With the rapid development of Internet of things technology,the efficiency of data transmission between devices has been significantly improved.However,the open network environment also poses serious security risks.Th...With the rapid development of Internet of things technology,the efficiency of data transmission between devices has been significantly improved.However,the open network environment also poses serious security risks.This paper proposes an innovative fingerprint template protection scheme,which generates key streams through an improved fourdimensional superchaotic system(4CSCS),uses the space-filling property of Hilbert curves to achieve pixel scrambling,and introduces dynamic DNA encoding to improve encryption.Experimental results show that this scheme has a large key space 2^(528),encrypts image information entropy of more than 7.9970,and shows excellent performance in defending against statistical attacks and differential attacks.Compared with existing methods,this scheme has significant advantages in terms of encryption performance and security,and provides a reliable protection mechanism for fingerprint authentication systems in the Internet of things environment.展开更多
Background:Four-dimensional(4D)ultrasound is increasingly being used for prenatal diagnosis of congenital heart disease(CHD).We aimed to perform a systematic review and meta-analysis to evaluate its diagnostic accurac...Background:Four-dimensional(4D)ultrasound is increasingly being used for prenatal diagnosis of congenital heart disease(CHD).We aimed to perform a systematic review and meta-analysis to evaluate its diagnostic accuracy for fetal CHD.Methods:This systematic review was conducted in accordance with the PRISMA-DTA guidelines.We systematically searched eight databases for studies published up to July 22,2025.Data were extracted to calculate diagnostic accuracy metrics,study quality was assessed using QUADAS-2,and a bivariate random-effects model was used for the meta-analysis.Results:A total of 49 studies were included,comprising 45 retrospective and 4 prospective studies,which were mainly(91.8%)conducted in China.These studies involved 23,397 fetuses,among which 2115 were diagnosed with congenital heart disease.The pooled sensitivity of 4D ultrasound for diagnosing fetal congenital heart disease was 0.91(95%CI:0.89-0.93),the pooled specificity was 0.98(95%CI:0.97-0.99),and the area under the summary receiver operating characteristic(SROC)curve(AUC)was 0.98(95%CI:0.96-0.99).Although 4D ultrasound technology can be implemented as early as 11 weeks of gestation,its diagnostic sensitivity and specificity reached a superior level and stabilized at an average of 20 weeks of gestation(range 14-28 weeks).Meta-regression indicated that sample size and prior suspicion of fetal CHD were significant contributors to heterogeneity(p<0.05).Conclusion:Four-dimensional ultrasound has high diagnostic efficacy for fetal CHD and is suitable for prenatal screening of fetal CHD,and the diagnostic effect is optimal and stable at an average gestational age of 20 weeks(range 14-28 weeks).展开更多
Leesmidt et al present a comprehensive analysis of abdominal vascular flow in children using four-dimensional(4D)flow magnetic resonance imaging(MRI),aim to establish normal hemodynamic values for the abdominal viscer...Leesmidt et al present a comprehensive analysis of abdominal vascular flow in children using four-dimensional(4D)flow magnetic resonance imaging(MRI),aim to establish normal hemodynamic values for the abdominal visceral organs and to assess the feasibility of 4D flow MRI(4D-f-MRI)in this population.The researchers performed 4D-f-MRI on 9 pediatric patients with a history or suspi-cion of bowel pathology.Flow velocities were measured in the abdominal aorta and superior and inferior mesenteric arteries.The quality of the 4D-f-MRI images was evaluated,and the agreement between the measured flow velocities and those obtained from Duplex ultrasound was established.However,due to the specific limitations of this work,future studies should address the issues of small sample size and the specific age group design.展开更多
Addressing the core weaknesses in the innovation and entrepreneurship capabilities of vocational college graduates,such as market insight and risk tolerance,as well as issues with the existing training model,including...Addressing the core weaknesses in the innovation and entrepreneurship capabilities of vocational college graduates,such as market insight and risk tolerance,as well as issues with the existing training model,including courses that are disconnected from industry,a lack of systematic practical training,and superficial school-enterprise cooperation,this paper constructs a“three-dimensional,four-dimensional”training system.The“three-dimensional”foundational framework encompasses three pillars:curriculum,general education layer,professional integration layer,practical application layer,practice as in three stages:introductory,simulated,and practical,and support including dual mentors,policies,and platforms.The“four-dimensional”differentiated strategies include four implementation pathways:professional differentiation,stage differentiation,addressing capability shortcomings,and school-government-industry collaboration.This system is grounded in theories such as multiple intelligences theory and systems theory,forming a closed-loop process of“theoretical input—practical application—support mechanisms”.Based on the practices of Guangdong Vocational Institute of Public Administration,the paper proposes a competency development pathway tailored by major and stage,which can effectively enhance the innovative and entrepreneurial core competencies of vocational college graduates.This provides a replicable systematic solution for vocational college innovative and entrepreneurial education,supporting vocational education reform and regional economic development.展开更多
As coal mining progresses to greater depths,controlling the stability of surrounding rock in deep roadways has become an increasingly complex challenge.Although four-dimensional(4D)support theoretically offers unique ...As coal mining progresses to greater depths,controlling the stability of surrounding rock in deep roadways has become an increasingly complex challenge.Although four-dimensional(4D)support theoretically offers unique advantages in maintaining the stability of rock mass,the disaster evolution processes and multi-source information response characteristics in deep roadways with 4D support remain unclear.Consequently,a large-scale physical model testing system and self-designed 4D support components were employed to conduct similarity model tests on the surrounding rock failure process under unsupported(U-1),traditional bolt-mesh-cable support(T-2),and 4D support(4D-R-3)conditions.Combined with multi-source monitoring techniques,including stress–strain,digital image correlation(DIC),acoustic emission(AE),microseismic(MS),parallel electric(PE),and electromagnetic radiation(EMR),the mechanical behavior and multi-source information responses were comprehensively analyzed.The results show that the peak stress and displacement of the models are positively correlated with the support strength.The multi-source information exhibits distinct response characteristics under different supports.The response frequency,energy,and fluctuationsof AE,MS,and EMR signals,along with the apparent resistivity(AR)high-resistivity zone,follow the trend U-1>T-2>4D-R-3.Furthermore,multi-source information exhibits significantdifferences in sensitivity across different phases.The AE,MS,and EMR signals exhibit active responses to rock mass activity at each phase.However,AR signals are only sensitive to the fracture propagation during the plastic yield and failure phases.In summary,the 4D support significantlyenhances the bearing capacity and plastic deformation of the models,while substantially reducing the frequency,energy,and fluctuationsof multi-source signals.展开更多
