The hose-drogue system is a common method for soft aerial refueling,whereby the refueling tanker tows the drogue through the hose.In this paper,a mathematical-physical model of the hose-drogue system is developed and ...The hose-drogue system is a common method for soft aerial refueling,whereby the refueling tanker tows the drogue through the hose.In this paper,a mathematical-physical model of the hose-drogue system is developed and simulated using the Absolute Nodal Coordinate Formulation(ANCF)finite element method.A numerical solution program based on ANCF and ALE(Arbitrary Eulerian-Lagrange)-ANCF method was developed to simulate and analyze the horizontal and elongation release processes of the hose-drogue system at different towing points(underneath the wing and the belly of the aircraft).This program was developed by introducing an ALE description.The numerical solution program,developed based on the ANCF and ALE-ANCF methods,represents a significant advancement in computational efficiency for the rigid-flexible coupled multibody system of the air refueling hose-drogue system.This program can provide a valuable reference for the qualitative design of the hose-drogue multibody system in soft air refueling,while maintaining the necessary accuracy.展开更多
Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,stressed that we should adhere to the“two integrations”(namely,integrating the basic tenets of Marxism with China’s specific realit...Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,stressed that we should adhere to the“two integrations”(namely,integrating the basic tenets of Marxism with China’s specific realities and fine traditional culture),root ourselves in Chinese soil,carry forward the Chinese cultural heritage,and strengthen the academic foundation.We should accelerate the building of an independent knowledge system for Chinese philosophy and social sciences,and formulate original concepts and develop systems of academic discipline,research and discourse,drawing on China’s rich experience of advancing human rights.In the face of changes of a magnitude not seen in a century,in the historic process of advancing the great rejuvenation of the Chinese nation on all fronts through Chinese modernization,we should and must strengthen our theoretical self-consciousness and confidence in the path of Chinese modernization.We need to enhance human rights research,develop the human rights theoretical system and paradigm that are based on Chinese realities and express Chinese voice,and an independent Chinese knowledge system for human rights.展开更多
Skin aging is a complicated process affected by extrinsic factors such as ultraviolet(UV)radiation and environmental pollutants,in addition to intrinsic factors such as oxidative stress and cellular senescence.These f...Skin aging is a complicated process affected by extrinsic factors such as ultraviolet(UV)radiation and environmental pollutants,in addition to intrinsic factors such as oxidative stress and cellular senescence.These factors initiate inflammation,collagen breakdown,and visible signs of aging.Polyherbal formulation with multiple plant extracts with synergistic bioactive compounds offers a sustainable and scientifically proven way of modulating the interrelated pathways that contribute to skin aging.This comprehensive review features 7 key anti-aging plants,including Curcuma longa,Curcuma aromatica,Glycyrrhiza glabra,Calendula officinalis,Boehavia diffusa,Withania somnifera,and Matricaria chamomilla,and discusses their active phytoconstituents such as curcumin,glabridin,withanolides,and apigenin.These agents improve the hydration of skin,increase collagen synthesis,inhibit matrix metalloproteinases(MMPs),and modulate oxidative stress.This review emphasizes the opportunity to combine some of the most sophisticated dermal delivery methods(e.g.,liposome,ethosome,and emulgel technologies)with traditional ethnobotanical knowledge to increase bioavailability and efficacy of herbal actives.All research indicates that polyherbal formulations offer a multi-targeted,sustainable,and therapeutically viable alternative to synthetic anti-aging pharmaceuticals,bridging traditional knowledge and contemporary cosmeceutical techniques.展开更多
The state estimation of the flexible multibody systems is a vital issue since it is the base of effective control and condition monitoring.The research on the state estimation method of flexible multibody system with ...The state estimation of the flexible multibody systems is a vital issue since it is the base of effective control and condition monitoring.The research on the state estimation method of flexible multibody system with large deformation and large rotation remains rare.In this investigation,a state estimator based on multiple nonlinear Kalman filtering algorithms was designed for the flexible multibody systems containing large flexibility components that were discretized by absolute nodal coordinate formulation(ANCF).The state variable vector was constructed based on the independent coordinates which are identified through the constraint Jacobian.Three types of Kalman filters were used to compare their performance in the state estimation for ANCF.Three cases including flexible planar rotating beam,flexible four-bar mechanism,and flexible rotating shaft were employed to verify the proposed state estimator.According to the different performances of the three types of Kalman filter,suggestions were given for the construction of the state estimator for the flexible multibody system.展开更多
The thoracic duct(TD),the largest lymphatic vessel in the human body,plays a critical role in returning lymph to the circulatory system.However,its dynamic,distensible nature and concealed anatomical location make int...The thoracic duct(TD),the largest lymphatic vessel in the human body,plays a critical role in returning lymph to the circulatory system.However,its dynamic,distensible nature and concealed anatomical location make intraoperative visualization critically challenging and increase the risk of injury.Real-time,high-resolution assessment of TD leaks remains an urgent clinical need.Here,we present a breakthrough molecular engineering strategy that leverages an intestinally lipophilic fluorescent formulation for dynamic in vivo TD imaging.Our rationally designed cyanine derivative IR790+,known for its rapid membrane permeability and endoplasmic reticulum(ER)targeting localization,demonstrates unprecedented chylomicron affinity,which subsequently transports the dye through the lymphatic system to the TD.Notably,dynamic,high-contrast intraoperative TD imaging is achieved from rat models to swine models.Administered orally as near-infrared(NIR)fluorescent contrast agent,this ultra-stable IR790+@oil formulation,engineered via flash nanoprecipitation,surpasses conventional counterparts by enabling non-invasive,real-time identification of TD.Intriguingly,this first-reported ER-targeting NIR formulation,delivered orally,represents a paradigm shift in fluorescence-guided surgery,significantly improving intraoperative accuracy.展开更多
This article reviews the research advances in traditional Chinese medicine rhubarb and its compound formulations in the treatment of sepsis,with particular emphasis on elucidating their mechanisms of action and clinic...This article reviews the research advances in traditional Chinese medicine rhubarb and its compound formulations in the treatment of sepsis,with particular emphasis on elucidating their mechanisms of action and clinical application value.Research has demonstrated that rhubarb and its compound formulations exert therapeutic effects via multiple targets and mechanisms,including anti-inflammatory actions,protection of the intestinal barrier,modulation of immune balance,inhibition of oxidative stress,and regulation of associated signaling pathways.Clinically,rhubarb has shown distinct advantages in enhancing gastrointestinal function,mitigating systemic inflammatory responses,and reducing mortality rates among patients with sepsis.These findings provide a foundational reference for the integrated prevention and treatment of sepsis through the combined use of traditional Chinese and Western medicine.展开更多
