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An Assembly Coastal Building Technique in Port Engineering 被引量:1
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作者 陈育民 刘汉龙 +1 位作者 陈泽 高玉峰 《China Ocean Engineering》 SCIE EI 2009年第2期379-386,共8页
The assembly coastal building technique initiated at home and abroad,is for a novel vertical standing harbor structure.Its main concept is the assembling components which can be combined and locked together to form a ... The assembly coastal building technique initiated at home and abroad,is for a novel vertical standing harbor structure.Its main concept is the assembling components which can be combined and locked together to form a large caisson.Its application and future are discussed for a building.After many years of application and tests,the technique has a high stability,a wide range of application,low workload and fast construction speed.It can be widely applied in future for harbor engineering projects. 展开更多
关键词 assembly techniques frame structure open-ended caisson port engineering
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Voice Control for an Industrial Robot as a Combination of Various Robotic Assembly Process Models 被引量:1
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作者 Svitlana Maksymova Rami Matarneh +1 位作者 Vyacheslav V. Lyashenko Nataliya V. Belova 《Journal of Computer and Communications》 2017年第11期1-15,共15页
Models for the design of assembly processes are considered. Various models for the voice control of an industrial robot are considered: a logical model, semantic networks, a frame model and Petri nets. It is shown tha... Models for the design of assembly processes are considered. Various models for the voice control of an industrial robot are considered: a logical model, semantic networks, a frame model and Petri nets. It is shown that this set of models allows describing the process of designing the technological process for an industrial robot. The logical model of the technological process allows you to define logical relationships. A model based on semantic networks describes the relationship between assembly units in a detail. This allows you to determine the order and method of registration, as well as the mutual orientation of assembly units in the product. The frame model provides the ability to streamline the execution of the build process. A model based on Petri nets allows one to describe the type and sequence of technological transitions. Based on the proposed models, a method of voice control for an industrial robot is developed. The basic principles of voice control for an industrial robot are considered. 展开更多
关键词 Robot VOICE Control frame MODEL PETRI NETS Logic MODEL SEMANTIC NETS Robotic assembly Processes
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Response Spectrum Analysis of 7-story Assembled Frame Structure with Energy Dissipation System 被引量:1
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作者 Jin Zhao Yi Wang Zhengwei Ma 《Structural Durability & Health Monitoring》 EI 2023年第2期159-173,共15页