BACKGROUND Four-dimensional(4D)flow magnetic resonance imaging(MRI)is used as a noninvasive modality for assessing hemodynamic information with neurovascular and body applications.The application of 4D flow MRI for as...BACKGROUND Four-dimensional(4D)flow magnetic resonance imaging(MRI)is used as a noninvasive modality for assessing hemodynamic information with neurovascular and body applications.The application of 4D flow MRI for assessment of bowel disease in children has not been previously described.AIM To determine feasibility of superior mesenteric venous and arterial flow quantitation in pediatric patients using 4D flow MRI.METHODS Nine pediatric patients(7-14 years old,5 male and 4 female)with history or suspicion of bowel pathology,who underwent magnetic resonance(MR)enterography with 4D flow MR protocol from November 2022 to October 2023.Field strength/sequence:3T MRI using 4D flow MR protocol.Flow velocity and peak speed measurements were performed by two diagnostic radiologists placing the region of interest in perpendicular plane to blood flow on each cross section of superior mesenteric artery(SMA)and superior mesenteric vein(SMV)at three predetermined levels.Bland-Altman analysis,showed good agreement of flow velocity and peak speed measurements of SMV and SMA between two readers.RESULTS Mean SMV flow velocity increased from proximal to mid to distal(0.14 L/minute,0.17 L/minute,0.22 L/minute respectively).Mean SMA flow velocity decreased from proximal to mid to distal(0.35 L/minute,0.27 L/minute,0.21 L/minute respectively).Observed agreement was good for flow velocity measurements of SMV(mean bias-0.01 L/minute and 95%limits of agreement,-0.09 to 0.08 L/minute)and SMA(mean bias-0.03 L/minute and 95%limits of agreement,-0.23 to 0.17 L/minute)between two readers.Good agreement for peak speed measurements of SMV(mean bias-1.2 cm/second and 95%limits of agreement,-9.4 to 7.0 cm/second)and SMA(mean bias-3.2 cm/second and 95%limits of agreement,-31.4 to 24.9 cm/second).CONCLUSION Flow quantitation using 4D Flow is feasible to provide hemodynamic information for SMV and SMA in children.展开更多
Carbon-based materials have gained significant attention in anticancer treatment because of their exceptional biocompatibility,yet critical challenges persist in establishing definitive correlations between their poro...Carbon-based materials have gained significant attention in anticancer treatment because of their exceptional biocompatibility,yet critical challenges persist in establishing definitive correlations between their porous structures and functional performance.We report the use of a silica template to guide pore formation in the design of mesoporous carbon spheres(mC)with tailored pore structures for improved combined photothermal-chemotherapy.The mesopore size of mC has been adjusted by kinetic control of the resin polymerization and silica hydrolysis.Structural characterization showed that 4.4 nm mesopores enabled an exceptional gemcitabine loading of 228 mg g^(−1) and a sustained pH/thermal dual-responsive release with>70%drug release under near-infrared(NIR)irradiation.Finite element analysis demonstrated pore size-dependent heat transfer dynamics,with the improved mC achieving a superior photothermal conversion efficiency of 62%by a combination of N-doping and defect engineering.In vitro evaluations confirmed outstanding biocompatibility with>95%cell viability at 200μg mL^(−1) and potent tumor suppression in pancreatic and biliary cancer models with an~5%cell viability at 25μg mL^(−1) where combined therapy showed a 3.7-fold increased cytotoxicity over monotherapy.The improved structure of mC facilitated cascade therapeutic effects with enhanced tumor permeability derived from NIR-triggered hyperthermia and prolonged therapeutic exposure due to pH-responsive drug release.This pore engineering strategy establishes a structure-function process for next-generation theranostic platforms,addressing the critical limitations of conventional pancreatic and biliary cancer therapies through spatiotemporal control of multimodal treatment.展开更多
The article"Assessment of superior mesenteric vascular flow quantitation in children using four-dimensional flow magnetic resonance imaging"suggests to use of four-dimensional(4D)flow magnetic resonance imag...The article"Assessment of superior mesenteric vascular flow quantitation in children using four-dimensional flow magnetic resonance imaging"suggests to use of four-dimensional(4D)flow magnetic resonance imaging(MRI)which is also to measure the blood flow in the superior mesenteric vein(SMV)in pediatric patients over the traditional method.The study focuses on assessing the potential of SMV and superior mesenteric artery(SMA)flow quantification in children utilizing 4D flow MRI.It included 9 pediatric patients aged 18 years and below where 5 were male and 4 were female patients,on whom magnetic resonance enterorrhaphy(MRE)with 4D flow MRI protocol was used.Statistical analysis was performed using MedCalc.Measurements of SMV and SMA between two readers were calculated using Bland-Altman analysis.The results stated that six patients showed no MRE evidence of active inflammatory bowel disease,two patients showed unmarkable bowel appearance on MRI and one patient showed normal MRE without endoscopy performed at the same timeframe.The study utilized available 4D flow MRI sequences in this study aiming to show the feasibility of 4D flow quantitation of SMA and SMV flow in pediatric patients.The study also discovered good agreement for both peak velocity and peak speed measurements of SMA and SMV.展开更多
Lithium-sulfur(Li-S)batteries boast a theoretical energy density as high as 2600 Wh·kg^(−1),positioning them as a highly attractive option for future advanced energy storage systems.Challenges such as slow transf...Lithium-sulfur(Li-S)batteries boast a theoretical energy density as high as 2600 Wh·kg^(−1),positioning them as a highly attractive option for future advanced energy storage systems.Challenges such as slow transformation kinetics and shuttle effects associated with lithium polysulfides(LiPSs)have seriously hindered their practical applications.In this paper,we present a new method for the synthesis of hollow carbon-sphere-supported Co monatomic catalysts(Co-N-C).This new synthesis method achieves pyrolytic coordination using a precursor rich in imide(-RC=N-)polymers.This synthesis method not only improves the adsorbability and catalytic activity of LiPS but also significantly weakens the shuttle effect and generates Co-N-C with superior conductivity,abundant hollow structures,and a high specific surface area,thus efficiently capturing and restricting the movement of LiPS intermediates.The dispersed Co monoatomic catalysts(Co SACs)were anchored to a highly conductive nitrogen-doped carbon framework and exhibited symmetric N-coordination active sites(Co-N_(4))to ensure fast redox kinetics of LiPS and Li_(2)S_(2)/Li_(2)S solid-state products.The lithium-sulfur battery with Co-N-C as the sulfur carrier showed excellent discharging capacity of 1146.6 mAh·g^(−1) at a discharge rate of 0.5 C and maintained excellent performance at a high discharge rate of 2 C.The capacity decay rate in 500 cycles was only 0.086%per cycle,reflecting excellent long-term cycle stability.This study highlights the key role of the synergistic effect between single-atom cobalt catalysts and hollow carbon spheres in enhancing the efficiency of lithium-sulfur(Li-S)batteries.It also provides valuable insights into the construction and fabrication of highly active monatomic catalysts.The catalytic conversion efficiency of lithium polysulfides is significantly enhanced when embedded in hollow carbon architectures,which serves as a critical strategy for optimizing the electrochemical behavior of next-generation Li-S batteries.展开更多
