A numerical program is built to simulate the performance of a spark ignited two-stroke free-piston engine coupled with a linear generator. The computational model combines a series of dynamic and thermodynamic equatio...A numerical program is built to simulate the performance of a spark ignited two-stroke free-piston engine coupled with a linear generator. The computational model combines a series of dynamic and thermodynamic equations that are solved simultaneously to predict the performances of the engines. The dynamic analysis performed consists of an evaluation of the frictional force and load force introduced by the generator. The thermodynamic analysis used a single zone model to describe the engine＇ s working cycle which includes intake, scavenging, compression, combustion and expansion, and to evaluate the effect of heat transfer based on the first law of thermodynamics and the ideal gas state equation. Because there is no crankshaft, a time based Wiebe equation was used to express the fraction of fuel burned in the combustion. The calculated results were validated by using the experimental data from another research group. The results indicate that the free-piston generator has some advantages over conventional engines.展开更多
The free-piston engine generator(FPEG)is regarded as the next generation of energy conversion system which may replace traditional engines in the future.The effect of key operational parameters like excess air ratio o...The free-piston engine generator(FPEG)is regarded as the next generation of energy conversion system which may replace traditional engines in the future.The effect of key operational parameters like excess air ratio of input mixture and ignition position on the engine performance of a dual-cylinder FPEG was investigated,and their sensitivity was analyzed in this paper.The operating compression ratio of the system is susceptible to changes in excess air ratio and ignition position.At the same time,it decreases from 15.8 to 6.6 when excess air ratio increases from 0.85 to 1.15,but it increases from 6.1 to 13.3 as ignition position increases from 15 mm to 20 mm.The operating frequency and indicated power are more sensitive to changes in excess air ratio than ignition position.But it is the opposite for the indicated thermal efficiency and friction loss.Excess air ratio and ignition position have a quite similar influence on heat transfer.Therefore,from the perspective of system operation and performance,it is preferable to keep excess air coefficient slightly below 1.0.In contrast,when selecting ignition position,it is of great importance to comprehensively consider the risk of structural damage caused by the increase in the compression ratio and in-cylinder gas pressure.展开更多
Methanol is a very promising clean alternative fuel with low carbon content and high octane number,and this makes it well suited to the free-piston engine generator(FPEG)with variable compression ratio characteristics...Methanol is a very promising clean alternative fuel with low carbon content and high octane number,and this makes it well suited to the free-piston engine generator(FPEG)with variable compression ratio characteristics.To the authors’knowledge there are no relevant studies on the application of methanol for FPEG in recent literatures.In this paper,the effects of methanol substitution ratios(MSR)and load ratios on the performances and combustion characteristics of a methane/methanol dual-fuel FPEG have been investigated experimentally and numerically.The results show that the under the gas-liquid two-phase combustion startup strategy,the methane/methanol dual-fuel FPEG can be successfully started and achieve steady operation.Due to higher laminar flame speed(LFS)and the oxygen content of methanol resulting in a faster burning rate,the peak pressure increases by 43.9%from 1.344 MPa for pure methane to 1.934 MPa for 15%of MSR and the corresponding cycle-to-cycle variation decreases from 3.36 to 1.62.The FPEG operating frequency and indicated power gradually increase with the increase of the MSR.Both of them reach maximum values of 34.6 Hz and 193 W at 15%of MSR,which are increased by 19.3%and 49.6%in comparison with the pure methane.However,under specific MSR,both of them decrease with the load ratio increasing because of the large electromagnetic resistance force from the linear generator.CO and CH emissions decrease with the increase of MSR because methanol addition promotes complete combustion of mixture.NOx emissions gradually decrease with MSR increasing owing to the low combustion temperature resulting from the high latent heat of methanol evaporation.The numerical results show that with the increase of MSR,the methane/methanol mixture presents faster flame propagation speed and higher combustion efficiency;while the ignition delay as well as CA10,CA50 and CA90 is significantly shortened due to the increase of active radicals such as H,OH,O and H_(2)O_(2).展开更多
Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for...Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.展开更多
