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mTORC1 and mTORC2 synergy in human neural development, disease, and regeneration 被引量:1
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作者 Navroop K.Dhaliwal Julien Muffat Yun Li 《Neural Regeneration Research》 2026年第4期1552-1553,共2页
The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regul... The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health. 展开更多
关键词 m tor neural development mtorc central nervous system cns mtor neurodevelopmental disorders neurodegenerative conditions
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Ecosystem management and agricultural green development in subtropical regions
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作者 Jinshui Wu Tony G.O’Donnell +4 位作者 Andrew Macrae Hongsong Chen Weiguo Cheng Zhihong Xu Zhengmiao Deng 《Journal of Integrative Agriculture》 2026年第2期399-401,共3页
The United Nations Sustainable Development Goal(SDG) 2 aims to achieve Zero Hunger by 2030.However,global hunger and food insecurity have continued to rise at an alarming rate(UN 2023).Subtropical regions are home to ... The United Nations Sustainable Development Goal(SDG) 2 aims to achieve Zero Hunger by 2030.However,global hunger and food insecurity have continued to rise at an alarming rate(UN 2023).Subtropical regions are home to more than 30% of the world's population,predominantly in developing countries where per capita farmland and food supply are only 40% of those in developed nations(FAO 2018).Meeting the Zero Hunger target amid ongoing population growth in these regions requires a substantial increase in agricultural production while minimizing soil degradation and adverse ecological impacts.This challenge is shared by many countries across South Asia,Africa,and Central and South America. 展开更多
关键词 ecosystem management developing countries subtropical regions sustainable development goal agricultural green development zero hunger sustainable development goal sdg population growth
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Innovation and Development Policy(中文名:《创新与发展政策(英文)》)征稿启事
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《科研管理》 北大核心 2026年第1期F0004-F0004,共1页
Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊... Innovation and Development Policy,简称“IDP”,中文名:《创新与发展政策(英文)》,是由中国科学院主管,中国科学院科技战略咨询研究院、中国科学学与科技政策研究会共同主办,国内外发行(ISSN:2096-5141,CN:10-1513/D)的英文国际期刊。目前期刊每年出版两期。已发表论文在期刊网站可以自由获取,http://idp-journal.casisd.cn/browse/al/al2019/。 展开更多
关键词 创新与发展政策 Innovation and development Policy
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Guiding the younger generation to explore new scenarios for participating in standards development and application
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作者 Li Zhiping 《China Standardization》 2026年第1期43-44,共2页
Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.You... Standards are the common language that consolidates global consensus and builds the most solid foundation for international partnerships.They are the cornerstone for global sustainable and high-quality development.Young students,with their active and vibrant minds,represent the future and hope of standardization. 展开更多
关键词 standards development sustainable development application standards international partnerships high quality development consolidates global consensus younger generation common language
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China’s Urban-Rural Integration:A Global Perspective on Sustainable Development
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作者 XIA YUANYUAN 《China Today》 2026年第1期36-38,共3页
China is carving out a distinctive development path which features urban-rural integration.This approach has not only yielded tangible results domestically but also drawn the attention of other countries.
