With the continuous development of the offshore wind industry,the design concept of composite foundation has been given attention in the past decade.This paper presents an accurate method for investigating the horizon...With the continuous development of the offshore wind industry,the design concept of composite foundation has been given attention in the past decade.This paper presents an accurate method for investigating the horizontal vibration of monopile-friction wheel composite foundations in layered saturated soil.Firstly,the three-dimensional continuum mechanics theory with the range of linear elasticity is introduced to calculate the frictional resistance distributed on the upper soil surface.Then,the resistances of multilayered soils and inviscid seawater to the pile shaft under horizontal harmonic excitation are obtained using Novak's plane strain model,Biot's porous media theory and radiationwave theory.Thirdly,the expressions for the deformation,bending moment and internal force of the Euler-Bernoulli pile are derived using the boundary conditions with definitephysical meaning and transfer matrix method.By comparing with the results of 1g laboratory test and the idealized formula reported by the literature,the rationality and accuracy of the developed dynamical model can be verified.Finally,this paper conducts a series of worked examples to investigate the influencesof the elastic modulus and thickness of three-layer saturated soil and the location of interlayer soil on the horizontal dynamic vibration of composite foundation.The results show that an increase in elastic modulus of the surface soil is an effective way to improve the dynamic stability of the composite foundation in service conditions.The conclusions drawn from the numerical examples can develop some guidelines for the current foundation design of offshore wind turbines.展开更多
Conventionally,foundations have been classified as shallow or deep in routine civil engineering practice.However,due to recent developments,two other approaches,semi-deep and ground modification foundations,are now av...Conventionally,foundations have been classified as shallow or deep in routine civil engineering practice.However,due to recent developments,two other approaches,semi-deep and ground modification foundations,are now available,complicating foundation categorization.Accordingly,a new concept for foundation categorization is introduced in this paper based on insights into the theory of structure analysis.Based on the form aspect,foundation systems can be categorized as one-dimensional(linear),two-dimensional(planar),and threedimensional(volumetric).Based on the load transfer aspect,foundations can also be categorized as vector-acting(piles),section or surface-acting(rafts and shells),and block-acting(piled rafts).As a step toward implementing this new categorization scheme,a database of 22 cases has been compiled,symbolizing novel introduced foundation systems.This compilation involves structures such as offshore jackets,high-rise buildings,towers and storages,and diverse geomaterials.Among them,a few have been selected for detailed evaluation,emphasizing influential factors in foundation selection,comprising superstructure,subsoil condition,foundation system,circumferential conditions,and supplementary considerations,that is,constructional and sustainability-based issues.Lessons learned from experience and these knowledge-based cases have described for foundation selection and implementation.Geotechnical and practical aspects with critical components have been realized as major performance assessment and comparison factors.Foundation systems have been compared and ranked using the improved analytic hierarchy process approach.Finally,four categories of buildings,from low-rise to towers and four prevailing levels of soil strength,from soft to very hard,have been considered to propose a perspective for building substructure implementation,adapted via relevant cases.Overall,the introduced categorization is recognized as an efficient algorithm for the experimentation of appropriate foundations for specific structures and subsoil conditions.展开更多
In this work,a computational modelling and analysis framework is developed to investigate the thermal buckling behavior of doubly-curved composite shells reinforced with graphene-origami(G-Ori)auxetic metamaterials.A ...In this work,a computational modelling and analysis framework is developed to investigate the thermal buckling behavior of doubly-curved composite shells reinforced with graphene-origami(G-Ori)auxetic metamaterials.A semi-analytical formulation based on the First-Order Shear Deformation Theory(FSDT)and the principle of virtual displacements is established,and closed-form solutions are derived via Navier’s method for simply supported boundary conditions.The G-Ori metamaterial reinforcements are treated as programmable constructs whose effective thermo-mechanical properties are obtained via micromechanical homogenization and incorporated into the shell model.A comprehensive parametric study examines the influence of folding geometry,dispersion arrangement,reinforcement weight fraction,curvature parameters,and elastic foundation support on the critical buckling temperature(CBT).The results reveal that,under optimal folding geometry and reinforcement alignment with principal stress trajectories,the CBT can increase by more than 150%.Furthermore,the combined effect of G-Ori reinforcement and elastic foundation substantially enhances thermal buckling resistance.These findings establish design guidelines for architected composite shells in applications such as aerospace thermal skins,morphing structures,and thermally-responsive systems,and illustrate the potential of auxetic graphene metamaterials for multifunctional,lightweight,and thermally robust structural components.展开更多
Installing internal bulkheads in a composite bucket foundation alters the rotational symmetry characteristic of a single-compartment bucket foundation,consequently influencing the stress distribution within the bucket...Installing internal bulkheads in a composite bucket foundation alters the rotational symmetry characteristic of a single-compartment bucket foundation,consequently influencing the stress distribution within the bucket and surrounding soil.During the seabed penetration of a spudcan from a jack-up wind turbine installation vessel,an angle may form between the spudcan’s axis and the axis of symmetry of the adjacent composite bucket foundation in the horizontal plane.Such a misalignment may affect load distribution and the non-uniform interaction between the foundation,soil,and spudcan,ultimately influencing the foundation’s stability.This study employs physical model tests to ascertain the trends in end resistance during spudcan penetration in sand,the extent of soil disturbance,and the backflow condition.The finite element coupled Eulerian-Lagrangian method is validated and utilized to determine the range of penetration angles that induce alterations in the maximum vertical displacement and tilt rate of the composite bucket foundation in sand.The differential contact stress distribution at the base of the bucket is analyzed,with qualitative criteria for sand backflow provided.Findings demonstrate that the maximum vertical displacement and tilt rate of the composite bucket foundation display a“wave-like”variation with the increasing spudcan penetration angle,peaking when the angle between the spudcan and bulkhead is the smallest.Stress distribution is predominantly concentrated at the base and apex of the bucket,becoming increasingly uneven as the penetration angle deviates from the foundation’s symmetry axis.The maximum stress gradually shifts to the junction of the bulkhead and bucket bottom on the side with the shortest net distance from the spudcan.Considering the in-place stability and stress state of the composite bucket foundation is therefore imperative,and particular attention should be paid to the foundation’s state when the angle between the spudcan and bulkhead is small.展开更多
