OBJECTIVE:To assess the efficacy and safety of the Qingyanyin formulated granules(轻燕饮配方颗粒,QYY),press needles(PN),and their combined application in addressing abdominal obesity(AO).This trial aims to offer a mor...OBJECTIVE:To assess the efficacy and safety of the Qingyanyin formulated granules(轻燕饮配方颗粒,QYY),press needles(PN),and their combined application in addressing abdominal obesity(AO).This trial aims to offer a more scientifically grounded therapeutic regimen for clinical interventions.METHODS:From March 2021 to July 2021,a multicenter,triple-blind,randomized 2×2 factorial design clinical trial was conducted across 7 centers in 4 major cities within China's mainland.The trial participants were patients diagnosed with AO.The trial followed a 1∶1∶1∶1 random allocation ratio,assigning participants to one of four groups:QYY placebo plus simulated press needles(SPN)(placebo+SPN),QYY plus SPN(QYY+SPN),QYY placebo plus PN(placebo+PN),and QYY plus PN(QYY+PN).The trial participants received treatment for 12 weeks.Observe the changes in waist circumference,body weight,body mass index(BMI),Beck Depression Inventory(BDI),Beck Anxiety Inventory(BAI)scores,and Pittsburgh Sleep Quality Index(PSQI)before and after treatment.RESULTS:The QYY+PN group exhibited significant improvements in waist circumference compared to placebo+PN[Difference=-1.59,95%CI(-3.03,-0.16)]and placebo+SPN groups[Difference=-2.01,95%CI(-3.46,-0.57)].QYY+PN demonstrated a significant advantage over placebo+SPN[Difference=-2.01,95%CI(-3.46,-0.57)],and no statistically significant interaction was observed between the two interventions(P>0.05).In terms of weight and BMI improvements,the QYY+PN,QYY+SPN,and the PN+placebo groups all experienced trending greater reductions in weight compared to the placebo group.In terms of the total scores of PSQI,BAI,and BDI,all four groups exhibited improvements compared to the baseline.Specifically,concerning the change in total PSQI scores,the QYY+PN group exhibited a greater reduction;Regarding the change in total BAI scores,the PN+placebo group demonstrated a greater decrease;As for the change in total BDI scores,the QYY+SPN group displayed a greater reduction.CONCLUSION:This study confirmed that QYY+PN can effectively reduce the waist circumference of patients with AO.Furthermore,the combined approach offers greater benefits than either treatment alone,all without any reported serious adverse events.展开更多
A spice formulation study in Burkina Faso was carried out using local ingredients for the benefit of households. The objective of this study was to propose some spice formulations based on local ingredients in order t...A spice formulation study in Burkina Faso was carried out using local ingredients for the benefit of households. The objective of this study was to propose some spice formulations based on local ingredients in order to reduce the use of chemical spices in the preparation of different dishes. The Design of Experiments (DOE) methodology was used for the formulation of the spices and their physicochemical, nutritional and sensory characteristics were evaluated by standardized and standard methods. The results obtained showed lipid contents (g/100 g DM) ranging from 10.41 ± 0.26 to 15.64 ± 0.68, total sugars from 4.39 ± 0.32 to 5.46 ± 0.31, protein from 3.65 ± 0.17 to 12.04 ± 0.35 and ash from 5.83 ± 0.01 to 7.02 ± 0.01. The polyphenol content ranged from 9.09 ± 1.60 to 11.33 ± 0.90, and the flavonoid content ranged from 0.65 ± 0.03 to 1.08 ± 0.13. The sensory analysis carried out showed that the spices have generally satisfactory organoleptic characteristics. These results constitute new information in the diet of populations and are an alternative to the chemical spices used in their cooking.展开更多
[Objective] The aim was to learn the soil nutrient status of the main rapeseed planting areas in Linxiang County,Yunnan Province,and propose full production potential of soil and fertilizer recommendations,thereby pro...[Objective] The aim was to learn the soil nutrient status of the main rapeseed planting areas in Linxiang County,Yunnan Province,and propose full production potential of soil and fertilizer recommendations,thereby promoting local rapeseed production and income.[Method] The soil samples collected in field and tested in laboratory,with amount of fertilizer needed by rapeseed investigation were combined to calculate the formulated fertilization.[Result] Most of the soil organic matter and nutrient content of NPK were at the middle or higher level in the main rapeseed planting areas in Linxiang County.However,more than half of the soils were acidic or strongly acidic,and the soil p H maintained below 5.5.The shortage soil boron was more serious,the average content and nearly 60% of the sample of soil available boron were less than 0.5 mg/kg.[Conclusion] The formulated fertilization recommendations were identified as follows.To achieve the goal of 3 750 kg/hm^2240,150 and 75 kg/ha,if the application amount of manure was 15 000 kg/h,the total fertilizer N,P2O5,K2 O amount applied were separately 300,195 and 195 kg/hm^2.The chemical fertilizer N,P2O5,K2 O amount applied should be respectively 240,150 and 75 kg/hm^2,if the application amount of manure was 15 000 kg/hm^2.The nitrogen species of urea（containing N 46%）,causing weakest effect on soil acidification,was selected and applied about with 525 kg/hm^2.The alkaline calcium magnesium phosphate（P2O520%）,alternating superphosphate,was applied with about 750 kg/hm^2.Sulfuric acid potassium（K2O 50%） was applied with about 150 kg/hm^2.About 7.5kg/hm^2 borax was applied into soil as basal fertilizer,while spraying 7.5 kg/hm^2 fluid boron at the Bolting stag.展开更多
