通过检索关键词,指定一个或多个类别标签实现文本的高效组织和自动分类,是发现文档中的隐含关系、推动知识传播和创新的重要途径。然而,检索关键词的获取位置、词性以及选取是否全面等因素,会导致关键词语义信息缺失和关键词识别准确性...通过检索关键词,指定一个或多个类别标签实现文本的高效组织和自动分类,是发现文档中的隐含关系、推动知识传播和创新的重要途径。然而,检索关键词的获取位置、词性以及选取是否全面等因素,会导致关键词语义信息缺失和关键词识别准确性较差;这两大问题,正是影响文档高效、精准自动分类的突出障碍。基于此,论文构建了一个融合TF-IDF(Term Frequency-Inverse Document Frequency)和GloVe(Global Vectors for Word Representation)的文本自动分类系统。该系统首先就词性影响因子和位置权重系数对TF-IDF算法进行改进,以弥补传统TF-IDF算法在关键词识别和语义分析上的不足;其次,使用GloVe模型对关键词集进一步扩充,使文本自动分类的准确率和召回率分别达到92.6%和90.9%;最后,通过实验比对,进一步验证该系统在处理多类别文本自动分类任务中的有效性。展开更多
针对畜禽疫病文本中特征项权重分配不准导致诊断准确率较低的问题,利用提出的TF-IIGM-NW(Term Frequency-Improved Inverse Gravity Moment With Normalization and Weighting)改进算法结合Word2vec词向量进行文本向量化表示。该方法在T...针对畜禽疫病文本中特征项权重分配不准导致诊断准确率较低的问题,利用提出的TF-IIGM-NW(Term Frequency-Improved Inverse Gravity Moment With Normalization and Weighting)改进算法结合Word2vec词向量进行文本向量化表示。该方法在TF-IIGM(Term Frequency-Improved Inverse Gravity Moment)算法的基础之上,对其进行归一化处理并结合基于关键词抽取算法设定的规则,进一步提升文本内核心关键词权重,然后将其与结合Word2vec词向量获取的文本向量化表示结果输入支持向量机(Support Vector Machine,SVM)进行畜禽疫病诊断。为了验证算法的有效性,基于自建的羊疫病文本数据集,将改进算法与现有词向量常见处理方式进行对比分析。结果表明,基于TF-IIGM-NW算法的macro-F1值与micro-F1值分别达到96.73%,96.76%;与传统经典算法TF-IDF(Term Frequency-Inverse Document Frequency)相比,分别提升2.25%,2.26%;与TF-IIGM算法相比,分别提高0.90%,0.97%。改进算法能够有效提升疫病诊断性能。通过SVM在每类疫病上的实验结果分析表明,羊口疮疫病类别最易被错判。展开更多
This study reviews the hepatotoxic chemicals,mechanisms of toxicity,and detoxification methods of Toosendan Fructus(TF).Limonin-type triterpenoids,as primary hepatotoxic components,mediate toxicity though inflammation...This study reviews the hepatotoxic chemicals,mechanisms of toxicity,and detoxification methods of Toosendan Fructus(TF).Limonin-type triterpenoids,as primary hepatotoxic components,mediate toxicity though inflammation,oxidative stress,mitochondrial dysfunction,ferroptosis,and apoptosis.Hepatotoxicity can be mitigated by controlling dosage,using processed forms of the herbs,and through rational herbal compatibility.The review provides insights for enhancing the safety and clinical application of TF.展开更多
Depression poses a considerable threat to global health,underscoring the critical need for safe treatments.Because of its homology of medicine and food,Gardeniae Fructus is widely used in clinical and everyday life co...Depression poses a considerable threat to global health,underscoring the critical need for safe treatments.Because of its homology of medicine and food,Gardeniae Fructus is widely used in clinical and everyday life contexts.Gardeniae Fructus oil(OGF)is a waste byproduct of the food industry with promising recycling potential.While previous research has demonstrated the antidepressant effects of OGF,the precise mechanism remains unclear.To fill this gap in the literature,this paper elucidates the composition and potential antidepressant mechanism of OGF.According to the results,OGF is mainly composed of fatty acids and unsaponifiable matter.OGF could effectively attenuate depression-like behaviors in mice with chronic unpredictable mild stress by modulating the microbiota-gut-brain axis.Mechanisms include improving gut dysbiosis,regulating short-chain fatty acids,protecting the intestinal barrier function,reducing hippocampal damage,and alleviating neuroinflammation by inhibiting the activation of the TLR4/NF-κB/NLRP3 pathway.Fecal microbiota transplantation experiments confirmed the involvement of the gut microbiota in the modulation of depression-like behavior by OGF.This study establishes the antidepressant effects of OGF as well as the underlying mechanism,demonstrating its potential as a novel dietary intervention for depression treatment.展开更多