In this paper,we propose a novel probabilistic method for predicting the undrained bearing capacity of spatially variable soils.Our approach combines a Gaussian process regression(GPR)-based surrogate model with rando...In this paper,we propose a novel probabilistic method for predicting the undrained bearing capacity of spatially variable soils.Our approach combines a Gaussian process regression(GPR)-based surrogate model with random cell-based smoothed finite analysis.The Gaussian process emulator(GPE)serves as a statistical tool for making predictions from a data set.First,we validate the accuracy and efficiency of kinematic limit analysis using the cell-based smoothed finite element method(CS-FEM)against the standard finite element method(FEM)and edge-based smoothed FEM(ES-FEM).The numerical results demonstrate that the CS-FEM framework surpasses traditional numerical approaches,establishing its reliability in computing collapse loads.Subsequently,we conduct several hundred simulations to develop a surrogate model for predicting the undrained bearing capacity of shallow foundations.By utilizing various kernel functions,we enhance the accuracy of the GPE in these predictions.This method offers a practical and efficient solution,effectively addressing multiple uncertainties.Numerical results indicate that the GPE significantly boosts computational efficiency,achieving satisfactory outcomes within minutes compared to the days required for conventional simulations.Notably,the mean absolute percentage error(MAPE)decreases from 2.38%to 1.82%for rough foundations when employing Matérn and rational quadratic kernel functions,respectively.Additionally,combining different kernel functions further enhances the accuracy of collapse load predictions.展开更多
High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging ...High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging foundation models and multimodal learning frameworks are enabling scalable and transferable representations of cellular states,while advances in interpretability and real-world data integration are bridging the gap between discovery and clinical application.This paper outlines a concise roadmap for AI-driven,transcriptome-centered multi-omics integration in precision medicine(Figure 1).展开更多
Deformations in high fill foundations comprising soil–stone mixtures must be accurately predicted to ensure construction quality and long-term operational safety.However,existing computational and analytical methods ...Deformations in high fill foundations comprising soil–stone mixtures must be accurately predicted to ensure construction quality and long-term operational safety.However,existing computational and analytical methods inadequately capture their complex mechanical behavior.We conducted a series of triaxial tests on unsaturated soil samples collected from a high fill project site in northwestern China under three stress paths.The incremental nonlinear and elastoplastic constitutive models for unsaturated soils were modified,and a calculation method was developed for the vertical and lateral deformations of high fill foundations using the layered summation approach.The results indicate that for soil samples with the same mixing ratio(m)and compaction coefficient(n),the strength of the sample and its tendency to exhibit shear dilation increase with the net confining pressure or matric suction.Additionally,the stress–strain curve of the soil sample gradually changes from the strain-hardening type to the ideal elastoplastic type as the compaction coefficient increases.Moreover,the compaction coefficient is an important factor influencing the magnitude of yield stress and yield suction in soil samples,and the yield points of both are similar in shape to the loadingcollapse(LC)and suction increase(SI)yield lines obtained using the Barcelona model in the net mean stress-generalized shear stress(p-s)plane,respectively.The modified incremental nonlinear instantaneous model simultaneously considers the effects of the compaction coefficient,suction and mixing ratio,and the model parameter can be simplified to the tangential modulus expression in the Duncan-Chang model when the suction is zero.Furthermore,the modified elastoplastic constitutive model,which considers the effects of the net mean stress,suction and partial stress,can be simplified to the elastoplastic constitutive relationship of saturated soil when the suction is zero.The proposed deformation calculation method,based on the layered summation theory,is applicable to both elastic and elastoplastic foundation states,as confirmed through numerical simulations.Our work can be used as a reference for the calculation of foundation deformation in similar mixed material high fill projects.展开更多
At the start of China’s 15th Five-Year Plan period(2026–2030),signals from March’s Two Sessions point to a subtle but notable change in direction.Policymakers are moving beyond an emphasis on headline growth figure...At the start of China’s 15th Five-Year Plan period(2026–2030),signals from March’s Two Sessions point to a subtle but notable change in direction.Policymakers are moving beyond an emphasis on headline growth figures and are instead concentrating on building a more resilient economic foundation in a volatile global environment.展开更多
With the emergence of general foundational models,such as Chat Generative Pre-trained Transformer(ChatGPT),researchers have shown considerable interest in the potential applications of foundation models in the process...With the emergence of general foundational models,such as Chat Generative Pre-trained Transformer(ChatGPT),researchers have shown considerable interest in the potential applications of foundation models in the process industry.This paper provides a comprehensive overview of the challenges and opportunities presented by the use of foundation models in the process industry,including the frameworks,core applications,and future prospects.First,this paper proposes a framework for foundation models for the process industry.Second,it summarizes the key capabilities of industrial foundation models and their practical applications.Finally,it highlights future research directions and identifies unresolved open issues related to the use of foundation models in the process industry.展开更多
Drains play an important role in seepage control in geotechnical engineering.The enormous number and one-dimensional(1D)geometry of drainage holes make their nature difficult to be accurately modeled in groundwater fl...Drains play an important role in seepage control in geotechnical engineering.The enormous number and one-dimensional(1D)geometry of drainage holes make their nature difficult to be accurately modeled in groundwater flow simulation.It has been well understood that drains function by presenting discharge boundaries,which can be characterized by water head,no-flux,unilateral or mixed water head-unilateral boundary condition.It has been found after years of practices that the flow simulation may become erroneous if the transitions among the drain boundary conditions are not properly considered.For this,a rigorous algorithm is proposed in this study to detect the onset of transitions among the water head,noflux and mixed water head-unilateral boundary conditions for downwards-drilled drainage holes,which theoretically completes the description of drain boundary conditions.After verification against a numerical example,the proposed algorithm is applied to numerical modeling of groundwater flow through a gravity dam foundation.The simulation shows that for hundreds of downwards-drilled drainage holes used to be prescribed with water head boundary condition,56%and 2%of them are transitioned to mixed water head-unilateral and no-flux boundary conditions,respectively.The phreatic surface around the drains will be overestimated by 25e33 m without the use of the mixed boundary condition.For the first time,this study underscores the importance of the mixed water head-unilateral boundary condition and the proposed transition algorithm in drain modeling,which may become more essential for simulation of transient flow because of groundwater dynamics.展开更多