We outline the smart manufacturing challenges for formulated products, which are typically multicom- ponent, structured, and multiphase. These challenges predominate in the food, pharmaceuticals, agricul- tural and sp...We outline the smart manufacturing challenges for formulated products, which are typically multicom- ponent, structured, and multiphase. These challenges predominate in the food, pharmaceuticals, agricul- tural and specialty chemicals, energy storage and energetic materials, and consumer goods industries, and are driven by fast-changing customer demand and, in some cases, a tight regulatory framework. This paper discusses progress in smart manufacturing namely, digitalization and the use of large data- sets with predictive models and solution- nding algorithms in these industries. While some progress has been achieved, there is a strong need for more demonstration of model-based tools on realistic prob- lems in order to demonstrate their bene ts and highlight any systemic weaknesses.展开更多
[Objectives]The purpose of this study was to provide technical support for high-yield cultivation of major crops in Burundi,thereby increasing local farmers'income and promoting sustainable development of agricult...[Objectives]The purpose of this study was to provide technical support for high-yield cultivation of major crops in Burundi,thereby increasing local farmers'income and promoting sustainable development of agriculture in Burundi.[Methods]In the IMBO and MOSO test stations of the Burundi Academy of Agricultural Sciences and the Burundi Fruit and Vegetable Extension and Service Center,soil testing and formulated fertilization test and demonstration was carried out in rice,maize and cabbage.The test set up three treatments,soil testing and formulated fertilization(STFF),local routine fertilization(RF)and non-fertilization(CK)to investigate the effects of soil testing and formulated fertilization on the yield and economic benefit of the crops.[Results]In the plot test,the yield and net economic benefit of rice,maize and cabbage were both highest in the STFF treatment.Compared with those in the RF treatment,the yield of rice,maize and cabbage increased by 19.0%,25.7%and 33.0%,respectively,and the net economic benefit increased by 4292,2837 and 8232 yuan/ha,respectively.In the field test,the yield and net economic benefit of rice,maize and cabbage were also both highest in the STFF treatment.The yield increased by 18.1%,24.3%and 25.9%,respectively,and the net economic benefit increased by 4142,2881 and 8665 yuan/ha,respectively compared with those in the RF treatment.[Conclusions]Soil testing and formulated fertilization not only increased rice,maize and cabbage yield per unit area,but also increased farmers'income in Burundi.It is one of the important technical measures to promote the increase of agricultural production and income in Burundi.展开更多
Solid waste and air pollution are never ending environmental problems that can be partially solved by turning waste into useful bio-products. In this study, enzymatic solutions were developed by formulating enzymatic ...Solid waste and air pollution are never ending environmental problems that can be partially solved by turning waste into useful bio-products. In this study, enzymatic solutions were developed by formulating enzymatic solutions from fish intestines and fruit peels. This aimed to help in biodegradation of organic solid wastes. Organic waste samples were treated with formulated enzymatic solutions for 7 days in aerated set-up for aerobic degradation. Biodegradability and odor of the waste samples were compared with commercial enzymatic solution. Determination of evolved carbon dioxide (CO2) using gravimetric analysis (GA) was used to determine the percent biodegradability, Dt, of organic solid waste and odor-ranking method was used to determine the odor intensity of the organic waste samples. The result showed that the weight loss and percentage biodegradability of organic waste sample treated with formulated enzymatic solution is comparable with that of the commercial enzymatic solution. In terms of odor intensity, waste treated with the product, formulated enzymatic solution (FES) is also comparable to the waste treated with commercial enzymatic solution. Thus, implying that the developed FES is as efficient as that of the commercial enzymatic solution. These significant results will be helpful to future researchers in providing ways on improving the degradation of organic solid waste and mitigating the increasing glitches on our environment. Enzyme kinetics, physical and chemical properties studies of the solution were recommended for future researchers to accurately determine the effectiveness of the formulated enzymatic solution in the degradation of organic solid waste.展开更多
The aim of the present study was to develop a formulated feed for improving skin pigmentation and growth performance of koi carp juveniles. Two experiments were conducted for determination of an optimal dietary astaxa...The aim of the present study was to develop a formulated feed for improving skin pigmentation and growth performance of koi carp juveniles. Two experiments were conducted for determination of an optimal dietary astaxanthin and FM （fish meal） ration for koi carp juveniles. In the first experiment, three isonitrogenous and isoenergetic dietary treatments were designed with three different levels of astaxanthin consisted of 60, 80 and 100 mg/kg and a commercial feed served as a control. For the second experiment, four isonitrogenous and isoenergetic dietary treatments were formulated with graded inclusions of dietary FM replaced from 0% to 60% at 20% increments by SM （soybean meal）, PBM （poultry by-product meal）, and a CD （control diet）. Obtained results demonstrated that skin pigmentation of koi carp juveniles fed the diet containing 80 mg/kg astaxanthin, 36.02% protein, 7.78% lipid, 4.20 Kcal/g GE （gross energy） were more better than those at the diet with lower estaxanthin content and commercial diet. Moreover, the highest growth and feed utilization of fish were observed at this diet with WG （weight gain）, SGR （specific growth rate） and FCR （feed conversion ratio） were 121.80%, 0.95 （%/day） and 1.6, respectively.展开更多
