Graphical representation of hierarchical clustering results is of final importance in hierarchical cluster analysis of data. Unfortunately, almost all mathematical or statistical software may have a weak capability of...Graphical representation of hierarchical clustering results is of final importance in hierarchical cluster analysis of data. Unfortunately, almost all mathematical or statistical software may have a weak capability of showcasing such clustering results. Particularly, most of clustering results or trees drawn cannot be represented in a dendrogram with a resizable, rescalable and free-style fashion. With the “dynamic” drawing instead of “static” one, this research works around these weak functionalities that restrict visualization of clustering results in an arbitrary manner. It introduces an algorithmic solution to these functionalities, which adopts seamless pixel rearrangements to be able to resize and rescale dendrograms or tree diagrams. The results showed that the algorithm developed makes clustering outcome representation a really free visualization of hierarchical clustering and bioinformatics analysis. Especially, it possesses features of selectively visualizing and/or saving results in a specific size, scale and style (different views).展开更多
Background:Reconstruction of large scalp defects after tumor resection is common and challenging.Free skin grafting or free flap transfer is always performed.However,these techniques can result in poor functional and ...Background:Reconstruction of large scalp defects after tumor resection is common and challenging.Free skin grafting or free flap transfer is always performed.However,these techniques can result in poor functional and cosmetic outcomes.Methods:In the Second Affiliated Hospital of Soochow University and the Second Affiliated Hospital of Chengdu Medical College,35 patients underwent jigsaw puzzle flap procedures based on a free-style perforator to repair large scalp defects after tumor resection from May 2013 to November 2022.The key to this procedure was to divide a large defect into several smaller parts that correspond to adjacent free-style perforators around the scalp defect.The free-style perforator flaps were designed in different ways,such as propeller flaps,rotation flaps,and V-Y advancement flaps,which were pedicled with free-style perforators.All of the small flaps were then mobilized to the defect and sutured to each other to create a new,large jigsaw puzzle-like flap to cover the large scalp defect.Finally,all the donor sites were closed directly.Results:Overall,35 patients were treated.The average defect size was 72 cm^(2)(range,25-91 cm^(2)).All flaps had a satisfactory appearance after follow-up periods of 6 months-10 years.Local tumor recurrence occurred in one case.Conclusion:The application of a jigsaw puzzle flap based on a free-style perforator is a suitable option for the reconstruction of large scalp defects after resection,yielding satisfactory functional and cosmetic results.展开更多
文摘Graphical representation of hierarchical clustering results is of final importance in hierarchical cluster analysis of data. Unfortunately, almost all mathematical or statistical software may have a weak capability of showcasing such clustering results. Particularly, most of clustering results or trees drawn cannot be represented in a dendrogram with a resizable, rescalable and free-style fashion. With the “dynamic” drawing instead of “static” one, this research works around these weak functionalities that restrict visualization of clustering results in an arbitrary manner. It introduces an algorithmic solution to these functionalities, which adopts seamless pixel rearrangements to be able to resize and rescale dendrograms or tree diagrams. The results showed that the algorithm developed makes clustering outcome representation a really free visualization of hierarchical clustering and bioinformatics analysis. Especially, it possesses features of selectively visualizing and/or saving results in a specific size, scale and style (different views).
基金supported by the National Natural Science Foundation of China(grant nos.32071238,82073477,and 82103773)Natural Science Project of Chengdu Medical College(grant nos.CYZZD20-01 and CYZ19-31)+3 种基金Science and Technology Project of Health Commission of Sichuan Province(grant no.21PJ158)Scientific Research Fund Project of China Baoyuan Investment Co.,Ltd.(grant no.CBYI202104)Nuclear Medical Science and Technology Innovation Project of China National Nuclear Corporation Medical Industry Management Co.,Ltd.(grant no.ZHYLTD2021002)Young Talent Project of China National Nuclear Corporation.
文摘Background:Reconstruction of large scalp defects after tumor resection is common and challenging.Free skin grafting or free flap transfer is always performed.However,these techniques can result in poor functional and cosmetic outcomes.Methods:In the Second Affiliated Hospital of Soochow University and the Second Affiliated Hospital of Chengdu Medical College,35 patients underwent jigsaw puzzle flap procedures based on a free-style perforator to repair large scalp defects after tumor resection from May 2013 to November 2022.The key to this procedure was to divide a large defect into several smaller parts that correspond to adjacent free-style perforators around the scalp defect.The free-style perforator flaps were designed in different ways,such as propeller flaps,rotation flaps,and V-Y advancement flaps,which were pedicled with free-style perforators.All of the small flaps were then mobilized to the defect and sutured to each other to create a new,large jigsaw puzzle-like flap to cover the large scalp defect.Finally,all the donor sites were closed directly.Results:Overall,35 patients were treated.The average defect size was 72 cm^(2)(range,25-91 cm^(2)).All flaps had a satisfactory appearance after follow-up periods of 6 months-10 years.Local tumor recurrence occurred in one case.Conclusion:The application of a jigsaw puzzle flap based on a free-style perforator is a suitable option for the reconstruction of large scalp defects after resection,yielding satisfactory functional and cosmetic results.