Cryptorhynchus lapathi L.,a globally distributed wood-boring pest,significantly threatens poplar(Populus spp.)and willow(Salix spp.)trees.Entomopathogenic fungi(EPFs),particularly Beauveria bassiana(Bals.-Criv.)Vuilla...Cryptorhynchus lapathi L.,a globally distributed wood-boring pest,significantly threatens poplar(Populus spp.)and willow(Salix spp.)trees.Entomopathogenic fungi(EPFs),particularly Beauveria bassiana(Bals.-Criv.)Vuilla,play a crucial role in integrated pest management because of their broad-spectrum insecticidal properties.This study clarifies the pathogenic mechanisms of B.bassiana CFCC81428 treatment and its oil-based formulation against male and female C.lapathi adults,alongside their impacts on cumulative mortality,enzyme activity and nutrient metabolism.The results indicated that the oil-based formulation significantly enhanced B.bassiana pathogenicity,achieving cumulative mortality rates of 91.7%and 83.8%for male and female adults,respectively,with LT50 values of 7.9 and 8.7 d,markedly outperforming the B.bassiana treatment.Scanning electron microscopy revealed that the oil-based formulation improved spore adhesion to the insects'cuticle,accelerated spore germination and hyphal growth,and significantly improved cuticular penetration efficiency.Within the host,the activities of detoxification enzymes(GST and CarE)were upregulated,whereas the activities of catalase and peroxidase enzymes were suppressed.Superoxide dismutase activity remained elevated throughout most of the observation time points.Polyphenol oxidase activity significantly increased between 24 and120 h postinfection,indicating its critical role in preventing B.bassiana invasion.The infection also triggered substantial shifts in the host's nutrient metabolism,with time-dependent changes observed in carbohydrates,free fatty acids,and soluble proteins.The oil-based formulation exacerbated the depletion of these nutrients,ultimately leading to metabolic collapse.This study indicates that the oil-based formulation optimizes spore germination conditions and accelerates infection,thereby significantly increasing B.bassiana pathogenicity in C.lapathi males,whereas female adults exhibited stronger physiological and metabolic responses,providing new insights for the application of B.bassiana in the biological control of pests.展开更多
Recently,with the efforts of food specialists,protein sources in the diet is rapidly changing.Consequently,novel products based on plant proteins or lab-grown proteins are increasingly being introduced to consumers.Ho...Recently,with the efforts of food specialists,protein sources in the diet is rapidly changing.Consequently,novel products based on plant proteins or lab-grown proteins are increasingly being introduced to consumers.However,the food industry is facing new challenges in creating natural,innovative,accessible,and nutritious dairy-free alternatives.Designing dairy-free cheese alternatives with beneficial nutritional profiles,bioavailability,and digestibility requires a thorough understanding of the molecular characteristics of plant-derived ingredients,their structural assembly,and their role in physicochemical and sensory properties of the final product.In other words,with a deep knowledge of the nature of plant-based ingredients and the intelligent control of intermolecular interactions,these ingredients can be used to produce dairy-free cheese alternatives with the same characteristics as dairy products.Therefore,this review aims to synthesize current knowledge on production techniques and key factors influencing the design of dairy-free cheese alternatives.By examining the interactions between carbohydrates,proteins,and other ingredients,as well as their ability to replicate the functional and textural properties of traditional dairy cheeses,this review provides valuable insights for the development of high-quality dairy-free cheese alternatives.In the design of these alternatives,fractionation and tissue disruption routes are employed.The difference in the number and distribution of their surface groups has a significant effect on ability of plant polysaccharides and proteins to interact with other molecules.Gel strength decreases with decreasing plant biopolymer concentration,bond strength,and crosslinking density.While heat treatment can unfold proteins and minimize their net charge,the hydrophobic attraction becomes the primary driver of protein-protein interactions in plant-based cheeses.In contrast,the 3D-structure of dairy cheeses is stabilized through a combination of hydrophobic interactions,hydrogen bonds,and calcium bridges.展开更多
We present a novel approach for calculating the energy budget components during the progressive failure process in cohesive-frictional geomaterials.The energy supplied through external loading can be either stored as ...We present a novel approach for calculating the energy budget components during the progressive failure process in cohesive-frictional geomaterials.The energy supplied through external loading can be either stored as elastic strain energy and plastic energy storage or dissipated through damage growth and irreversible plastic deformation mechanisms.Analytical functions describing energy budget components are derived based on a thermodynamic formulation in geomaterials fracture.The thermodynamically consistent derivation leads to a non-local ductile damage model,which is solved numerically in a non-linear finite element framework.The proposed model captures geomaterial fractures in three benchmark examples,including tensile and biaxial-compressive shear scenarios and slope stability analysis.The aspects of shear fracture propagation and energy budget mechanisms are elaborately investigated,considering different material properties and stochastic distributions.The numerical results are validated against existing experimental data and other analytical methods.The model provides a physics-based understanding of energy budget in geomaterials fracture,leading to advances in ground improvement and other geotechnical supporting systems.展开更多
Quasi-periodic solutions with multiple base frequencies exhibit the feature of 2π-periodicity with respect to each of the hyper-time variables.However,it remains a challenge work,due to the lack of effective solution...Quasi-periodic solutions with multiple base frequencies exhibit the feature of 2π-periodicity with respect to each of the hyper-time variables.However,it remains a challenge work,due to the lack of effective solution methods,to solve and track the quasi-periodic solutions with multiple base frequencies until now.In this work,a multi-steps variable-coefficient formulation is proposed,which provides a unified framework to enable either harmonic balance method or collocation method or finite difference method to solve quasi-periodic solutions with multiple base frequencies.For this purpose,a method of alternating U and S domain is also developed to efficiently evaluate the nonlinear force terms.Furthermore,a new robust phase condition is presented for all of the three methods to make them track the quasi-periodic solutions with prior unknown multiple base frequencies,while the stability of the quasi-periodic solutions is assessed by mean of Lyapunov exponents.The feasibility of the constructed methods under the above framework is verified by application to three nonlinear systems.展开更多