Parkinson’s disease is characterized by synucleinopathy-associated neurodegeneration.Previous studies have shown that glucagon-like peptide-1(GLP-1)has beneficial effects in a mouse model of Parkinson’s disease indu...Parkinson’s disease is characterized by synucleinopathy-associated neurodegeneration.Previous studies have shown that glucagon-like peptide-1(GLP-1)has beneficial effects in a mouse model of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.However,the effect of GLP-1 on intrinsic synuclein malfunction remains unclear.In this study,we investigated the effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism in SncaA53T transgenic mice and explored the underlying mechanisms.Our data showed that Lactococcus lactis MG1363-pMG36e-GLP-1 inhibited dopaminergic neuronal death,reduced pathological aggregation ofα-synuclein,and decreased movement disorders in SncaA53T transgenic mice.Furthermore,Lactococcus lactis MG1363-pMG36e-GLP-1 downregulated lipopolysaccharide-related inflammation,reduced cerebral activation of microglia and astrocytes,and promoted cell survival via the GLP-1 receptor/PI3K/Akt pathway in the substantia nigra.Additionally,Lactococcus lactis MG1363-pMG36e-GLP-1 decreased serum levels of pro-inflammatory molecules including lipopolysaccharide,lipopolysaccharide binding protein,interleukin-1β,and interleukin-6.Gut histopathology and western blotting further revealed that Lactococcus lactis MG1363-pMG36e-GLP-1 increased the expression of gut integrity-related proteins and reduced lipopolysaccharide-related inflammation by reversing gut dysbiosis in SncaA53T transgenic mice.Our findings showed that the beneficial effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism traits in SncaA53T transgenic mice is mediated by microglial polarization and the reversal of dysbiosis.Collectively,our findings suggest that Lactococcus lactis MG1363-pMG36e-GLP-1 is a promising therapeutic agent for the treatment of Parkinson’s disease.展开更多
Free-piston engine generators (FPEGs) can be applied as decarbonized range extenders for electric vehicles because of their high thermal efficiency, low friction loss, and ultimate fuel flexibility. In this paper, a p...Free-piston engine generators (FPEGs) can be applied as decarbonized range extenders for electric vehicles because of their high thermal efficiency, low friction loss, and ultimate fuel flexibility. In this paper, a parameter-decoupling approach is proposed to model the design of an FPEG. The parameter-decoupling approach first divides the FPEG into three parts: a two-stroke engine, an integrated scavenging pump, and a linear permanent magnet synchronous machine (LPMSM). Then, each of these is designed according to predefined specifications and performance targets. Using this decoupling approach, a numerical model of the FPEG, including the three aforementioned parts, was developed. Empirical equations were adopted to design the engine and scavenging pump, while special considerations were applied for the LPMSM. A finite element model with a multi-objective genetic algorithm was adopted for its design. The finite element model results were fed back to the numerical model to update the LPMSM with increased fidelity. The designed FPEG produced 10.2 kW of electric power with an overall system efficiency of 38.5% in a stable manner. The model provides a solid foundation for the manufacturing of related FPEG prototypes.展开更多
In this paper,the effect of disturbances on the operation process of a methane-fueled free-piston engine generator(FPEG)was experimentally investigated.Four disturbance sources,namely step change of external load,mixt...In this paper,the effect of disturbances on the operation process of a methane-fueled free-piston engine generator(FPEG)was experimentally investigated.Four disturbance sources,namely step change of external load,mixture flow rate fluctuation,random misfire of a cylinder,and elastic collision,were identified and applied to the FPEG.The results showed that the FPEG successfully achieved a steady-state operation with load.The maximum instantaneous electric power of 127 W and the average effective electric power of 38.9 W were obtained.When an external load was instantaneously disconnected,the engine frequency increased from 26.7 Hz to 31.3 Hz.The fluctuation amplitudes of induced voltage,pressure and compression ratio were 18.9%,24.7%and 52.2%respectively in the disturbance.By contrast,when the external load was instantaneously connected,the corresponding values were 42.2%,31.3%and 64.3%respectively,indicating that the instantaneous external load connection had a greater disturbance impact on the FPEG operation stability.Despite encountering the step change of external load,the FPEG can still restore stable operation and show good anti-disturbance ability.Compared with increasing mixture flow rate,reducing the mixture flow rate has a greater disturbance impact on the engine operation stability.Although random misfire of a cylinder will cause remarkable fluctuations in piston displacement and cylinder pressure,the FPEG will not stop running,but continues to work as a single-piston engine.Minor collision event may adversely affect the stability of engine operation,but will not lead to the FPEG shutdown.However,serious collision event may lead to ignition failure and shutdown accident.展开更多