As one of the most common metabolic diseases,type 2 diabetes(T2D)has become a public health concern with rising global prevalence.Corni fructus(CF),a traditional Chinese herb utilized for centuries as homologous medic...As one of the most common metabolic diseases,type 2 diabetes(T2D)has become a public health concern with rising global prevalence.Corni fructus(CF),a traditional Chinese herb utilized for centuries as homologous medicinal and food resources,has been widely used to treat glucose and lipid metabolism disorders.However,as a core active ingredient of CF,whether and how morroniside(MOR)improves T2D is still unclear.This study aimed to explore the pathways by which MOR ameliorates T2D in mice induced by high-fat diet(HFD)and low-dose streptozotocin through 16S rRNA gene sequencing.We found that MOR treatment significantly ameliorated body weight loss,hyperglycemia,hyperlipidemia and insulin resistance in T2D mice.In addition,MOR remarkably improved inflammation-and oxidative stress-driven hepatic and pancreatic injuries in the model mice.Mechanistically,MOR rehabilitated the dysregulated diversity and constitution of the gut microbiota in T2D mice,with significant changes in relative abundance in genus such as Lactobacillus,Lachnospiraceae_NK4A136_group,and Lachnospiraceae_UCG-006 which are believed to be highly correlated with serum parameters and insulin resistance in mice with T2D.Therefore,we infer that MOR improves T2D at least partially by maintaining the host microbiota homeostasis,and MOR may be a promising candidate for T2D treatment.展开更多
Trichosanthis Fructus(Gualou)is the dried ripe fruit of Trichosanthes kirilowii Maxim.or Trichosanthes rosthornii Harms(Cucurbitaceae family).It demonstrates significant therapeutic effects in treating coronary heart ...Trichosanthis Fructus(Gualou)is the dried ripe fruit of Trichosanthes kirilowii Maxim.or Trichosanthes rosthornii Harms(Cucurbitaceae family).It demonstrates significant therapeutic effects in treating coronary heart disease and diabetes mellitus,while also possessing anti-cancer and anti-aging properties.Both Trichosanthis Pericarpium(Gualoupi)and Trichosanthis Semen(Gualouzi)are used medicinally.With the increasing clinical application of Trichosanthes medicinal materials and their preparations(such as Gualou Injection and Gualou Tablets),the demand for them is expected to grow substantially.To further investigate Trichosanthis Fructus,explore its medicinal effects and new applications,and promote the development of Trichosanthis Fructus-based products,this paper reviewed the chemical components of Trichosanthis Fructus.Furthermore,the differences in major chemical components among Trichosanthis Fructus,Trichosanthis Pericarpium and Trichosanthis Semen were compared,providing a scientific basis for establishing quality evaluation standards of Trichosanthes medicinal materials.展开更多
Diaphragma juglandis(D.juglandis)Fructus is a brownish lamellar structure located between walnut kernels.As a traditional Chinese herbal medicine,it exhibits therapeutic effects including spleen-strengthening,kidney c...Diaphragma juglandis(D.juglandis)Fructus is a brownish lamellar structure located between walnut kernels.As a traditional Chinese herbal medicine,it exhibits therapeutic effects including spleen-strengthening,kidney consolidation,astringency,diuresis,and heat-clearing.In this study,the polyphenolic constituents of D.juglandis and its functional instant tea were investigated in this study.Three polyphenolic compounds were isolated from 70%ethanol extract of D.juglandis Fructus as 2-methoxy juglone,regiolone and quercetin.The HPLC method was