Uplift of segmental linings in shield tunnels presents considerable challenges,potentially compromising the structural integrity of tunnels.The uplift movement can be physically modelled using a Timoshenko beam on a W...Uplift of segmental linings in shield tunnels presents considerable challenges,potentially compromising the structural integrity of tunnels.The uplift movement can be physically modelled using a Timoshenko beam on a Winkler foundation.This study introduces an innovative method employing a physicsinformed neural network(PINN)to solve the governing differential equations of shield tunnel linings under specifiedboundary conditions,known loads,and foundation parameters.Importantly,the PINN does not rely on empirical data for training;instead,it incorporates physics-based constraints to accurately capture spatial variations in load and foundation stiffness during grouting and construction phases.The PINN model was validated with fielddata from a shield tunnel in the Pazhou branch of the Guangzhou-Dongguan-Shenzhen intercity railway line.The results demonstrate the effectiveness of the model in predicting segment uplift.Furthermore,compared to traditional analytical solutions,the PINN model provides a more realistic representation of fieldconditions by integrating spatial variations in loading and foundation support.展开更多
Under the combination of currents and waves, seabed scour occurs around offshore wind turbine foundations, which affects the stability and safe operation of offshore wind turbines. In this study, physical model experi...Under the combination of currents and waves, seabed scour occurs around offshore wind turbine foundations, which affects the stability and safe operation of offshore wind turbines. In this study, physical model experiments under unidirectional flow, bidirectional flow, and wave-current interactions with different flow directions around the pile group foundation were first conducted to investigate the development of scour around the pile group foundation.Additionally, a three-dimensional scour numerical model was established via the open-source software REEF3D to simulate the flow field and scour around the prototype-scale foundation. The impact of flow on scour was discussed.Under unidirectional flow, scour equilibrium was reached more quickly, with the maximum scour depth reaching approximately 1.2 times the pile diameter and the extent of the scour hole spanning about 4.9 times the pile diameter.Compared with those under unidirectional flow, the scour depths under combinations of currents and waves, as well as bidirectional flow, were slightly smaller. However, the morphology of scour holes was more uniform and symmetrical. The numerical simulation results show good agreement with the experimental data, demonstrating the impact of varying flow directions on the velocity distribution around the foundation, the morphology of scour holes, and the location of the maximum scour depth.展开更多
On April 26,the China Foundation for Peace and Development(CFPD),in collaboration with the Shenzhen Foundation for International Exchange and Cooperation(SFIEC),the Shenzhen Ye Chenghai Charity Foundation and the Chin...On April 26,the China Foundation for Peace and Development(CFPD),in collaboration with the Shenzhen Foundation for International Exchange and Cooperation(SFIEC),the Shenzhen Ye Chenghai Charity Foundation and the China-Myanmar Economic Cooperation and Development Promotion Association(Myanmar),held a handover ceremony at Yangon Airport to donate five tons of medicine to the disasterstricken areas of Myanmar.展开更多
The existing analytical models for umbrella arch method(UAM)based on elastic foundation beams often overlook the influence of the surrounding soil beyond the beam edges on the shear stresses acting on the beam.Consequ...The existing analytical models for umbrella arch method(UAM)based on elastic foundation beams often overlook the influence of the surrounding soil beyond the beam edges on the shear stresses acting on the beam.Consequently,such models fail to adequately reflect the continuity characteristics of soil deformation.Leveraging the Pasternak foundation-Euler beam model,this study considers the generalized shear force on the beam to account for the influence of soil outside the beam ends on the shear stress.An analytical model for the deformation and internal forces of finite-length beams subjected to arbitrary loads is derived based on the initial parameter method under various conditions.The mechanical model of the elastic foundation beam for advanced umbrella arch under typical tunnel excavation cycles is established,yielding analytical solutions for the longitudinal response of the umbrella arch.The reliability of the analytical model is verified with the existing test data.The improved model addresses anomalies in existing models,such as abnormal upward deformation in the loosened segment and maximum deflection occurring within the soil mass.Additionally,dimensionless characteristic parameters reflecting the relative stiffness between the umbrella arch structure and the foundation soil are proposed.Results indicate that the magnitude of soil characteristic parameters significantly influences the deformation and internal forces of the umbrella arch.Within common ranges of soil values,the maximum deformation and internal forces of the umbrella arch under semi-logarithmic coordinates exhibit nearly linear decay with decreasing soil characteristic parameters.The impact of tunnel excavation height on the stress of unsupported sections of the umbrella arch is minor,but it is more significant for umbrella arch buried within the soil mass.Conversely,the influence of tunnel excavation advance on the umbrella arch is opposite.展开更多