Despite the superior advantages of specific emitter identification in extracting emitter features from in-phase and quadrature(I/Q)signals,challenges persist due to signal-type confusion and background noise interfere...Despite the superior advantages of specific emitter identification in extracting emitter features from in-phase and quadrature(I/Q)signals,challenges persist due to signal-type confusion and background noise interference.To address those limitations,this paper proposes a multi-channel contrast prediction coding and complex-valued residuals network(MCPC-MCVResNet)framework.This model employs contrast prediction techniques to directly extract discriminative features from electromagnetic signal sequences,effectively capturing both amplitude and phase information within I/Q data.A core innovation of this approach is the sphere space softmax(SS-softmax)loss,which optimizes intra-class clustering density of while establishing well-defined boundaries between distinct emitters.The SS-softmax mechanism significantly enhances the model's capacity to discern subtle variations among radiation emitters.Experimental results demonstrate superior identification accuracy,rapid convergence,and exceptional robustness in low signal-to-noise ratio environments.展开更多
In the common theory of the Universe, the redshift of the light wavelength from distant stars indicates the speed of the star. In this study, the model of the Universe is the surface volume of the four-dimensional sph...In the common theory of the Universe, the redshift of the light wavelength from distant stars indicates the speed of the star. In this study, the model of the Universe is the surface volume of the four-dimensional sphere, and the shape of the Universe results in the most of the redshift of light wavelength. Therefore, there is no dark energy accelerating the Universe. The surface of the four-dimensional sphere is a volume, and this volume is a good model for the Universe. The surface volume of the four-dimensional sphere has been explained by a model of four-dimensional cube, within which the forming of surface volume can be easily shown. The model of four-dimensional cube containing six side cubes is ingenious for explaining the structure of the four-dimensional Universe, but it is not enough because the four-dimensional cube has not six side cubes, but eight side cubes. Therefore, in this study a better method has been created to construct the four-dimensional cube. Our three-dimensional Universe is the surface of the four-dimensional sphere Universe. The volume of our three-dimensional Universe is finite, and beneath it is the infinite volume four-dimensional Super Universe. Two important basic formulae have been derived: The surface volume of the four-dimensional sphere is π<sup>3</sup>R<sup>3</sup> in which R is the radius of the sphere, and the fourth-power volume of the four-dimensional sphere is 1/4 π<sup>3</sup>R<sup>4</sup>. The volume of the Universe has been calculated π<sup>3</sup>R<sup>3</sup> = 62 × 10<sup>30</sup> ly<sup>3</sup>. Time as the fourth dimension of the space takes effect only near the speed of light, and therefore it has been ignored in this study.展开更多
This study examines the performance of coupling the deterministic four-dimensional variational assimilation system （4DVAR） with an ensemble Kalman filter （EnKF） to produce a superior hybrid approach for data assim...This study examines the performance of coupling the deterministic four-dimensional variational assimilation system （4DVAR） with an ensemble Kalman filter （EnKF） to produce a superior hybrid approach for data assimilation. The coupled assimilation scheme （E4DVAR） benefits from using the state-dependent uncertainty provided by EnKF while taking advantage of 4DVAR in preventing filter divergence： the 4DVAR analysis produces posterior maximum likelihood solutions through minimization of a cost function about which the ensemble perturbations are transformed, and the resulting ensemble analysis can be propagated forward both for the next assimilation cycle and as a basis for ensemble forecasting. The feasibility and effectiveness of this coupled approach are demonstrated in an idealized model with simulated observations. It is found that the E4DVAR is capable of outperforming both 4DVAR and the EnKF under both perfect- and imperfect-model scenarios. The performance of the coupled scheme is also less sensitive to either the ensemble size or the assimilation window length than those for standard EnKF or 4DVAR implementations.展开更多
The rectifier filter circuit is widely applied.However,it is difficult to gain a global solution for the optimization design.4-D visual analysis and design optimization of the single-phase uncontrolled bridge rectifie...The rectifier filter circuit is widely applied.However,it is difficult to gain a global solution for the optimization design.4-D visual analysis and design optimization of the single-phase uncontrolled bridge rectifier with an LC filter are presented in this paper.展开更多
A four-dimensional variational （4D-Var） data assimilation method is implemented in an improved intermediate coupled model （ICM） of the tropical Pacific. A twin experiment is designed to evaluate the impact of the ...A four-dimensional variational （4D-Var） data assimilation method is implemented in an improved intermediate coupled model （ICM） of the tropical Pacific. A twin experiment is designed to evaluate the impact of the 4D-Var data assimilation algorithm on ENSO analysis and prediction based on the ICM. The model error is assumed to arise only from the parameter uncertainty. The ＂observation＂ of the SST anomaly, which is sampled from a ＂truth＂ model simulation that takes default parameter values and has Gaussian noise added, is directly assimilated into the assimilation model with its parameters set erroneously. Results show that 4D-Var effectively reduces the error of ENSO analysis and therefore improves the prediction skill of ENSO events compared with the non-assimilation case. These results provide a promising way for the ICM to achieve better real-time ENSO prediction.展开更多
A heavy rainfall event along the mei-yu front during 22-23 June 2002 was chosen for this study. To assess the impact of the routine and additional IOP (intensive observation period) radiosonde observations on the meso...A heavy rainfall event along the mei-yu front during 22-23 June 2002 was chosen for this study. To assess the impact of the routine and additional IOP (intensive observation period) radiosonde observations on the mesoscale heavy rainfall forecast, a series of four-dimensional variational (4DVAR) data assimilation and model simulation experiments was conducted using nonhydrostatic mesoscale model MM5 and the MM5 4DVAR system. The effects of the intensive observations in the different areas on the heavy rainfall forecast were also investigated. The results showed that improvement of the forecast skill for mesoscale heavy rainfall intensity was possible from the assimilation of the IOP radiosonde observations. However, the impact of the IOP observations on the forecast of the rainfall pattern was not significant. Initial conditions obtained through the 4DVAR experiments with a 12-h assimilation window were capable of improving the 24-h forecast. The simulated results after the assimilation showed that it would be best to perform the intensive radiosonde observations in the upstream of the rainfall area and in the moisture passageway area at the same time. Initial conditions created by the 4DVAR led to the low-level moisture convergence over the rainfall area, enhanced frontogenesis and upward motion within the mei-yu front, and intensified middle- and high-level unstable stratification in front of the mei-yu front. Consequently, the heavy rainfall forecast was improved.展开更多
