A mathematical model based on Fick's first lawwas established to describe the process of ultrasonic-assisted extraction of arctigenin from acid hydrolyzed FructusArctii.Acid hydrolization with hydrochloric acid pr...A mathematical model based on Fick's first lawwas established to describe the process of ultrasonic-assisted extraction of arctigenin from acid hydrolyzed FructusArctii.Acid hydrolization with hydrochloric acid promotes the conversion of arctiin to arctigenin in the arctiin-rich active pharmaceutical ingredient, and the hydrolyzed products were further examined to investigate the process setup. By considering the mechanism of the extraction process and experimental data, the effects of parameters including solven to solid ratio, particle size of hydrolyzed samples, ethano volume fraction, ultrasound power, extraction temperature and extraction time on concentration of arctigenin were analyzed in detail. The model was suitable for simulating the process of ultrasonic-assisted extraction of arctigenin. The simulation results of the model agree well with experimental data with the deviation below13%, indicating that the mathematical mode can provide valuable guidance for the extraction of arctigenin from acid hydrolyzed FructusArctii.展开更多
基金The National Natural Science Foundation of China(No.21406272,21676291)the Fundamental Research Funds for the Central Universities(No.2632017ZD01)Jiangsu Planned Projects for Postdoctoral Research Funds(No.1402060B)
文摘A mathematical model based on Fick's first lawwas established to describe the process of ultrasonic-assisted extraction of arctigenin from acid hydrolyzed FructusArctii.Acid hydrolization with hydrochloric acid promotes the conversion of arctiin to arctigenin in the arctiin-rich active pharmaceutical ingredient, and the hydrolyzed products were further examined to investigate the process setup. By considering the mechanism of the extraction process and experimental data, the effects of parameters including solven to solid ratio, particle size of hydrolyzed samples, ethano volume fraction, ultrasound power, extraction temperature and extraction time on concentration of arctigenin were analyzed in detail. The model was suitable for simulating the process of ultrasonic-assisted extraction of arctigenin. The simulation results of the model agree well with experimental data with the deviation below13%, indicating that the mathematical mode can provide valuable guidance for the extraction of arctigenin from acid hydrolyzed FructusArctii.
