Since the introduction of the dual carbon goals,countries worldwide have been actively exploring next-generation green and clean energy technologies.E-fuels have gained widespread international attention as an effecti...Since the introduction of the dual carbon goals,countries worldwide have been actively exploring next-generation green and clean energy technologies.E-fuels have gained widespread international attention as an effective supplement to the current energy system and a novel approach to reducing carbon emissions.By tracking and understanding the current status and technological advancements of e-fuels,we can better support the strategic planning of China's new energy initiatives.展开更多
Hepatic portal venous gas(HPVG)is a rare yet clinically significant radiological manifestation characterized by diverse etiologies,unclear pathophysiology,and nonspecific clinical presentations.Its appearance frequent...Hepatic portal venous gas(HPVG)is a rare yet clinically significant radiological manifestation characterized by diverse etiologies,unclear pathophysiology,and nonspecific clinical presentations.Its appearance frequently heralds a severe underlying condition,with a reported mortality rate as high as 75%,earning it the moniker“harbinger of death”.In recent years,with advancements in diagnosis and treatment of HPVG,its mortality rate has been reduced to below 40%.Nevertheless,the infrequency of HPVG,coupled with its complex etiologies and rapid progression,often leaves clinicians failing to provide timely intervention due to a lack of awareness,resulting in the death of patient.Currently,there is no consensus on the standardized diagnosis and treatment strategies for HPVG.The purpose of this review is to synthesize the existing literature on HPVG and to discuss the advancements in understanding its clinical manifestation,etiologies,pathogenesis,diagnostic methods,and treatment strategies,as well as to emphasize the necessity for further research to enhance our comprehension of its pathophysiology and to refine diagnostic and therapeutic approaches.展开更多
Some 20 years ago,10-yearold Wang Xingxing watched a documentary that featured a bipedal robot designed by Marc Raibert,now president of U.S.-based robot company Boston Dynamics.That moment planted the seed for his fu...Some 20 years ago,10-yearold Wang Xingxing watched a documentary that featured a bipedal robot designed by Marc Raibert,now president of U.S.-based robot company Boston Dynamics.That moment planted the seed for his future in innovation.Today,operating in China’s private sector,Wang’s company,Hangzhou-based Unitree Robotics in Zhejiang Province,is a globally recognized name in producing high-performance,general-purpose quadruped and humanoid robots.展开更多
Since the proposal of achieving dual carbon goals,countries worldwide have been actively seeking next-generation energy technologies.Ammonia energy,particularly green ammonia,has recently become a focal point of globa...Since the proposal of achieving dual carbon goals,countries worldwide have been actively seeking next-generation energy technologies.Ammonia energy,particularly green ammonia,has recently become a focal point of global attention.The global green ammonia market is expected to grow from USD 17 million in 2021 to USD 5.415 billion by 2030,with a growth rate of 90.2%during this period.As a fossil energy company primarily focused on oil and natural gas,CNPC faces significant pressure to transition to low-carbon operations and achieve dual carbon goals.Keeping track of the current status and technological advancements in ammonia energy development can support CNPC in more effectively implementing its new energy strategy.展开更多
Owing to the complex and often asymptomatic presentations,the diagnosis of biliopancreatic diseases,including pancreatic and biliary malignancies,remains challenging.Recent technological advancements have remarkably i...Owing to the complex and often asymptomatic presentations,the diagnosis of biliopancreatic diseases,including pancreatic and biliary malignancies,remains challenging.Recent technological advancements have remarkably improved the diagnostic accuracy and patient outcomes in these diseases.This review explores key advancements in diagnostic modalities,including biomarkers,imaging techniques,and artificial intelligence(AI)-based technologies.Biomarkers,such as cancer antigen 19-9,KRAS mutations,and inflammatory markers,provide crucial insights into disease progression and treatment responses.Advanced imaging modalities include enhanced computed tomography(CT),positron emission tomography-CT,magnetic resonance cholangiopancreatography,and endoscopic ultrasound.AI integration in imaging and pathology has enhanced diagnostic precision through deep learning algorithms that analyze medical images,automate routine diagnostic tasks,and provide predictive analytics for personalized treatment strategies.The applications of these technologies are diverse,ranging from early cancer detection to therapeutic guidance and real-time imaging.Biomarker-based liquid biopsies and AI-assisted imaging tools are essential for non-invasive diagnostics and individualized patient management.Furthermore,AI-driven models are transforming disease stratification,thus enhancing risk assessment and decision-making.Future studies should explore standardizing biomarker validation,improving AI-driven diagnostics,and expanding the accessibility of advanced imaging technologies in resource-limited settings.The continued development of non-invasive diagnostic techniques and precision medicine approaches is crucial for optimizing the detection and management of biliopancreatic diseases.Collaborative efforts between clinicians,researchers,and industry stakeholders will be pivotal in applying these advancements in clinical practice.展开更多
This commentary critically appraises the study by Li et al which pioneered the exploration of the triglyceride-glucose(TyG)index as a prognostic marker in hepatitis B virus-related advanced hepatocellular carcinoma pa...This commentary critically appraises the study by Li et al which pioneered the exploration of the triglyceride-glucose(TyG)index as a prognostic marker in hepatitis B virus-related advanced hepatocellular carcinoma patients undergoing combined camrelizumab and lenvatinib therapy.While we acknowledge the study’s clinical relevance in proposing an easily accessible metabolic biomarker,we delve into the mechanistic plausibility linking insulin resistance to immunotherapy response and angiogenic inhibition.We further critically examine the methodological limitations,including the retrospective design,the populationspecific TyG cut-off value,and unaddressed metabolic confounders.We highlight the imperative for future research to validate its utility across diverse etiologies and treatment settings,and to unravel the underlying immunometabolic pathways.展开更多