Since its introduction in the 1970’s,magnetic resonance imaging(MRI)has become a standard imaging modality.With its broad and standardized application,it is firmly established in the clinical routine and an essential...Since its introduction in the 1970’s,magnetic resonance imaging(MRI)has become a standard imaging modality.With its broad and standardized application,it is firmly established in the clinical routine and an essential element in cardiovascular and abdominal imaging.In addition to sonography and computer tomography,MRI is a valuable tool for diagnosing cardiovascular and abdominal diseases,for determining disease severity,and for assessing therapeutic success.MRI techniques have improved over the last few decades,revealing not just morphologic information,but functional information about perfusion,diffusion and hemodynamics as well.Four-dimensional(4D)flow MRI,a time-resolved phase contrast-MRI with three-dimensional(3D)anatomic coverage and velocity encoding along all three flow directions has been used to comprehensively assess complex cardiovascular hemodynamics in multiple regions of the body.The technique enables visualization of 3D blood flow patterns and retrospective quantification of blood flow parameters in a region of interest.Over the last few years,4D flow MRI has been increasingly performed in the abdominal region.By applying different acceleration techniques,taking 4D flow MRI measurements has dropped to a reasonable scanning time of 8 to 12 min.These new developments have encouraged a growing number of patient studies in the literature validating the technique’s potential for enhanced evaluation of blood flow parameters within the liver’s complex vascular system.The purpose of this review article is to broaden our understanding of 4D flow MRI for the assessment of liver hemodynamics by providing insights into acquisition,data analysis,visualization and quantification.Furthermore,in this article we highlight its development,focussing on the clinical application of the technique.展开更多
Aircraft ground movement plays a key role in improving airport efficiency,as it acts as a link to all other ground operations.Finding novel approaches to coordinate the movements of a fleet of aircraft at an airport i...Aircraft ground movement plays a key role in improving airport efficiency,as it acts as a link to all other ground operations.Finding novel approaches to coordinate the movements of a fleet of aircraft at an airport in order to improve system resilience to disruptions with increasing autonomy is at the center of many key studies for airport airside operations.Moreover,autonomous taxiing is envisioned as a key component in future digitalized airports.However,state-of-the-art routing and scheduling algorithms for airport ground movements do not consider high-fidelity aircraft models at both the proactive and reactive planning phases.The majority of such algorithms do not actively seek to optimize fuel efficiency and reduce harmful greenhouse gas emissions.This paper proposes a new approach for generating efficient four-dimensional trajectories(4DTs)on the basis of a high-fidelity aircraft model and gainscheduling control strategy.Working in conjunction with a routing and scheduling algorithm that determines the taxi route,waypoints,and time deadlines,the proposed approach generates fuel-efficient 4DTs in real time,while respecting operational constraints.The proposed approach can be used in two contexts:①as a reactive decision support tool to generate new trajectories that can resolve unprecedented events;and②as an autopilot system for both partial and fully autonomous taxiing.The proposed methodology is realistic and simple to implement.Moreover,simulation studies show that the proposed approach is capable of providing an up to 11%reduction in the fuel consumed during the taxiing of a large Boeing 747-100 jumbo jet.展开更多
A new four-dimensional quadratic smooth autonomous chaotic system is presented in this paper, which can exhibit periodic orbit and chaos under the conditions on the system parameters. Importantly, the system can gener...A new four-dimensional quadratic smooth autonomous chaotic system is presented in this paper, which can exhibit periodic orbit and chaos under the conditions on the system parameters. Importantly, the system can generate one-, two-, three- and four-scroll chaotic attractors with appropriate choices of parameters. Interestingly, all the attractors are generated only by changing a single parameter. The dynamic analysis approach in the paper involves time series, phase portraits, Poincare maps, a bifurcation diagram, and Lyapunov exponents, to investigate some basic dynamical behaviours of the proposed four-dimensional system.展开更多
Consider a four-dimensional system having a two-dimensional invariant surface. By analyzing the solutions of bifurcation equations, this paper studied the bifurcation phenomena of a k multiple closed orbit in the inva...Consider a four-dimensional system having a two-dimensional invariant surface. By analyzing the solutions of bifurcation equations, this paper studied the bifurcation phenomena of a k multiple closed orbit in the invariant surface. Sufficient conditions for the existence of periodic orbits generated by the k multiple closed orbit were given.展开更多
In this paper, we propose a novel four-dimensional autonomous chaotic system. Of particular interest is that this novel system can generate one-, two, three- and four-wing chaotic attractors with the variation of a si...In this paper, we propose a novel four-dimensional autonomous chaotic system. Of particular interest is that this novel system can generate one-, two, three- and four-wing chaotic attractors with the variation of a single parameter, and the multi-wing type of the chaotic attractors can be displayed in all directions. The system is simple with a large positive Lyapunov exponent and can exhibit some interesting and complicated dynamical behaviours. Basic dynamical properties of the four-dimensional chaotic system, such as equilibrium points, the Poincare map, the bifurcation diagram and the Lyapunov exponents are investigated by using either theoretical analysis or numerical method. Finally, a circuit is designed for the implementation of the multi-wing chaotic attractors. The electronic workbench observations axe in good agreement with the numerical simulation results.展开更多
文摘With the rapid development of Internet of things technology,the efficiency of data transmission between devices has been significantly improved.However,the open network environment also poses serious security risks.This paper proposes an innovative fingerprint template protection scheme,which generates key streams through an improved fourdimensional superchaotic system(4CSCS),uses the space-filling property of Hilbert curves to achieve pixel scrambling,and introduces dynamic DNA encoding to improve encryption.Experimental results show that this scheme has a large key space 2^(528),encrypts image information entropy of more than 7.9970,and shows excellent performance in defending against statistical attacks and differential attacks.Compared with existing methods,this scheme has significant advantages in terms of encryption performance and security,and provides a reliable protection mechanism for fingerprint authentication systems in the Internet of things environment.