established for determination of the content of quercetin in the instant tea samples under the premise that the methodology was verifi ed to meet the standard requirements.The preparation process of D.juglandis Fructus instant tea was optimized through single factor experiments and Box-Behnken design-response surface methodology and the optimal conditions were determined as follows:feed rate of 10 mL/min,inlet temperature of 151℃,andβ-cyclodextrin addition of 9%.Then the antioxidant activity of each sample was evaluated using DPPH and ABTS radical scavenging assays.The results showed that the quercetin had significant antioxidant activity.The instant tea group demonstrated superior antioxidant effects compared to the extracts group at 50,200,and 800μg/mL(P<0.001),likely due to the optimized spray-drying process,which might have enhanced the solubility,stability,and bioavailability of the active compounds.The results provided critical foundational data for the deep processing and comprehensive utilization of D.juglandis Fructus.展开更多
文摘通过检索关键词,指定一个或多个类别标签实现文本的高效组织和自动分类,是发现文档中的隐含关系、推动知识传播和创新的重要途径。然而,检索关键词的获取位置、词性以及选取是否全面等因素,会导致关键词语义信息缺失和关键词识别准确性较差;这两大问题,正是影响文档高效、精准自动分类的突出障碍。基于此,论文构建了一个融合TF-IDF(Term Frequency-Inverse Document Frequency)和GloVe(Global Vectors for Word Representation)的文本自动分类系统。该系统首先就词性影响因子和位置权重系数对TF-IDF算法进行改进,以弥补传统TF-IDF算法在关键词识别和语义分析上的不足;其次,使用GloVe模型对关键词集进一步扩充,使文本自动分类的准确率和召回率分别达到92.6%和90.9%;最后,通过实验比对,进一步验证该系统在处理多类别文本自动分类任务中的有效性。
文摘This study reviews the hepatotoxic chemicals,mechanisms of toxicity,and detoxification methods of Toosendan Fructus(TF).Limonin-type triterpenoids,as primary hepatotoxic components,mediate toxicity though inflammation,oxidative stress,mitochondrial dysfunction,ferroptosis,and apoptosis.Hepatotoxicity can be mitigated by controlling dosage,using processed forms of the herbs,and through rational herbal compatibility.The review provides insights for enhancing the safety and clinical application of TF.
基金supported by the Natural Science Foundation of Hubei Province(2024AFD225)the Major Task Innovation Project of Hubei Province(2023BEB011)+1 种基金the Natural Science Foundation of Hubei Province(2023AFB403)the Central Guided Local Science and Technology Development Special Project of Hubei Province(2019ZYYD069)。
文摘Depression poses a considerable threat to global health,underscoring the critical need for safe treatments.Because of its homology of medicine and food,Gardeniae Fructus is widely used in clinical and everyday life contexts.Gardeniae Fructus oil(OGF)is a waste byproduct of the food industry with promising recycling potential.While previous research has demonstrated the antidepressant effects of OGF,the precise mechanism remains unclear.To fill this gap in the literature,this paper elucidates the composition and potential antidepressant mechanism of OGF.According to the results,OGF is mainly composed of fatty acids and unsaponifiable matter.OGF could effectively attenuate depression-like behaviors in mice with chronic unpredictable mild stress by modulating the microbiota-gut-brain axis.Mechanisms include improving gut dysbiosis,regulating short-chain fatty acids,protecting the intestinal barrier function,reducing hippocampal damage,and alleviating neuroinflammation by inhibiting the activation of the TLR4/NF-κB/NLRP3 pathway.Fecal microbiota transplantation experiments confirmed the involvement of the gut microbiota in the modulation of depression-like behavior by OGF.This study establishes the antidepressant effects of OGF as well as the underlying mechanism,demonstrating its potential as a novel dietary intervention for depression treatment.