Formulations of Gaviscon based on novel alginate raft forming system have been developed to prevent gastroesophageal reflux disease（GERD） symptoms. Alginate gel becomes buoyant and CO2-aerated as soon as Gaviscon co...Formulations of Gaviscon based on novel alginate raft forming system have been developed to prevent gastroesophageal reflux disease（GERD） symptoms. Alginate gel becomes buoyant and CO2-aerated as soon as Gaviscon comes into contact with gastric contents. This system can be characterized by several indicators, such as strength or coherence, volume, buoyancy, reflux resistance and resilience. In addition, the strength of the raft is influenced by many factors, such as molecular weight and the ratio of D-mannuronic and L-guluronic acid residues（M/G）, which are intrinsic factors in this formulation. Besides, there are several extrinsic factors, such as the presence of specific cations, the amount of carbon dioxide generated and entrapped in the raft. This review focused on how to evaluate the raft, introduced some factors that impact the raft and summarized the degradation of alginate and future advance.展开更多
In this paper, nonlinear modeling for flexible multibody system with large deformation is investigated. Absolute nodal coordinates are employed to describe the displacement, and variational motion equations of a flexi...In this paper, nonlinear modeling for flexible multibody system with large deformation is investigated. Absolute nodal coordinates are employed to describe the displacement, and variational motion equations of a flexible body are derived on the basis of the geometric nonlinear theory, in which both the shear strain and the transverse normal strain are taken into account. By separating the inner and the boundary nodal coordinates, the motion equations of a flexible multibody system are assembled. The advantage of such formulation is that the constraint equations and the forward recursive equations become linear because the absolute nodal coordinates are used. A spatial double pendulum connected to the ground with a spherical joint is simulated to investigate the dynamic performance of flexible beams with large deformation. Finally, the resultant constant total energy validates the present formulation.展开更多
The previous low-order approximate nonlinear formulations succeeded in capturing the stiffening terms, but failed in simulation of mechanical systems with large deformation due to the neglect of the high-order deforma...The previous low-order approximate nonlinear formulations succeeded in capturing the stiffening terms, but failed in simulation of mechanical systems with large deformation due to the neglect of the high-order deformation terms. In this paper, a new hybrid-coordinate formulation is proposed, which is suitable for flexible multibody systems with large deformation. On the basis of exact strain- displacement relation, equations of motion for flexible multi-body system are derived by using virtual work principle. A matrix separation method is put forward to improve the efficiency of the calculation. Agreement of the present results with those obtained by absolute nodal coordinate formulation （ANCF） verifies the correctness of the proposed formulation. Furthermore, the present results are compared with those obtained by use of the linear model and the low-order approximate nonlinear model to show the suitability of the proposed models.展开更多
This paper presents extensions to the traditional calculus of variations for mechanico-electrical systems containing fractional derivatives. The Euler Lagrange equations and the Hamilton formalism of the mechanico-ele...This paper presents extensions to the traditional calculus of variations for mechanico-electrical systems containing fractional derivatives. The Euler Lagrange equations and the Hamilton formalism of the mechanico-electrical systems with fractional derivatives are established. The definition and the criteria for the fractional generalized Noether quasi- symmetry are presented. Furthermore, the fractional Noether theorem and conseved quantities of the systems are obtained by virtue of the invariance of the Hamiltonian action under the infinitesimal transformations. An example is presented to illustrate the application of the results.展开更多
Androgens have an intense consequence on the human scalp and body hair.Scalp hair sprouts fundamentally in awol of androgens whereas the body hair hike is vulnerable to the activity of androgens.Androgenetic alopecia(...Androgens have an intense consequence on the human scalp and body hair.Scalp hair sprouts fundamentally in awol of androgens whereas the body hair hike is vulnerable to the activity of androgens.Androgenetic alopecia(AGA)invoked as males emulate Alopecia due to the cause of the dynamic reduction of scalp hair.Androgens are medium of terminus growth of hair although the body.Local and system androgens convert the extensive terminal follicles into lesser vellus like structure.The out start of this type of alopecia is intensely irregular and the reason behind this existence of enough circulating steroidal hormones androgens and due to genetic predisposition.Effective treatments are available in the market as well as under clinical and preclinical testing.Many herbal formulations are also available but not FDA approved.Different conventional and NDDS formulations are already available in the market.To avoid various systemic side effects of both Finasteride and Minoxidil,topical formulations and natural products(nutrients,minerals,vitamins)now a days are being widely used to treat Androgenic alopecia.CAM(complementary and alternative medicine)provides the option to elect favorable,low-risk,adjuvant and alternative therapies.Herein,we offer a widespread review of topical marketed formulations,natural products,and CAM treatment options for AGA.展开更多
The major challenge faced by today's pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration,especially for the ...The major challenge faced by today's pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration,especially for the treatment of anterior segment diseases. Delivery of drugs to the targeted ocular tissues is restricted by various precorneal,dynamic and static ocular barriers. Also,therapeutic drug levels are not maintained for longer duration in target tissues. In the past two decades,ocular drug delivery research acceleratedly advanced towards developing a novel,safe and patient compliant formulation and drug delivery devices/techniques,which may surpass these barriers and maintain drug levels in tissues. Anterior segment drug delivery advances are witnessed by modulation of conventional topical solutions with permeation and viscosity enhancers. Also,it includes development of conventional topical formulations such as suspensions,emulsions and ointments. Various nanoformulations have also been introduced for anterior segment ocular drug delivery. On the other hand,for posterior ocular delivery,research has been immensely focused towards development of drug releasing devices and nanoformulations for treating chronic vitreo-retinal diseases. These novel devices and/or formulations may help to surpass ocular barriers and associated side effects with conventional topicaldrops. Also,these novel devices and/or formulations are easy to formulate,no/negligibly irritating,possess high precorneal residence time,sustain the drug release,and enhance ocular bioavailability of therapeutics. An update of current research advancement in ocular drug delivery necessitates and helps drug delivery scientists to modulate their think process and develop novel and safe drug delivery strategies. Current review intends to summarize the existing conventional formulations for ocular delivery and their advancements followed by current nanotechnology based formulation developments. Also,recent developments with other ocular drug delivery strategies employing in situ gels,implants,contact lens and microneedles have been discussed.展开更多
The therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus(HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility and consequnt low bioavailability. ...The therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus(HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility and consequnt low bioavailability. Thus, we aimed to design a supersaturated selfmicroemulsifying drug delivery system(S-SMEDDS) that can maintain a high concentration of saquinavir in gastro-intestinal fluid thorugh inhibiting the drug precipitation to enhance the lymphatic transport of saquinavir and to increase the bioavailability of saquinavir considerably. Solubilizing capacity of different oils, surfactants, and cosurfactants for saquinavir was evaluated to select optimal ingredients for preparation of SMEDDS.Through the construction of pseudo-ternary phase diagram, SMEDDS formulations were established. A polymer as a precipitation inhibitor was selected based on its viscosity and drug precipitation inhibiting capacity. The S-SMEDDS and SMEDDS designed were administered at an equal dose to rats. At predetermined time points, levels of saquinavir in lymph collected from the rats were assessed. SMEDDS prepared presented a proper selfmicroemulsification efficiency and dispersion stability. The S-SMEDDS fabricated using the SMEDDS and hydroxypropyl methyl cellulose 2910 as a precipitation inhibitor exhibited a signficantly enhanced solubilizing capacity for saquinavir. The drug concentration in a simulated intestinal fluid evaluated with the S-SMEDDS was also maintained at higher levels for prolonged time than that examined with the SMEDDS. The S-SMEDDS showed a considerably enhanced lymphatic absoprtion of saquinavir in rats compared to the SMEDDS.Therefore, the S-SMEDDS would be usefully exploited to enhance the lymphatic absorption of hydrophobic drugs that need to be targeted to the lymphatic system.展开更多
Since the start of the Precision Medicine Initiative by the United States of America in 2015,interest in personalized medicine has grown extensively.In short,personalized medicine is a term that describes medical trea...Since the start of the Precision Medicine Initiative by the United States of America in 2015,interest in personalized medicine has grown extensively.In short,personalized medicine is a term that describes medical treatment that is tuned to the individual.One possible way to realize personalized medicine is 3D printing.When using materials that can be tuned upon stimulation,4D printing is established.In recent years,many studies have been exploring a new field that combines 3D and 4D printing with therapeutics.This has resulted in many concepts of pharmaceutical devices and formulations that can be printed and,possibly,tailored to an individual.Moreover,the first 3D printed drug,Spritam®,has already found its way to the clinic.This review gives an overview of various 3D and 4D printing techniques and their applications in the pharmaceutical field as drug delivery systems and personalized medicine.展开更多
Methods based on numerical optimization are useful and effective in the design of control systems. This paper describes the design of retarded fractional delay differential systems （RFDDSs） by the method of inequali...Methods based on numerical optimization are useful and effective in the design of control systems. This paper describes the design of retarded fractional delay differential systems （RFDDSs） by the method of inequalities, in which the design problem is formulated so that it is suitable for solution by numerical methods. Zakian＇s original formulation, which was first proposed in connection with rational systems, is extended to the case of RFDDSs. In making the use of this formulation possible for RFDDSs, the associated stability problems are resolved by using the stability test and the numerical algorithm for computing the abscissa of stability recently developed by the authors. During the design process, the time responses are obtained by a known method for the numerical inversion of Laplace transforms. Two numerical examples are given, where fractional controllers are designed for a time-delay and a heat-conduction plants.展开更多
In the present study,the dynamics of the tendon system of a tension-leg platform(TLP)is investigated through the absolute nodal coordinate formulation(ANCF).Based on the energy conversion principle,the stiffness,gener...In the present study,the dynamics of the tendon system of a tension-leg platform(TLP)is investigated through the absolute nodal coordinate formulation(ANCF).Based on the energy conversion principle,the stiffness,generalized elastic force,external load and mass matrices of the element are deduced to perform the element assembling by using the finite element method.Then the motion equation of the tendon/riser is established.In this study,the TLP in the International Ship Structures Committee(ISSC)model under the first and second wave forces is considered as the case study.The simulation is performed in the MATLAB environment.Moreover,the accuracy and reliability of the programs are verified for cases of beam model with theoretical solutions.It is found that the motion response of tendons is affected by the TLP movement and environmental load,simultaneously.Then,the motion response is calculated using the SESAM software and exported as the boundary of ANCF tendons.Finally,the static and dynamic characteristics of the four tendons of ISSC TLP are analyzed systematically by the ANCF method.Performed analysis proves the effectiveness and feasibility of the ANCF method.It is concluded that the proposed method is a powerful scheme for calculating the dynamics of tendon/riser in the field of ocean engineering.展开更多
基金the support from the National Natural Science Foundation of China(No.52472384)the Fundamental Research Funds for the Central Universities,China(No.G2024KY0615)+1 种基金sponsored by the Foundations of National Key Laboratory of Unmanned Aerial Vehicle Technology in NPU,(No.WR202411-2)the National Key Laboratory of Aircraft Configuration Design,China(No.JBGS-2024-01)。
文摘The hose-drogue system is a common method for soft aerial refueling,whereby the refueling tanker tows the drogue through the hose.In this paper,a mathematical-physical model of the hose-drogue system is developed and simulated using the Absolute Nodal Coordinate Formulation(ANCF)finite element method.A numerical solution program based on ANCF and ALE(Arbitrary Eulerian-Lagrange)-ANCF method was developed to simulate and analyze the horizontal and elongation release processes of the hose-drogue system at different towing points(underneath the wing and the belly of the aircraft).This program was developed by introducing an ALE description.The numerical solution program,developed based on the ANCF and ALE-ANCF methods,represents a significant advancement in computational efficiency for the rigid-flexible coupled multibody system of the air refueling hose-drogue system.This program can provide a valuable reference for the qualitative design of the hose-drogue multibody system in soft air refueling,while maintaining the necessary accuracy.