The micro free-piston swing engine （MFPSE） is a new structure, free-piston internal combustion engine. The dynamic model integrated MFPSE with a power generator and thermodynamic models in compression, power and sca...The micro free-piston swing engine （MFPSE） is a new structure, free-piston internal combustion engine. The dynamic model integrated MFPSE with a power generator and thermodynamic models in compression, power and scavenge processes based on the open thermodynamic systems were presented. A simulation was executed at given geometric parameters and initial conditions. The results manifest that the working principle of MFPSE is feasible.展开更多
Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent bioc...Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke.However,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency.By utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly improved.Furthermore,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic stroke.Small extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke therapy.In this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification methodologies.Given the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment process.Moreover,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.展开更多
Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orien...Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orientation,rendering it inseparable from being merely a derivative of geographical science or technology.This paper defines geographical engineering and introduces its development history through the lens of Chinese geographical engineering praxises.Furthermore,it is highlighted the logical and functional consistency between the theory of human-earth system and the praxis of geographical engineering.Six modern cases of geographical engineering projects are presented in detail to demonstrate the points and characteristics of different types of modern geographical engineering.Geographical engineering serves as an engine for promoting integrated geography research,and in response to the challenge posed by fragmented geographies,this paper advocates for an urgent revitalization of geographical engineering.The feasibility of revitalizing geographical engineering is guaranteed because it aligns with China’s national strategies.展开更多
With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenu...With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenues for digital transformation and intelligent upgrading.Industry 5.0,a further extension and development of Industry 4.0,has become an important development trend in industry with more emphasis on human-centered sustainability and flexibility.Accordingly,both the industrial metaverse and digital twins have attracted much attention in this new era.However,the relationship between them is not clear enough.In this paper,a comparison between digital twins and the metaverse in industry is made firstly.Then,we propose the concept and framework of Digital Twin Systems Engineering(DTSE)to demonstrate how digital twins support the industrial metaverse in the era of Industry 5.0 by integrating systems engineering principles.Furthermore,we discuss the key technologies and challenges of DTSE,in particular how artificial intelligence enhances the application of DTSE.Finally,a specific application scenario in the aviation field is presented to illustrate the application prospects of DTSE.展开更多
The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analys...The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analysis of bridge inspection materials,the principle of ultrasonic non-destructive testing technology and its adaptability to bridge engineering are elaborated.Subsequently,starting from the preparation work before inspection until damage assessment,the entire process of ultrasonic non-destructive testing is studied,and finally,a technical system of ultrasonic non-destructive testing for bridge engineering that runs through the entire process is formed.It is hoped that this article can provide technical reference value for relevant units in China,and promote the high-quality development of China’s bridge engineering from a macro perspective.展开更多
Construction engineering and management(CEM)has become increasingly complicated with the increasing size of engineering projects under different construction environments,motivating the digital transformation of CEM.T...Construction engineering and management(CEM)has become increasingly complicated with the increasing size of engineering projects under different construction environments,motivating the digital transformation of CEM.To contribute to a better understanding of the state of the art of smart techniques for engineering projects,this paper provides a comprehensive review of multi-criteria decision-making(MCDM)techniques,intelligent techniques,and their applications in CEM.First,a comprehensive framework detailing smart technologies for construction projects is developed.Next,the characteristics of CEM are summarized.A bibliometric review is then conducted to investigate the keywords,journals,and clusters related to the application of smart techniques in CEM during 2000-2022.Recent advancements in intelligent techniques are also discussed under the following six topics:①big data technology;②computer vision;③speech recognition;④natural language processing;⑤machine learning;and⑥knowledge representation,understanding,and reasoning.The applications of smart techniques are then illustrated via underground space exploitation.Finally,future research directions for the sustainable development of smart construction are highlighted.展开更多