This paper proposes a longitudinal vulnerability-based analysis method to evaluate the impact of foundation pit excavation on shield tunnels,accounting for geological uncertainties.First,the shield tunnel is modeled a...This paper proposes a longitudinal vulnerability-based analysis method to evaluate the impact of foundation pit excavation on shield tunnels,accounting for geological uncertainties.First,the shield tunnel is modeled as an Euler Bernoulli beam resting on the Pasternak foundation incorporating variability in subgrade parameters along the tunnel’s length.A random analysis method using random field theory is introduced to evaluate the tunnel’s longitudinal responses to excavation.Next,a risk assessment index system is established.The normalized relative depth between the excavation and the shield tunnel is used as a risk index,while the maximum longitudinal deformation,the maximum circumferential opening,and the maximum longitudinal bending moment serve as performance indicators.Based on these,a method for analyzing the longitudinal fragility of shield tunnels under excavation-induced disturbances is proposed.Finally,the technique is applied to a case study involving a foundation pit excavation above a shield tunnel,which is the primary application scenario of this method.Vulnerability curves for different performance indicators are derived,and the effects of tunnel stiffness and subgrade stiffness on the tunnel vulnerability are explored.The results reveal significant differences in vulnerability curves depending on the performance index used.Compared to the maximum circumferential opening and the maximum longitudinal bending moment,selecting the maximum longitudinal deformation as the control index better ensures the tunnel’s usability and safety under excavation disturbances.The longitudinal vulnerability of the shield tunnel nonlinearly decreases with the increase of the tunnel stiffness and subgrade stiffness,and the subgrade stiffness has a more pronounced effect.Parametric analyses suggest that actively reinforcing the substratum is more effective on reducing the risk of tunnel failure due to adjacent excavations than passive reinforcement of the tunnel structure.展开更多
At the invitation of the Friedrich Ebert Foundation(Friedrich-Ebert-Stiftung),the Thai-Chinese Culture and Economy Association and the Viet Nam Union of Friendship Organisations,a CAFIU delegation headed by President ...At the invitation of the Friedrich Ebert Foundation(Friedrich-Ebert-Stiftung),the Thai-Chinese Culture and Economy Association and the Viet Nam Union of Friendship Organisations,a CAFIU delegation headed by President Ji Bingxuan,also Vice-Chairperson of the Standing Committee of the 13th National People's Congress of China visited Germany,Thailand and Vietnam from 26 November to 5 December 2024.展开更多
Hu Junhui,president of Tianfu Association(Singapore)and recipient of the Public Service Medal(PBM),has been leading community efforts to help new Chinese immigrants integrate into Singaporean society.Originally from H...Hu Junhui,president of Tianfu Association(Singapore)and recipient of the Public Service Medal(PBM),has been leading community efforts to help new Chinese immigrants integrate into Singaporean society.Originally from Hebei Province in China,Hu arrived in Singapore in 1994 as one of the first technical professionals dispatched by China.Since then,he has built a life and career firmly rooted in Singapore.Over more than four years at China Construction(South Pacific)Development Co Pte Ltd,he rose through the ranks from project engineer to site manager and eventually project director.In 1999,he left the company to start his own business,setting up a construction firm with several partners.His focus shifted to real estate in 2007,when he co-founded JVA Venture Pte Ltd.展开更多
Gastrointestinal(GI)cancers represent a major global health concern due to their high incidence and mortality rates.Foundation models(FMs),also referred to as large models,represent a novel class of artificial intelli...Gastrointestinal(GI)cancers represent a major global health concern due to their high incidence and mortality rates.Foundation models(FMs),also referred to as large models,represent a novel class of artificial intelligence technologies that have demonstrated considerable potential in addressing these challenges.These models encompass large language models(LLMs),vision FMs(VFMs),and multimodal LLMs(MLLMs),all of which utilize transformer architectures and self-supervised pre-training on extensive unlabeled datasets to achieve robust cross-domain generalization.This review delineates the principal applications of these models:LLMs facilitate the structuring of clinical narratives,extraction of insights from medical records,and enhancement of physician-patient communication;VFMs are employed in the analysis of endoscopic,radiological,and pathological images for lesion detection and staging;MLLMs integrate heterogeneous data modalities,including imaging,textual information,and genomic data,to support diagnostic processes,treatment prediction,and prognostic evaluation.Despite these promising developments,several challenges remain,such as the need for data standardization,limited diversity within training datasets,substantial computational resource requirements,and ethical-legal concerns.In conclusion,FMs exhibit significant potential to advance research and clinical management of GI cancers.Future research efforts should prioritize the refinement of these models,promote international collaborations,and adopt interdisciplinary approaches.Such a comprehensive strategy is essential to fully harness the capabilities of FMs,driving substantial progress in the fight against GI malignancies.展开更多
Periodontitis has emerged as one of the most critical oral diseases, and research on this condition holds great importance for the advancement of stomatology. As the most authoritative national scientific research fun...Periodontitis has emerged as one of the most critical oral diseases, and research on this condition holds great importance for the advancement of stomatology. As the most authoritative national scientific research funding institution in China, the National Natural Science Foundation of China (NSFC) has played a pivotal role in driving the progress of periodontal science by supporting research on periodontitis. This article provides a comprehensive review of the research and development progress related to periodontitis in China from 2014 to 2023, highlighting the significant contributions of the NSFC to this field. We have summarized the detailed funding information from the NSFC, including the number of applicant codes, funded programs and the distribution of funded scholars. These data illustrate the efforts of the NSFC in cultivating young scientists and building research groups to address key challenges in national scientific research. This study offers an overview of the current hot topics, recent breakthroughs and future research prospects related to periodontitis in China.展开更多
Establish an efficacy evaluation method for foundation products in vivo and vitro.The hiding power,whiteness,waterproof and anti-sweat effect were evaluated in vitro test,where CR ratio,Individual Type Angle (ITA°...Establish an efficacy evaluation method for foundation products in vivo and vitro.The hiding power,whiteness,waterproof and anti-sweat effect were evaluated in vitro test,where CR ratio,Individual Type Angle (ITA°) and chromatic aberration (E) were measured as evaluation indicators by standard black/white cardboard,artificial leather and artificial sweat.In clinical assessment,the anti-stain,waterproof,anti-sweat effect of the foundation products were evaluated through the ΔE change,before and after the treatment of products by staining,wetting,sweating in forearm skin.There were significant differences in CR ratio of different types of samples on standard black and white cardboards (P<0.05),ITA° of artificial leather has a significant increase after treatment (P<0.05),?E﹤1.5 in black cloth after dipping test,while ΔE﹤1.5 in leather after water and artificial sweat treatment.Clinical assessment showed that ?E ﹤50%,which had no significant difference in human skin color,before and after the test (P>0.05).The change trend of efficacy evaluation in vitro test was basically consistent with that of visual evaluation and clinical assessment,indicated that the efficacy evaluation methods of foundation products in vivo and vitro are intuitive,quantifiable,and can be used to evaluate the efficacy of foundation products.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.52178329),the China Scholarship Council(Grant No.202306130155)the Postgraduate Scientific Research Innovation Project of Hunan Province,China(Grant No.CX20230442).