基金supported by the Open Research Fund of National Health Commission Key Laboratory of Birth Defects Prevention&Henan Key Laboratory of Population Defects Prevention(ZD202308).
文摘Background:Four-dimensional(4D)ultrasound is increasingly being used for prenatal diagnosis of congenital heart disease(CHD).We aimed to perform a systematic review and meta-analysis to evaluate its diagnostic accuracy for fetal CHD.Methods:This systematic review was conducted in accordance with the PRISMA-DTA guidelines.We systematically searched eight databases for studies published up to July 22,2025.Data were extracted to calculate diagnostic accuracy metrics,study quality was assessed using QUADAS-2,and a bivariate random-effects model was used for the meta-analysis.Results:A total of 49 studies were included,comprising 45 retrospective and 4 prospective studies,which were mainly(91.8%)conducted in China.These studies involved 23,397 fetuses,among which 2115 were diagnosed with congenital heart disease.The pooled sensitivity of 4D ultrasound for diagnosing fetal congenital heart disease was 0.91(95%CI:0.89-0.93),the pooled specificity was 0.98(95%CI:0.97-0.99),and the area under the summary receiver operating characteristic(SROC)curve(AUC)was 0.98(95%CI:0.96-0.99).Although 4D ultrasound technology can be implemented as early as 11 weeks of gestation,its diagnostic sensitivity and specificity reached a superior level and stabilized at an average of 20 weeks of gestation(range 14-28 weeks).Meta-regression indicated that sample size and prior suspicion of fetal CHD were significant contributors to heterogeneity(p<0.05).Conclusion:Four-dimensional ultrasound has high diagnostic efficacy for fetal CHD and is suitable for prenatal screening of fetal CHD,and the diagnostic effect is optimal and stable at an average gestational age of 20 weeks(range 14-28 weeks).
文摘Leesmidt et al present a comprehensive analysis of abdominal vascular flow in children using four-dimensional(4D)flow magnetic resonance imaging(MRI),aim to establish normal hemodynamic values for the abdominal visceral organs and to assess the feasibility of 4D flow MRI(4D-f-MRI)in this population.The researchers performed 4D-f-MRI on 9 pediatric patients with a history or suspi-cion of bowel pathology.Flow velocities were measured in the abdominal aorta and superior and inferior mesenteric arteries.The quality of the 4D-f-MRI images was evaluated,and the agreement between the measured flow velocities and those obtained from Duplex ultrasound was established.However,due to the specific limitations of this work,future studies should address the issues of small sample size and the specific age group design.
基金2024 University-level Innovation and Entrepreneurship Educational Reform Project,“Research on the Innovation and Entrepreneurship Education Model of Higher Vocational Colleges Based on the Theory of Technological Innovation Diffusion”(Project No.:CYJG202414)Academic Year Higher Education Institution Graduate Employment and Entrepreneurship Research Project,“Research on Strategies for Cultivating Innovation and Entrepreneurship Abilities Among Graduates of Higher Vocational Colleges”(Project No.:GJXY2024N083)2024 Guangdong Province General Higher Education Institution Specialized Innovation Project,“Research on a Specialized-Entrepreneurial Integration Talent Development System Guided by Core Competencies in the Era of Artificial Intelligence”(Project No.:2024WTSCX339)。
文摘Addressing the core weaknesses in the innovation and entrepreneurship capabilities of vocational college graduates,such as market insight and risk tolerance,as well as issues with the existing training model,including courses that are disconnected from industry,a lack of systematic practical training,and superficial school-enterprise cooperation,this paper constructs a“three-dimensional,four-dimensional”training system.The“three-dimensional”foundational framework encompasses three pillars:curriculum,general education layer,professional integration layer,practical application layer,practice as in three stages:introductory,simulated,and practical,and support including dual mentors,policies,and platforms.The“four-dimensional”differentiated strategies include four implementation pathways:professional differentiation,stage differentiation,addressing capability shortcomings,and school-government-industry collaboration.This system is grounded in theories such as multiple intelligences theory and systems theory,forming a closed-loop process of“theoretical input—practical application—support mechanisms”.Based on the practices of Guangdong Vocational Institute of Public Administration,the paper proposes a competency development pathway tailored by major and stage,which can effectively enhance the innovative and entrepreneurial core competencies of vocational college graduates.This provides a replicable systematic solution for vocational college innovative and entrepreneurial education,supporting vocational education reform and regional economic development.
基金supported by the National Natural Science Foundation of China(Grant Nos.U22A20598 and 52104107)the"Qinglan Project"of Jiangsu Colleges and Universities,Young Elite Scientists Sponsorship Program of Jiangsu Province(Grant No.TJ-2023-086).