文摘Xi Jinping,general secretary of the Communist Party of China(CPC)Central Committee,stressed that we should adhere to the“two integrations”(namely,integrating the basic tenets of Marxism with China’s specific realities and fine traditional culture),root ourselves in Chinese soil,carry forward the Chinese cultural heritage,and strengthen the academic foundation.We should accelerate the building of an independent knowledge system for Chinese philosophy and social sciences,and formulate original concepts and develop systems of academic discipline,research and discourse,drawing on China’s rich experience of advancing human rights.In the face of changes of a magnitude not seen in a century,in the historic process of advancing the great rejuvenation of the Chinese nation on all fronts through Chinese modernization,we should and must strengthen our theoretical self-consciousness and confidence in the path of Chinese modernization.We need to enhance human rights research,develop the human rights theoretical system and paradigm that are based on Chinese realities and express Chinese voice,and an independent Chinese knowledge system for human rights.
文摘Skin aging is a complicated process affected by extrinsic factors such as ultraviolet(UV)radiation and environmental pollutants,in addition to intrinsic factors such as oxidative stress and cellular senescence.These factors initiate inflammation,collagen breakdown,and visible signs of aging.Polyherbal formulation with multiple plant extracts with synergistic bioactive compounds offers a sustainable and scientifically proven way of modulating the interrelated pathways that contribute to skin aging.This comprehensive review features 7 key anti-aging plants,including Curcuma longa,Curcuma aromatica,Glycyrrhiza glabra,Calendula officinalis,Boehavia diffusa,Withania somnifera,and Matricaria chamomilla,and discusses their active phytoconstituents such as curcumin,glabridin,withanolides,and apigenin.These agents improve the hydration of skin,increase collagen synthesis,inhibit matrix metalloproteinases(MMPs),and modulate oxidative stress.This review emphasizes the opportunity to combine some of the most sophisticated dermal delivery methods(e.g.,liposome,ethosome,and emulgel technologies)with traditional ethnobotanical knowledge to increase bioavailability and efficacy of herbal actives.All research indicates that polyherbal formulations offer a multi-targeted,sustainable,and therapeutically viable alternative to synthetic anti-aging pharmaceuticals,bridging traditional knowledge and contemporary cosmeceutical techniques.
基金supported by the National Natural Science Foundation of China(Grant Nos.12272123 and 12302047)the Natural Science Foundation of Jiangsu Province(Grant No.BK20231185)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(Grant No.SJCX24_0192).
文摘The state estimation of the flexible multibody systems is a vital issue since it is the base of effective control and condition monitoring.The research on the state estimation method of flexible multibody system with large deformation and large rotation remains rare.In this investigation,a state estimator based on multiple nonlinear Kalman filtering algorithms was designed for the flexible multibody systems containing large flexibility components that were discretized by absolute nodal coordinate formulation(ANCF).The state variable vector was constructed based on the independent coordinates which are identified through the constraint Jacobian.Three types of Kalman filters were used to compare their performance in the state estimation for ANCF.Three cases including flexible planar rotating beam,flexible four-bar mechanism,and flexible rotating shaft were employed to verify the proposed state estimator.According to the different performances of the three types of Kalman filter,suggestions were given for the construction of the state estimator for the flexible multibody system.
基金supported by the National Natural Science Foundation of China(22225805,81400681,32394001,32121005)the Shanghai Science and Technology Innovation Action Plan(22Y11907200,23J21901600)the Innovation Program of Shanghai Municipal Education Commission,Shanghai Municipal Health Commission(2024ZZ2025)。
文摘The thoracic duct(TD),the largest lymphatic vessel in the human body,plays a critical role in returning lymph to the circulatory system.However,its dynamic,distensible nature and concealed anatomical location make intraoperative visualization critically challenging and increase the risk of injury.Real-time,high-resolution assessment of TD leaks remains an urgent clinical need.Here,we present a breakthrough molecular engineering strategy that leverages an intestinally lipophilic fluorescent formulation for dynamic in vivo TD imaging.Our rationally designed cyanine derivative IR790+,known for its rapid membrane permeability and endoplasmic reticulum(ER)targeting localization,demonstrates unprecedented chylomicron affinity,which subsequently transports the dye through the lymphatic system to the TD.Notably,dynamic,high-contrast intraoperative TD imaging is achieved from rat models to swine models.Administered orally as near-infrared(NIR)fluorescent contrast agent,this ultra-stable IR790+@oil formulation,engineered via flash nanoprecipitation,surpasses conventional counterparts by enabling non-invasive,real-time identification of TD.Intriguingly,this first-reported ER-targeting NIR formulation,delivered orally,represents a paradigm shift in fluorescence-guided surgery,significantly improving intraoperative accuracy.
