attenuation of colonic inflammation and oxidative stress to protect the intestinal barrier function.FTE supplement also maintained the intestinal barrier integrity by improving histological appearance and promoting ZO-1,Occludin,and Claudin-1 protein expression levels.Meanwhile,FTE supplement alleviated the gut microbiota dysbiosis by enhancing the Firmicutes/Bacteroidetes(F/B)ratio and stimulating the colonization of probiotic bacteria such as Akkermansia,Lactobacillus,Adlercreutzia,and Bacteroides.These findings collectively suggest that Fu brick tea could alleviate MetS and MetS-associated traits with the mechanism relevant to the protection of intestinal barrier and gut microbiota regulation.展开更多
茯茶属黑茶类,为后发酵茶,因其独特的制作工艺和保健功效在茶叶消费市场备受欢迎,发展潜能较大,并逐步成为茶学研究重点之一。文章以中国知网(CNKI)和Web of Science(WOS)数据库近30年茯茶和茯砖茶相关文献作为数据源,利用Excel对相关...茯茶属黑茶类,为后发酵茶,因其独特的制作工艺和保健功效在茶叶消费市场备受欢迎,发展潜能较大,并逐步成为茶学研究重点之一。文章以中国知网(CNKI)和Web of Science(WOS)数据库近30年茯茶和茯砖茶相关文献作为数据源,利用Excel对相关文献的发表年份、文献来源、机构作者、关键词和摘要进行统计分析;并利用CiteSpace软件对中外文文献的关键词、作者和机构进行可视化分析,探究茯茶研究热点和发展趋势。结果表明,近年来茯茶文献研究方向的多样性在一定程度上有所提高,茯茶的相关研究领域经历了缓慢起步阶段、逐渐发展阶段和全面发展提升阶段3个时期。随着政策扶持和研究引领,茯茶科学研究和产业发展正在逐渐提升。研究结果对确定目前茯茶研究热点、探究茯茶产业化发展方向和未来发展趋势具有重要参考价值。展开更多
基金supported by the Earmarked Fund for the Modern Agricultural Industry Technology System(CARS19),Research on Quality Chemical Characteristics and Healthy Function of Xianyang Brick Tea(2021kjc-js231)Research on Metabolite Alteration and Mechanism in Fu Brick Tea under the Action of Eurotium cristatum(31471706).
文摘This study investigated the therapeutic effects on metabolic syndrome(MetS)and the impact on the intestinal barrier and gut microbiota of Fu brick tea aqueous extracts(FTE)on MetS in rats fed with a high-fat diet(HFD).Here,the results showed that FTE supplement significantly reduced HFD-induced weight gain,adiposity,dyslipidemia,fasting blood glucose(FBG)increment,and non-alcoholic fatty liver disease(NAFLD).Moreover,FTE supplement resulted in a decline in lipopolysaccharide(LPS)level and attenuation of colonic inflammation and oxidative stress to protect the intestinal barrier function.FTE supplement also maintained the intestinal barrier integrity by improving histological appearance and promoting ZO-1,Occludin,and Claudin-1 protein expression levels.Meanwhile,FTE supplement alleviated the gut microbiota dysbiosis by enhancing the Firmicutes/Bacteroidetes(F/B)ratio and stimulating the colonization of probiotic bacteria such as Akkermansia,Lactobacillus,Adlercreutzia,and Bacteroides.These findings collectively suggest that Fu brick tea could alleviate MetS and MetS-associated traits with the mechanism relevant to the protection of intestinal barrier and gut microbiota regulation.
文摘茯茶属黑茶类,为后发酵茶,因其独特的制作工艺和保健功效在茶叶消费市场备受欢迎,发展潜能较大,并逐步成为茶学研究重点之一。文章以中国知网(CNKI)和Web of Science(WOS)数据库近30年茯茶和茯砖茶相关文献作为数据源,利用Excel对相关文献的发表年份、文献来源、机构作者、关键词和摘要进行统计分析;并利用CiteSpace软件对中外文文献的关键词、作者和机构进行可视化分析,探究茯茶研究热点和发展趋势。结果表明,近年来茯茶文献研究方向的多样性在一定程度上有所提高,茯茶的相关研究领域经历了缓慢起步阶段、逐渐发展阶段和全面发展提升阶段3个时期。随着政策扶持和研究引领,茯茶科学研究和产业发展正在逐渐提升。研究结果对确定目前茯茶研究热点、探究茯茶产业化发展方向和未来发展趋势具有重要参考价值。