关键词 sustainable development urban rural integration China development path
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Standards lead the high-quality development of intelligent construction in China
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作者 Cheng Zhijun 《China Standardization》 2026年第1期49-49,共1页
To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction fou... To advance intelligent construction,standards must come first.The Ministry of Housing and Urban-Rural Development has issued the List for Replicable Experience and Practices for Developing Intelligent Construction four times successively and the Technical Guidelines for Intelligent Construction(Trial). 展开更多
关键词 STANDARDS technical guidelines high quality development Ministry Housing Urban Rural development intelligent constructionstandards replicable experience intelligent construction
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Rolling Out a Technocentric Rural Development Blueprint
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作者 ZHONG YU 《China Today》 2026年第1期26-29,共4页
China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have alwa... China aims to build on its achievements of the past five years to accelerate rural revitalization during the 15th Five-Year Plan period.IN China,issues relating to agriculture,rural areas,and rural residents have always been a priority in national development.At its fourth plenary session held in October 2025,the 20th Central Committee of the Communist Party of China(CPC)once again emphasized the need to accelerate agricultural and rural modernization,and advance all-around rural revitalization over the next five years. 展开更多
关键词 technocentric rural areas agricultural modernization accelerate agricultural rural modernizationand rural development five year plan rural revitalization national development
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Intersection of mitochondrial dysfunction and myelination:An overlooked aspect in neurodevelopmental disorders
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作者 Ariel Nir Sade Gal Wiener Boaz Barak 《Neural Regeneration Research》 2026年第2期659-660,共2页
Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables th... Neurodevelopmental processes represent a finely tuned interplay between genetic and environmental factors,shaping the dynamic landscape of the developing brain.A major component of the developing brain that enables this dynamic is the white matter(WM),known to be affected in neurodevelopmental disorders(NDDs)(Rokach et al.,2024).WM formation is mediated by myelination,a multifactorial process driven by neuro-glia interactions dependent on proper neuronal functionality(Simons and Trajkovic,2006).Another key aspect of neurodevelopmental abnormalities involves neuronal dynamics and function,with recent advances significantly enhancing our understanding of both neuronal and glial mitochondrial function(Devine and Kittler,2018;Rojas-Charry et al.,2021).Energy homeostasis in neurons,attributed largely to mitochondrial function,is critical for proper functionality and interactions with oligodendrocytes(OLs),the cells forming myelin in the brain’s WM.We herein discuss the interplay between these processes and speculate on potential dysfunction in NDDs. 展开更多
关键词 neurodevelopmental disorders ndds rokach white matter developing brain MYELINATION neurodevelopmental processes mitochondrial dysfunction white matter wm known developing braina
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Study on the development,applications,and standardization status of environmental DNA(eDNA)technology in China
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作者 Li Xiawei Duan Bin +3 位作者 Lu Jing Li Xueling Wang Min Yang Yongqi 《China Standardization》 2026年第1期54-59,共6页
Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications i... Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications in aquatic and terrestrial ecosystems and assessing China’s standardization progress.It delineates four developmental phases from single-species detection to high-throughput sequencing,and highlights China’s contribution to the development of technical standards.While significant progress has been made,challenges persist in quantitative accuracy,methodological consistency,and large-scale implementation.Future efforts should prioritize enhanced standardization,improved quantification techniques,broader applications,and international collaboration to drive innovation in eDNA technology. 展开更多
关键词 environmental DNA development application standardization status
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3D genomic alterations during development of skeletal muscle in chicken
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作者 Zhongxian Xu Tao Wang +16 位作者 Wei Zhu Maosen Yang Dong Leng Ziyu Li Jiaman Zhang PengliangLiu Zhoulin Wu Mengnan He Yan Li Hua Kui Xue Bai Bo Zeng Yao Zhang Qing Zhu XiaolingZhao Mingzhou Li Diyan Li 《Journal of Integrative Agriculture》 2026年第1期207-226,共20页
The development of skeletal muscle are complicated processes involving genes responsible for proper muscle morphology,contractility,cell proliferation,differentiation,interactions,migration,and death.The three-dimensi... The development of skeletal muscle are complicated processes involving genes responsible for proper muscle morphology,contractility,cell proliferation,differentiation,interactions,migration,and death.The three-dimensional chromatin architecture of skeletal muscle development has not been studied intensively although dynamic transcriptional regulation during differentiation of muscle cells is one of the most deeply studied processes.The RNA-seq was used to analyze the transcriptome pattern during chicken muscle development across 12 stages.Hi-C was used to build chromatin architectures during four representative stages.Ch IP-seq was conducted to identify enhancers and promoters in these four stages,which are occupied by histone H3K27ac and H3K4me3 peaks.Results show that large-scale genome architecture changes are mostly unidirectional,and coupled by complex on/off dynamic patterns of gene expression.Specifically,we observed 258.30 Mb of the genome undergoing A/B compartment switching.Notable alterations(316.57 Mb)of interaction frequencies within TADs were observed.Substantial aging-associated genes exhibited ascending connectivity with the compartment transition from repressive to active status during muscle development.Some muscle-related gene promoters that interacted with active enhancers during development,and some myopathy/aging-associated genes that were activated in aging muscle were founded.These results provide key insights into skeletal muscle development in vivo,and offer a valuable resource that allows in-depth functional characterization of candidate genes. 展开更多
关键词 skeletal muscle development gene expression chromatin architecture
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National development requires the younger generation to cultivate the standardization consciousness and mindset
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作者 Zhang Xiaogang 《China Standardization》 2026年第1期42-42,共1页
The International Standardization Youth Star Competition is held for three consecutive years.We have witnessed continuous improvement in the competition each year,which is a result of our collective efforts.