Selective catalytic reduction of NO_(x) with CO(CO-SCR)is a process that purifies both NO and CO pollutants through a catalytic reaction.Specifically,the cleavage of NO on the catalyst surface is crucial for promoting...Selective catalytic reduction of NO_(x) with CO(CO-SCR)is a process that purifies both NO and CO pollutants through a catalytic reaction.Specifically,the cleavage of NO on the catalyst surface is crucial for promoting the reaction.During the reaction,the presence of oxygen vacancies can extract oxygen from NO,thereby facilitating the cleavage of NO on the catalyst surface.Thus,the formation of oxygen vacancies is key to accelerating the CO-SCR reaction,with different types of oxygen vacancies being more conducive to their generation.In this study,Rh/CeCuO_(x) catalysts were synthesized using the co-crystallization and impregnation methods,and asymmetric oxygen vacancies were induced through hydrogen thermal treatment.This structuralmodification was aimed at regulating the behavior of NO on the catalyst surface.The Rh/Ce0.95Cu0.05O_(x)-H_(2) catalyst exhibited the best performance in CO-SCR,achieving above 90%NO conversion at 162℃.Various characterization techniques showed that the H_(2) treatment effectively reduced some of the CuO and Rh_(2)O_(3),creating asymmetric oxygen vacancies that accelerated the cleavage of NO on the catalyst surface,rather than forming difficult-to-decompose nitrates.This study offers a novel approach to constructing oxygen vacancies in new CO-SCR catalysts.展开更多
The trajectory of human history is characterized by a persistent battle against disease.Over time,the field of medicine has transitioned from enigmatic witch doctors and herbal remedies to a sophisticated realm of con...The trajectory of human history is characterized by a persistent battle against disease.Over time,the field of medicine has transitioned from enigmatic witch doctors and herbal remedies to a sophisticated realm of contemporary medicine that includes fundamental medical and health sciences,clinical medicine,and public health.Nevertheless,the present phase of medical advancement encounters significant challenges,particularly in effectively translating basic research findings into practical applications in clinical and public health settings.Scientists increasingly collaborate with clinical experts to overcome these obstacles and address specific clinical issues by delving deeper into fundamental mechanisms.This collaborative effort has created a new interdisciplinary field:engineering medicine(EngMed),which focuses on addressing clinical and public health needs by integrating various scientific disciplines.This article discusses the definition,key tasks,significance,educational implications,and future trends in EngMed.展开更多
文摘A numerical program is built to simulate the performance of a spark ignited two-stroke free-piston engine coupled with a linear generator. The computational model combines a series of dynamic and thermodynamic equations that are solved simultaneously to predict the performances of the engines. The dynamic analysis performed consists of an evaluation of the frictional force and load force introduced by the generator. The thermodynamic analysis used a single zone model to describe the engine＇ s working cycle which includes intake, scavenging, compression, combustion and expansion, and to evaluate the effect of heat transfer based on the first law of thermodynamics and the ideal gas state equation. Because there is no crankshaft, a time based Wiebe equation was used to express the fraction of fuel burned in the combustion. The calculated results were validated by using the experimental data from another research group. The results indicate that the free-piston generator has some advantages over conventional engines.
基金Projects(51675043,52005038)supported by the National Natural Science Foundation of China。
文摘The free-piston engine generator(FPEG)is regarded as the next generation of energy conversion system which may replace traditional engines in the future.The effect of key operational parameters like excess air ratio of input mixture and ignition position on the engine performance of a dual-cylinder FPEG was investigated,and their sensitivity was analyzed in this paper.The operating compression ratio of the system is susceptible to changes in excess air ratio and ignition position.At the same time,it decreases from 15.8 to 6.6 when excess air ratio increases from 0.85 to 1.15,but it increases from 6.1 to 13.3 as ignition position increases from 15 mm to 20 mm.The operating frequency and indicated power are more sensitive to changes in excess air ratio than ignition position.But it is the opposite for the indicated thermal efficiency and friction loss.Excess air ratio and ignition position have a quite similar influence on heat transfer.Therefore,from the perspective of system operation and performance,it is preferable to keep excess air coefficient slightly below 1.0.In contrast,when selecting ignition position,it is of great importance to comprehensively consider the risk of structural damage caused by the increase in the compression ratio and in-cylinder gas pressure.