文摘With the continuous development of the offshore wind industry,the design concept of composite foundation has been given attention in the past decade.This paper presents an accurate method for investigating the horizontal vibration of monopile-friction wheel composite foundations in layered saturated soil.Firstly,the three-dimensional continuum mechanics theory with the range of linear elasticity is introduced to calculate the frictional resistance distributed on the upper soil surface.Then,the resistances of multilayered soils and inviscid seawater to the pile shaft under horizontal harmonic excitation are obtained using Novak's plane strain model,Biot's porous media theory and radiationwave theory.Thirdly,the expressions for the deformation,bending moment and internal force of the Euler-Bernoulli pile are derived using the boundary conditions with definitephysical meaning and transfer matrix method.By comparing with the results of 1g laboratory test and the idealized formula reported by the literature,the rationality and accuracy of the developed dynamical model can be verified.Finally,this paper conducts a series of worked examples to investigate the influencesof the elastic modulus and thickness of three-layer saturated soil and the location of interlayer soil on the horizontal dynamic vibration of composite foundation.The results show that an increase in elastic modulus of the surface soil is an effective way to improve the dynamic stability of the composite foundation in service conditions.The conclusions drawn from the numerical examples can develop some guidelines for the current foundation design of offshore wind turbines.
文摘Conventionally,foundations have been classified as shallow or deep in routine civil engineering practice.However,due to recent developments,two other approaches,semi-deep and ground modification foundations,are now available,complicating foundation categorization.Accordingly,a new concept for foundation categorization is introduced in this paper based on insights into the theory of structure analysis.Based on the form aspect,foundation systems can be categorized as one-dimensional(linear),two-dimensional(planar),and threedimensional(volumetric).Based on the load transfer aspect,foundations can also be categorized as vector-acting(piles),section or surface-acting(rafts and shells),and block-acting(piled rafts).As a step toward implementing this new categorization scheme,a database of 22 cases has been compiled,symbolizing novel introduced foundation systems.This compilation involves structures such as offshore jackets,high-rise buildings,towers and storages,and diverse geomaterials.Among them,a few have been selected for detailed evaluation,emphasizing influential factors in foundation selection,comprising superstructure,subsoil condition,foundation system,circumferential conditions,and supplementary considerations,that is,constructional and sustainability-based issues.Lessons learned from experience and these knowledge-based cases have described for foundation selection and implementation.Geotechnical and practical aspects with critical components have been realized as major performance assessment and comparison factors.Foundation systems have been compared and ranked using the improved analytic hierarchy process approach.Finally,four categories of buildings,from low-rise to towers and four prevailing levels of soil strength,from soft to very hard,have been considered to propose a perspective for building substructure implementation,adapted via relevant cases.Overall,the introduced categorization is recognized as an efficient algorithm for the experimentation of appropriate foundations for specific structures and subsoil conditions.
文摘In this work,a computational modelling and analysis framework is developed to investigate the thermal buckling behavior of doubly-curved composite shells reinforced with graphene-origami(G-Ori)auxetic metamaterials.A semi-analytical formulation based on the First-Order Shear Deformation Theory(FSDT)and the principle of virtual displacements is established,and closed-form solutions are derived via Navier’s method for simply supported boundary conditions.The G-Ori metamaterial reinforcements are treated as programmable constructs whose effective thermo-mechanical properties are obtained via micromechanical homogenization and incorporated into the shell model.A comprehensive parametric study examines the influence of folding geometry,dispersion arrangement,reinforcement weight fraction,curvature parameters,and elastic foundation support on the critical buckling temperature(CBT).The results reveal that,under optimal folding geometry and reinforcement alignment with principal stress trajectories,the CBT can increase by more than 150%.Furthermore,the combined effect of G-Ori reinforcement and elastic foundation substantially enhances thermal buckling resistance.These findings establish design guidelines for architected composite shells in applications such as aerospace thermal skins,morphing structures,and thermally-responsive systems,and illustrate the potential of auxetic graphene metamaterials for multifunctional,lightweight,and thermally robust structural components.
文摘Installing internal bulkheads in a composite bucket foundation alters the rotational symmetry characteristic of a single-compartment bucket foundation,consequently influencing the stress distribution within the bucket and surrounding soil.During the seabed penetration of a spudcan from a jack-up wind turbine installation vessel,an angle may form between the spudcan’s axis and the axis of symmetry of the adjacent composite bucket foundation in the horizontal plane.Such a misalignment may affect load distribution and the non-uniform interaction between the foundation,soil,and spudcan,ultimately influencing the foundation’s stability.This study employs physical model tests to ascertain the trends in end resistance during spudcan penetration in sand,the extent of soil disturbance,and the backflow condition.The finite element coupled Eulerian-Lagrangian method is validated and utilized to determine the range of penetration angles that induce alterations in the maximum vertical displacement and tilt rate of the composite bucket foundation in sand.The differential contact stress distribution at the base of the bucket is analyzed,with qualitative criteria for sand backflow provided.Findings demonstrate that the maximum vertical displacement and tilt rate of the composite bucket foundation display a“wave-like”variation with the increasing spudcan penetration angle,peaking when the angle between the spudcan and bulkhead is the smallest.Stress distribution is predominantly concentrated at the base and apex of the bucket,becoming increasingly uneven as the penetration angle deviates from the foundation’s symmetry axis.The maximum stress gradually shifts to the junction of the bulkhead and bucket bottom on the side with the shortest net distance from the spudcan.Considering the in-place stability and stress state of the composite bucket foundation is therefore imperative,and particular attention should be paid to the foundation’s state when the angle between the spudcan and bulkhead is small.