关键词 collective efforts youth competition national development improvement standardization consciousness
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The role of m^(6)A in plant development,stress response,and agricultural practices
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作者 Jin Qi Shaoxia Li +3 位作者 Jun Su Yushi Lu Wenjin Yu Changxia Li 《Horticultural Plant Journal》 2026年第1期19-35,共17页
N6-methyladenosine(m^(6)A)modification,the most abundant internal modification in messenger RNA(mRNA)and long non-coding RNA(lncRNA),has emerged as a critical epitranscriptomic regulatory mechanism in eukaryotes.While... N6-methyladenosine(m^(6)A)modification,the most abundant internal modification in messenger RNA(mRNA)and long non-coding RNA(lncRNA),has emerged as a critical epitranscriptomic regulatory mechanism in eukaryotes.While the importance of m^(6)A modification in various biological processes has been recognized,a comprehensive understanding of its diverse roles in plant biology and agricultural applications remains fragmented.This review analyzes recent advances inm^(6)A modification's biological functions in plants.m^(6)A modification plays crucial roles in multiple aspects of plant life,including seed germination,organ development,and reproductive structure formation.Furthermore,m^(6)A has been found to significantly influence plant responses to environmental stresses,including salt,drought,temperature,and heavy metal exposure.We also uncover m^(6)A involvement in important agricultural traits.This review provides insights into the mechanistic understanding of m^(6)A modification in plants and highlights its applications in agricultural improvement,offering a foundation for future research in crop enhancement and stress resistance. 展开更多
关键词 N6-methyladenosine Epitranscriptomics Plant development STRESS Agricultural production
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A Governance Quality Lens on the Influence of Chinese Outward Investment on Human Development in Belt and Road Initiative Countries
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作者 YANG Bo EBN JALAL Md Jahid +5 位作者 SARKAR Md Abdur Rouf ALAM Mohammad Jahangir DING Shijun BEGUM Ismat Ara RAHMAN Md.Naimur LO Kevin 《Chinese Geographical Science》 2026年第1期64-81,共18页
In the evolving global economy,China’s Outward Foreign Direct Investment(OFDI)holds increasing significance,specially within the context of the Belt and Road Initiative(BRI).Despite earlier studies have acknowledged ... In the evolving global economy,China’s Outward Foreign Direct Investment(OFDI)holds increasing significance,specially within the context of the Belt and Road Initiative(BRI).Despite earlier studies have acknowledged the role of governance quality in at-tracting Chinese OFDI,their explanatory capacity regarding human development has not received sufficient attention.This study ad-dresses this gap,investigating the relationship between Chinese OFDI and human development,emphasizing the governance quality’s moderating role.Using data from 122 BRI countries from 2004 to 2021,we employed the Panel Corrected Standard Error model through Prais-Winsten regression,complimented by robustness check via the Spatial Durbin Model.Our analysis revealed a significant positive relationship between Chinese OFDI and human development in BRI countries,indicating that Chinese investments act as cata-lysts for improved well-being.More importantly,governance quality plays a vital role in shaping this relationship,revealing that effect-ive governance enhanced the human development outcomes of OFDI.Post-hoc analysis of governance indicators,both as a composite index and individual dimensions,supported this finding.Regional heterogeneity analysis further showed that Chinese OFDI has stronger effects on Human Development Index(HDI)in Asia and Africa compared to Europe,Latin America,and Oceania.However,the moder-ating effect of governance quality seemed more prominent in Oceania and Latin America,indicating its role in fostering the benefits of Chinese investments in these regions.These findings hold implications for academia and policy,emphasizing the need for transparent,accountable,and effective governance to drive sustainable and inclusive human development within the BRI framework. 展开更多
关键词 overseas investment human development governance quality moderating effect China
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Parental exposure to ocean acidification impacts the larval development and transcriptome of the Pacific oyster Crassostrea gigas
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作者 Hailun FU Wen TENG +3 位作者 Shoudu ZHANG Zhangjie PENG Jiulin CHAN Linlin ZHANG 《Journal of Oceanology and Limnology》 2026年第1期433-444,共12页