Recent years have witnessed transformative changes brought about by artificial intelligence(AI)techniques with billions of parameters for the realization of high accuracy,proposing high demand for the advanced and AI ...Recent years have witnessed transformative changes brought about by artificial intelligence(AI)techniques with billions of parameters for the realization of high accuracy,proposing high demand for the advanced and AI chip to solve these AI tasks efficiently and powerfully.Rapid progress has been made in the field of advanced chips recently,such as the development of photonic computing,the advancement of the quantum processors,the boost of the biomimetic chips,and so on.Designs tactics of the advanced chips can be conducted with elaborated consideration of materials,algorithms,models,architectures,and so on.Though a few reviews present the development of the chips from their unique aspects,reviews in the view of the latest design for advanced and AI chips are few.Here,the newest development is systematically reviewed in the field of advanced chips.First,background and mechanisms are summarized,and subsequently most important considerations for co-design of the software and hardware are illustrated.Next,strategies are summed up to obtain advanced and AI chips with high excellent performance by taking the important information processing steps into consideration,after which the design thought for the advanced chips in the future is proposed.Finally,some perspectives are put forward.展开更多
BACKGROUND Paternal perinatal depression(PPD)is closely associated with maternal mental health challenges,marital strain,and adverse child developmental outcomes.Despite its significant impact,PPD remains under-recogn...BACKGROUND Paternal perinatal depression(PPD)is closely associated with maternal mental health challenges,marital strain,and adverse child developmental outcomes.Despite its significant impact,PPD remains under-recognized in family-centered clinical practice.Concurrently,against the backdrop of rising rates of delayed marriage and China’s Maternity Incentive Policy,the proportion of women giving birth at an advanced maternal age is increasing.Nevertheless,research specifically examining PPD among spouses of older mothers remains critically scarce,both in China and globally.AIM To investigate PPD and its influencing factors in Chinese advanced maternal age families.METHODS This cross-sectional study included 358 participants;it was conducted among fathers of pregnant women of advanced maternal age at five hospitals in the Pearl River Delta region of China from September 2023 to June 2024.Data were collected via a general information questionnaire,the Social Support Rating Scale,and the Edinburgh Postnatal Depression Scale.Latent profile analysis and regression mixture models(RMMs)were adopted to analyze the latent PPD types and factors that influenced PPD.RESULTS The incidence of PPD was 16.48%,and three profiles were identified:Low-symptomatic(175 cases,48.89%),monophasic(140 cases,39.10%),and high-symptomatic(43 cases,12.01%).The RMM analysis revealed that first pregnancy,low income(<¥3000/month),part-time work,and a history of abnormal pregnancy were positively associated with the high-symptomatic type(P<0.05).Conversely,high subjective support and support utilization were negatively associated with the high-symptomatic type compared with the low-symptomatic type(P<0.05).Good couple relationships,high objective and subjective support,and high support utilization were negatively associated with monophasic disorder(P<0.05).CONCLUSION PPD incidence is high among Chinese fathers with advanced maternal age partners,and the characteristics of depression are varied.Healthcare practitioners should prioritize individuals with low levels of social support.展开更多
AIM:To investigate the efficacy of the anal fistula plug(AFP) compared to the mucosa advancement flap(MAF),considered the best procedure for patients with a complex anal fistula.METHODS:The literature search included ...AIM:To investigate the efficacy of the anal fistula plug(AFP) compared to the mucosa advancement flap(MAF),considered the best procedure for patients with a complex anal fistula.METHODS:The literature search included PubMed,EMBASE,Cochrane Library and OVID original studies on the topic of AFP compared to MAF for complex fistula-in-ano that had a deadline for publication by April 2011.Randomized controlled trials,controlled clinical trials and prospective cohort studies were included in the review.After information collection,a meta-analysis was performed using data on overall success rates as well as incidence of incontinence and morbidity.The quality of postoperative life was also included with the clinical results.RESULTS:Six studies involving 408 patients(AFP = 167,MAF = 241) were included in the meta-analysis.The differences in the overall success rates and incidence of fistula recurrence were not statistically significant between the AFP and MAF [risk difference(RD) =-0.12,95%CI:-0.39-0.14;RD = 0.13;95%CI:-0.18-0.43,respectively].However,for the AFP,the risk of postoperative impaired continence was lower(RD =-0.08,95%CI:-0.15--0.02) as was the incidence of other complications(RD =-0.06,95%CI:-0.11-0.00).The postoperative quality of life,for patients treated using the AFP was superior to that of the MAF patients.Patients treated with the AFP had less persistent pain of a shorter duration and the healing time of the fistula and hospital stay were also reduced.CONCLUSION:The AFP is an effective procedure for patients with a complex anal fistula;it has the same success rate but a lower risk of complications than the MAF and may also be associated with an improved postoperative quality of life.Additional evidence is needed to confirm these findings.展开更多
The history and current status of research and development of wave energy in the world is briefly introduced. The main problems existing in these studies are pointed out. The description is focused on the current stat...The history and current status of research and development of wave energy in the world is briefly introduced. The main problems existing in these studies are pointed out. The description is focused on the current status and the advancements achieved in China. After analysis of the wave energy resources and practical situations in China, it is pointed out that the studies on wave energy should be not only concentrated on the conversion efficiency and costs of wave energy devices, but also focused on the technology of independent operation and stable output of electricity. Finally, the perspectives of application of wave energy in China are discussed.展开更多
This review article aims to analyze and evaluate the advantages, shortcomings, technological advancements and hereafter prospects in welding and processing of magnesium and its alloys. Studies have accounted that repl...This review article aims to analyze and evaluate the advantages, shortcomings, technological advancements and hereafter prospects in welding and processing of magnesium and its alloys. Studies have accounted that replacing other metals with Mg alloys will bring about in monumental weight reduction with significant addition in strength that could lead to dramatic transformation of metallic era of 21st century and onwards. However,wide application of Mg and its alloys depends on the development of advanced welding &joining technologies. The current paradigm and progress in welding,joining and processing of magnesium and its alloys are reviewed,and research trend in this field is briefly discussed.展开更多
