Foxtrot Mike Products公司是美国一家小型公司,主要生产基于AR平台的步枪及“手枪”,Ranch步枪是其产品之一,Ranch中文意为“牧场”,从名称即可看出该枪主要用于守护牧场,也可用于狩猎。该枪采用基于AR系的气吹式导气系统,但缩短了枪...Foxtrot Mike Products公司是美国一家小型公司,主要生产基于AR平台的步枪及“手枪”,Ranch步枪是其产品之一,Ranch中文意为“牧场”,从名称即可看出该枪主要用于守护牧场,也可用于狩猎。该枪采用基于AR系的气吹式导气系统,但缩短了枪机长度,复进簧安装在机匣内而非缓冲管内,因此机匣尾部可安装运动型枪托或其他类型的枪托。其上、下机匣由7075-T6铝合金铣削而成,表面经硬质阳极氧化处理。展开更多
Colon cancer continues to be one of the leading causes of mortality and morbidity throughout the world despite the availability of reliable screening tools and effective therapies.The majority of patients with colon c...Colon cancer continues to be one of the leading causes of mortality and morbidity throughout the world despite the availability of reliable screening tools and effective therapies.The majority of patients with colon cancer are diagnosed at an early stage(stages I to III),which provides an opportunity for cure.The current treatment paradigm of early stage colon cancer consists of surgery followed by adjuvant chemotherapy in a select group of patients,which is directed at the eradication of minimal residual disease to achieve a cure.Surgery alone is curative for the vast majority of colon cancer patients.Currently,surgery and adjuvant chemotherapy can achieve long term survival in about two-thirds of colon cancer patients with nodal involvement.Adjuvant chemotherapy is recommended for all patients with stage III colon cancer,while the benefit in stage II patients is not unequivocally established despite several large clinical trials.Contemporary research in early stage colon cancer is focused on minimally invasive surgical techniques,strategies to limit treatment-related toxicities,precise patient selection for adjuvant therapy,utilization of molecular and clinicopathologic information to personalize therapy and exploration of new therapies exploiting the evolving knowledge of tumor biology.In this review,we will discuss the current standard treatment,evolving treatment paradigms,and the emerging biomarkers,that will likely help improve patient selection and personalization of therapy leading to superior outcomes.展开更多
文摘Foxtrot Mike Products公司是美国一家小型公司,主要生产基于AR平台的步枪及“手枪”,Ranch步枪是其产品之一,Ranch中文意为“牧场”,从名称即可看出该枪主要用于守护牧场,也可用于狩猎。该枪采用基于AR系的气吹式导气系统,但缩短了枪机长度,复进簧安装在机匣内而非缓冲管内,因此机匣尾部可安装运动型枪托或其他类型的枪托。其上、下机匣由7075-T6铝合金铣削而成,表面经硬质阳极氧化处理。
文摘Colon cancer continues to be one of the leading causes of mortality and morbidity throughout the world despite the availability of reliable screening tools and effective therapies.The majority of patients with colon cancer are diagnosed at an early stage(stages I to III),which provides an opportunity for cure.The current treatment paradigm of early stage colon cancer consists of surgery followed by adjuvant chemotherapy in a select group of patients,which is directed at the eradication of minimal residual disease to achieve a cure.Surgery alone is curative for the vast majority of colon cancer patients.Currently,surgery and adjuvant chemotherapy can achieve long term survival in about two-thirds of colon cancer patients with nodal involvement.Adjuvant chemotherapy is recommended for all patients with stage III colon cancer,while the benefit in stage II patients is not unequivocally established despite several large clinical trials.Contemporary research in early stage colon cancer is focused on minimally invasive surgical techniques,strategies to limit treatment-related toxicities,precise patient selection for adjuvant therapy,utilization of molecular and clinicopathologic information to personalize therapy and exploration of new therapies exploiting the evolving knowledge of tumor biology.In this review,we will discuss the current standard treatment,evolving treatment paradigms,and the emerging biomarkers,that will likely help improve patient selection and personalization of therapy leading to superior outcomes.