The main objective of the study is to improve the removal efficiency of Ourlago-kaolin (Kao), sodium montmorillonite (Na-MMT), and two formulated clay-lime (F13 and F23) towards CI Acid Orange 52 dye (AO52). F13 and F...The main objective of the study is to improve the removal efficiency of Ourlago-kaolin (Kao), sodium montmorillonite (Na-MMT), and two formulated clay-lime (F13 and F23) towards CI Acid Orange 52 dye (AO52). F13 and F23 were obtained by chemical stabilization through thermal treatment at 300°C. Fourier Transform Infrared spectra showed different surface functional groups on the clay materials, X-ray diffraction patterns revealed the raw materials contain many crystalline phases, scanning electron microscopy micrographs showed the variation of the layered structures of different clay materials, energy dispersive X-Ray analysis micrographs revealed compositional information and thermogravimetric-differential scanning calorimetry curves indicated the higher weight loss of 11.26% and 11.38% were observed for F13 and F23 respectively. BET surface area analyzed gave 133.0071 m<sup>2</sup>•g<sup>−1</sup> for F13 and 132.34803 m<sup>2</sup>•g<sup>−1</sup> for F23. The optimum pH value was 2.0 for Kao and Na-MMT. The adsorption experiments indicated that F13 and F23 have the maximum uptake abilities of 7.8740 and 3.1645 mg•g<sup>−1</sup>, respectively, compared to Kao (0.8761 mg•g<sup>−1</sup>) and Na-MMT (2.6178 mg•g<sup>−1</sup>). The pseudo-second-order model well described the adsorption kinetic model of AO52 dye onto the overall samples;Langmuir and Freundlich’s isotherms appropriately described the uptake mechanism. The positive values of ∆G° and negative value ∆H° indicated that the adsorption process was spontaneous and endothermic for Na-MMT, and non-spontaneous and exothermic for Kao, F13, and F23 because of their positive values of ∆G° and negative value of ∆H°. The modified clays have higher adsorption capacities and better life cycles compared hence opening new avenues for efficient wastewater treatment.展开更多
A geometrically exact Kirchhoff beam formulation(GEKBF)established on the Lie group SO(3)for simulating the dynamics of a slender beam is proposed.The kinematic description,dynamic equilibrium equations and their line...A geometrically exact Kirchhoff beam formulation(GEKBF)established on the Lie group SO(3)for simulating the dynamics of a slender beam is proposed.The kinematic description,dynamic equilibrium equations and their linearization are derived in this framework.Then,a second-order interpolation function for the torsion angle is introduced to improve the convergence of the element.Next,the rotation vector parameterization is developed to reduce the geometric nonlinearity caused by the rotation of the rigid body.In addition,the influence of the reference frame is considered,and the derivation of the elastic force and Jacobian matrix is simplified using the spatial-parallel transport.The semi-discrete equations of motion are in the form of a second-order ordinary differential equation on Lie group,which are solved using the Lie group generalizedα-method.Finally,the accuracy of the proposed formulation is verified using several numerical examples.展开更多
In light of the use of Lannea barteri in the management of diverse illnesses and treatment of wounds in traditional medicine, the current study was conducted to assess the wound-healing efficacy of crude aqueous extra...In light of the use of Lannea barteri in the management of diverse illnesses and treatment of wounds in traditional medicine, the current study was conducted to assess the wound-healing efficacy of crude aqueous extract of the stem bark of Lannea barteri and its shea butter formulated ointment using an excision wound model in the rabbit. The herbal ointment (5%, w/w) exhibited a significant wound healing activity, showing 99.9% ± 0.3% wound contraction at the end of the experiment (24th day). There was no significant difference (p > 0.05) between the 5% (w/w) herbal ointment compared with Silver Sulphadiazine cream (positive control), which showed a 97.8% ± 1.0% rate of excision wound contraction on day 24. Compared with the negative control group (administered with only shea butter), the wound healing activity of the ointment was significant (p Lannea barteri for the treatment of wounds and demonstrates that shea butter usage as a base in formulating an herbal ointment might aid in topical application for wound repair and regeneration, as well as the potential for enhanced wound healing.展开更多
In the multi-billion dollar formulated product industry, state of the art continues to rely heavily on experts during the "generate, make and test" steps of formulation design. We propose automation aids to ...In the multi-billion dollar formulated product industry, state of the art continues to rely heavily on experts during the "generate, make and test" steps of formulation design. We propose automation aids to each step with a knowledge graph of relevant information as the central artifact. The generate step usually focuses on coming up with new recipes for intended formulation. We propose to aid the experts who generally carry out this step manually by providing a recommendation system and a templating system on top of the knowledge graph. Using the former, the expert can create a recipe from scratch using historical formulations and related data. With the latter, the expert starts with a recipe template created by our system and substitutes the requisite constituents to form a recipe. In the current state of practice, the three steps mentioned above operate in a fragmented manner wherein observations from one step do not aid other steps in a streamlined manner. Instead of manually operated labs for the make and test steps, we assume automated or robotic labs and in-silico testing, respectively. Using two formulations, namely face cream and an exterior coating, we show how the knowledge graph may help integrate and streamline the communication between the generate, the make, and the test steps. Our initial exploration shows considerable promise.展开更多