Viscoelastic damper is an effective passive damping device,which can reduce the seismic response of the structure by increasing the damping and dissipating the vibration energy of structures.It has a wide application ... Viscoelastic damper is an effective passive damping device,which can reduce the seismic response of the structure by increasing the damping and dissipating the vibration energy of structures.It has a wide application prospect in actual structural vibration control because of simple device and economical material.In view of the poor seismic behaviors of assembled frame structure connections,various energy dissipation devices are proposed to improve the seismic performance.The finite element numerical analysis method is adopted to analyze relevant energy dissipation structural parameters.The response spectrum of a 7-story assembled frame structure combined the ordinary steel support,ordinary viscoelastic damper,and viscoelastic damper with displacement amplification device is analyzed.The analysis results show that the mechanical behavior of assembled frame structure with ordinary steel supports are not significantly different from those without energy dissipation devices.The assembled frame structure with viscoelastic damper has better seismic performance and energy dissipation,especially for the viscoelastic damper with displacement amplification devices.The maximum value of inter-story displacement angle decreases by 32.24%;the maximum floor displacement decreases by 31.91%,and the base shear decreases by 13.62%compared with the assembled frame structures without energy dissipation devices.The results show that the seismic fortification ability of the structure is significantly improved,and the overall structure is more uniformly stressed.The damping structure with viscoelastic damper mainly reduces the dynamic response of the structure by increasing the damping coefficient,rather than by changing the natural vibration period of the structure.This paper provides an effective theoretical basis and reference for improving the energy dissipation system and the seismic performance of assembled frame structures. 展开更多
关键词 assembled frame structure energy dissipation devices response spectrum analysis viscoelastic damper
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新型箱式集成房顶框组件力学性能研究
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作者 陈志华 刘雪杰 +2 位作者 刘佳迪 孙鹏 红涛 《建筑钢结构进展》 北大核心 2026年第1期105-118,共14页
文中阐述了一种由预制轻钢构件与螺栓连接而成的新型箱式集成房顶框组件,为研究其受力性能,对该组件进行了足尺承载力试验,分析了在各级荷载作用下顶框组件位移和应变的变化规律,还研究了该组件的传力机理及破坏模式。试验结果表明:新... 文中阐述了一种由预制轻钢构件与螺栓连接而成的新型箱式集成房顶框组件,为研究其受力性能,对该组件进行了足尺承载力试验,分析了在各级荷载作用下顶框组件位移和应变的变化规律,还研究了该组件的传力机理及破坏模式。试验结果表明:新型箱式集成房顶框组件具有较好的承载能力;试件的破坏模式主要表现为:长边主梁发生弯扭变形的同时,短边次梁发生屈曲破坏;之后,采用ABAQUS有限元软件建立了该组件的有限元计算模型,对比了各关键位置的荷载-位移曲线,且有限元模型计算结果与试验结果吻合较好。基于验证后的有限元模型,对长边主梁、短边次梁截面厚度、短边次梁间距、钢材强度以及主次梁节点连接形式等影响因素进行了参数分析,以揭示各因素对结构整体力学性能的影响规律。结果表明:增加长边主梁与短边次梁截面厚度、减小短边次梁间距、提高短边次梁钢材强度、优化主次梁节点连接形式等方式均可以提高顶框组件的承载能力。 展开更多
关键词 箱式集成房 顶框组件 螺栓连接 承载力试验 破坏模式 有限元分析 参数分析
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单层单跨装配式PEC框架抗火性能研究