文摘In this paper,we propose a novel probabilistic method for predicting the undrained bearing capacity of spatially variable soils.Our approach combines a Gaussian process regression(GPR)-based surrogate model with random cell-based smoothed finite analysis.The Gaussian process emulator(GPE)serves as a statistical tool for making predictions from a data set.First,we validate the accuracy and efficiency of kinematic limit analysis using the cell-based smoothed finite element method(CS-FEM)against the standard finite element method(FEM)and edge-based smoothed FEM(ES-FEM).The numerical results demonstrate that the CS-FEM framework surpasses traditional numerical approaches,establishing its reliability in computing collapse loads.Subsequently,we conduct several hundred simulations to develop a surrogate model for predicting the undrained bearing capacity of shallow foundations.By utilizing various kernel functions,we enhance the accuracy of the GPE in these predictions.This method offers a practical and efficient solution,effectively addressing multiple uncertainties.Numerical results indicate that the GPE significantly boosts computational efficiency,achieving satisfactory outcomes within minutes compared to the days required for conventional simulations.Notably,the mean absolute percentage error(MAPE)decreases from 2.38%to 1.82%for rough foundations when employing Matérn and rational quadratic kernel functions,respectively.Additionally,combining different kernel functions further enhances the accuracy of collapse load predictions.
文摘High-throughput transcriptomics has evolved from bulk RNA-seq to single-cell and spatial profiling,yet its clinical translation still depends on effective integration across diverse omics and data modalities.Emerging foundation models and multimodal learning frameworks are enabling scalable and transferable representations of cellular states,while advances in interpretability and real-world data integration are bridging the gap between discovery and clinical application.This paper outlines a concise roadmap for AI-driven,transcriptome-centered multi-omics integration in precision medicine(Figure 1).
基金funded by the National Natural Science Foundation of China(Grant Nos.52368049,52168051,and 42462028)Lanzhou Young Scientific and Technological Talents Innovation Project(Grant Nos.2023-QN-27 and 2023-QN-52)Major Project of the Joint Scientific Research Fund of Gansu Province(Grant No.25JRRL007)。
文摘Deformations in high fill foundations comprising soil–stone mixtures must be accurately predicted to ensure construction quality and long-term operational safety.However,existing computational and analytical methods inadequately capture their complex mechanical behavior.We conducted a series of triaxial tests on unsaturated soil samples collected from a high fill project site in northwestern China under three stress paths.The incremental nonlinear and elastoplastic constitutive models for unsaturated soils were modified,and a calculation method was developed for the vertical and lateral deformations of high fill foundations using the layered summation approach.The results indicate that for soil samples with the same mixing ratio(m)and compaction coefficient(n),the strength of the sample and its tendency to exhibit shear dilation increase with the net confining pressure or matric suction.Additionally,the stress–strain curve of the soil sample gradually changes from the strain-hardening type to the ideal elastoplastic type as the compaction coefficient increases.Moreover,the compaction coefficient is an important factor influencing the magnitude of yield stress and yield suction in soil samples,and the yield points of both are similar in shape to the loadingcollapse(LC)and suction increase(SI)yield lines obtained using the Barcelona model in the net mean stress-generalized shear stress(p-s)plane,respectively.The modified incremental nonlinear instantaneous model simultaneously considers the effects of the compaction coefficient,suction and mixing ratio,and the model parameter can be simplified to the tangential modulus expression in the Duncan-Chang model when the suction is zero.Furthermore,the modified elastoplastic constitutive model,which considers the effects of the net mean stress,suction and partial stress,can be simplified to the elastoplastic constitutive relationship of saturated soil when the suction is zero.The proposed deformation calculation method,based on the layered summation theory,is applicable to both elastic and elastoplastic foundation states,as confirmed through numerical simulations.Our work can be used as a reference for the calculation of foundation deformation in similar mixed material high fill projects.
文摘At the start of China’s 15th Five-Year Plan period(2026–2030),signals from March’s Two Sessions point to a subtle but notable change in direction.Policymakers are moving beyond an emphasis on headline growth figures and are instead concentrating on building a more resilient economic foundation in a volatile global environment.
基金supported by the National Natural Science Foundation of China(62225302,623B2014,and 62173023).
文摘With the emergence of general foundational models,such as Chat Generative Pre-trained Transformer(ChatGPT),researchers have shown considerable interest in the potential applications of foundation models in the process industry.This paper provides a comprehensive overview of the challenges and opportunities presented by the use of foundation models in the process industry,including the frameworks,core applications,and future prospects.First,this paper proposes a framework for foundation models for the process industry.Second,it summarizes the key capabilities of industrial foundation models and their practical applications.Finally,it highlights future research directions and identifies unresolved open issues related to the use of foundation models in the process industry.
基金Financial support from the National Natural Science Foundation of China(Grant Nos.51925906 and U2340228)the Natural Science Foundation of Hubei Province(Grant No.2022CFA028)is acknowledged.