基金supported by the Space Application System of China Manned Space Program.
文摘Methanol is a very promising clean alternative fuel with low carbon content and high octane number,and this makes it well suited to the free-piston engine generator(FPEG)with variable compression ratio characteristics.To the authors’knowledge there are no relevant studies on the application of methanol for FPEG in recent literatures.In this paper,the effects of methanol substitution ratios(MSR)and load ratios on the performances and combustion characteristics of a methane/methanol dual-fuel FPEG have been investigated experimentally and numerically.The results show that the under the gas-liquid two-phase combustion startup strategy,the methane/methanol dual-fuel FPEG can be successfully started and achieve steady operation.Due to higher laminar flame speed(LFS)and the oxygen content of methanol resulting in a faster burning rate,the peak pressure increases by 43.9%from 1.344 MPa for pure methane to 1.934 MPa for 15%of MSR and the corresponding cycle-to-cycle variation decreases from 3.36 to 1.62.The FPEG operating frequency and indicated power gradually increase with the increase of the MSR.Both of them reach maximum values of 34.6 Hz and 193 W at 15%of MSR,which are increased by 19.3%and 49.6%in comparison with the pure methane.However,under specific MSR,both of them decrease with the load ratio increasing because of the large electromagnetic resistance force from the linear generator.CO and CH emissions decrease with the increase of MSR because methanol addition promotes complete combustion of mixture.NOx emissions gradually decrease with MSR increasing owing to the low combustion temperature resulting from the high latent heat of methanol evaporation.The numerical results show that with the increase of MSR,the methane/methanol mixture presents faster flame propagation speed and higher combustion efficiency;while the ignition delay as well as CA10,CA50 and CA90 is significantly shortened due to the increase of active radicals such as H,OH,O and H_(2)O_(2).
基金support from the Contract Research(“Development of Breathable Fabrics with Nano-Electrospun Membrane”,CityU ref.:9231419“Research and application of antibacterial and healing-promoting smart nanofiber dressing for children’s burn wounds”,CityU ref:PJ9240111)+1 种基金the National Natural Science Foundation of China(“Study of Multi-Responsive Shape Memory Polyurethane Nanocomposites Inspired by Natural Fibers”,Grant No.51673162)Startup Grant of CityU(“Laboratory of Wearable Materials for Healthcare”,Grant No.9380116).
文摘Radiative cooling systems(RCSs)possess the distinctive capability to dissipate heat energy via solar and thermal radiation,making them suitable for thermal regulation and energy conservation applications,essential for mitigating the energy crisis.A comprehensive review connecting the advancements in engineered radiative cooling systems(ERCSs),encompassing material and structural design as well as thermal and energy-related applications,is currently absent.Herein,this review begins with a concise summary of the essential concepts of ERCSs,followed by an introduction to engineered materials and structures,containing nature-inspired designs,chromatic materials,meta-structural configurations,and multilayered constructions.It subsequently encapsulates the primary applications,including thermal-regulating textiles and energy-saving devices.Next,it highlights the challenges of ERCSs,including maximized thermoregulatory effects,environmental adaptability,scalability and sustainability,and interdisciplinary integration.It seeks to offer direction for forthcoming fundamental research and industrial advancement of radiative cooling systems in real-world applications.
基金supported by grants from the Jiangxi Provincial Natural Science Foundation,No.20242BAB26134(to XF)the National Natural Science Foundation of China,Nos.82060638(to TC),82060222(to XF),82460237(to XF)+1 种基金the Major Disciplines of Academic and Technical Leaders Project of Jiangxi Province,Nos.20194BCJ22032(to TC),20213BCJL22049(to XF)Science and Technology Plan of Jiangxi Health Planning Committee,No.202210390(to XF).