Select group of patients with concurrent esophagealand gastric stricturing secondary to corrosive intake requires colonic or free jejunal transfer. These technically demanding reconstructions are associated with signi...Select group of patients with concurrent esophagealand gastric stricturing secondary to corrosive intake requires colonic or free jejunal transfer. These technically demanding reconstructions are associated with significant complications and have up to 18% ischemic conduit necrosis. Following corrosive intake, up to 30% of such patients have stricturing at the pyloro-duodenal canal area only and rest of the stomach is available for rather less complex and better perfused gastrointestinal reconstruction. Here we describe an alternative technique where we utilize stomach following distal gastric resection along with Roux-en-Y reconstruction instead of colonic or jejunal interposition. This neo-conduit is potentially superior in terms of perfusion, lower risk of gastro-esophageal anastomotic leakage and technical ease as opposed to colonic and jejunal counterparts. We have utilized the said technique in three patients with acceptable postoperative outcome. In addition this technique offers a feasible reconstruction plan in patients where colon is not available for reconstruction due to concomitant pathology. Utility of this technique may also merit consideration for gastroesophageal junction tumors.展开更多
BACKGROUND Mandibular retraction is the main etiological mechanism of class II malocclusion in China and the subsequent distal molar relationship can cause functional discomfort in mastication,breathing and the tempor...BACKGROUND Mandibular retraction is the main etiological mechanism of class II malocclusion in China and the subsequent distal molar relationship can cause functional discomfort in mastication,breathing and the temporomandibular joint.The use of mandibular advancement(MA)devices has recently emerged as an adolescent mandibular retraction treatment;however,current studies regarding the effect thereof are relatively few,and there is lack of sufficient clinical support.AIM To investigate the clinical effect of invisalign MA on the treatment of mandibular retraction in adolescents.METHODS This study included 30 adolescent patients who underwent treatment with the MA appliances from December 2017 to June 2021.The lateral cephalometric data before and after treatment were collected and imported into Dolphin Imaging software.The changes were measured by linear measurement superimposed with lateral cephalometric trajectory based on the Pancherz technology.RESULTS There was no significant difference in the length and position of maxilla before and after the treatment.The position of the mandible moved 3.13 mm,the length increased 4.14 mm,the mandibular ramus length increased 4.09 mm,the body length increased 4.25 mm,and the position of the condyle moved 1.03 mm forward after treatment.Additionally,changes in the incisor sagittal position and labial inclination were observed.The position of the upper incisor point moved back 1.33 mm,without statistical difference,the inclination and tooth angle decreased by 3.44°and 4.06°,respectively;the position of the lower incisor point was moved 2.98 mm,and the inclination and tooth angle increased by 2.62°and 1.23°,respectively.Furthermore,changes in the incisor overjet and molar relationship were seen.Overjet decreased by 4.31 mm,of which 1.78 mm was due to dental factors,accounting for 41.3%of the effect as opposed to 58.7%due to skeletal factors.Molar relationship improved 3.87 mm,with 1.34 mm due to dental factors,and dental and skeletal factors were accounted for 34.6%and 65.4%of the effect,respectively.CONCLUSION For adolescent patients with mandible retraction,invisalign MA can effectively promote the mandible growth,and it was proven to be mainly due to skeletal effects.展开更多
Ultrasound is extensively studied for biomedical engineering applications.As the core part of the ultrasonic system,the ultrasound transducer plays a significant role.For the purpose of meeting the requirement of prec...Ultrasound is extensively studied for biomedical engineering applications.As the core part of the ultrasonic system,the ultrasound transducer plays a significant role.For the purpose of meeting the requirement of precision medicine,the main challenge for the development of ultrasound transducer is to further enhance its performance.In this article,an overview of recent developments in ultrasound transducer technologies that use a variety of material strategies and device designs based on both the piezoelectric and photoacoustic mechanisms is provided.Practical applications are also presented,including ultrasound imaging,ultrasound therapy,particle/cell manipulation,drug delivery,and nerve stimulation.Finally,perspectives and opportunities are also highlighted.展开更多
This paper presents a review of the position-sensitive detector(PSD) sensor, covering different types of PSD and recent works related to this field. Furthermore, it explains the theoretical concepts and provides infor...This paper presents a review of the position-sensitive detector(PSD) sensor, covering different types of PSD and recent works related to this field. Furthermore, it explains the theoretical concepts and provides information about its structure and principles of operation. Moreover, it includes the main information about the available commercial PSDs from different companies, along with a comparison between the common modules. The PSD features include high position resolution, fast response, and a wide dynamic range. These features make it suitable for various fields and applications, such as imaging, spectrometry, spectroscopy and others.展开更多
BACKGROUND Microcystic adnexal carcinoma(MAC)is a rare malignant tumor of the skin that is commonly found on the face.It grows slowly and has a low mortality rate.However,for various reasons,including strong histologi...BACKGROUND Microcystic adnexal carcinoma(MAC)is a rare malignant tumor of the skin that is commonly found on the face.It grows slowly and has a low mortality rate.However,for various reasons,including strong histological invasiveness,clinical inexperience and inadequate procedure design,immediate or permanent facial deformity may occur after surgical operations.CASE SUMMARY This article describes a middle-aged female artist who was diagnosed with MAC on the left upper lip.She declined the recommended treatment plan,which included two-stage reconstruction,skin grafting,or surgery that could have resulted in obvious facial dysfunction or esthetic deformity.We accurately designed a personalized procedure involving a“jigsaw puzzle advancement flap”for the patient based on the lesion location and the estimated area of skin loss.The procedure was successful;both pathological R0 resection and immediate and long-term esthetic reconstruction effects were achieved.CONCLUSION This study suggests that when treating facial MAC or other skin malignancies,a surgical team should have sufficient plastic surgery-related knowledge and skills.An optimal surgical plan for an individual is needed to achieve good facial esthetics and functional recovery and shorten the treatment course.展开更多