文摘Drains play an important role in seepage control in geotechnical engineering.The enormous number and one-dimensional(1D)geometry of drainage holes make their nature difficult to be accurately modeled in groundwater flow simulation.It has been well understood that drains function by presenting discharge boundaries,which can be characterized by water head,no-flux,unilateral or mixed water head-unilateral boundary condition.It has been found after years of practices that the flow simulation may become erroneous if the transitions among the drain boundary conditions are not properly considered.For this,a rigorous algorithm is proposed in this study to detect the onset of transitions among the water head,noflux and mixed water head-unilateral boundary conditions for downwards-drilled drainage holes,which theoretically completes the description of drain boundary conditions.After verification against a numerical example,the proposed algorithm is applied to numerical modeling of groundwater flow through a gravity dam foundation.The simulation shows that for hundreds of downwards-drilled drainage holes used to be prescribed with water head boundary condition,56%and 2%of them are transitioned to mixed water head-unilateral and no-flux boundary conditions,respectively.The phreatic surface around the drains will be overestimated by 25e33 m without the use of the mixed boundary condition.For the first time,this study underscores the importance of the mixed water head-unilateral boundary condition and the proposed transition algorithm in drain modeling,which may become more essential for simulation of transient flow because of groundwater dynamics.
基金funded by“The Pearl River Talent Recruitment Program”in 2019(Grant No.2019CX01G338)Guangdong Province and Guangdong Provincial Basic and Applied Basic Research Fund Committee(2022A1515240073).
文摘Uplift of segmental linings in shield tunnels presents considerable challenges,potentially compromising the structural integrity of tunnels.The uplift movement can be physically modelled using a Timoshenko beam on a Winkler foundation.This study introduces an innovative method employing a physicsinformed neural network(PINN)to solve the governing differential equations of shield tunnel linings under specifiedboundary conditions,known loads,and foundation parameters.Importantly,the PINN does not rely on empirical data for training;instead,it incorporates physics-based constraints to accurately capture spatial variations in load and foundation stiffness during grouting and construction phases.The PINN model was validated with fielddata from a shield tunnel in the Pazhou branch of the Guangzhou-Dongguan-Shenzhen intercity railway line.The results demonstrate the effectiveness of the model in predicting segment uplift.Furthermore,compared to traditional analytical solutions,the PINN model provides a more realistic representation of fieldconditions by integrating spatial variations in loading and foundation support.
基金financially supported by the National Key Research and Development Program of China (Grant No. 2021YFB2601100)the National Natural Science Foundation of China (Grant No. 51979190)。
文摘Under the combination of currents and waves, seabed scour occurs around offshore wind turbine foundations, which affects the stability and safe operation of offshore wind turbines. In this study, physical model experiments under unidirectional flow, bidirectional flow, and wave-current interactions with different flow directions around the pile group foundation were first conducted to investigate the development of scour around the pile group foundation.Additionally, a three-dimensional scour numerical model was established via the open-source software REEF3D to simulate the flow field and scour around the prototype-scale foundation. The impact of flow on scour was discussed.Under unidirectional flow, scour equilibrium was reached more quickly, with the maximum scour depth reaching approximately 1.2 times the pile diameter and the extent of the scour hole spanning about 4.9 times the pile diameter.Compared with those under unidirectional flow, the scour depths under combinations of currents and waves, as well as bidirectional flow, were slightly smaller. However, the morphology of scour holes was more uniform and symmetrical. The numerical simulation results show good agreement with the experimental data, demonstrating the impact of varying flow directions on the velocity distribution around the foundation, the morphology of scour holes, and the location of the maximum scour depth.
文摘On April 26,the China Foundation for Peace and Development(CFPD),in collaboration with the Shenzhen Foundation for International Exchange and Cooperation(SFIEC),the Shenzhen Ye Chenghai Charity Foundation and the China-Myanmar Economic Cooperation and Development Promotion Association(Myanmar),held a handover ceremony at Yangon Airport to donate five tons of medicine to the disasterstricken areas of Myanmar.
基金Projects(52008403,52378421)supported by the National Natural Science Foundation of ChinaProject(2022-Key-10)supported by the Science and Technology Research and Development Program Project of China Railway Group LimitedProject(202207)supported by the Hunan Provincial Transportation Science and Technology,China。
文摘The existing analytical models for umbrella arch method(UAM)based on elastic foundation beams often overlook the influence of the surrounding soil beyond the beam edges on the shear stresses acting on the beam.Consequently,such models fail to adequately reflect the continuity characteristics of soil deformation.Leveraging the Pasternak foundation-Euler beam model,this study considers the generalized shear force on the beam to account for the influence of soil outside the beam ends on the shear stress.An analytical model for the deformation and internal forces of finite-length beams subjected to arbitrary loads is derived based on the initial parameter method under various conditions.The mechanical model of the elastic foundation beam for advanced umbrella arch under typical tunnel excavation cycles is established,yielding analytical solutions for the longitudinal response of the umbrella arch.The reliability of the analytical model is verified with the existing test data.The improved model addresses anomalies in existing models,such as abnormal upward deformation in the loosened segment and maximum deflection occurring within the soil mass.Additionally,dimensionless characteristic parameters reflecting the relative stiffness between the umbrella arch structure and the foundation soil are proposed.Results indicate that the magnitude of soil characteristic parameters significantly influences the deformation and internal forces of the umbrella arch.Within common ranges of soil values,the maximum deformation and internal forces of the umbrella arch under semi-logarithmic coordinates exhibit nearly linear decay with decreasing soil characteristic parameters.The impact of tunnel excavation height on the stress of unsupported sections of the umbrella arch is minor,but it is more significant for umbrella arch buried within the soil mass.Conversely,the influence of tunnel excavation advance on the umbrella arch is opposite.
