[Objectives]This study was conducted to optimize the Formulation Process of glucosamine chondroitin sulfate tablets. [Methods] The orthogonal design with three levels was carried out with microcrystalline cellulose, c...[Objectives]This study was conducted to optimize the Formulation Process of glucosamine chondroitin sulfate tablets. [Methods] The orthogonal design with three levels was carried out with microcrystalline cellulose, calcium hydrophosphate and cross-linked polyvinylpyrrolidone as three factors to optimize the preparation process. [Results] When microcrystalline cellulose 200 mg/tablet, calcium hydrophosphate 150 mg/tablet, and cross-linked polyvinylpyrrolidone 80 mg/tablet were added, the angle of repose could meet the requirements of tablet pressing, and the dissolution could reach more than 95% in 30 min. The results of the orthogonal test showed that the dissolution effect of self-made tablets was faster than that of commercial products. [Conclusions] The glucosamine hydrochloride chondroitin sulfate tablets prepared by this prescription have better quality.展开更多
The Universal Declaration of Human Rights was the first common commitment of the international community to human rights. It demonstrated the belief and determination of humanity to maintain peace, democracy and human...The Universal Declaration of Human Rights was the first common commitment of the international community to human rights. It demonstrated the belief and determination of humanity to maintain peace, democracy and human dignity. The process of formulating the Declaration was difficult. But in the spirit of cooperation,countries finally succeeded in reaching a consensus on human rights.The making of the Universal Declaration of Human Rights had great value and significance for promoting world peace and development,and it has had a far-reaching impact on the rule of law in international human rights and the development of the human rights legal systems in various countries. A re-examination and analysis of the process of formulating the Universal Declaration of Human Rights will help us understand the purposes and objectives of the Declaration and review the great value of the spirit of the Declaration to the world today.展开更多
As a subsequent work of previous studies of authors, a new parallel computation approach is proposed to simulate the coupled dynamics of a rigid-flexible multibody system and compressible fluid. In this approach, the ...As a subsequent work of previous studies of authors, a new parallel computation approach is proposed to simulate the coupled dynamics of a rigid-flexible multibody system and compressible fluid. In this approach, the smoothed particle hydrodynamics(SPH) method is used to model the compressible fluid, the natural coordinate formulation(NCF) and absolute nodal coordinate formulation(ANCF) are used to model the rigid and flexible bodies, respectively. In order to model the compressible fluid properly and efficiently via SPH method, three measures are taken as follows. The first is to use the Riemann solver to cope with the fluid compressibility, the second is to define virtual particles of SPH to model the dynamic interaction between the fluid and the multibody system, and the third is to impose the boundary conditions of periodical inflow and outflow to reduce the number of SPH particles involved in the computation process. Afterwards, a parallel computation strategy is proposed based on the graphics processing unit(GPU) to detect the neighboring SPH particles and to solve the dynamic equations of SPH particles in order to improve the computation efficiency. Meanwhile, the generalized-alpha algorithm is used to solve the dynamic equations of the multibody system. Finally, four case studies are given to validate the proposed parallel computation approach.展开更多
Oral dissolving film(ODF)emerges as a novel active substance delivery system,offering portability,safety,and compliance.ODF presents superior gastrointestinal absorption compared to conventional food products,making i...Oral dissolving film(ODF)emerges as a novel active substance delivery system,offering portability,safety,and compliance.ODF presents superior gastrointestinal absorption compared to conventional food products,making it ideal for providing nutrition and medication support to vulnerable populations such as children,the elderly,and individuals with dysphagia.With promising applications in pharmaceuticals and especially food industry,ODFs offer a highly absorbable method for delivering nutritious and healthy foods.This review underscores the potential of orally dissolving films in active substance delivery,outlining their advantages over traditional oral delivery methods and their current market status.Additionally,the review discusses the formulation procedure,production methods,and quality evaluation methods for film dosage forms of ODFs.Lastly,it examines the limitations of ODFs and speculates on their future trends in the food industry.This study serves as a valuable reference for the development and utilization of orally dissolving films in the food sector.展开更多
基金Supported by School-level High-level Talent Project (XGY2021A022)Doctoral Research Startup Fund of Department of Science&Technology of Liaoning Province (2021-BS-252)。
文摘[Objectives]This study was conducted to optimize the Formulation Process of glucosamine chondroitin sulfate tablets. [Methods] The orthogonal design with three levels was carried out with microcrystalline cellulose, calcium hydrophosphate and cross-linked polyvinylpyrrolidone as three factors to optimize the preparation process. [Results] When microcrystalline cellulose 200 mg/tablet, calcium hydrophosphate 150 mg/tablet, and cross-linked polyvinylpyrrolidone 80 mg/tablet were added, the angle of repose could meet the requirements of tablet pressing, and the dissolution could reach more than 95% in 30 min. The results of the orthogonal test showed that the dissolution effect of self-made tablets was faster than that of commercial products. [Conclusions] The glucosamine hydrochloride chondroitin sulfate tablets prepared by this prescription have better quality.