文摘Parkinson’s disease is characterized by synucleinopathy-associated neurodegeneration.Previous studies have shown that glucagon-like peptide-1(GLP-1)has beneficial effects in a mouse model of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.However,the effect of GLP-1 on intrinsic synuclein malfunction remains unclear.In this study,we investigated the effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism in SncaA53T transgenic mice and explored the underlying mechanisms.Our data showed that Lactococcus lactis MG1363-pMG36e-GLP-1 inhibited dopaminergic neuronal death,reduced pathological aggregation ofα-synuclein,and decreased movement disorders in SncaA53T transgenic mice.Furthermore,Lactococcus lactis MG1363-pMG36e-GLP-1 downregulated lipopolysaccharide-related inflammation,reduced cerebral activation of microglia and astrocytes,and promoted cell survival via the GLP-1 receptor/PI3K/Akt pathway in the substantia nigra.Additionally,Lactococcus lactis MG1363-pMG36e-GLP-1 decreased serum levels of pro-inflammatory molecules including lipopolysaccharide,lipopolysaccharide binding protein,interleukin-1β,and interleukin-6.Gut histopathology and western blotting further revealed that Lactococcus lactis MG1363-pMG36e-GLP-1 increased the expression of gut integrity-related proteins and reduced lipopolysaccharide-related inflammation by reversing gut dysbiosis in SncaA53T transgenic mice.Our findings showed that the beneficial effect of Lactococcus lactis MG1363-pMG36e-GLP-1 on parkinsonism traits in SncaA53T transgenic mice is mediated by microglial polarization and the reversal of dysbiosis.Collectively,our findings suggest that Lactococcus lactis MG1363-pMG36e-GLP-1 is a promising therapeutic agent for the treatment of Parkinson’s disease.
基金the Shanghai Science and Technology Commission(No.19511108500).
文摘Free-piston engine generators (FPEGs) can be applied as decarbonized range extenders for electric vehicles because of their high thermal efficiency, low friction loss, and ultimate fuel flexibility. In this paper, a parameter-decoupling approach is proposed to model the design of an FPEG. The parameter-decoupling approach first divides the FPEG into three parts: a two-stroke engine, an integrated scavenging pump, and a linear permanent magnet synchronous machine (LPMSM). Then, each of these is designed according to predefined specifications and performance targets. Using this decoupling approach, a numerical model of the FPEG, including the three aforementioned parts, was developed. Empirical equations were adopted to design the engine and scavenging pump, while special considerations were applied for the LPMSM. A finite element model with a multi-objective genetic algorithm was adopted for its design. The finite element model results were fed back to the numerical model to update the LPMSM with increased fidelity. The designed FPEG produced 10.2 kW of electric power with an overall system efficiency of 38.5% in a stable manner. The model provides a solid foundation for the manufacturing of related FPEG prototypes.
基金supported by the National Natural Science Foundation of China(No.52076007)Project of Educational Commission of Henan Province of China(No.22A470007 and No.20A470008)。
文摘In this paper,the effect of disturbances on the operation process of a methane-fueled free-piston engine generator(FPEG)was experimentally investigated.Four disturbance sources,namely step change of external load,mixture flow rate fluctuation,random misfire of a cylinder,and elastic collision,were identified and applied to the FPEG.The results showed that the FPEG successfully achieved a steady-state operation with load.The maximum instantaneous electric power of 127 W and the average effective electric power of 38.9 W were obtained.When an external load was instantaneously disconnected,the engine frequency increased from 26.7 Hz to 31.3 Hz.The fluctuation amplitudes of induced voltage,pressure and compression ratio were 18.9%,24.7%and 52.2%respectively in the disturbance.By contrast,when the external load was instantaneously connected,the corresponding values were 42.2%,31.3%and 64.3%respectively,indicating that the instantaneous external load connection had a greater disturbance impact on the FPEG operation stability.Despite encountering the step change of external load,the FPEG can still restore stable operation and show good anti-disturbance ability.Compared with increasing mixture flow rate,reducing the mixture flow rate has a greater disturbance impact on the engine operation stability.Although random misfire of a cylinder will cause remarkable fluctuations in piston displacement and cylinder pressure,the FPEG will not stop running,but continues to work as a single-piston engine.Minor collision event may adversely affect the stability of engine operation,but will not lead to the FPEG shutdown.However,serious collision event may lead to ignition failure and shutdown accident.
