Psoriasis is a common and chronic immune-mediated disorder that severely impacts the life quality of patients.Phosphodiesterase-4(PDE4)inhibitors have attracted significant interests in the psoriasis treatment due to ...Psoriasis is a common and chronic immune-mediated disorder that severely impacts the life quality of patients.Phosphodiesterase-4(PDE4)inhibitors have attracted significant interests in the psoriasis treatment due to their ability to suppress the inflammatory cascades.In this study,extensive screening of an in-house library of 1200 Chinese medicinal plant extracts identified Platycladus orientalis(L.)Franco(P.orientalis)as a potent PDE4 inhibitor,exhibiting 42.7%inhibition at 0.2μg/m L.Subsequent bioassayguided isolation revealed flavonoids,particularly amentoflavone(AMF),as the principal component responsible for PDE4 inhibition.To enrich the effective ingredients,a purification protocol using microporous resin was developed,yielding a flavonoid-rich extract(FLDs)that efficiently increased AMF content from 6.2%to 72.3%and improved PDE4 inhibitory activity to 74.2%at 0.2μg/mL.Notably,P.orientalis with favorable safety profiles demonstrated superior in vitro and in vivo anti-psoriasis effects to both AMF and the approved PDE4 inhibitor apremilast.These findings highlight the potential of P.orientalis as a novel therapeutic agent for psoriasis and provide valuable insights for its development in psoriasis treatment.展开更多
China is the third largest country in the world, with a land area of about 9.6 million km2. It is endowed with abundant mineral resources, and the metal mining activity can be traced back to ca. 8000 years ago. Howeve...China is the third largest country in the world, with a land area of about 9.6 million km2. It is endowed with abundant mineral resources, and the metal mining activity can be traced back to ca. 8000 years ago. However, due to language barrier, little has been known about the geology and tectonics to the outside world until 1980s. In the last three decades, a great deal of knowledge has been gained, enhanced by a vigorous cooperation between Chinese and Western geologists. Research papers about geological, geochemical, and geochronological features of mineral deposits of China are widely published and cited in international journals. A comprehen- sive and comprehensible English literature that summarises the features of mineral deposits in China, however, is still lacking.展开更多
This study was designed to investigate the anti-inflammatory effects of volatile oil of Platycladus orientalis(L.)Franco leaves(VOPF)and the underlying molecular mechanisms by using the non-infectious inflammation rat...This study was designed to investigate the anti-inflammatory effects of volatile oil of Platycladus orientalis(L.)Franco leaves(VOPF)and the underlying molecular mechanisms by using the non-infectious inflammation rat models and infectious inflammation mouse models.Ear swelling and intraperitoneal capillary permeability in mice,and carrageenan-induced toe swelling and cotton ball-induced granuloma in rats were used to reveal anti-inflammatory effects of VOPF.Moreover,the lipopolysaccharide(LPS)-induced mouse model of acute lung injury was used to explore the anti-inflammatory mechanism of VOPF.The results showed that VOPF could significantly inhibit auricular swelling,intraperitoneal capillary permeability in mice,and reduce granuloma swelling and paw swelling in rats.Furthermore,it significantly alleviated the pathological damage of the lung tissue.In addition,VOPF could reduce the contents of IL-1β and TNF-αand increase the content of IL-10 in the serum.It had little effect on the expression of p65 but reduced the phosphorylation level of p65 and IκB in NF-κB pathway.In conclusion,VOPF has anti-inflammatory effects and the mechanisms involve the down-regulation of the phosphorylation levels of p65 and IκB and blockage of the NF-κB signaling pathway.展开更多
My f irst impression of Franco Ng came during his visit to our Beijing offices.At that time,he was in Beijing as a vip with the National Bank of Canada speaking about his educational experiences growing up in Canada...My f irst impression of Franco Ng came during his visit to our Beijing offices.At that time,he was in Beijing as a vip with the National Bank of Canada speaking about his educational experiences growing up in Canada,while promoting“The Win”,a Global Youth Venture Competition he established with the World Youth Leadership Foundation this year.展开更多
中学英语课本中出现 Franco-Prussian War(普法战争),新闻中出现 Sino-Japanese relations(中日关系)等复合词语。这里Franco- 即 French,of France 或 French and 之意,前面的Franco- ,Sino- 等系外来语,而且较古,被英语吸收。如Sino-
Radio Espana Independiente [REI] [1941-1977], La Pirenaica, was the repository for the public remembrance of the victims of the Franco regime, through letters that its listeners regularly sent to the broadcaster＇s he...Radio Espana Independiente [REI] [1941-1977], La Pirenaica, was the repository for the public remembrance of the victims of the Franco regime, through letters that its listeners regularly sent to the broadcaster＇s headquarters in Bucharest. A study of the 15,500 letters contained in the Spanish Communist Party＇s [PCE] Historical Archive in Madrid confirms this broadcaster＇s major role in the construction of the mythical symbolic image of the anti-Franco movement. Beyond their function as propaganda instruments of the PCE, La Pirenaica＇s letters reveal the radio station＇s role as a vehicle for the expression of public solidarity and ideological and cultural resistance. La Pirenaica was the voice of the defeated after the Spanish Civil War, and was their confidante and advisor. La Pirenaica＇s letters are the chronicle of the horror that anti-Franco society suffered and endured in Spain.展开更多