基金Project(52178402) supported by the National Natural Science Foundation of China。
文摘This paper proposes a longitudinal vulnerability-based analysis method to evaluate the impact of foundation pit excavation on shield tunnels,accounting for geological uncertainties.First,the shield tunnel is modeled as an Euler Bernoulli beam resting on the Pasternak foundation incorporating variability in subgrade parameters along the tunnel’s length.A random analysis method using random field theory is introduced to evaluate the tunnel’s longitudinal responses to excavation.Next,a risk assessment index system is established.The normalized relative depth between the excavation and the shield tunnel is used as a risk index,while the maximum longitudinal deformation,the maximum circumferential opening,and the maximum longitudinal bending moment serve as performance indicators.Based on these,a method for analyzing the longitudinal fragility of shield tunnels under excavation-induced disturbances is proposed.Finally,the technique is applied to a case study involving a foundation pit excavation above a shield tunnel,which is the primary application scenario of this method.Vulnerability curves for different performance indicators are derived,and the effects of tunnel stiffness and subgrade stiffness on the tunnel vulnerability are explored.The results reveal significant differences in vulnerability curves depending on the performance index used.Compared to the maximum circumferential opening and the maximum longitudinal bending moment,selecting the maximum longitudinal deformation as the control index better ensures the tunnel’s usability and safety under excavation disturbances.The longitudinal vulnerability of the shield tunnel nonlinearly decreases with the increase of the tunnel stiffness and subgrade stiffness,and the subgrade stiffness has a more pronounced effect.Parametric analyses suggest that actively reinforcing the substratum is more effective on reducing the risk of tunnel failure due to adjacent excavations than passive reinforcement of the tunnel structure.
文摘At the invitation of the Friedrich Ebert Foundation(Friedrich-Ebert-Stiftung),the Thai-Chinese Culture and Economy Association and the Viet Nam Union of Friendship Organisations,a CAFIU delegation headed by President Ji Bingxuan,also Vice-Chairperson of the Standing Committee of the 13th National People's Congress of China visited Germany,Thailand and Vietnam from 26 November to 5 December 2024.
文摘Hu Junhui,president of Tianfu Association(Singapore)and recipient of the Public Service Medal(PBM),has been leading community efforts to help new Chinese immigrants integrate into Singaporean society.Originally from Hebei Province in China,Hu arrived in Singapore in 1994 as one of the first technical professionals dispatched by China.Since then,he has built a life and career firmly rooted in Singapore.Over more than four years at China Construction(South Pacific)Development Co Pte Ltd,he rose through the ranks from project engineer to site manager and eventually project director.In 1999,he left the company to start his own business,setting up a construction firm with several partners.His focus shifted to real estate in 2007,when he co-founded JVA Venture Pte Ltd.
基金Supported by the Open Project Program of Panxi Crops Research and Utilization Key Laboratory of Sichuan Province,No.SZKF202302the Fundamental Research Funds for the Central Universities No.2019CDYGYB024.
文摘Gastrointestinal(GI)cancers represent a major global health concern due to their high incidence and mortality rates.Foundation models(FMs),also referred to as large models,represent a novel class of artificial intelligence technologies that have demonstrated considerable potential in addressing these challenges.These models encompass large language models(LLMs),vision FMs(VFMs),and multimodal LLMs(MLLMs),all of which utilize transformer architectures and self-supervised pre-training on extensive unlabeled datasets to achieve robust cross-domain generalization.This review delineates the principal applications of these models:LLMs facilitate the structuring of clinical narratives,extraction of insights from medical records,and enhancement of physician-patient communication;VFMs are employed in the analysis of endoscopic,radiological,and pathological images for lesion detection and staging;MLLMs integrate heterogeneous data modalities,including imaging,textual information,and genomic data,to support diagnostic processes,treatment prediction,and prognostic evaluation.Despite these promising developments,several challenges remain,such as the need for data standardization,limited diversity within training datasets,substantial computational resource requirements,and ethical-legal concerns.In conclusion,FMs exhibit significant potential to advance research and clinical management of GI cancers.Future research efforts should prioritize the refinement of these models,promote international collaborations,and adopt interdisciplinary approaches.Such a comprehensive strategy is essential to fully harness the capabilities of FMs,driving substantial progress in the fight against GI malignancies.
文摘Periodontitis has emerged as one of the most critical oral diseases, and research on this condition holds great importance for the advancement of stomatology. As the most authoritative national scientific research funding institution in China, the National Natural Science Foundation of China (NSFC) has played a pivotal role in driving the progress of periodontal science by supporting research on periodontitis. This article provides a comprehensive review of the research and development progress related to periodontitis in China from 2014 to 2023, highlighting the significant contributions of the NSFC to this field. We have summarized the detailed funding information from the NSFC, including the number of applicant codes, funded programs and the distribution of funded scholars. These data illustrate the efforts of the NSFC in cultivating young scientists and building research groups to address key challenges in national scientific research. This study offers an overview of the current hot topics, recent breakthroughs and future research prospects related to periodontitis in China.
文摘Establish an efficacy evaluation method for foundation products in vivo and vitro.The hiding power,whiteness,waterproof and anti-sweat effect were evaluated in vitro test,where CR ratio,Individual Type Angle (ITA°) and chromatic aberration (E) were measured as evaluation indicators by standard black/white cardboard,artificial leather and artificial sweat.In clinical assessment,the anti-stain,waterproof,anti-sweat effect of the foundation products were evaluated through the ΔE change,before and after the treatment of products by staining,wetting,sweating in forearm skin.There were significant differences in CR ratio of different types of samples on standard black and white cardboards (P<0.05),ITA° of artificial leather has a significant increase after treatment (P<0.05),?E﹤1.5 in black cloth after dipping test,while ΔE﹤1.5 in leather after water and artificial sweat treatment.Clinical assessment showed that ?E ﹤50%,which had no significant difference in human skin color,before and after the test (P>0.05).The change trend of efficacy evaluation in vitro test was basically consistent with that of visual evaluation and clinical assessment,indicated that the efficacy evaluation methods of foundation products in vivo and vitro are intuitive,quantifiable,and can be used to evaluate the efficacy of foundation products.