文摘As coal mining progresses to greater depths,controlling the stability of surrounding rock in deep roadways has become an increasingly complex challenge.Although four-dimensional(4D)support theoretically offers unique advantages in maintaining the stability of rock mass,the disaster evolution processes and multi-source information response characteristics in deep roadways with 4D support remain unclear.Consequently,a large-scale physical model testing system and self-designed 4D support components were employed to conduct similarity model tests on the surrounding rock failure process under unsupported(U-1),traditional bolt-mesh-cable support(T-2),and 4D support(4D-R-3)conditions.Combined with multi-source monitoring techniques,including stress–strain,digital image correlation(DIC),acoustic emission(AE),microseismic(MS),parallel electric(PE),and electromagnetic radiation(EMR),the mechanical behavior and multi-source information responses were comprehensively analyzed.The results show that the peak stress and displacement of the models are positively correlated with the support strength.The multi-source information exhibits distinct response characteristics under different supports.The response frequency,energy,and fluctuationsof AE,MS,and EMR signals,along with the apparent resistivity(AR)high-resistivity zone,follow the trend U-1>T-2>4D-R-3.Furthermore,multi-source information exhibits significantdifferences in sensitivity across different phases.The AE,MS,and EMR signals exhibit active responses to rock mass activity at each phase.However,AR signals are only sensitive to the fracture propagation during the plastic yield and failure phases.In summary,the 4D support significantlyenhances the bearing capacity and plastic deformation of the models,while substantially reducing the frequency,energy,and fluctuationsof multi-source signals.
文摘BACKGROUND Four-dimensional(4D)flow magnetic resonance imaging(MRI)is used as a noninvasive modality for assessing hemodynamic information with neurovascular and body applications.The application of 4D flow MRI for assessment of bowel disease in children has not been previously described.AIM To determine feasibility of superior mesenteric venous and arterial flow quantitation in pediatric patients using 4D flow MRI.METHODS Nine pediatric patients(7-14 years old,5 male and 4 female)with history or suspicion of bowel pathology,who underwent magnetic resonance(MR)enterography with 4D flow MR protocol from November 2022 to October 2023.Field strength/sequence:3T MRI using 4D flow MR protocol.Flow velocity and peak speed measurements were performed by two diagnostic radiologists placing the region of interest in perpendicular plane to blood flow on each cross section of superior mesenteric artery(SMA)and superior mesenteric vein(SMV)at three predetermined levels.Bland-Altman analysis,showed good agreement of flow velocity and peak speed measurements of SMV and SMA between two readers.RESULTS Mean SMV flow velocity increased from proximal to mid to distal(0.14 L/minute,0.17 L/minute,0.22 L/minute respectively).Mean SMA flow velocity decreased from proximal to mid to distal(0.35 L/minute,0.27 L/minute,0.21 L/minute respectively).Observed agreement was good for flow velocity measurements of SMV(mean bias-0.01 L/minute and 95%limits of agreement,-0.09 to 0.08 L/minute)and SMA(mean bias-0.03 L/minute and 95%limits of agreement,-0.23 to 0.17 L/minute)between two readers.Good agreement for peak speed measurements of SMV(mean bias-1.2 cm/second and 95%limits of agreement,-9.4 to 7.0 cm/second)and SMA(mean bias-3.2 cm/second and 95%limits of agreement,-31.4 to 24.9 cm/second).CONCLUSION Flow quantitation using 4D Flow is feasible to provide hemodynamic information for SMV and SMA in children.
文摘Carbon-based materials have gained significant attention in anticancer treatment because of their exceptional biocompatibility,yet critical challenges persist in establishing definitive correlations between their porous structures and functional performance.We report the use of a silica template to guide pore formation in the design of mesoporous carbon spheres(mC)with tailored pore structures for improved combined photothermal-chemotherapy.The mesopore size of mC has been adjusted by kinetic control of the resin polymerization and silica hydrolysis.Structural characterization showed that 4.4 nm mesopores enabled an exceptional gemcitabine loading of 228 mg g^(−1) and a sustained pH/thermal dual-responsive release with>70%drug release under near-infrared(NIR)irradiation.Finite element analysis demonstrated pore size-dependent heat transfer dynamics,with the improved mC achieving a superior photothermal conversion efficiency of 62%by a combination of N-doping and defect engineering.In vitro evaluations confirmed outstanding biocompatibility with>95%cell viability at 200μg mL^(−1) and potent tumor suppression in pancreatic and biliary cancer models with an~5%cell viability at 25μg mL^(−1) where combined therapy showed a 3.7-fold increased cytotoxicity over monotherapy.The improved structure of mC facilitated cascade therapeutic effects with enhanced tumor permeability derived from NIR-triggered hyperthermia and prolonged therapeutic exposure due to pH-responsive drug release.This pore engineering strategy establishes a structure-function process for next-generation theranostic platforms,addressing the critical limitations of conventional pancreatic and biliary cancer therapies through spatiotemporal control of multimodal treatment.
文摘The article"Assessment of superior mesenteric vascular flow quantitation in children using four-dimensional flow magnetic resonance imaging"suggests to use of four-dimensional(4D)flow magnetic resonance imaging(MRI)which is also to measure the blood flow in the superior mesenteric vein(SMV)in pediatric patients over the traditional method.The study focuses on assessing the potential of SMV and superior mesenteric artery(SMA)flow quantification in children utilizing 4D flow MRI.It included 9 pediatric patients aged 18 years and below where 5 were male and 4 were female patients,on whom magnetic resonance enterorrhaphy(MRE)with 4D flow MRI protocol was used.Statistical analysis was performed using MedCalc.Measurements of SMV and SMA between two readers were calculated using Bland-Altman analysis.The results stated that six patients showed no MRE evidence of active inflammatory bowel disease,two patients showed unmarkable bowel appearance on MRI and one patient showed normal MRE without endoscopy performed at the same timeframe.The study utilized available 4D flow MRI sequences in this study aiming to show the feasibility of 4D flow quantitation of SMA and SMV flow in pediatric patients.The study also discovered good agreement for both peak velocity and peak speed measurements of SMA and SMV.
基金supported by the National Natural Science Foundation of China(No.52064035)the Key Research and Development Program of Gansu Province,China(No.25YFGA024)the Natural Science Foundation of Zhejiang Province,China(No.LGG22E020003).