基金Supported by National Natural Science Foundation of China(82374346)Double Hundred Outstanding Young and Middle-aged Medical and Health Talents of Wuxi City(BJ2023071)Scientific Research Project of Wuxi Municipal Health Commission(Q202358).
文摘This article reviews the research advances in traditional Chinese medicine rhubarb and its compound formulations in the treatment of sepsis,with particular emphasis on elucidating their mechanisms of action and clinical application value.Research has demonstrated that rhubarb and its compound formulations exert therapeutic effects via multiple targets and mechanisms,including anti-inflammatory actions,protection of the intestinal barrier,modulation of immune balance,inhibition of oxidative stress,and regulation of associated signaling pathways.Clinically,rhubarb has shown distinct advantages in enhancing gastrointestinal function,mitigating systemic inflammatory responses,and reducing mortality rates among patients with sepsis.These findings provide a foundational reference for the integrated prevention and treatment of sepsis through the combined use of traditional Chinese and Western medicine.
基金supported by the“Applied Technology Research and Development Project of Heilongjiang Province(GA20B401-2)”“The Key Research and Development Project of Heilongjiang Province(2023ZX02B05)”。
文摘Cryptorhynchus lapathi L.,a globally distributed wood-boring pest,significantly threatens poplar(Populus spp.)and willow(Salix spp.)trees.Entomopathogenic fungi(EPFs),particularly Beauveria bassiana(Bals.-Criv.)Vuilla,play a crucial role in integrated pest management because of their broad-spectrum insecticidal properties.This study clarifies the pathogenic mechanisms of B.bassiana CFCC81428 treatment and its oil-based formulation against male and female C.lapathi adults,alongside their impacts on cumulative mortality,enzyme activity and nutrient metabolism.The results indicated that the oil-based formulation significantly enhanced B.bassiana pathogenicity,achieving cumulative mortality rates of 91.7%and 83.8%for male and female adults,respectively,with LT50 values of 7.9 and 8.7 d,markedly outperforming the B.bassiana treatment.Scanning electron microscopy revealed that the oil-based formulation improved spore adhesion to the insects'cuticle,accelerated spore germination and hyphal growth,and significantly improved cuticular penetration efficiency.Within the host,the activities of detoxification enzymes(GST and CarE)were upregulated,whereas the activities of catalase and peroxidase enzymes were suppressed.Superoxide dismutase activity remained elevated throughout most of the observation time points.Polyphenol oxidase activity significantly increased between 24 and120 h postinfection,indicating its critical role in preventing B.bassiana invasion.The infection also triggered substantial shifts in the host's nutrient metabolism,with time-dependent changes observed in carbohydrates,free fatty acids,and soluble proteins.The oil-based formulation exacerbated the depletion of these nutrients,ultimately leading to metabolic collapse.This study indicates that the oil-based formulation optimizes spore germination conditions and accelerates infection,thereby significantly increasing B.bassiana pathogenicity in C.lapathi males,whereas female adults exhibited stronger physiological and metabolic responses,providing new insights for the application of B.bassiana in the biological control of pests.
基金funding from the European Union's Horizon 2022 Research and Innovation Programme under the Marie Sklodowska-Curie(MSCA-Postdoctoral Fellowships 2022),grant agreement No.101105558-NovelPBC-HORIZON-MSCA-2022-PF-01。
文摘Recently,with the efforts of food specialists,protein sources in the diet is rapidly changing.Consequently,novel products based on plant proteins or lab-grown proteins are increasingly being introduced to consumers.However,the food industry is facing new challenges in creating natural,innovative,accessible,and nutritious dairy-free alternatives.Designing dairy-free cheese alternatives with beneficial nutritional profiles,bioavailability,and digestibility requires a thorough understanding of the molecular characteristics of plant-derived ingredients,their structural assembly,and their role in physicochemical and sensory properties of the final product.In other words,with a deep knowledge of the nature of plant-based ingredients and the intelligent control of intermolecular interactions,these ingredients can be used to produce dairy-free cheese alternatives with the same characteristics as dairy products.Therefore,this review aims to synthesize current knowledge on production techniques and key factors influencing the design of dairy-free cheese alternatives.By examining the interactions between carbohydrates,proteins,and other ingredients,as well as their ability to replicate the functional and textural properties of traditional dairy cheeses,this review provides valuable insights for the development of high-quality dairy-free cheese alternatives.In the design of these alternatives,fractionation and tissue disruption routes are employed.The difference in the number and distribution of their surface groups has a significant effect on ability of plant polysaccharides and proteins to interact with other molecules.Gel strength decreases with decreasing plant biopolymer concentration,bond strength,and crosslinking density.While heat treatment can unfold proteins and minimize their net charge,the hydrophobic attraction becomes the primary driver of protein-protein interactions in plant-based cheeses.In contrast,the 3D-structure of dairy cheeses is stabilized through a combination of hydrophobic interactions,hydrogen bonds,and calcium bridges.
基金supported by the National Natural Science Foundation of China(Grant No.52179128)the Sand Hazards and Opportunities for Resilience,Energy,and Sustainability(SHORES)Center,funded by Tamkeen under the NYUAD Research Institute Award CG013.