Cell membrane-engineered nano-delivery systems have evolved as a promising strategy to enhance drug bioavailability,offering an alternative for reversing drug resistance in cancer therapy.Herein,a formulated nano-lipo...Cell membrane-engineered nano-delivery systems have evolved as a promising strategy to enhance drug bioavailability,offering an alternative for reversing drug resistance in cancer therapy.Herein,a formulated nano-liposome that fabricated by hybridizing cisplatin-resistant A549 cell line(A549/cis)cancer cell membrane and phospholipids for co-delivery of cisplatin and nuclear protein zeste homolog 2(EZH2)-targeting peptide EIP103,referred to as cLCE,was developed.In vitro results indicated that the formulated nano-liposome can efficiently inhibit A549/cis cancer cell invasion and metastasis through the down-regulation of Ncadherin and vimentin proteins.Mechanistic studies demonstrated that the reduction of nerve growth factor receptor(NGFR)levels and the increase of peroxisome proliferator-activated receptorγ(PPARγ)levels achieved by EIP103 may contribute to the reversal of cisplatin resistance.In vivo results demonstrated that the encapsulation of both cisplatin and EIP103 within cLCE leads to increased intratumoral accumulation and prolonged survival in A549/cis cancer-bearing mice as compared to the individual drugs alone.This can be attributed to the enhanced tumor homing capability of cLCE achieved through the presence of inherited membrane proteins derived from A549/cis cells.Taken together,this study may provide a highly promising therapeutic strategy to improve clinical treatments for cisplatin-resistance non-small-cell lung cancer(NSCLC)as well as other malignant cancers.展开更多
This article reviews the research advances in traditional Chinese medicine rhubarb and its compound formulations in the treatment of sepsis,with particular emphasis on elucidating their mechanisms of action and clinic...This article reviews the research advances in traditional Chinese medicine rhubarb and its compound formulations in the treatment of sepsis,with particular emphasis on elucidating their mechanisms of action and clinical application value.Research has demonstrated that rhubarb and its compound formulations exert therapeutic effects via multiple targets and mechanisms,including anti-inflammatory actions,protection of the intestinal barrier,modulation of immune balance,inhibition of oxidative stress,and regulation of associated signaling pathways.Clinically,rhubarb has shown distinct advantages in enhancing gastrointestinal function,mitigating systemic inflammatory responses,and reducing mortality rates among patients with sepsis.These findings provide a foundational reference for the integrated prevention and treatment of sepsis through the combined use of traditional Chinese and Western medicine.展开更多
We present a novel approach for calculating the energy budget components during the progressive failure process in cohesive-frictional geomaterials.The energy supplied through external loading can be either stored as ...We present a novel approach for calculating the energy budget components during the progressive failure process in cohesive-frictional geomaterials.The energy supplied through external loading can be either stored as elastic strain energy and plastic energy storage or dissipated through damage growth and irreversible plastic deformation mechanisms.Analytical functions describing energy budget components are derived based on a thermodynamic formulation in geomaterials fracture.The thermodynamically consistent derivation leads to a non-local ductile damage model,which is solved numerically in a non-linear finite element framework.The proposed model captures geomaterial fractures in three benchmark examples,including tensile and biaxial-compressive shear scenarios and slope stability analysis.The aspects of shear fracture propagation and energy budget mechanisms are elaborately investigated,considering different material properties and stochastic distributions.The numerical results are validated against existing experimental data and other analytical methods.The model provides a physics-based understanding of energy budget in geomaterials fracture,leading to advances in ground improvement and other geotechnical supporting systems.展开更多
Quasi-periodic solutions with multiple base frequencies exhibit the feature of 2π-periodicity with respect to each of the hyper-time variables.However,it remains a challenge work,due to the lack of effective solution...Quasi-periodic solutions with multiple base frequencies exhibit the feature of 2π-periodicity with respect to each of the hyper-time variables.However,it remains a challenge work,due to the lack of effective solution methods,to solve and track the quasi-periodic solutions with multiple base frequencies until now.In this work,a multi-steps variable-coefficient formulation is proposed,which provides a unified framework to enable either harmonic balance method or collocation method or finite difference method to solve quasi-periodic solutions with multiple base frequencies.For this purpose,a method of alternating U and S domain is also developed to efficiently evaluate the nonlinear force terms.Furthermore,a new robust phase condition is presented for all of the three methods to make them track the quasi-periodic solutions with prior unknown multiple base frequencies,while the stability of the quasi-periodic solutions is assessed by mean of Lyapunov exponents.The feasibility of the constructed methods under the above framework is verified by application to three nonlinear systems.展开更多