Mandibular advancement devices(MADs)are one of the treatments used for Obstructive sleep apnea(OSA).MADs try to maintain the mandible in an advanced position to keep the upper airways open when sleeping.To achieve thi...Mandibular advancement devices(MADs)are one of the treatments used for Obstructive sleep apnea(OSA).MADs try to maintain the mandible in an advanced position to keep the upper airways open when sleeping.To achieve this goal,most current MADs limit the mouth opening to a few millimetres.The study of the kinematic behaviour of the patient’s jaw is essential in order to design devices that allow greater aperture ranges.For this purpose,a 3D multibody model that reproduces jaw movement has been developed in this work.To this end,the movement of the lower incisor has been determined by means of a vision system and reflective markers.In addition,the kinematics of the temporomandibular joint has been modelled.Next,the device is designed and printed using a cam-follower mechanism.This way,the cam profiles and the followers are optimally designed and positioned for each patient depending on the physiognomy of the jaw and the opening and advancing movement prescribed by the specialist.展开更多
Neurological diseases and injuries present some of the great- est challenges in modern medicine, often causing irrevers- ible and lifelong burdens in the people whom they afflict. Conditions of stroke, traumatic brain...Neurological diseases and injuries present some of the great- est challenges in modern medicine, often causing irrevers- ible and lifelong burdens in the people whom they afflict. Conditions of stroke, traumatic brain injury, spinal cord injury, and neurodegenerative diseases have devastating con- sequences on millions of people each year, and yet there are currently no therapies or interventions that can repair the structure of neural circuits and restore neural tissue function in the brain and spinal cord. Despite the challenges of over- coming these limitations, there are many new approaches under development that hold much promise. Neural tissue engineering aims to restore and influence the function of damaged or diseased neural tissue generally through the use of stem cells and biomaterials. Many types of biomaterials may be implemented in various designs to influence the survival, differentiation, and function of developing stem cells, as well as to guide neurite extension and morphological architecture of cell cultures. Such designs may aim to reca- pitulate the cellular interactions, extracellular matrix char- acteristics, biochemical factors, and sequences of events that occur in neurodevelopment, in addition to supporting cell survival, differentiation, and integration into innate neural tissue.展开更多
The present study aimed to examine the relationship of organizational intelligence with innovation management and career advancement in an organization. Considering its objective, this was a descriptive-correlational ...The present study aimed to examine the relationship of organizational intelligence with innovation management and career advancement in an organization. Considering its objective, this was a descriptive-correlational study. The statistical population included all high school managers in Zahedan at the year 2015. The sample contained 52 male managers and 51 female managers whom were selected through applying stratified random sampling method. To collect data, Organizational Intelligence Questionnaire, Innovation Management Inventory and Questionnaire of Career Advancement were used, the validity of which was assessed through applying the standpoint of a number of university professors and their reliability was obtained 0.74, 0.76, 0.84, respectively, using Cronbach’s alpha coefficient. Results indicated that considering managers’ perspectives, the status of organizational intelligence and career advancement were desirable;however, the status of innovation management was moderate. Moreover, organizational intelligence and its components were significantly and positively correlated with innovation management (r = 0.512, P < 0.01), and there was a significant and positive relationship between organizational intelligence and career advancement (r = 0.334, P < 0.01). Findings demonstrated that components of desire to change, spirit, unity and agreement, application of knowledge, performance pressure were significantly correlated to career advancement. However, components of strategic perspective and common fate were not significantly correlated with career advancement. Additionally, among the components of organizational intelligence, in the first step, application of knowledge and in the second step, desire to change were the best predicators of innovation management (which together could predict 28%). Application of knowledge was the only variable which entered the predictive model and predicted 16% of career advancement. Results of independent t-test indicated that no significant difference was found between male and female managers, considering their organizational intelligence, innovation management and career advancement.展开更多
We carry out a field survey on the implementation of the"Whole Village Advancement"poverty alleviation model in Lisizhuang Village,Shunping County,Hebei Province.Based on the"Whole Village Advancement&q...We carry out a field survey on the implementation of the"Whole Village Advancement"poverty alleviation model in Lisizhuang Village,Shunping County,Hebei Province.Based on the"Whole Village Advancement"poverty alleviation model,we put forth the following recommendations:(i)Oriented by the market,fostering the function of"blood-refreshing";(ii)Strengthening the new ideas of using projects to attract investment;(iii)Implementing the new strategy of"driven by the able person";(iv)Improving the farmers'quality;(v)Adhering to the diversification of financing channels.展开更多
基金The study on regeneration of invalid amine solvent(RISE2023KY13)。
文摘Since the introduction of the dual carbon goals,countries worldwide have been actively exploring next-generation green and clean energy technologies.E-fuels have gained widespread international attention as an effective supplement to the current energy system and a novel approach to reducing carbon emissions.By tracking and understanding the current status and technological advancements of e-fuels,we can better support the strategic planning of China's new energy initiatives.