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作者 邓雄 毛小勇 《土木工程与绿色建筑》 2026年第2期32-36,50,共6页
文章为研究装配式PEC框架高温下的耐火性能,应用ABAQUS有限元软件建立了单层单跨装配式PEC框架温度场和热-力耦合分析模型,分析了截面温度场分布情况和框架破坏形态特征,以及柱火灾轴压比、梁火灾荷载比、线刚度比、截面形状系数和配筋... 文章为研究装配式PEC框架高温下的耐火性能,应用ABAQUS有限元软件建立了单层单跨装配式PEC框架温度场和热-力耦合分析模型,分析了截面温度场分布情况和框架破坏形态特征,以及柱火灾轴压比、梁火灾荷载比、线刚度比、截面形状系数和配筋率等参数对装配式PEC框架耐火性能的影响。研究结果表明,框架梁柱截面温度呈现倒“8”字形;框架破坏模式主要为柱破坏形式,其中线刚度比与梁火灾荷载比会影响框架破坏模式;荷载比与截面形状系数对框架耐火极限的影响显著。文章在参数分析的基础上,提出装配式PEC框架耐火极限的计算公式,可为装配式PEC框架抗火设计提供参考。 展开更多
关键词 装配式PEC框架 抗火性能 耐火极限 破坏形态
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铁路隧道初期支护大机配套设备改进与应用
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作者 刘小弟 范伯达 《中国高新科技》 2026年第1期89-91,共3页
软岩大变形施工初期存在难以准确判定大变形发生的段落和等级问题,常规工法对大变形的控制适应性较差,导致初期软岩大变形控制较难,出现变形造成钢架扭曲、地板隆起、混凝土剥落掉块等现象。文章以某软岩大变形隧道为研究对象,通过机械... 软岩大变形施工初期存在难以准确判定大变形发生的段落和等级问题,常规工法对大变形的控制适应性较差,导致初期软岩大变形控制较难,出现变形造成钢架扭曲、地板隆起、混凝土剥落掉块等现象。文章以某软岩大变形隧道为研究对象,通过机械设备改进,提高超前支护、钢拱架、锚杆、锚索等初期支护施工质量,有效解决了软岩大变形隧道变形难以控制的问题,实现以设备保工艺、以工艺保质量、以质量保安全、以安全提效益的目的。 展开更多
关键词 锚索 拱架 拼装台车 锚注一体机 凿岩台车
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商用车车架涂装工艺对比分析研究
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作者 宋亚飞 《上海涂料》 2026年第1期51-55,共5页
随着商用车车架防腐与耐久性要求的不断提升,其涂装工艺正经历重要升级,传统总成电泳工艺逐渐向散件电泳+面漆/粉末喷涂的复合涂层体系转型。该工艺变革有效强化了车架的防腐蚀与耐老化性能,对提升整车使用寿命和运行可靠性具有重要工... 随着商用车车架防腐与耐久性要求的不断提升,其涂装工艺正经历重要升级,传统总成电泳工艺逐渐向散件电泳+面漆/粉末喷涂的复合涂层体系转型。该工艺变革有效强化了车架的防腐蚀与耐老化性能,对提升整车使用寿命和运行可靠性具有重要工程价值。本研究以电泳后水性聚氨酯面漆喷涂、聚酯粉末喷涂两种工艺为研究对象,从工艺流程、工艺参数、涂层性能、成本投入等方面进行对比,并验证散件电泳后总成粉末喷涂技术的综合应用优势,为商用车车架涂装工艺的选型优化与质量提升提供参考。 展开更多
关键词 商用车 车架 散件电泳 总成喷粉 耐盐雾 抗老化
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热塑性复合材料汽车座椅骨架总成极限强度仿真及参数优化设计
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作者 万晓飞 王定 +2 位作者 徐云 李国林 李天奇 《计算机辅助工程》 2026年第1期41-48,共8页
提出一种使用连续纤维增强热塑性复合材料代替传统金属材料的汽车座椅靠背骨架设计方案,构建热塑性复合材料座椅骨架总成在极限载荷工况下的有限元模型,对比分析座椅骨架总成在不同极限载荷工况下的受力状态,结果显示复合材料靠背在不... 提出一种使用连续纤维增强热塑性复合材料代替传统金属材料的汽车座椅靠背骨架设计方案,构建热塑性复合材料座椅骨架总成在极限载荷工况下的有限元模型,对比分析座椅骨架总成在不同极限载荷工况下的受力状态,结果显示复合材料靠背在不同载荷工况下的失效指数均明显小于1。运用多学科优化平台HyperStudy构建复合材料座椅骨架总成在不同极限载荷工况下的参数化有限元仿真模型,利用全局响应面法和遗传算法对有撕裂风险的靠背骨架金属零部件进行参数优化设计,在确保不同极限载荷作用下金属零部件强度均满足要求的条件下,优化后的座椅骨架总成质量仅增加1.73%。 展开更多
关键词 汽车座椅骨架总成 热塑性复合材料靠背 极限强度 数值仿真 参数优化
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纯电动城市客车碳纤维车身结构设计与安装工艺研究
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作者 魏仕胜 《客车技术与研究》 2026年第2期34-37,55,共5页
本文阐述了纯电动城市客车碳纤维车身的结构设计特点与制造工艺,并介绍了侧围与顶盖所采用的一体化结构形式。针对整车不同部件间的连接,重点分析了采用角钢作为过渡连接件的方案,该方案有效解决了因骨架材料差异而无法直接焊接拼装的... 本文阐述了纯电动城市客车碳纤维车身的结构设计特点与制造工艺,并介绍了侧围与顶盖所采用的一体化结构形式。针对整车不同部件间的连接,重点分析了采用角钢作为过渡连接件的方案,该方案有效解决了因骨架材料差异而无法直接焊接拼装的难题。在蒙皮安装工艺方面,探讨了采用铝垫块配合小方管共同支撑蒙皮的具体施工方案。本文对碳纤维车身结构与安装工艺的分析,可为同类客车的生产制造提供参考。 展开更多
关键词 纯电动城市客车 碳纤维车身 轻量化设计 骨架总拼 蒙皮安装工艺
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隧道装配式锁脚锚杆与钢架连接器变形及其受力承载特性
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作者 丁文云 郭永发 +1 位作者 李志丹 李贵民 《建筑技术》 2026年第2期190-194,共5页
提出了一种新型装配式锁脚锚杆与支护钢架连接器,旨在解决传统隧道施工中初期支护结构稳定性与承载能力不足的问题。基于数值模拟和足尺模型试验,研究了该连接器在复杂荷载下的变形演化规律及承载特性。研究结果表明,新型连接器在不同... 提出了一种新型装配式锁脚锚杆与支护钢架连接器,旨在解决传统隧道施工中初期支护结构稳定性与承载能力不足的问题。基于数值模拟和足尺模型试验,研究了该连接器在复杂荷载下的变形演化规律及承载特性。研究结果表明,新型连接器在不同荷载阶段均能维持结构整体性,表现出良好的变形能力和承载性能,极限承载力达到设计值的1.5倍,破坏模式主要为螺杆根部断裂和夹块塑性屈曲。连接器通过模块化设计与力学优化,有效解决传统支护的技术瓶颈,其变形演化规律与承载特性为软弱围岩隧道支护设计提供标准化参数,为隧道支护体系的优化设计提供了理论依据和技术支持,具有显著的安全性与经济性价值。 展开更多