This year,concerts have become immensely popular in China and brought sizable economic benefits to host cities.Going to another city to see a concert has become a new fashion among young people.A recent example is pop...This year,concerts have become immensely popular in China and brought sizable economic benefits to host cities.Going to another city to see a concert has become a new fashion among young people.A recent example is pop singer Jay Chou's four-day concerts in early September in Tianjin Municipality in north China,which attracted an audience of 185,000,of whom 62 percent were from other cities.The concerts generated 3 billion yuan($411 million)of consumption in the city.展开更多
China is coming into line with international practice in terms of the standards and regulations of the safety and emissions of motor vehicles. However, the sector of fuel economy has been a blank sheet. Along with the...China is coming into line with international practice in terms of the standards and regulations of the safety and emissions of motor vehicles. However, the sector of fuel economy has been a blank sheet. Along with the ever increasing of vehicle population in China, the reality of petroleum energy shortage urges people to pay attention to vehicle fuel economy. Recently, the first standard on the consumption of fuels in China,展开更多
With the approval of the State Council,the Ministry of Environmental Protection,the National Development and Reform Commission,the Ministry of Water Conservancy and the Ministry of Real Estate and Municipal Constructi...With the approval of the State Council,the Ministry of Environmental Protection,the National Development and Reform Commission,the Ministry of Water Conservancy and the Ministry of Real Estate and Municipal Construction have recently formulated the"Program for the Water Pollution Control in Major River Reaches such as the Huai River,展开更多
In 1999,China released its first edition of the“Guidelines for the Prevention and Treatment of Hypertension”,which was subsequently updated in 2005,2010,and 2018,establishing a diagnostic,assessment,grading,stratifi...In 1999,China released its first edition of the“Guidelines for the Prevention and Treatment of Hypertension”,which was subsequently updated in 2005,2010,and 2018,establishing a diagnostic,assessment,grading,stratification,prevention,intervention,and management framework for hypertension tailored to the unique characteristics of the Chinese population.Over the past two decades,these guidelines have been widely implemented in clinical practice across China and have played a significant role in the management of hypertension and chronic diseases,the development of grassroots guidelines,the formulation of clinical pathways,and the implementation of health insurance policies.展开更多
Peptic ulcer(PU)is characterized by inflammation,necrosis,and erosion of the gastrointestinal mucosa caused by various pathogenic factors,leading to ulcer formation.The stomach and duodenum are the most commonly affec...Peptic ulcer(PU)is characterized by inflammation,necrosis,and erosion of the gastrointestinal mucosa caused by various pathogenic factors,leading to ulcer formation.The stomach and duodenum are the most commonly affected sites.Bletilla striata,a traditional Chinese medicinal herb,contains diverse chemical constituents and exhibits multiple pharmacological effects.As a key component in various traditional Chinese medicine compound formulations,it has demonstrated notable clinical efficacy.Moreover,it has a solid research foundation and broad application prospects in the treatment of gastrointestinal diseases.This paper systematically elaborates on the clinical efficacy and mechanisms of action of Bletilla striata in the treatment of PUs,drawing from ancient medical literature and traditional formula applications to provide support for clinical use.展开更多
基金National Key Research and Development Project:Clinical Evaluation of the Interventional Techniques for Abdominal Obesity(No.2019YFC1710102)。
文摘OBJECTIVE:To assess the efficacy and safety of the Qingyanyin formulated granules(轻燕饮配方颗粒,QYY),press needles(PN),and their combined application in addressing abdominal obesity(AO).This trial aims to offer a more scientifically grounded therapeutic regimen for clinical interventions.METHODS:From March 2021 to July 2021,a multicenter,triple-blind,randomized 2×2 factorial design clinical trial was conducted across 7 centers in 4 major cities within China's mainland.The trial participants were patients diagnosed with AO.The trial followed a 1∶1∶1∶1 random allocation ratio,assigning participants to one of four groups:QYY placebo plus simulated press needles(SPN)(placebo+SPN),QYY plus SPN(QYY+SPN),QYY placebo plus PN(placebo+PN),and QYY plus PN(QYY+PN).The trial participants received treatment for 12 weeks.Observe the changes in waist circumference,body weight,body mass index(BMI),Beck Depression Inventory(BDI),Beck Anxiety Inventory(BAI)scores,and Pittsburgh Sleep Quality Index(PSQI)before and after treatment.RESULTS:The QYY+PN group exhibited significant improvements in waist circumference compared to placebo+PN[Difference=-1.59,95%CI(-3.03,-0.16)]and placebo+SPN groups[Difference=-2.01,95%CI(-3.46,-0.57)].QYY+PN demonstrated a significant advantage over placebo+SPN[Difference=-2.01,95%CI(-3.46,-0.57)],and no statistically significant interaction was observed between the two interventions(P>0.05).In terms of weight and BMI improvements,the QYY+PN,QYY+SPN,and the PN+placebo groups all experienced trending greater reductions in weight compared to the placebo group.In terms of the total scores of PSQI,BAI,and BDI,all four groups exhibited improvements compared to the baseline.Specifically,concerning the change in total PSQI scores,the QYY+PN group exhibited a greater reduction;Regarding the change in total BAI scores,the PN+placebo group demonstrated a greater decrease;As for the change in total BDI scores,the QYY+SPN group displayed a greater reduction.CONCLUSION:This study confirmed that QYY+PN can effectively reduce the waist circumference of patients with AO.Furthermore,the combined approach offers greater benefits than either treatment alone,all without any reported serious adverse events.