文摘Hepatic portal venous gas(HPVG)is a rare yet clinically significant radiological manifestation characterized by diverse etiologies,unclear pathophysiology,and nonspecific clinical presentations.Its appearance frequently heralds a severe underlying condition,with a reported mortality rate as high as 75%,earning it the moniker“harbinger of death”.In recent years,with advancements in diagnosis and treatment of HPVG,its mortality rate has been reduced to below 40%.Nevertheless,the infrequency of HPVG,coupled with its complex etiologies and rapid progression,often leaves clinicians failing to provide timely intervention due to a lack of awareness,resulting in the death of patient.Currently,there is no consensus on the standardized diagnosis and treatment strategies for HPVG.The purpose of this review is to synthesize the existing literature on HPVG and to discuss the advancements in understanding its clinical manifestation,etiologies,pathogenesis,diagnostic methods,and treatment strategies,as well as to emphasize the necessity for further research to enhance our comprehension of its pathophysiology and to refine diagnostic and therapeutic approaches.
文摘Some 20 years ago,10-yearold Wang Xingxing watched a documentary that featured a bipedal robot designed by Marc Raibert,now president of U.S.-based robot company Boston Dynamics.That moment planted the seed for his future in innovation.Today,operating in China’s private sector,Wang’s company,Hangzhou-based Unitree Robotics in Zhejiang Province,is a globally recognized name in producing high-performance,general-purpose quadruped and humanoid robots.
基金Integrating method of absorption and reaeration for CO_(2) capture(2023ZZ0101).
文摘Since the proposal of achieving dual carbon goals,countries worldwide have been actively seeking next-generation energy technologies.Ammonia energy,particularly green ammonia,has recently become a focal point of global attention.The global green ammonia market is expected to grow from USD 17 million in 2021 to USD 5.415 billion by 2030,with a growth rate of 90.2%during this period.As a fossil energy company primarily focused on oil and natural gas,CNPC faces significant pressure to transition to low-carbon operations and achieve dual carbon goals.Keeping track of the current status and technological advancements in ammonia energy development can support CNPC in more effectively implementing its new energy strategy.
文摘Owing to the complex and often asymptomatic presentations,the diagnosis of biliopancreatic diseases,including pancreatic and biliary malignancies,remains challenging.Recent technological advancements have remarkably improved the diagnostic accuracy and patient outcomes in these diseases.This review explores key advancements in diagnostic modalities,including biomarkers,imaging techniques,and artificial intelligence(AI)-based technologies.Biomarkers,such as cancer antigen 19-9,KRAS mutations,and inflammatory markers,provide crucial insights into disease progression and treatment responses.Advanced imaging modalities include enhanced computed tomography(CT),positron emission tomography-CT,magnetic resonance cholangiopancreatography,and endoscopic ultrasound.AI integration in imaging and pathology has enhanced diagnostic precision through deep learning algorithms that analyze medical images,automate routine diagnostic tasks,and provide predictive analytics for personalized treatment strategies.The applications of these technologies are diverse,ranging from early cancer detection to therapeutic guidance and real-time imaging.Biomarker-based liquid biopsies and AI-assisted imaging tools are essential for non-invasive diagnostics and individualized patient management.Furthermore,AI-driven models are transforming disease stratification,thus enhancing risk assessment and decision-making.Future studies should explore standardizing biomarker validation,improving AI-driven diagnostics,and expanding the accessibility of advanced imaging technologies in resource-limited settings.The continued development of non-invasive diagnostic techniques and precision medicine approaches is crucial for optimizing the detection and management of biliopancreatic diseases.Collaborative efforts between clinicians,researchers,and industry stakeholders will be pivotal in applying these advancements in clinical practice.