文摘The Universal Declaration of Human Rights was the first common commitment of the international community to human rights. It demonstrated the belief and determination of humanity to maintain peace, democracy and human dignity. The process of formulating the Declaration was difficult. But in the spirit of cooperation,countries finally succeeded in reaching a consensus on human rights.The making of the Universal Declaration of Human Rights had great value and significance for promoting world peace and development,and it has had a far-reaching impact on the rule of law in international human rights and the development of the human rights legal systems in various countries. A re-examination and analysis of the process of formulating the Universal Declaration of Human Rights will help us understand the purposes and objectives of the Declaration and review the great value of the spirit of the Declaration to the world today.
基金supported by the 111 China Project(Grant No.B16003)the National Natural Science Foundation of China(Grant Nos.11290151,11702022,and 11221202)
文摘As a subsequent work of previous studies of authors, a new parallel computation approach is proposed to simulate the coupled dynamics of a rigid-flexible multibody system and compressible fluid. In this approach, the smoothed particle hydrodynamics(SPH) method is used to model the compressible fluid, the natural coordinate formulation(NCF) and absolute nodal coordinate formulation(ANCF) are used to model the rigid and flexible bodies, respectively. In order to model the compressible fluid properly and efficiently via SPH method, three measures are taken as follows. The first is to use the Riemann solver to cope with the fluid compressibility, the second is to define virtual particles of SPH to model the dynamic interaction between the fluid and the multibody system, and the third is to impose the boundary conditions of periodical inflow and outflow to reduce the number of SPH particles involved in the computation process. Afterwards, a parallel computation strategy is proposed based on the graphics processing unit(GPU) to detect the neighboring SPH particles and to solve the dynamic equations of SPH particles in order to improve the computation efficiency. Meanwhile, the generalized-alpha algorithm is used to solve the dynamic equations of the multibody system. Finally, four case studies are given to validate the proposed parallel computation approach.
基金supported by the National Natural Science Foundation of China(32202074)the Scientific Research Foundation of Shenyang Agricultural University(Grant No.880418027).
文摘Oral dissolving film(ODF)emerges as a novel active substance delivery system,offering portability,safety,and compliance.ODF presents superior gastrointestinal absorption compared to conventional food products,making it ideal for providing nutrition and medication support to vulnerable populations such as children,the elderly,and individuals with dysphagia.With promising applications in pharmaceuticals and especially food industry,ODFs offer a highly absorbable method for delivering nutritious and healthy foods.This review underscores the potential of orally dissolving films in active substance delivery,outlining their advantages over traditional oral delivery methods and their current market status.Additionally,the review discusses the formulation procedure,production methods,and quality evaluation methods for film dosage forms of ODFs.Lastly,it examines the limitations of ODFs and speculates on their future trends in the food industry.This study serves as a valuable reference for the development and utilization of orally dissolving films in the food sector.