基金supported by the Administration of Traditional Chinese Medicine Special Fund of Shaanxi Province(2021-QYZL-01,2021-QYZL-03)Special Funding for Basic Research Operating Expenses of the Central Universities(GK202205001,GK202205010)Hebei Province Innovation Capacity Enhancement Program Project(225A2501D).
文摘As one of the most common metabolic diseases,type 2 diabetes(T2D)has become a public health concern with rising global prevalence.Corni fructus(CF),a traditional Chinese herb utilized for centuries as homologous medicinal and food resources,has been widely used to treat glucose and lipid metabolism disorders.However,as a core active ingredient of CF,whether and how morroniside(MOR)improves T2D is still unclear.This study aimed to explore the pathways by which MOR ameliorates T2D in mice induced by high-fat diet(HFD)and low-dose streptozotocin through 16S rRNA gene sequencing.We found that MOR treatment significantly ameliorated body weight loss,hyperglycemia,hyperlipidemia and insulin resistance in T2D mice.In addition,MOR remarkably improved inflammation-and oxidative stress-driven hepatic and pancreatic injuries in the model mice.Mechanistically,MOR rehabilitated the dysregulated diversity and constitution of the gut microbiota in T2D mice,with significant changes in relative abundance in genus such as Lactobacillus,Lachnospiraceae_NK4A136_group,and Lachnospiraceae_UCG-006 which are believed to be highly correlated with serum parameters and insulin resistance in mice with T2D.Therefore,we infer that MOR improves T2D at least partially by maintaining the host microbiota homeostasis,and MOR may be a promising candidate for T2D treatment.
基金Supported by Xuzhou Science and Technology Planning Project(KC22059)Qinglan Project Foundation of Jiangsu ProvinceHigh Level Talent Project of XZCIT(XGY2021EG08).
文摘Trichosanthis Fructus(Gualou)is the dried ripe fruit of Trichosanthes kirilowii Maxim.or Trichosanthes rosthornii Harms(Cucurbitaceae family).It demonstrates significant therapeutic effects in treating coronary heart disease and diabetes mellitus,while also possessing anti-cancer and anti-aging properties.Both Trichosanthis Pericarpium(Gualoupi)and Trichosanthis Semen(Gualouzi)are used medicinally.With the increasing clinical application of Trichosanthes medicinal materials and their preparations(such as Gualou Injection and Gualou Tablets),the demand for them is expected to grow substantially.To further investigate Trichosanthis Fructus,explore its medicinal effects and new applications,and promote the development of Trichosanthis Fructus-based products,this paper reviewed the chemical components of Trichosanthis Fructus.Furthermore,the differences in major chemical components among Trichosanthis Fructus,Trichosanthis Pericarpium and Trichosanthis Semen were compared,providing a scientific basis for establishing quality evaluation standards of Trichosanthes medicinal materials.
文摘Diaphragma juglandis(D.juglandis)Fructus is a brownish lamellar structure located between walnut kernels.As a traditional Chinese herbal medicine,it exhibits therapeutic effects including spleen-strengthening,kidney consolidation,astringency,diuresis,and heat-clearing.In this study,the polyphenolic constituents of D.juglandis and its functional instant tea were investigated in this study.Three polyphenolic compounds were isolated from 70%ethanol extract of D.juglandis Fructus as 2-methoxy juglone,regiolone and quercetin.The HPLC method was established for determination of the content of quercetin in the instant tea samples under the premise that the methodology was verifi ed to meet the standard requirements.The preparation process of D.juglandis Fructus instant tea was optimized through single factor experiments and Box-Behnken design-response surface methodology and the optimal conditions were determined as follows:feed rate of 10 mL/min,inlet temperature of 151℃,andβ-cyclodextrin addition of 9%.Then the antioxidant activity of each sample was evaluated using DPPH and ABTS radical scavenging assays.The results showed that the quercetin had significant antioxidant activity.The instant tea group demonstrated superior antioxidant effects compared to the extracts group at 50,200,and 800μg/mL(P<0.001),likely due to the optimized spray-drying process,which might have enhanced the solubility,stability,and bioavailability of the active compounds.The results provided critical foundational data for the deep processing and comprehensive utilization of D.juglandis Fructus.