文摘We present a novel approach for calculating the energy budget components during the progressive failure process in cohesive-frictional geomaterials.The energy supplied through external loading can be either stored as elastic strain energy and plastic energy storage or dissipated through damage growth and irreversible plastic deformation mechanisms.Analytical functions describing energy budget components are derived based on a thermodynamic formulation in geomaterials fracture.The thermodynamically consistent derivation leads to a non-local ductile damage model,which is solved numerically in a non-linear finite element framework.The proposed model captures geomaterial fractures in three benchmark examples,including tensile and biaxial-compressive shear scenarios and slope stability analysis.The aspects of shear fracture propagation and energy budget mechanisms are elaborately investigated,considering different material properties and stochastic distributions.The numerical results are validated against existing experimental data and other analytical methods.The model provides a physics-based understanding of energy budget in geomaterials fracture,leading to advances in ground improvement and other geotechnical supporting systems.
基金supported by the National Natural Science Foundation of China(Grant Nos.12172267 and 12302014).
文摘Quasi-periodic solutions with multiple base frequencies exhibit the feature of 2π-periodicity with respect to each of the hyper-time variables.However,it remains a challenge work,due to the lack of effective solution methods,to solve and track the quasi-periodic solutions with multiple base frequencies until now.In this work,a multi-steps variable-coefficient formulation is proposed,which provides a unified framework to enable either harmonic balance method or collocation method or finite difference method to solve quasi-periodic solutions with multiple base frequencies.For this purpose,a method of alternating U and S domain is also developed to efficiently evaluate the nonlinear force terms.Furthermore,a new robust phase condition is presented for all of the three methods to make them track the quasi-periodic solutions with prior unknown multiple base frequencies,while the stability of the quasi-periodic solutions is assessed by mean of Lyapunov exponents.The feasibility of the constructed methods under the above framework is verified by application to three nonlinear systems.
文摘Formulations of Gaviscon based on novel alginate raft forming system have been developed to prevent gastroesophageal reflux disease（GERD） symptoms. Alginate gel becomes buoyant and CO2-aerated as soon as Gaviscon comes into contact with gastric contents. This system can be characterized by several indicators, such as strength or coherence, volume, buoyancy, reflux resistance and resilience. In addition, the strength of the raft is influenced by many factors, such as molecular weight and the ratio of D-mannuronic and L-guluronic acid residues（M/G）, which are intrinsic factors in this formulation. Besides, there are several extrinsic factors, such as the presence of specific cations, the amount of carbon dioxide generated and entrapped in the raft. This review focused on how to evaluate the raft, introduced some factors that impact the raft and summarized the degradation of alginate and future advance.
基金The project supported by the National Natural Science Foundation of China(10472066,10372057)The English text was polished by Yunming Chen.
文摘In this paper, nonlinear modeling for flexible multibody system with large deformation is investigated. Absolute nodal coordinates are employed to describe the displacement, and variational motion equations of a flexible body are derived on the basis of the geometric nonlinear theory, in which both the shear strain and the transverse normal strain are taken into account. By separating the inner and the boundary nodal coordinates, the motion equations of a flexible multibody system are assembled. The advantage of such formulation is that the constraint equations and the forward recursive equations become linear because the absolute nodal coordinates are used. A spatial double pendulum connected to the ground with a spherical joint is simulated to investigate the dynamic performance of flexible beams with large deformation. Finally, the resultant constant total energy validates the present formulation.
基金the National Natural Science Foundation of China(10472066,50475021).
文摘The previous low-order approximate nonlinear formulations succeeded in capturing the stiffening terms, but failed in simulation of mechanical systems with large deformation due to the neglect of the high-order deformation terms. In this paper, a new hybrid-coordinate formulation is proposed, which is suitable for flexible multibody systems with large deformation. On the basis of exact strain- displacement relation, equations of motion for flexible multi-body system are derived by using virtual work principle. A matrix separation method is put forward to improve the efficiency of the calculation. Agreement of the present results with those obtained by absolute nodal coordinate formulation （ANCF） verifies the correctness of the proposed formulation. Furthermore, the present results are compared with those obtained by use of the linear model and the low-order approximate nonlinear model to show the suitability of the proposed models.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 11072218 and 60575055)
文摘This paper presents extensions to the traditional calculus of variations for mechanico-electrical systems containing fractional derivatives. The Euler Lagrange equations and the Hamilton formalism of the mechanico-electrical systems with fractional derivatives are established. The definition and the criteria for the fractional generalized Noether quasi- symmetry are presented. Furthermore, the fractional Noether theorem and conseved quantities of the systems are obtained by virtue of the invariance of the Hamiltonian action under the infinitesimal transformations. An example is presented to illustrate the application of the results.
文摘Androgens have an intense consequence on the human scalp and body hair.Scalp hair sprouts fundamentally in awol of androgens whereas the body hair hike is vulnerable to the activity of androgens.Androgenetic alopecia(AGA)invoked as males emulate Alopecia due to the cause of the dynamic reduction of scalp hair.Androgens are medium of terminus growth of hair although the body.Local and system androgens convert the extensive terminal follicles into lesser vellus like structure.The out start of this type of alopecia is intensely irregular and the reason behind this existence of enough circulating steroidal hormones androgens and due to genetic predisposition.Effective treatments are available in the market as well as under clinical and preclinical testing.Many herbal formulations are also available but not FDA approved.Different conventional and NDDS formulations are already available in the market.To avoid various systemic side effects of both Finasteride and Minoxidil,topical formulations and natural products(nutrients,minerals,vitamins)now a days are being widely used to treat Androgenic alopecia.CAM(complementary and alternative medicine)provides the option to elect favorable,low-risk,adjuvant and alternative therapies.Herein,we offer a widespread review of topical marketed formulations,natural products,and CAM treatment options for AGA.