文摘This commentary critically appraises the study by Li et al which pioneered the exploration of the triglyceride-glucose(TyG)index as a prognostic marker in hepatitis B virus-related advanced hepatocellular carcinoma patients undergoing combined camrelizumab and lenvatinib therapy.While we acknowledge the study’s clinical relevance in proposing an easily accessible metabolic biomarker,we delve into the mechanistic plausibility linking insulin resistance to immunotherapy response and angiogenic inhibition.We further critically examine the methodological limitations,including the retrospective design,the populationspecific TyG cut-off value,and unaddressed metabolic confounders.We highlight the imperative for future research to validate its utility across diverse etiologies and treatment settings,and to unravel the underlying immunometabolic pathways.
基金supported by the Hong Kong Polytechnic University(1-WZ1Y,1-W34U,4-YWER).
文摘Recent years have witnessed transformative changes brought about by artificial intelligence(AI)techniques with billions of parameters for the realization of high accuracy,proposing high demand for the advanced and AI chip to solve these AI tasks efficiently and powerfully.Rapid progress has been made in the field of advanced chips recently,such as the development of photonic computing,the advancement of the quantum processors,the boost of the biomimetic chips,and so on.Designs tactics of the advanced chips can be conducted with elaborated consideration of materials,algorithms,models,architectures,and so on.Though a few reviews present the development of the chips from their unique aspects,reviews in the view of the latest design for advanced and AI chips are few.Here,the newest development is systematically reviewed in the field of advanced chips.First,background and mechanisms are summarized,and subsequently most important considerations for co-design of the software and hardware are illustrated.Next,strategies are summed up to obtain advanced and AI chips with high excellent performance by taking the important information processing steps into consideration,after which the design thought for the advanced chips in the future is proposed.Finally,some perspectives are put forward.
基金Supported by High-level Professional Groups in Gangdong Province,No.GSPZYQ2020101Guangdong Province Educational Research Planning Project,No.2024GXJK742。
文摘BACKGROUND Paternal perinatal depression(PPD)is closely associated with maternal mental health challenges,marital strain,and adverse child developmental outcomes.Despite its significant impact,PPD remains under-recognized in family-centered clinical practice.Concurrently,against the backdrop of rising rates of delayed marriage and China’s Maternity Incentive Policy,the proportion of women giving birth at an advanced maternal age is increasing.Nevertheless,research specifically examining PPD among spouses of older mothers remains critically scarce,both in China and globally.AIM To investigate PPD and its influencing factors in Chinese advanced maternal age families.METHODS This cross-sectional study included 358 participants;it was conducted among fathers of pregnant women of advanced maternal age at five hospitals in the Pearl River Delta region of China from September 2023 to June 2024.Data were collected via a general information questionnaire,the Social Support Rating Scale,and the Edinburgh Postnatal Depression Scale.Latent profile analysis and regression mixture models(RMMs)were adopted to analyze the latent PPD types and factors that influenced PPD.RESULTS The incidence of PPD was 16.48%,and three profiles were identified:Low-symptomatic(175 cases,48.89%),monophasic(140 cases,39.10%),and high-symptomatic(43 cases,12.01%).The RMM analysis revealed that first pregnancy,low income(<¥3000/month),part-time work,and a history of abnormal pregnancy were positively associated with the high-symptomatic type(P<0.05).Conversely,high subjective support and support utilization were negatively associated with the high-symptomatic type compared with the low-symptomatic type(P<0.05).Good couple relationships,high objective and subjective support,and high support utilization were negatively associated with monophasic disorder(P<0.05).CONCLUSION PPD incidence is high among Chinese fathers with advanced maternal age partners,and the characteristics of depression are varied.Healthcare practitioners should prioritize individuals with low levels of social support.
文摘AIM:To investigate the efficacy of the anal fistula plug(AFP) compared to the mucosa advancement flap(MAF),considered the best procedure for patients with a complex anal fistula.METHODS:The literature search included PubMed,EMBASE,Cochrane Library and OVID original studies on the topic of AFP compared to MAF for complex fistula-in-ano that had a deadline for publication by April 2011.Randomized controlled trials,controlled clinical trials and prospective cohort studies were included in the review.After information collection,a meta-analysis was performed using data on overall success rates as well as incidence of incontinence and morbidity.The quality of postoperative life was also included with the clinical results.RESULTS:Six studies involving 408 patients(AFP = 167,MAF = 241) were included in the meta-analysis.The differences in the overall success rates and incidence of fistula recurrence were not statistically significant between the AFP and MAF [risk difference(RD) =-0.12,95%CI:-0.39-0.14;RD = 0.13;95%CI:-0.18-0.43,respectively].However,for the AFP,the risk of postoperative impaired continence was lower(RD =-0.08,95%CI:-0.15--0.02) as was the incidence of other complications(RD =-0.06,95%CI:-0.11-0.00).The postoperative quality of life,for patients treated using the AFP was superior to that of the MAF patients.Patients treated with the AFP had less persistent pain of a shorter duration and the healing time of the fistula and hospital stay were also reduced.CONCLUSION:The AFP is an effective procedure for patients with a complex anal fistula;it has the same success rate but a lower risk of complications than the MAF and may also be associated with an improved postoperative quality of life.Additional evidence is needed to confirm these findings.