文摘Lithium-sulfur(Li-S)batteries boast a theoretical energy density as high as 2600 Wh·kg^(−1),positioning them as a highly attractive option for future advanced energy storage systems.Challenges such as slow transformation kinetics and shuttle effects associated with lithium polysulfides(LiPSs)have seriously hindered their practical applications.In this paper,we present a new method for the synthesis of hollow carbon-sphere-supported Co monatomic catalysts(Co-N-C).This new synthesis method achieves pyrolytic coordination using a precursor rich in imide(-RC=N-)polymers.This synthesis method not only improves the adsorbability and catalytic activity of LiPS but also significantly weakens the shuttle effect and generates Co-N-C with superior conductivity,abundant hollow structures,and a high specific surface area,thus efficiently capturing and restricting the movement of LiPS intermediates.The dispersed Co monoatomic catalysts(Co SACs)were anchored to a highly conductive nitrogen-doped carbon framework and exhibited symmetric N-coordination active sites(Co-N_(4))to ensure fast redox kinetics of LiPS and Li_(2)S_(2)/Li_(2)S solid-state products.The lithium-sulfur battery with Co-N-C as the sulfur carrier showed excellent discharging capacity of 1146.6 mAh·g^(−1) at a discharge rate of 0.5 C and maintained excellent performance at a high discharge rate of 2 C.The capacity decay rate in 500 cycles was only 0.086%per cycle,reflecting excellent long-term cycle stability.This study highlights the key role of the synergistic effect between single-atom cobalt catalysts and hollow carbon spheres in enhancing the efficiency of lithium-sulfur(Li-S)batteries.It also provides valuable insights into the construction and fabrication of highly active monatomic catalysts.The catalytic conversion efficiency of lithium polysulfides is significantly enhanced when embedded in hollow carbon architectures,which serves as a critical strategy for optimizing the electrochemical behavior of next-generation Li-S batteries.
基金supported by the National Natural Science Foundation of China(62201602)。
文摘Despite the superior advantages of specific emitter identification in extracting emitter features from in-phase and quadrature(I/Q)signals,challenges persist due to signal-type confusion and background noise interference.To address those limitations,this paper proposes a multi-channel contrast prediction coding and complex-valued residuals network(MCPC-MCVResNet)framework.This model employs contrast prediction techniques to directly extract discriminative features from electromagnetic signal sequences,effectively capturing both amplitude and phase information within I/Q data.A core innovation of this approach is the sphere space softmax(SS-softmax)loss,which optimizes intra-class clustering density of while establishing well-defined boundaries between distinct emitters.The SS-softmax mechanism significantly enhances the model's capacity to discern subtle variations among radiation emitters.Experimental results demonstrate superior identification accuracy,rapid convergence,and exceptional robustness in low signal-to-noise ratio environments.
文摘In the common theory of the Universe, the redshift of the light wavelength from distant stars indicates the speed of the star. In this study, the model of the Universe is the surface volume of the four-dimensional sphere, and the shape of the Universe results in the most of the redshift of light wavelength. Therefore, there is no dark energy accelerating the Universe. The surface of the four-dimensional sphere is a volume, and this volume is a good model for the Universe. The surface volume of the four-dimensional sphere has been explained by a model of four-dimensional cube, within which the forming of surface volume can be easily shown. The model of four-dimensional cube containing six side cubes is ingenious for explaining the structure of the four-dimensional Universe, but it is not enough because the four-dimensional cube has not six side cubes, but eight side cubes. Therefore, in this study a better method has been created to construct the four-dimensional cube. Our three-dimensional Universe is the surface of the four-dimensional sphere Universe. The volume of our three-dimensional Universe is finite, and beneath it is the infinite volume four-dimensional Super Universe. Two important basic formulae have been derived: The surface volume of the four-dimensional sphere is π<sup>3</sup>R<sup>3</sup> in which R is the radius of the sphere, and the fourth-power volume of the four-dimensional sphere is 1/4 π<sup>3</sup>R<sup>4</sup>. The volume of the Universe has been calculated π<sup>3</sup>R<sup>3</sup> = 62 × 10<sup>30</sup> ly<sup>3</sup>. Time as the fourth dimension of the space takes effect only near the speed of light, and therefore it has been ignored in this study.
基金sponsored by the U.S. National Science Foundation (Grant No.ATM0205599)the U.S. Offce of Navy Research under Grant N000140410471Dr. James A. Hansen was partially supported by US Offce of Naval Research (Grant No. N00014-06-1-0500)
文摘This study examines the performance of coupling the deterministic four-dimensional variational assimilation system （4DVAR） with an ensemble Kalman filter （EnKF） to produce a superior hybrid approach for data assimilation. The coupled assimilation scheme （E4DVAR） benefits from using the state-dependent uncertainty provided by EnKF while taking advantage of 4DVAR in preventing filter divergence： the 4DVAR analysis produces posterior maximum likelihood solutions through minimization of a cost function about which the ensemble perturbations are transformed, and the resulting ensemble analysis can be propagated forward both for the next assimilation cycle and as a basis for ensemble forecasting. The feasibility and effectiveness of this coupled approach are demonstrated in an idealized model with simulated observations. It is found that the E4DVAR is capable of outperforming both 4DVAR and the EnKF under both perfect- and imperfect-model scenarios. The performance of the coupled scheme is also less sensitive to either the ensemble size or the assimilation window length than those for standard EnKF or 4DVAR implementations.
文摘The rectifier filter circuit is widely applied.However,it is difficult to gain a global solution for the optimization design.4-D visual analysis and design optimization of the single-phase uncontrolled bridge rectifier with an LC filter are presented in this paper.
基金supported by the National Natural Science Foundation of China(Grant Nos.41490644,41475101 and 41421005)the CAS Strategic Priority Project(the Western Pacific Ocean System+2 种基金Project Nos.XDA11010105,XDA11020306 and XDA11010301)the NSFC-Shandong Joint Fund for Marine Science Research Centers(Grant No.U1406401)the NSFC Innovative Group Grant(Project No.41421005)
文摘A four-dimensional variational （4D-Var） data assimilation method is implemented in an improved intermediate coupled model （ICM） of the tropical Pacific. A twin experiment is designed to evaluate the impact of the 4D-Var data assimilation algorithm on ENSO analysis and prediction based on the ICM. The model error is assumed to arise only from the parameter uncertainty. The ＂observation＂ of the SST anomaly, which is sampled from a ＂truth＂ model simulation that takes default parameter values and has Gaussian noise added, is directly assimilated into the assimilation model with its parameters set erroneously. Results show that 4D-Var effectively reduces the error of ENSO analysis and therefore improves the prediction skill of ENSO events compared with the non-assimilation case. These results provide a promising way for the ICM to achieve better real-time ENSO prediction.