关键词 软岩隧道 装配式连接器 锁脚锚杆 支护钢架 模型试验 承载特性
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小车架钢构连续流产线制造周期缩短路径研究
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作者 汪子旸 《今日自动化》 2026年第1期55-57,共3页
文章以上海振华重工小车架钢构生产为研究对象,针对传统批量生产周期长、物流效率低、工序协同性差的问题,提出了“智能流水线优化+智能管控体系”的双驱动方案,旨在为重型装备产线智能化升级与周期优化提供参考。
关键词 小车架钢构 连续流产线 制造周期 智能流水线 精益生产 智能管控系统
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基于Fork/Join多核并行框架的梯级水库群优化调度 被引量:5
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作者 王森 马志鹏 +2 位作者 李善综 王凌河 熊静 《水利水电科技进展》 CSCD 北大核心 2017年第2期48-54,共7页
为了满足大规模梯级水库群优化调度精细化管理需求,解决决策计算耗时长及求解效率低等困难,提出了基于Fork/Join多核并行框架的梯级水库群优化调度并行求解方法,并以离散微分动态规划方法并行化为例,给出了梯级水库群优化调度方法在Fork... 为了满足大规模梯级水库群优化调度精细化管理需求,解决决策计算耗时长及求解效率低等困难,提出了基于Fork/Join多核并行框架的梯级水库群优化调度并行求解方法,并以离散微分动态规划方法并行化为例,给出了梯级水库群优化调度方法在Fork/Join框架下的并行化实现方式。红水河大规模梯级水库群长期发电优化调度测试结果表明,并行计算能够充分发挥多核处理器的加速性能,有效缩短计算耗时,提高求解效率;选择合理的Fork/Join框架规模控制阈值是充分发挥并行优势的关键因素。 展开更多
关键词 梯级水库群 优化调度 fork/Join并行框架 多核处理器 并行计算
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Improvement of durability of membrane electrode assembly by frame sealing structure in temperature shock
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作者 Yanbo Wang Tiankuo Chu 《Frontiers in Energy》 2025年第3期326-333,共8页
The frame of membrane electrode assembly(MEA)influences the durability of proton exchange membrane fuel cell(PEMFC).In this paper,the thermal shock bench was applied as an accelerated aging test to explore the effect ... The frame of membrane electrode assembly(MEA)influences the durability of proton exchange membrane fuel cell(PEMFC).In this paper,the thermal shock bench was applied as an accelerated aging test to explore the effect of frame sealing structure on MEA durability at different temperatures.Analysis of scanning electron microscope(SEM)images reveals that thermal shock results in the formation of cracks on the exposed proton exchange membrane(PEM)at the gap between the frame and the active area.Moreover,it breaks the bonding interface between the frame and the membrane and leads to the debonding of the adhesive,which exacerbates the risk of crossover of the reactant gas.A comparison of the single-layer and improved double-layer frame structures reveal that the mechanical damage is caused by frequent membrane wrinkles in the gap under temperature shock.However,addition of a cushion layer improves the continuity between the frame and the active area,and reduces deformation of the membrane,thereby preventing membrane damage. 展开更多
关键词 frame fuel cells membrane electrode assembly(MEA) MEMBRANE thermal shock
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Finite particle method for kinematically indeterminate bar assemblies 被引量:15
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作者 Ying YU Yao-zhi LUO 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2009年第5期669-676,共8页