文摘A spice formulation study in Burkina Faso was carried out using local ingredients for the benefit of households. The objective of this study was to propose some spice formulations based on local ingredients in order to reduce the use of chemical spices in the preparation of different dishes. The Design of Experiments (DOE) methodology was used for the formulation of the spices and their physicochemical, nutritional and sensory characteristics were evaluated by standardized and standard methods. The results obtained showed lipid contents (g/100 g DM) ranging from 10.41 ± 0.26 to 15.64 ± 0.68, total sugars from 4.39 ± 0.32 to 5.46 ± 0.31, protein from 3.65 ± 0.17 to 12.04 ± 0.35 and ash from 5.83 ± 0.01 to 7.02 ± 0.01. The polyphenol content ranged from 9.09 ± 1.60 to 11.33 ± 0.90, and the flavonoid content ranged from 0.65 ± 0.03 to 1.08 ± 0.13. The sensory analysis carried out showed that the spices have generally satisfactory organoleptic characteristics. These results constitute new information in the diet of populations and are an alternative to the chemical spices used in their cooking.
基金The National Key Technology R&D Program(2012BAD40B02)~~
文摘[Objective] The aim was to learn the soil nutrient status of the main rapeseed planting areas in Linxiang County,Yunnan Province,and propose full production potential of soil and fertilizer recommendations,thereby promoting local rapeseed production and income.[Method] The soil samples collected in field and tested in laboratory,with amount of fertilizer needed by rapeseed investigation were combined to calculate the formulated fertilization.[Result] Most of the soil organic matter and nutrient content of NPK were at the middle or higher level in the main rapeseed planting areas in Linxiang County.However,more than half of the soils were acidic or strongly acidic,and the soil p H maintained below 5.5.The shortage soil boron was more serious,the average content and nearly 60% of the sample of soil available boron were less than 0.5 mg/kg.[Conclusion] The formulated fertilization recommendations were identified as follows.To achieve the goal of 3 750 kg/hm^2240,150 and 75 kg/ha,if the application amount of manure was 15 000 kg/h,the total fertilizer N,P2O5,K2 O amount applied were separately 300,195 and 195 kg/hm^2.The chemical fertilizer N,P2O5,K2 O amount applied should be respectively 240,150 and 75 kg/hm^2,if the application amount of manure was 15 000 kg/hm^2.The nitrogen species of urea（containing N 46%）,causing weakest effect on soil acidification,was selected and applied about with 525 kg/hm^2.The alkaline calcium magnesium phosphate（P2O520%）,alternating superphosphate,was applied with about 750 kg/hm^2.Sulfuric acid potassium（K2O 50%） was applied with about 150 kg/hm^2.About 7.5kg/hm^2 borax was applied into soil as basal fertilizer,while spraying 7.5 kg/hm^2 fluid boron at the Bolting stag.
文摘We outline the smart manufacturing challenges for formulated products, which are typically multicom- ponent, structured, and multiphase. These challenges predominate in the food, pharmaceuticals, agricul- tural and specialty chemicals, energy storage and energetic materials, and consumer goods industries, and are driven by fast-changing customer demand and, in some cases, a tight regulatory framework. This paper discusses progress in smart manufacturing namely, digitalization and the use of large data- sets with predictive models and solution- nding algorithms in these industries. While some progress has been achieved, there is a strong need for more demonstration of model-based tools on realistic prob- lems in order to demonstrate their bene ts and highlight any systemic weaknesses.
基金Special Scientific and Technological Assistance Program of Ministry of Science and Technology of the People's Republic of China to Developing Countries(Demonstration and Popularization of Key Technologies for Increasing Grain Yield in Africa)Scientific Research and Technology Development Plan Project of Guangxi Zhuang Autonomous Region,China(Gui Ke He 1346009-4,Gui Ke He 14125007-2-7).
文摘[Objectives]The purpose of this study was to provide technical support for high-yield cultivation of major crops in Burundi,thereby increasing local farmers'income and promoting sustainable development of agriculture in Burundi.[Methods]In the IMBO and MOSO test stations of the Burundi Academy of Agricultural Sciences and the Burundi Fruit and Vegetable Extension and Service Center,soil testing and formulated fertilization test and demonstration was carried out in rice,maize and cabbage.The test set up three treatments,soil testing and formulated fertilization(STFF),local routine fertilization(RF)and non-fertilization(CK)to investigate the effects of soil testing and formulated fertilization on the yield and economic benefit of the crops.[Results]In the plot test,the yield and net economic benefit of rice,maize and cabbage were both highest in the STFF treatment.Compared with those in the RF treatment,the yield of rice,maize and cabbage increased by 19.0%,25.7%and 33.0%,respectively,and the net economic benefit increased by 4292,2837 and 8232 yuan/ha,respectively.In the field test,the yield and net economic benefit of rice,maize and cabbage were also both highest in the STFF treatment.The yield increased by 18.1%,24.3%and 25.9%,respectively,and the net economic benefit increased by 4142,2881 and 8665 yuan/ha,respectively compared with those in the RF treatment.[Conclusions]Soil testing and formulated fertilization not only increased rice,maize and cabbage yield per unit area,but also increased farmers'income in Burundi.It is one of the important technical measures to promote the increase of agricultural production and income in Burundi.