文摘The history and current status of research and development of wave energy in the world is briefly introduced. The main problems existing in these studies are pointed out. The description is focused on the current status and the advancements achieved in China. After analysis of the wave energy resources and practical situations in China, it is pointed out that the studies on wave energy should be not only concentrated on the conversion efficiency and costs of wave energy devices, but also focused on the technology of independent operation and stable output of electricity. Finally, the perspectives of application of wave energy in China are discussed.
基金Sponsored by the State Key Laboratory of Advanced Welding and Joining,Harbin Institute of Technology(Grant No.AWJ-Z16-05)
文摘This review article aims to analyze and evaluate the advantages, shortcomings, technological advancements and hereafter prospects in welding and processing of magnesium and its alloys. Studies have accounted that replacing other metals with Mg alloys will bring about in monumental weight reduction with significant addition in strength that could lead to dramatic transformation of metallic era of 21st century and onwards. However,wide application of Mg and its alloys depends on the development of advanced welding &joining technologies. The current paradigm and progress in welding,joining and processing of magnesium and its alloys are reviewed,and research trend in this field is briefly discussed.
文摘Select group of patients with concurrent esophagealand gastric stricturing secondary to corrosive intake requires colonic or free jejunal transfer. These technically demanding reconstructions are associated with significant complications and have up to 18% ischemic conduit necrosis. Following corrosive intake, up to 30% of such patients have stricturing at the pyloro-duodenal canal area only and rest of the stomach is available for rather less complex and better perfused gastrointestinal reconstruction. Here we describe an alternative technique where we utilize stomach following distal gastric resection along with Roux-en-Y reconstruction instead of colonic or jejunal interposition. This neo-conduit is potentially superior in terms of perfusion, lower risk of gastro-esophageal anastomotic leakage and technical ease as opposed to colonic and jejunal counterparts. We have utilized the said technique in three patients with acceptable postoperative outcome. In addition this technique offers a feasible reconstruction plan in patients where colon is not available for reconstruction due to concomitant pathology. Utility of this technique may also merit consideration for gastroesophageal junction tumors.
基金This study was reviewed and approved by the Medical Ethics Committee of The Affiliated Hospital of Qingdao University(authorisation number:QYFYWZLL26729).
文摘BACKGROUND Mandibular retraction is the main etiological mechanism of class II malocclusion in China and the subsequent distal molar relationship can cause functional discomfort in mastication,breathing and the temporomandibular joint.The use of mandibular advancement(MA)devices has recently emerged as an adolescent mandibular retraction treatment;however,current studies regarding the effect thereof are relatively few,and there is lack of sufficient clinical support.AIM To investigate the clinical effect of invisalign MA on the treatment of mandibular retraction in adolescents.METHODS This study included 30 adolescent patients who underwent treatment with the MA appliances from December 2017 to June 2021.The lateral cephalometric data before and after treatment were collected and imported into Dolphin Imaging software.The changes were measured by linear measurement superimposed with lateral cephalometric trajectory based on the Pancherz technology.RESULTS There was no significant difference in the length and position of maxilla before and after the treatment.The position of the mandible moved 3.13 mm,the length increased 4.14 mm,the mandibular ramus length increased 4.09 mm,the body length increased 4.25 mm,and the position of the condyle moved 1.03 mm forward after treatment.Additionally,changes in the incisor sagittal position and labial inclination were observed.The position of the upper incisor point moved back 1.33 mm,without statistical difference,the inclination and tooth angle decreased by 3.44°and 4.06°,respectively;the position of the lower incisor point was moved 2.98 mm,and the inclination and tooth angle increased by 2.62°and 1.23°,respectively.Furthermore,changes in the incisor overjet and molar relationship were seen.Overjet decreased by 4.31 mm,of which 1.78 mm was due to dental factors,accounting for 41.3%of the effect as opposed to 58.7%due to skeletal factors.Molar relationship improved 3.87 mm,with 1.34 mm due to dental factors,and dental and skeletal factors were accounted for 34.6%and 65.4%of the effect,respectively.CONCLUSION For adolescent patients with mandible retraction,invisalign MA can effectively promote the mandible growth,and it was proven to be mainly due to skeletal effects.
基金supported by the Natural Science Foundation of China (Grant nos.11774117 and 12102140)Shenzhen Basic Science Research (JCYJ20200109110006136)China Postdoctoral Science Foundation (2021M70130).
文摘Ultrasound is extensively studied for biomedical engineering applications.As the core part of the ultrasonic system,the ultrasound transducer plays a significant role.For the purpose of meeting the requirement of precision medicine,the main challenge for the development of ultrasound transducer is to further enhance its performance.In this article,an overview of recent developments in ultrasound transducer technologies that use a variety of material strategies and device designs based on both the piezoelectric and photoacoustic mechanisms is provided.Practical applications are also presented,including ultrasound imaging,ultrasound therapy,particle/cell manipulation,drug delivery,and nerve stimulation.Finally,perspectives and opportunities are also highlighted.
文摘This paper presents a review of the position-sensitive detector(PSD) sensor, covering different types of PSD and recent works related to this field. Furthermore, it explains the theoretical concepts and provides information about its structure and principles of operation. Moreover, it includes the main information about the available commercial PSDs from different companies, along with a comparison between the common modules. The PSD features include high position resolution, fast response, and a wide dynamic range. These features make it suitable for various fields and applications, such as imaging, spectrometry, spectroscopy and others.