This study presents a structural analysis algorithm called the finite particle method (FPM) for kinematically indeterminate bar assemblies. Different from the traditional analysis method, FPM is based on the combina... This study presents a structural analysis algorithm called the finite particle method (FPM) for kinematically indeterminate bar assemblies. Different from the traditional analysis method, FPM is based on the combination of the vector mechanics and numerical calculations. It models the analyzed domain composed of finite particles. Newton's second law is adopted to describe the motions of all particles. A convected material flame and explicit time integration for the solution procedure is also adopted in this method. By using the FPM, there is no need to solve any nonlinear equations, to calculate the stiffness matrix or equilibrium matrix, which is very helpful in the analysis of kinematically indeterminate structures. The basic formulations for the space bar are derived, following its solution procedures for bar assemblies. Three numerical examples are analyzed using the FPM. Results obtained from both the straight pretension cable and the suspension cable assembly show that the FPM can produce a more accurate analysis result. The motion simulation of the four-bar space assembly demonstrates the capability of this method in the analysis ofkinematically indeterminate structures. 展开更多
关键词 Finite particle method (FPM) Vector mechanics Convected material frame Explicit time integrations Kinematicallyindeterminate bar assemblies
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RC Frame-Prefabricated HPFRCC Energy Wall Structure System Energy Distribution Research
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作者 Yiting Chen 《World Journal of Engineering and Technology》 2024年第4期1046-1074,共29页
The weak layer of steel concrete (RC) frame structure is easy to destroy under the action of the earthquake, the damage mechanism is more difficult to control. Severe damage to the building structure after the earthqu... The weak layer of steel concrete (RC) frame structure is easy to destroy under the action of the earthquake, the damage mechanism is more difficult to control. Severe damage to the building structure after the earthquake, resulting in too high repair costs or having to dismantle and rebuild. In order to improve and enhance the anti-seismic performance of the RC framework structure, energy consumption devices are added between the frame columns to achieve the effect of reducing the RC frame structure damage and improving the seismic performance of the RC frame structure. In this article, high-performance fiber-enhanced cement base composite materials fabricated energy consumption walls are prepared in the RC frame structure to form a new type of seismic structure system of RC frame-prefabricated HPFRCC energy consumption wall. This article uses the power timing analysis of the ABAQUS finite element software to study the anti-seismic performance, influencing factors and energy consumption distribution of the RC frame-prefabricated HPFRCC energy wall structural system. 展开更多