基金National Natural Science Foundation(50375078)Key Discipline Construction Program of Beijing.
文摘The micro free-piston swing engine （MFPSE） is a new structure, free-piston internal combustion engine. The dynamic model integrated MFPSE with a power generator and thermodynamic models in compression, power and scavenge processes based on the open thermodynamic systems were presented. A simulation was executed at given geometric parameters and initial conditions. The results manifest that the working principle of MFPSE is feasible.
基金supported by the grants from University of Macao,China,Nos.MYRG2022-00221-ICMS(to YZ)and MYRG-CRG2022-00011-ICMS(to RW)the Natural Science Foundation of Guangdong Province,No.2023A1515010034(to YZ)。
文摘Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on society.Extracellular vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke.However,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency.By utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly improved.Furthermore,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic stroke.Small extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke therapy.In this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification methodologies.Given the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment process.Moreover,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.
基金Under the auspices of National Natural Science Foundation of China(No.42293270)。
文摘Throughout the contemporary Chinese history of geography,geographical engineering has consistently played a pivotal role as a fundamental scientific activity.It possesses its distinct ontological basis and value orientation,rendering it inseparable from being merely a derivative of geographical science or technology.This paper defines geographical engineering and introduces its development history through the lens of Chinese geographical engineering praxises.Furthermore,it is highlighted the logical and functional consistency between the theory of human-earth system and the praxis of geographical engineering.Six modern cases of geographical engineering projects are presented in detail to demonstrate the points and characteristics of different types of modern geographical engineering.Geographical engineering serves as an engine for promoting integrated geography research,and in response to the challenge posed by fragmented geographies,this paper advocates for an urgent revitalization of geographical engineering.The feasibility of revitalizing geographical engineering is guaranteed because it aligns with China’s national strategies.
基金Supported by Beijing Municipal Natural Science Foundation of China(Grant No.24JL002)China Postdoctoral Science Foundation(Grant No.2024M754054)+2 种基金National Natural Science Foundation of China(Grant No.52120105008)Beijing Municipal Outstanding Young Scientis Program of Chinathe New Cornerstone Science Foundation through the XPLORER PRIZE。
文摘With the continuous advancement and maturation of technologies such as big data,artificial intelligence,virtual reality,robotics,human-machine collaboration,and augmented reality,many enterprises are finding new avenues for digital transformation and intelligent upgrading.Industry 5.0,a further extension and development of Industry 4.0,has become an important development trend in industry with more emphasis on human-centered sustainability and flexibility.Accordingly,both the industrial metaverse and digital twins have attracted much attention in this new era.However,the relationship between them is not clear enough.In this paper,a comparison between digital twins and the metaverse in industry is made firstly.Then,we propose the concept and framework of Digital Twin Systems Engineering(DTSE)to demonstrate how digital twins support the industrial metaverse in the era of Industry 5.0 by integrating systems engineering principles.Furthermore,we discuss the key technologies and challenges of DTSE,in particular how artificial intelligence enhances the application of DTSE.Finally,a specific application scenario in the aviation field is presented to illustrate the application prospects of DTSE.
文摘The purpose of this study is to analyze the application of ultrasonic non-destructive testing technology in bridge engineering.During the research phase,based on literature collection and reading,as well as the analysis of bridge inspection materials,the principle of ultrasonic non-destructive testing technology and its adaptability to bridge engineering are elaborated.Subsequently,starting from the preparation work before inspection until damage assessment,the entire process of ultrasonic non-destructive testing is studied,and finally,a technical system of ultrasonic non-destructive testing for bridge engineering that runs through the entire process is formed.It is hoped that this article can provide technical reference value for relevant units in China,and promote the high-quality development of China’s bridge engineering from a macro perspective.
