Forrestiacids C(1)and D(2),a pair of C-25 epimeric triterpene–diterpene adducts were isolated from the needles and twigs of the vulnerable conifer Pseudotsuga forrestii.This unprecedented class of compounds might be ...Forrestiacids C(1)and D(2),a pair of C-25 epimeric triterpene–diterpene adducts were isolated from the needles and twigs of the vulnerable conifer Pseudotsuga forrestii.This unprecedented class of compounds might be generated via an intermolecular Michael addition reaction of a rearranged 6/6/5/5-fused spiro-lanostene with an abietene.Their structures were established by spectroscopic data and X-ray crystallography.The adducts showed inhibitory activities against the ATP-citrate lyase(ACL)and acetyl-CoA carboxylase 1(ACC1),two rate-limiting enzymes in the de novo lipogenesis pathway.展开更多
基金supported by grants from the National Natural Science Foundation of China(Nos.21937002,81773599,21772025)。
文摘Forrestiacids C(1)and D(2),a pair of C-25 epimeric triterpene–diterpene adducts were isolated from the needles and twigs of the vulnerable conifer Pseudotsuga forrestii.This unprecedented class of compounds might be generated via an intermolecular Michael addition reaction of a rearranged 6/6/5/5-fused spiro-lanostene with an abietene.Their structures were established by spectroscopic data and X-ray crystallography.The adducts showed inhibitory activities against the ATP-citrate lyase(ACL)and acetyl-CoA carboxylase 1(ACC1),two rate-limiting enzymes in the de novo lipogenesis pathway.