关键词 Reinforced Concrete frame Construction HPFRCC Material assembly Energy Dissipation Wall Seismic Performance Hysteresis Energy Dissipation Distribution
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Analysis of Design Points and Common Problems of Prefabricated Frame Structure
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作者 YUFeng ZHANGHaiying 《外文科技期刊数据库(文摘版)工程技术》 2022年第10期027-032,共6页
With the rising labor cost, energy saving and environmental protection, formwork-free and bracing-free and other fabricated building technologies gradually mature, and the construction market has been promoted from th... With the rising labor cost, energy saving and environmental protection, formwork-free and bracing-free and other fabricated building technologies gradually mature, and the construction market has been promoted from the original government encouragement to the present construction units independent requirements to adopt fabricated practices. Nowadays, many industrial factories and civil frame structures have adopted prefabricated technology. Compared with traditional frame structures, prefabricated buildings have higher requirements in design, production and construction and some problems have been exposed in the process of promotion and implementation which requires us to consider more comprehensively and work more carefully in the design of prefabricated frame structures. 展开更多
关键词 PREFABRICATION assembly frame structure design points frequently asked questions
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Prefabricated Construction of Reinforced Concrete Frame Structure with High Prefabrication Rate
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作者 LOU Taoqun 《外文科技期刊数据库(文摘版)工程技术》 2021年第6期304-308,共9页
In this paper, the structural form of the project is frame structure, and the prefabrication rate is 80%. The main structures such as column, beam, laminated plate, balcony plate, toilet plate, exterior wall plate, gu... In this paper, the structural form of the project is frame structure, and the prefabrication rate is 80%. The main structures such as column, beam, laminated plate, balcony plate, toilet plate, exterior wall plate, gutter and parapet and so on are prefabricated components. According to the construction organization process of the project, the construction process of the assembled integral concrete frame structure is discussed. Firstly, the key preparation work in the early stage of prefabricated construction site is analyzed from three aspects: construction flow section division, component yard layout and component delivery plan. Secondly, the paper analyzes the construction organization process of the project, focusing on the interpenetration of construction processes. Finally, considering the key construction procedures and main influencing factors, the construction methods and solutions are put forward and applied to improve the adjustment of column reserved reinforcement, vertical grouting connection of precast column, supporting mode of external retaining wall of frame structure, hoisting mode of high prefabricated component and special planning of prefabricated construction with BIM Technology. For the next step in-depth study of the prefabricated construction technology and provide the basis for guiding the prefabricated construction of frame structure. 展开更多