基金funded by the project of Guangdong Provincial Basic and Applied Basic Research Fund Committee(2022A1515240073)the Pearl River Talent Recruitment Program(2019CX01G338),Guangdong Province.
文摘Construction engineering and management(CEM)has become increasingly complicated with the increasing size of engineering projects under different construction environments,motivating the digital transformation of CEM.To contribute to a better understanding of the state of the art of smart techniques for engineering projects,this paper provides a comprehensive review of multi-criteria decision-making(MCDM)techniques,intelligent techniques,and their applications in CEM.First,a comprehensive framework detailing smart technologies for construction projects is developed.Next,the characteristics of CEM are summarized.A bibliometric review is then conducted to investigate the keywords,journals,and clusters related to the application of smart techniques in CEM during 2000-2022.Recent advancements in intelligent techniques are also discussed under the following six topics:①big data technology;②computer vision;③speech recognition;④natural language processing;⑤machine learning;and⑥knowledge representation,understanding,and reasoning.The applications of smart techniques are then illustrated via underground space exploitation.Finally,future research directions for the sustainable development of smart construction are highlighted.
基金supported by the support of the National Natural Science Foundation of China(Nos.22072141,22176185 and 52304429)the National Key Research and Development Program of China(Nos.2022YFB3504200,2021YFB3501900)+4 种基金the Natural Science Foundation of Jiangxi Province for Distinguished Young Scholars(No.20232ACB213004)Jiangxi Provincial Key Research and Development Program(No.20232BBG70012)Jiangxi Provincial Natural Science Foundation(No.20212BAB213032)the Youth Innovation Promotion Association of Chinese Academy of Sciences(No.2018263)the Research Projects of Ganjiang Innovation Academy,Chinese Academy of Sciences(No.E355C001).
文摘Selective catalytic reduction of NO_(x) with CO(CO-SCR)is a process that purifies both NO and CO pollutants through a catalytic reaction.Specifically,the cleavage of NO on the catalyst surface is crucial for promoting the reaction.During the reaction,the presence of oxygen vacancies can extract oxygen from NO,thereby facilitating the cleavage of NO on the catalyst surface.Thus,the formation of oxygen vacancies is key to accelerating the CO-SCR reaction,with different types of oxygen vacancies being more conducive to their generation.In this study,Rh/CeCuO_(x) catalysts were synthesized using the co-crystallization and impregnation methods,and asymmetric oxygen vacancies were induced through hydrogen thermal treatment.This structuralmodification was aimed at regulating the behavior of NO on the catalyst surface.The Rh/Ce0.95Cu0.05O_(x)-H_(2) catalyst exhibited the best performance in CO-SCR,achieving above 90%NO conversion at 162℃.Various characterization techniques showed that the H_(2) treatment effectively reduced some of the CuO and Rh_(2)O_(3),creating asymmetric oxygen vacancies that accelerated the cleavage of NO on the catalyst surface,rather than forming difficult-to-decompose nitrates.This study offers a novel approach to constructing oxygen vacancies in new CO-SCR catalysts.
基金supported by the National Natural Science Innovative Research Group Project(61821002)the Frontier Funda-mental Research Program of Jiangsu Province for Leading Technology(BK20222002).
文摘The trajectory of human history is characterized by a persistent battle against disease.Over time,the field of medicine has transitioned from enigmatic witch doctors and herbal remedies to a sophisticated realm of contemporary medicine that includes fundamental medical and health sciences,clinical medicine,and public health.Nevertheless,the present phase of medical advancement encounters significant challenges,particularly in effectively translating basic research findings into practical applications in clinical and public health settings.Scientists increasingly collaborate with clinical experts to overcome these obstacles and address specific clinical issues by delving deeper into fundamental mechanisms.This collaborative effort has created a new interdisciplinary field:engineering medicine(EngMed),which focuses on addressing clinical and public health needs by integrating various scientific disciplines.This article discusses the definition,key tasks,significance,educational implications,and future trends in EngMed.