文摘BACKGROUND Microcystic adnexal carcinoma(MAC)is a rare malignant tumor of the skin that is commonly found on the face.It grows slowly and has a low mortality rate.However,for various reasons,including strong histological invasiveness,clinical inexperience and inadequate procedure design,immediate or permanent facial deformity may occur after surgical operations.CASE SUMMARY This article describes a middle-aged female artist who was diagnosed with MAC on the left upper lip.She declined the recommended treatment plan,which included two-stage reconstruction,skin grafting,or surgery that could have resulted in obvious facial dysfunction or esthetic deformity.We accurately designed a personalized procedure involving a“jigsaw puzzle advancement flap”for the patient based on the lesion location and the estimated area of skin loss.The procedure was successful;both pathological R0 resection and immediate and long-term esthetic reconstruction effects were achieved.CONCLUSION This study suggests that when treating facial MAC or other skin malignancies,a surgical team should have sufficient plastic surgery-related knowledge and skills.An optimal surgical plan for an individual is needed to achieve good facial esthetics and functional recovery and shorten the treatment course.
基金A substantial part of the work described in this article was supported by the research Contracts 806/31.4830 and 806/31.5511 between the private company Laboratorio Ortoplus S.L.and the University of Málaga,which is acknowledgedwith gratefulness.
文摘Mandibular advancement devices(MADs)are one of the treatments used for Obstructive sleep apnea(OSA).MADs try to maintain the mandible in an advanced position to keep the upper airways open when sleeping.To achieve this goal,most current MADs limit the mouth opening to a few millimetres.The study of the kinematic behaviour of the patient’s jaw is essential in order to design devices that allow greater aperture ranges.For this purpose,a 3D multibody model that reproduces jaw movement has been developed in this work.To this end,the movement of the lower incisor has been determined by means of a vision system and reflective markers.In addition,the kinematics of the temporomandibular joint has been modelled.Next,the device is designed and printed using a cam-follower mechanism.This way,the cam profiles and the followers are optimally designed and positioned for each patient depending on the physiognomy of the jaw and the opening and advancing movement prescribed by the specialist.
文摘Neurological diseases and injuries present some of the great- est challenges in modern medicine, often causing irrevers- ible and lifelong burdens in the people whom they afflict. Conditions of stroke, traumatic brain injury, spinal cord injury, and neurodegenerative diseases have devastating con- sequences on millions of people each year, and yet there are currently no therapies or interventions that can repair the structure of neural circuits and restore neural tissue function in the brain and spinal cord. Despite the challenges of over- coming these limitations, there are many new approaches under development that hold much promise. Neural tissue engineering aims to restore and influence the function of damaged or diseased neural tissue generally through the use of stem cells and biomaterials. Many types of biomaterials may be implemented in various designs to influence the survival, differentiation, and function of developing stem cells, as well as to guide neurite extension and morphological architecture of cell cultures. Such designs may aim to reca- pitulate the cellular interactions, extracellular matrix char- acteristics, biochemical factors, and sequences of events that occur in neurodevelopment, in addition to supporting cell survival, differentiation, and integration into innate neural tissue.
文摘The present study aimed to examine the relationship of organizational intelligence with innovation management and career advancement in an organization. Considering its objective, this was a descriptive-correlational study. The statistical population included all high school managers in Zahedan at the year 2015. The sample contained 52 male managers and 51 female managers whom were selected through applying stratified random sampling method. To collect data, Organizational Intelligence Questionnaire, Innovation Management Inventory and Questionnaire of Career Advancement were used, the validity of which was assessed through applying the standpoint of a number of university professors and their reliability was obtained 0.74, 0.76, 0.84, respectively, using Cronbach’s alpha coefficient. Results indicated that considering managers’ perspectives, the status of organizational intelligence and career advancement were desirable;however, the status of innovation management was moderate. Moreover, organizational intelligence and its components were significantly and positively correlated with innovation management (r = 0.512, P < 0.01), and there was a significant and positive relationship between organizational intelligence and career advancement (r = 0.334, P < 0.01). Findings demonstrated that components of desire to change, spirit, unity and agreement, application of knowledge, performance pressure were significantly correlated to career advancement. However, components of strategic perspective and common fate were not significantly correlated with career advancement. Additionally, among the components of organizational intelligence, in the first step, application of knowledge and in the second step, desire to change were the best predicators of innovation management (which together could predict 28%). Application of knowledge was the only variable which entered the predictive model and predicted 16% of career advancement. Results of independent t-test indicated that no significant difference was found between male and female managers, considering their organizational intelligence, innovation management and career advancement.
基金Supported by National Social Science Foundation(11XRK004)National Soft Science Project(2010GXS5D271)Presidential Foundation of Tarim University(TDSKZD1102)
文摘We carry out a field survey on the implementation of the"Whole Village Advancement"poverty alleviation model in Lisizhuang Village,Shunping County,Hebei Province.Based on the"Whole Village Advancement"poverty alleviation model,we put forth the following recommendations:(i)Oriented by the market,fostering the function of"blood-refreshing";(ii)Strengthening the new ideas of using projects to attract investment;(iii)Implementing the new strategy of"driven by the able person";(iv)Improving the farmers'quality;(v)Adhering to the diversification of financing channels.