关键词 high prefabrication rate frame structure assembly construction BIM technology application
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新型全装配框-剪结构抗震性能研究 被引量:1
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作者 樊禹江 赵宇琪 +2 位作者 徐子轩 余滨杉 熊二刚 《长安大学学报(自然科学版)》 北大核心 2025年第5期92-104,共13页
在已有新型装配式剪力墙抗震性能研究的基础上,提出一种新型全装配框-剪结构,能够实现中小地震作用下等同现浇、大震时大量消耗地震能量的功能。通过ABAQUS软件建立新型全装配框-剪结构有限元模型,其中混凝土本构模型采用损伤塑性模型,... 在已有新型装配式剪力墙抗震性能研究的基础上,提出一种新型全装配框-剪结构,能够实现中小地震作用下等同现浇、大震时大量消耗地震能量的功能。通过ABAQUS软件建立新型全装配框-剪结构有限元模型,其中混凝土本构模型采用损伤塑性模型,钢筋和钢板采用弹塑性本构模型,螺栓采用双折线本构模型,结构中混凝土与钢板构件之间施加绑定约束,涉及螺栓、钢板等可转动部件通过施加表面接触和螺栓预紧力的方式来提供足够的摩擦力。对结构底部施加自由度约束条件后进行低周往复抗震性能分析,研究不同轴压比、螺栓预紧力变化下该结构抗震性能的变化规律。研究结果表明:所设计的新型全装配框-剪结构能够满足规范极限承载力的需求,耗能效果良好;各水平连接装置均未在结构达到极限承载力之前破坏;剪力墙和柱顶的轴压比越大,结构承载力越高,且当结构转动到限位后,滞回曲线捏缩明显,等效黏滞阻尼系数明显降低;同一水平位移作用下,结构的耗能能力与所施加的螺栓预紧力呈线性关系。 展开更多
关键词 结构工程 新型全装配框-剪结构 数值模拟 极限承载力 摩擦耗能 抗震性能
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全螺栓分层装配式钢框架梁柱节点抗震性能试验研究 被引量:1
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作者 褚云朋 夏珲 +1 位作者 罗萍 何祥荣 《建筑结构》 北大核心 2025年第8期43-52,共10页
与传统柱贯通节点相比,全螺栓分层装配式钢框架梁柱节点连接部位梁贯通连续,两者构造差异性较大,传力路径与工作机理不同。为满足"强节点、弱构件"的抗震设防准则,对全螺栓分层装配式梁柱节点的抗震性能及构造加强措施进行研... 与传统柱贯通节点相比,全螺栓分层装配式钢框架梁柱节点连接部位梁贯通连续,两者构造差异性较大,传力路径与工作机理不同。为满足"强节点、弱构件"的抗震设防准则,对全螺栓分层装配式梁柱节点的抗震性能及构造加强措施进行研究。考虑节点类型及轴压比影响,进行了4个节点试件的低周往复加载试验,对节点试件的承载力、抗震性能及破坏模式等进行分析,获得节点试件的工作机理。结果表明:全螺栓分层装配式钢框架梁柱节点试件具有较强的刚度和耗能能力,破坏时仅发生梁端部的明显屈曲,节点域损伤极小,能较好地满足"强节点、弱构件"的抗震设防准则,但要加强螺栓连接板的抗破坏能力。试件加腋能显著提高节点的耗能能力及承载能力,但需提高焊缝焊接质量,避免焊缝过早开裂。节点试件的位移延性系数均大于3,高于传统的柱贯通节点试件,但随轴压比的增大,延性会降低。 展开更多
关键词 全螺栓分层装配式钢框架梁柱节点 抗震性能 传力机理 破坏模式 位移延性系数
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SF-1谱系垂体腺瘤组织中miRNA-133、FOXC1表达水平与临床特征及预后的关系
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作者 董晓柳 董伟 +2 位作者 张利 张欢 张于 《脑与神经疾病杂志》 2025年第11期707-712,共6页
目的探讨类固醇生成因子-1(SF-1)谱系垂体腺瘤组织中微小RNA-133(miRNA-133)、叉头框C1(FOXC1)表达水平与临床特征及预后的关系。方法选取2020年4月至2023年2月唐山市人民医院神经外科收治的116例垂体腺瘤患者。依据入组患者预后情况,... 目的探讨类固醇生成因子-1(SF-1)谱系垂体腺瘤组织中微小RNA-133(miRNA-133)、叉头框C1(FOXC1)表达水平与临床特征及预后的关系。方法选取2020年4月至2023年2月唐山市人民医院神经外科收治的116例垂体腺瘤患者。依据入组患者预后情况,分为预后良好组(n=85)与预后不良组(n=31)。用qRT-PCR测miRNA-133 mRNA、FOXC1 mRNA表达;荧光原位杂交和免疫组化法分别测miRNA-133、FOXC1表达。Pearson法分析两者相关性,多因素Logistic回归分析预后影响因素,受试者工作特征(ROC)曲线评估miRNA-133 mRNA、FOXC1 mRNA对预后的诊断价值。结果miRNA-133、FOXC1与肿瘤直径、侵袭性生长、临床分期相关(P<0.05)。分层回归显示,侵袭性生长负向影响miRNA-133 mRNA(P<0.05),侵袭性生长、临床分期正向影响FOXC1 mRNA(P<0.05)。Pearson分析表明,SF-1谱系垂体腺瘤组织中FOXC1 mRNA与miRNA-133 mRNA表达负相关(P<0.05)。多因素Logistic回归显示,侵袭性生长、miRNA-133 mRNA、FOXC1 mRNA水平是SF-1谱系垂体腺瘤患者预后不良独立危险因素。miRNA-133 mRNA、FOXC1 mRNA单独预测预后曲线下面积(AUC)为0.864、0.825,联合预测AUC为0.913,优于二者单独预测(Z二者联合=1.569,ZmiRNA-133 mRNA、二者联合=2.548,ZFOXC1 mRNA、二者联合=3.209,~均P<0.05)。结论SF-1谱系垂体腺瘤组织中miRNA-133表达水平显著降低,FOXC1表达水平显著升高,两者与临床特征及预后密切相关。 展开更多
关键词 SF-1谱系 垂体腺瘤 微小RNA-133 叉头框C1 临床特征
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