文摘Solid waste and air pollution are never ending environmental problems that can be partially solved by turning waste into useful bio-products. In this study, enzymatic solutions were developed by formulating enzymatic solutions from fish intestines and fruit peels. This aimed to help in biodegradation of organic solid wastes. Organic waste samples were treated with formulated enzymatic solutions for 7 days in aerated set-up for aerobic degradation. Biodegradability and odor of the waste samples were compared with commercial enzymatic solution. Determination of evolved carbon dioxide (CO2) using gravimetric analysis (GA) was used to determine the percent biodegradability, Dt, of organic solid waste and odor-ranking method was used to determine the odor intensity of the organic waste samples. The result showed that the weight loss and percentage biodegradability of organic waste sample treated with formulated enzymatic solution is comparable with that of the commercial enzymatic solution. In terms of odor intensity, waste treated with the product, formulated enzymatic solution (FES) is also comparable to the waste treated with commercial enzymatic solution. Thus, implying that the developed FES is as efficient as that of the commercial enzymatic solution. These significant results will be helpful to future researchers in providing ways on improving the degradation of organic solid waste and mitigating the increasing glitches on our environment. Enzyme kinetics, physical and chemical properties studies of the solution were recommended for future researchers to accurately determine the effectiveness of the formulated enzymatic solution in the degradation of organic solid waste.
文摘The aim of the present study was to develop a formulated feed for improving skin pigmentation and growth performance of koi carp juveniles. Two experiments were conducted for determination of an optimal dietary astaxanthin and FM （fish meal） ration for koi carp juveniles. In the first experiment, three isonitrogenous and isoenergetic dietary treatments were designed with three different levels of astaxanthin consisted of 60, 80 and 100 mg/kg and a commercial feed served as a control. For the second experiment, four isonitrogenous and isoenergetic dietary treatments were formulated with graded inclusions of dietary FM replaced from 0% to 60% at 20% increments by SM （soybean meal）, PBM （poultry by-product meal）, and a CD （control diet）. Obtained results demonstrated that skin pigmentation of koi carp juveniles fed the diet containing 80 mg/kg astaxanthin, 36.02% protein, 7.78% lipid, 4.20 Kcal/g GE （gross energy） were more better than those at the diet with lower estaxanthin content and commercial diet. Moreover, the highest growth and feed utilization of fish were observed at this diet with WG （weight gain）, SGR （specific growth rate） and FCR （feed conversion ratio） were 121.80%, 0.95 （%/day） and 1.6, respectively.
文摘The main objective of the study is to improve the removal efficiency of Ourlago-kaolin (Kao), sodium montmorillonite (Na-MMT), and two formulated clay-lime (F13 and F23) towards CI Acid Orange 52 dye (AO52). F13 and F23 were obtained by chemical stabilization through thermal treatment at 300°C. Fourier Transform Infrared spectra showed different surface functional groups on the clay materials, X-ray diffraction patterns revealed the raw materials contain many crystalline phases, scanning electron microscopy micrographs showed the variation of the layered structures of different clay materials, energy dispersive X-Ray analysis micrographs revealed compositional information and thermogravimetric-differential scanning calorimetry curves indicated the higher weight loss of 11.26% and 11.38% were observed for F13 and F23 respectively. BET surface area analyzed gave 133.0071 m<sup>2</sup>•g<sup>−1</sup> for F13 and 132.34803 m<sup>2</sup>•g<sup>−1</sup> for F23. The optimum pH value was 2.0 for Kao and Na-MMT. The adsorption experiments indicated that F13 and F23 have the maximum uptake abilities of 7.8740 and 3.1645 mg•g<sup>−1</sup>, respectively, compared to Kao (0.8761 mg•g<sup>−1</sup>) and Na-MMT (2.6178 mg•g<sup>−1</sup>). The pseudo-second-order model well described the adsorption kinetic model of AO52 dye onto the overall samples;Langmuir and Freundlich’s isotherms appropriately described the uptake mechanism. The positive values of ∆G° and negative value ∆H° indicated that the adsorption process was spontaneous and endothermic for Na-MMT, and non-spontaneous and exothermic for Kao, F13, and F23 because of their positive values of ∆G° and negative value of ∆H°. The modified clays have higher adsorption capacities and better life cycles compared hence opening new avenues for efficient wastewater treatment.
基金the National Natural Science Foundation of China(Grant Nos.12102033,12072026,and 11832005).
文摘A geometrically exact Kirchhoff beam formulation(GEKBF)established on the Lie group SO(3)for simulating the dynamics of a slender beam is proposed.The kinematic description,dynamic equilibrium equations and their linearization are derived in this framework.Then,a second-order interpolation function for the torsion angle is introduced to improve the convergence of the element.Next,the rotation vector parameterization is developed to reduce the geometric nonlinearity caused by the rotation of the rigid body.In addition,the influence of the reference frame is considered,and the derivation of the elastic force and Jacobian matrix is simplified using the spatial-parallel transport.The semi-discrete equations of motion are in the form of a second-order ordinary differential equation on Lie group,which are solved using the Lie group generalizedα-method.Finally,the accuracy of the proposed formulation is verified using several numerical examples.
文摘In light of the use of Lannea barteri in the management of diverse illnesses and treatment of wounds in traditional medicine, the current study was conducted to assess the wound-healing efficacy of crude aqueous extract of the stem bark of Lannea barteri and its shea butter formulated ointment using an excision wound model in the rabbit. The herbal ointment (5%, w/w) exhibited a significant wound healing activity, showing 99.9% ± 0.3% wound contraction at the end of the experiment (24th day). There was no significant difference (p > 0.05) between the 5% (w/w) herbal ointment compared with Silver Sulphadiazine cream (positive control), which showed a 97.8% ± 1.0% rate of excision wound contraction on day 24. Compared with the negative control group (administered with only shea butter), the wound healing activity of the ointment was significant (p Lannea barteri for the treatment of wounds and demonstrates that shea butter usage as a base in formulating an herbal ointment might aid in topical application for wound repair and regeneration, as well as the potential for enhanced wound healing.