Atmospheric carbon dioxide(CO_(2))levels are escalating at an unprecedented rate,leading to the phenomenon of ocean acidification(OA).Parental exposure to acidification has the potential to enhance offspring resilienc... Atmospheric carbon dioxide(CO_(2))levels are escalating at an unprecedented rate,leading to the phenomenon of ocean acidification(OA).Parental exposure to acidification has the potential to enhance offspring resilience through cross-generation plasticity.In this study,we analyzed larval growth and transcriptomic profiles in the Pacific oyster,Crassostrea gigas,a species of significant ecological relevance,under both control and elevated CO_(2)conditions experienced by their parental generation.Our findings indicate that the oyster populations exposed to OA exhibited a higher incidence of abnormalities during the D-shaped larval stage,followed by accelerated growth at the eyed stage.Through a comparative transcriptomic investigation of eyed larvae(25 d after fertilization),we observed that parental exposure to OA substantially influenced the gene expression in the offspring.Genes associated with lipid catabolism and shell formation were notably upregulated in oysters with parental OA exposure,potentially playing a role in cross-generational conditioning and conferring resilience to OA stressors.These results underscore the profound impact of OA on oyster larval development via cross-generational mechanisms and shed light on the molecular underpinnings of cross-generation plasticity. 展开更多
关键词 cross-generation plasticity OYSTER ocean acidification(OA) larval development TRANSCRIPTOME
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Coupling Development Between Digital Economy–Agriculture Integration and Rural Revitalization in China:Spatiotemporal Disparities and Evolution Trends
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作者 Peng Xiangjun Jia Qingsong 《Contemporary Social Sciences》 2026年第1期71-89,共19页
This study aims to promote the optimization and upgrading of the economic structure in rural areas of China by focusing on the coupling coordination mechanism between digital economy–agriculture integration and rural... This study aims to promote the optimization and upgrading of the economic structure in rural areas of China by focusing on the coupling coordination mechanism between digital economy–agriculture integration and rural revitalization.By examining panel data from 30 Chinese provinces,autonomous regions,and municipalities between 2011 and 2022,the research constructs a weight-based evaluation system that integrates subjective and objective methods and a coupling coordination model to reveal its dynamic evolution patterns.Key findings indicate that digital economy–agriculture integration and rural revitalization achieve cross-coupling through critical activities.The impact of digital-agriculture integration on advancing rural revitalization lags by 2–3 years.Although the coupling development degree between the two systems continues to improve,it remains at the stage of primary coordination.Regional disparities are significant,showing a gradient pattern of“high degree of coupling development in the east and low degree of coupling development in the west.” 展开更多
关键词 digital economy-agriculture integration rural revitalization coupling coordination coupling development
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Ideas in Motion--Xi Jinping:The Governance of China sparks fresh reflections on Africa’s development pathways
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《ChinAfrica》 2026年第1期14-19,共6页
Governance debates gained strong momentum in Africa in early December 2025 as the China-Kenya Readers Forum on Xi Jinping:The Governance of China convened in Nairobi on 1 December 2025,followed by a promotional event ... Governance debates gained strong momentum in Africa in early December 2025 as the China-Kenya Readers Forum on Xi Jinping:The Governance of China convened in Nairobi on 1 December 2025,followed by a promotional event for the English edition of the book’s fifth volume on 3 December 2025 in Johannesburg,South Africa. 展开更多
关键词 NAIROBI JOHANNESBURG South Africa China Kenya Xi Jinping development pathways GOVERNANCE
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Seeking Shared Prosperity——East China’s Zhejiang strives to improve the lives of all people through diversified development strategies
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作者 TAO XING 《ChinAfrica》 2026年第2期18-21,共4页
Fifty-five-year-old Shi Yizhong never imagined fireflies could become the foundation of a serious business.In 2022,Longshan Village in Huzhou’s Wuxing District collaborated with a young entrepreneurial team to create... Fifty-five-year-old Shi Yizhong never imagined fireflies could become the foundation of a serious business.In 2022,Longshan Village in Huzhou’s Wuxing District collaborated with a young entrepreneurial team to create a firefly campsite-a natural attraction where visitors can observe these glowing insects in a preserved habitat.The site quickly drew waves of tourists,who shared their experience online,recouping its initial investment in just two years. 展开更多