文摘The major challenge faced by today's pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration,especially for the treatment of anterior segment diseases. Delivery of drugs to the targeted ocular tissues is restricted by various precorneal,dynamic and static ocular barriers. Also,therapeutic drug levels are not maintained for longer duration in target tissues. In the past two decades,ocular drug delivery research acceleratedly advanced towards developing a novel,safe and patient compliant formulation and drug delivery devices/techniques,which may surpass these barriers and maintain drug levels in tissues. Anterior segment drug delivery advances are witnessed by modulation of conventional topical solutions with permeation and viscosity enhancers. Also,it includes development of conventional topical formulations such as suspensions,emulsions and ointments. Various nanoformulations have also been introduced for anterior segment ocular drug delivery. On the other hand,for posterior ocular delivery,research has been immensely focused towards development of drug releasing devices and nanoformulations for treating chronic vitreo-retinal diseases. These novel devices and/or formulations may help to surpass ocular barriers and associated side effects with conventional topicaldrops. Also,these novel devices and/or formulations are easy to formulate,no/negligibly irritating,possess high precorneal residence time,sustain the drug release,and enhance ocular bioavailability of therapeutics. An update of current research advancement in ocular drug delivery necessitates and helps drug delivery scientists to modulate their think process and develop novel and safe drug delivery strategies. Current review intends to summarize the existing conventional formulations for ocular delivery and their advancements followed by current nanotechnology based formulation developments. Also,recent developments with other ocular drug delivery strategies employing in situ gels,implants,contact lens and microneedles have been discussed.
基金the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIP)(no.2015R1A5A1008958)supported by the Industry Technology Development Program(10077593)funded by the Ministry of Trade,Industry&Energy(MOTIE,Korea)。
文摘The therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus(HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility and consequnt low bioavailability. Thus, we aimed to design a supersaturated selfmicroemulsifying drug delivery system(S-SMEDDS) that can maintain a high concentration of saquinavir in gastro-intestinal fluid thorugh inhibiting the drug precipitation to enhance the lymphatic transport of saquinavir and to increase the bioavailability of saquinavir considerably. Solubilizing capacity of different oils, surfactants, and cosurfactants for saquinavir was evaluated to select optimal ingredients for preparation of SMEDDS.Through the construction of pseudo-ternary phase diagram, SMEDDS formulations were established. A polymer as a precipitation inhibitor was selected based on its viscosity and drug precipitation inhibiting capacity. The S-SMEDDS and SMEDDS designed were administered at an equal dose to rats. At predetermined time points, levels of saquinavir in lymph collected from the rats were assessed. SMEDDS prepared presented a proper selfmicroemulsification efficiency and dispersion stability. The S-SMEDDS fabricated using the SMEDDS and hydroxypropyl methyl cellulose 2910 as a precipitation inhibitor exhibited a signficantly enhanced solubilizing capacity for saquinavir. The drug concentration in a simulated intestinal fluid evaluated with the S-SMEDDS was also maintained at higher levels for prolonged time than that examined with the SMEDDS. The S-SMEDDS showed a considerably enhanced lymphatic absoprtion of saquinavir in rats compared to the SMEDDS.Therefore, the S-SMEDDS would be usefully exploited to enhance the lymphatic absorption of hydrophobic drugs that need to be targeted to the lymphatic system.
文摘Since the start of the Precision Medicine Initiative by the United States of America in 2015,interest in personalized medicine has grown extensively.In short,personalized medicine is a term that describes medical treatment that is tuned to the individual.One possible way to realize personalized medicine is 3D printing.When using materials that can be tuned upon stimulation,4D printing is established.In recent years,many studies have been exploring a new field that combines 3D and 4D printing with therapeutics.This has resulted in many concepts of pharmaceutical devices and formulations that can be printed and,possibly,tailored to an individual.Moreover,the first 3D printed drug,Spritam®,has already found its way to the clinic.This review gives an overview of various 3D and 4D printing techniques and their applications in the pharmaceutical field as drug delivery systems and personalized medicine.
基金supported by the AUN/SEED-Net collaborative research program.
文摘Methods based on numerical optimization are useful and effective in the design of control systems. This paper describes the design of retarded fractional delay differential systems （RFDDSs） by the method of inequalities, in which the design problem is formulated so that it is suitable for solution by numerical methods. Zakian＇s original formulation, which was first proposed in connection with rational systems, is extended to the case of RFDDSs. In making the use of this formulation possible for RFDDSs, the associated stability problems are resolved by using the stability test and the numerical algorithm for computing the abscissa of stability recently developed by the authors. During the design process, the time responses are obtained by a known method for the numerical inversion of Laplace transforms. Two numerical examples are given, where fractional controllers are designed for a time-delay and a heat-conduction plants.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.51879047 and 51890915)the Engineering Development Program of Deepwater Semi-submersible Production Storage and Unloading Platform of China(Grant No.SSBQ-2020-HN-03-03)the Natural Science Foundation of Heilongjiang Province of China(Grant No.E2017029)。
文摘In the present study,the dynamics of the tendon system of a tension-leg platform(TLP)is investigated through the absolute nodal coordinate formulation(ANCF).Based on the energy conversion principle,the stiffness,generalized elastic force,external load and mass matrices of the element are deduced to perform the element assembling by using the finite element method.Then the motion equation of the tendon/riser is established.In this study,the TLP in the International Ship Structures Committee(ISSC)model under the first and second wave forces is considered as the case study.The simulation is performed in the MATLAB environment.Moreover,the accuracy and reliability of the programs are verified for cases of beam model with theoretical solutions.It is found that the motion response of tendons is affected by the TLP movement and environmental load,simultaneously.Then,the motion response is calculated using the SESAM software and exported as the boundary of ANCF tendons.Finally,the static and dynamic characteristics of the four tendons of ISSC TLP are analyzed systematically by the ANCF method.Performed analysis proves the effectiveness and feasibility of the ANCF method.It is concluded that the proposed method is a powerful scheme for calculating the dynamics of tendon/riser in the field of ocean engineering.