It is my great honor to be invited to the China International Conference in Commemoration of the 60th Anniversary of the Chinese People’s Association for Friendship with Foreign Countries(CPAFFC)today,which indicates...It is my great honor to be invited to the China International Conference in Commemoration of the 60th Anniversary of the Chinese People’s Association for Friendship with Foreign Countries(CPAFFC)today,which indicates that CPAFFC fully recognizes the importance of the work done by San Marino-China Friendship Association(SCFA).I have the privilege of being the President of the SCFA for up to 26years.During these years,the SCFA展开更多
基金supported by the National Key R&D Program of China(No.2023YFF1205102)National Natural Science Foundation of China(Nos.22277019,22307031,22377023 and 22077143)+2 种基金the Fundamental Research Funds for Hainan University(Nos.RZ2200001094,KYQD(ZR)-21031,and KYQD(ZR)-21108)Collaborative Innovation Center Funds for Hainan University(No.XTCX2022JKA01)the Science Foundation of Hainan Province(Nos.KJRC2023B10 and 824YXQN420)。
文摘Psoriasis is a common and chronic immune-mediated disorder that severely impacts the life quality of patients.Phosphodiesterase-4(PDE4)inhibitors have attracted significant interests in the psoriasis treatment due to their ability to suppress the inflammatory cascades.In this study,extensive screening of an in-house library of 1200 Chinese medicinal plant extracts identified Platycladus orientalis(L.)Franco(P.orientalis)as a potent PDE4 inhibitor,exhibiting 42.7%inhibition at 0.2μg/m L.Subsequent bioassayguided isolation revealed flavonoids,particularly amentoflavone(AMF),as the principal component responsible for PDE4 inhibition.To enrich the effective ingredients,a purification protocol using microporous resin was developed,yielding a flavonoid-rich extract(FLDs)that efficiently increased AMF content from 6.2%to 72.3%and improved PDE4 inhibitory activity to 74.2%at 0.2μg/mL.Notably,P.orientalis with favorable safety profiles demonstrated superior in vitro and in vivo anti-psoriasis effects to both AMF and the approved PDE4 inhibitor apremilast.These findings highlight the potential of P.orientalis as a novel therapeutic agent for psoriasis and provide valuable insights for its development in psoriasis treatment.
文摘China is the third largest country in the world, with a land area of about 9.6 million km2. It is endowed with abundant mineral resources, and the metal mining activity can be traced back to ca. 8000 years ago. However, due to language barrier, little has been known about the geology and tectonics to the outside world until 1980s. In the last three decades, a great deal of knowledge has been gained, enhanced by a vigorous cooperation between Chinese and Western geologists. Research papers about geological, geochemical, and geochronological features of mineral deposits of China are widely published and cited in international journals. A comprehen- sive and comprehensible English literature that summarises the features of mineral deposits in China, however, is still lacking.
基金the National Natural Science Foundation of China(No.31200264)the Fundamental Research Funds for Central Universities(South-Central University for NationalitiesNo.CZY19028,No.CZY20048).
文摘This study was designed to investigate the anti-inflammatory effects of volatile oil of Platycladus orientalis(L.)Franco leaves(VOPF)and the underlying molecular mechanisms by using the non-infectious inflammation rat models and infectious inflammation mouse models.Ear swelling and intraperitoneal capillary permeability in mice,and carrageenan-induced toe swelling and cotton ball-induced granuloma in rats were used to reveal anti-inflammatory effects of VOPF.Moreover,the lipopolysaccharide(LPS)-induced mouse model of acute lung injury was used to explore the anti-inflammatory mechanism of VOPF.The results showed that VOPF could significantly inhibit auricular swelling,intraperitoneal capillary permeability in mice,and reduce granuloma swelling and paw swelling in rats.Furthermore,it significantly alleviated the pathological damage of the lung tissue.In addition,VOPF could reduce the contents of IL-1β and TNF-αand increase the content of IL-10 in the serum.It had little effect on the expression of p65 but reduced the phosphorylation level of p65 and IκB in NF-κB pathway.In conclusion,VOPF has anti-inflammatory effects and the mechanisms involve the down-regulation of the phosphorylation levels of p65 and IκB and blockage of the NF-κB signaling pathway.
文摘My f irst impression of Franco Ng came during his visit to our Beijing offices.At that time,he was in Beijing as a vip with the National Bank of Canada speaking about his educational experiences growing up in Canada,while promoting“The Win”,a Global Youth Venture Competition he established with the World Youth Leadership Foundation this year.
文摘中学英语课本中出现 Franco-Prussian War(普法战争),新闻中出现 Sino-Japanese relations(中日关系)等复合词语。这里Franco- 即 French,of France 或 French and 之意,前面的Franco- ,Sino- 等系外来语,而且较古,被英语吸收。如Sino-
文摘Radio Espana Independiente [REI] [1941-1977], La Pirenaica, was the repository for the public remembrance of the victims of the Franco regime, through letters that its listeners regularly sent to the broadcaster＇s headquarters in Bucharest. A study of the 15,500 letters contained in the Spanish Communist Party＇s [PCE] Historical Archive in Madrid confirms this broadcaster＇s major role in the construction of the mythical symbolic image of the anti-Franco movement. Beyond their function as propaganda instruments of the PCE, La Pirenaica＇s letters reveal the radio station＇s role as a vehicle for the expression of public solidarity and ideological and cultural resistance. La Pirenaica was the voice of the defeated after the Spanish Civil War, and was their confidante and advisor. La Pirenaica＇s letters are the chronicle of the horror that anti-Franco society suffered and endured in Spain.
文摘It is my great honor to be invited to the China International Conference in Commemoration of the 60th Anniversary of the Chinese People’s Association for Friendship with Foreign Countries(CPAFFC)today,which indicates that CPAFFC fully recognizes the importance of the work done by San Marino-China Friendship Association(SCFA).I have the privilege of being the President of the SCFA for up to 26years.During these years,the SCFA