关键词 diversified development strategies natural attraction shared prosperity tourism firefly campsite
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MimicStudio:One-Stop Development Framework for Dynamic Heterogeneous Redundancy Architecture
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作者 Hu Jingjing Li Yu +3 位作者 Sun Yuanhang Yu Bo Liu Qinrang Wu Jiangxing 《China Communications》 2026年第1期125-139,共15页
Fault-tolerant systems are crucial for ensuring the reliability and availability of missioncritical applications in modern computing environments.The dynamic heterogeneous redundancy(DHR)architecture is a key componen... Fault-tolerant systems are crucial for ensuring the reliability and availability of missioncritical applications in modern computing environments.The dynamic heterogeneous redundancy(DHR)architecture is a key component in constructing fault-tolerant systems,particularly in areas such as national security,power networks,and banking private networks.DHR is transforming the cyberspace security industry chain by accommodating a broader range of applications and increasingly capturing the market.However,the development of applications for DHR architecture encounters challenges due to the complexities of handling heterogeneity,managing dynamism,and maintaining usability.To address these issues,we introduce MimicStudio,a comprehensive development framework with a standardized workflow.To our knowledge,MimicStudio is the first effective solution for DHR software development.We present a detailed implementation of MimicStudio with a heterogeneous microcontroller unit project,encompassing three CPUs with different instruction set architectures.The paper evaluates MimicStudio’s support for essential features,including zero-copy synchronization,parallelized build,multi-core collaborative debugging,and dynamic adjustment of the software system’s structure.Our results show that MimicStudio provides a flexible and efficient solution for supporting the dynamic,heterogeneous,and redundant features of fault-tolerant systems. 展开更多
关键词 cyberspace security development enviroment dynamic heterogeneous redundancy architecture endogenous security MimicStudio
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Progress in Offshore Oilfield Development Planning
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作者 L.M.R.Silva C.Guedes Soares 《哈尔滨工程大学学报(英文版)》 2026年第1期136-161,共26页
This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and cat... This study examines the methods to plan the development of offshore oilfields over the years,which are used to support the decision-making on the development of offshore oilfields.About 100 papers are analysed and categorised into different groups of main early-stage decisions.The present study stands in contrast to the contributions of the operations research and system engineering review articles,on the one hand,and the petroleum engineering review articles,on the other.This is because it does not focus on one methodological approach,nor does it limit the literature analysis by offshore oilfield characteristics.Consequently,the present analysis may offer valuable insights,for instance,by identifying environmental planning decisions as a recent yet highly significant concern that is currently being imposed on decision-making process.Thus,it is evident that the incorporation of safety criteria within the technical-economic decision-making process for the design of production systems would be a crucial requirement at development phase. 展开更多
关键词 Offshore oilfield development Oilfield planning decisions Production system design Decision-making process
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Building Bonds,Advancing Development——Wang Yi’s Africa visit highlights joint efforts on trade, infrastructure and modernisation
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作者 NI XIAOWEI MA HANZHI 《ChinAfrica》 2026年第2期14-15,共2页
The year 2026 marks the 70th anniversary of the establishment of diplomatic relations between China and African countries.It also marks the launch of the China-Africa Year of People-to-People Exchanges.At this pivotal... The year 2026 marks the 70th anniversary of the establishment of diplomatic relations between China and African countries.It also marks the launch of the China-Africa Year of People-to-People Exchanges.At this pivotal juncture linking past achievements with future development,Wang Yi,member of the Political Bureau of the Communist Party of China Central Committee and foreign minister,continued the longstanding diplomatic tradition under which the Chinese foreign minister makes Africa the destination of the first overseas visit of the year,a practice upheld for 36 consecutive years,underscoring the stability,continuity and sincerity of China’s policy towards Africa. 展开更多
关键词 diplomatic relations TRADE wang yi INFRASTRUCTURE BONDS advancing development china africa relations modernisation
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