文摘A heavy rainfall event along the mei-yu front during 22-23 June 2002 was chosen for this study. To assess the impact of the routine and additional IOP (intensive observation period) radiosonde observations on the mesoscale heavy rainfall forecast, a series of four-dimensional variational (4DVAR) data assimilation and model simulation experiments was conducted using nonhydrostatic mesoscale model MM5 and the MM5 4DVAR system. The effects of the intensive observations in the different areas on the heavy rainfall forecast were also investigated. The results showed that improvement of the forecast skill for mesoscale heavy rainfall intensity was possible from the assimilation of the IOP radiosonde observations. However, the impact of the IOP observations on the forecast of the rainfall pattern was not significant. Initial conditions obtained through the 4DVAR experiments with a 12-h assimilation window were capable of improving the 24-h forecast. The simulated results after the assimilation showed that it would be best to perform the intensive radiosonde observations in the upstream of the rainfall area and in the moisture passageway area at the same time. Initial conditions created by the 4DVAR led to the low-level moisture convergence over the rainfall area, enhanced frontogenesis and upward motion within the mei-yu front, and intensified middle- and high-level unstable stratification in front of the mei-yu front. Consequently, the heavy rainfall forecast was improved.
文摘Since its introduction in the 1970’s,magnetic resonance imaging(MRI)has become a standard imaging modality.With its broad and standardized application,it is firmly established in the clinical routine and an essential element in cardiovascular and abdominal imaging.In addition to sonography and computer tomography,MRI is a valuable tool for diagnosing cardiovascular and abdominal diseases,for determining disease severity,and for assessing therapeutic success.MRI techniques have improved over the last few decades,revealing not just morphologic information,but functional information about perfusion,diffusion and hemodynamics as well.Four-dimensional(4D)flow MRI,a time-resolved phase contrast-MRI with three-dimensional(3D)anatomic coverage and velocity encoding along all three flow directions has been used to comprehensively assess complex cardiovascular hemodynamics in multiple regions of the body.The technique enables visualization of 3D blood flow patterns and retrospective quantification of blood flow parameters in a region of interest.Over the last few years,4D flow MRI has been increasingly performed in the abdominal region.By applying different acceleration techniques,taking 4D flow MRI measurements has dropped to a reasonable scanning time of 8 to 12 min.These new developments have encouraged a growing number of patient studies in the literature validating the technique’s potential for enhanced evaluation of blood flow parameters within the liver’s complex vascular system.The purpose of this review article is to broaden our understanding of 4D flow MRI for the assessment of liver hemodynamics by providing insights into acquisition,data analysis,visualization and quantification.Furthermore,in this article we highlight its development,focussing on the clinical application of the technique.
基金This work was funded by the UK Engineering and Physical Sciences Research Council(EP/N029496/1,EP/N029496/2,EP/N029356/1,EP/N029577/1,and EP/N029577/2).
文摘Aircraft ground movement plays a key role in improving airport efficiency,as it acts as a link to all other ground operations.Finding novel approaches to coordinate the movements of a fleet of aircraft at an airport in order to improve system resilience to disruptions with increasing autonomy is at the center of many key studies for airport airside operations.Moreover,autonomous taxiing is envisioned as a key component in future digitalized airports.However,state-of-the-art routing and scheduling algorithms for airport ground movements do not consider high-fidelity aircraft models at both the proactive and reactive planning phases.The majority of such algorithms do not actively seek to optimize fuel efficiency and reduce harmful greenhouse gas emissions.This paper proposes a new approach for generating efficient four-dimensional trajectories(4DTs)on the basis of a high-fidelity aircraft model and gainscheduling control strategy.Working in conjunction with a routing and scheduling algorithm that determines the taxi route,waypoints,and time deadlines,the proposed approach generates fuel-efficient 4DTs in real time,while respecting operational constraints.The proposed approach can be used in two contexts:①as a reactive decision support tool to generate new trajectories that can resolve unprecedented events;and②as an autopilot system for both partial and fully autonomous taxiing.The proposed methodology is realistic and simple to implement.Moreover,simulation studies show that the proposed approach is capable of providing an up to 11%reduction in the fuel consumed during the taxiing of a large Boeing 747-100 jumbo jet.
文摘A new four-dimensional quadratic smooth autonomous chaotic system is presented in this paper, which can exhibit periodic orbit and chaos under the conditions on the system parameters. Importantly, the system can generate one-, two-, three- and four-scroll chaotic attractors with appropriate choices of parameters. Interestingly, all the attractors are generated only by changing a single parameter. The dynamic analysis approach in the paper involves time series, phase portraits, Poincare maps, a bifurcation diagram, and Lyapunov exponents, to investigate some basic dynamical behaviours of the proposed four-dimensional system.
文摘Consider a four-dimensional system having a two-dimensional invariant surface. By analyzing the solutions of bifurcation equations, this paper studied the bifurcation phenomena of a k multiple closed orbit in the invariant surface. Sufficient conditions for the existence of periodic orbits generated by the k multiple closed orbit were given.
文摘In this paper, we propose a novel four-dimensional autonomous chaotic system. Of particular interest is that this novel system can generate one-, two, three- and four-wing chaotic attractors with the variation of a single parameter, and the multi-wing type of the chaotic attractors can be displayed in all directions. The system is simple with a large positive Lyapunov exponent and can exhibit some interesting and complicated dynamical behaviours. Basic dynamical properties of the four-dimensional chaotic system, such as equilibrium points, the Poincare map, the bifurcation diagram and the Lyapunov exponents are investigated by using either theoretical analysis or numerical method. Finally, a circuit is designed for the implementation of the multi-wing chaotic attractors. The electronic workbench observations axe in good agreement with the numerical simulation results.