文摘In the multi-billion dollar formulated product industry, state of the art continues to rely heavily on experts during the "generate, make and test" steps of formulation design. We propose automation aids to each step with a knowledge graph of relevant information as the central artifact. The generate step usually focuses on coming up with new recipes for intended formulation. We propose to aid the experts who generally carry out this step manually by providing a recommendation system and a templating system on top of the knowledge graph. Using the former, the expert can create a recipe from scratch using historical formulations and related data. With the latter, the expert starts with a recipe template created by our system and substitutes the requisite constituents to form a recipe. In the current state of practice, the three steps mentioned above operate in a fragmented manner wherein observations from one step do not aid other steps in a streamlined manner. Instead of manually operated labs for the make and test steps, we assume automated or robotic labs and in-silico testing, respectively. Using two formulations, namely face cream and an exterior coating, we show how the knowledge graph may help integrate and streamline the communication between the generate, the make, and the test steps. Our initial exploration shows considerable promise.
基金supported by the National Natural Science Foundation of China(Nos.32101130,21721002,and 31971295)Financial support from Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000)is also gratefully acknowledged.
文摘Cell membrane-engineered nano-delivery systems have evolved as a promising strategy to enhance drug bioavailability,offering an alternative for reversing drug resistance in cancer therapy.Herein,a formulated nano-liposome that fabricated by hybridizing cisplatin-resistant A549 cell line(A549/cis)cancer cell membrane and phospholipids for co-delivery of cisplatin and nuclear protein zeste homolog 2(EZH2)-targeting peptide EIP103,referred to as cLCE,was developed.In vitro results indicated that the formulated nano-liposome can efficiently inhibit A549/cis cancer cell invasion and metastasis through the down-regulation of Ncadherin and vimentin proteins.Mechanistic studies demonstrated that the reduction of nerve growth factor receptor(NGFR)levels and the increase of peroxisome proliferator-activated receptorγ(PPARγ)levels achieved by EIP103 may contribute to the reversal of cisplatin resistance.In vivo results demonstrated that the encapsulation of both cisplatin and EIP103 within cLCE leads to increased intratumoral accumulation and prolonged survival in A549/cis cancer-bearing mice as compared to the individual drugs alone.This can be attributed to the enhanced tumor homing capability of cLCE achieved through the presence of inherited membrane proteins derived from A549/cis cells.Taken together,this study may provide a highly promising therapeutic strategy to improve clinical treatments for cisplatin-resistance non-small-cell lung cancer(NSCLC)as well as other malignant cancers.
基金Supported by National Natural Science Foundation of China(82374346)Double Hundred Outstanding Young and Middle-aged Medical and Health Talents of Wuxi City(BJ2023071)Scientific Research Project of Wuxi Municipal Health Commission(Q202358).
文摘This article reviews the research advances in traditional Chinese medicine rhubarb and its compound formulations in the treatment of sepsis,with particular emphasis on elucidating their mechanisms of action and clinical application value.Research has demonstrated that rhubarb and its compound formulations exert therapeutic effects via multiple targets and mechanisms,including anti-inflammatory actions,protection of the intestinal barrier,modulation of immune balance,inhibition of oxidative stress,and regulation of associated signaling pathways.Clinically,rhubarb has shown distinct advantages in enhancing gastrointestinal function,mitigating systemic inflammatory responses,and reducing mortality rates among patients with sepsis.These findings provide a foundational reference for the integrated prevention and treatment of sepsis through the combined use of traditional Chinese and Western medicine.
基金supported by the National Natural Science Foundation of China(Grant No.52179128)the Sand Hazards and Opportunities for Resilience,Energy,and Sustainability(SHORES)Center,funded by Tamkeen under the NYUAD Research Institute Award CG013.
文摘We present a novel approach for calculating the energy budget components during the progressive failure process in cohesive-frictional geomaterials.The energy supplied through external loading can be either stored as elastic strain energy and plastic energy storage or dissipated through damage growth and irreversible plastic deformation mechanisms.Analytical functions describing energy budget components are derived based on a thermodynamic formulation in geomaterials fracture.The thermodynamically consistent derivation leads to a non-local ductile damage model,which is solved numerically in a non-linear finite element framework.The proposed model captures geomaterial fractures in three benchmark examples,including tensile and biaxial-compressive shear scenarios and slope stability analysis.The aspects of shear fracture propagation and energy budget mechanisms are elaborately investigated,considering different material properties and stochastic distributions.The numerical results are validated against existing experimental data and other analytical methods.The model provides a physics-based understanding of energy budget in geomaterials fracture,leading to advances in ground improvement and other geotechnical supporting systems.
基金supported by the National Natural Science Foundation of China(Grant Nos.12172267 and 12302014).
文摘Quasi-periodic solutions with multiple base frequencies exhibit the feature of 2π-periodicity with respect to each of the hyper-time variables.However,it remains a challenge work,due to the lack of effective solution methods,to solve and track the quasi-periodic solutions with multiple base frequencies until now.In this work,a multi-steps variable-coefficient formulation is proposed,which provides a unified framework to enable either harmonic balance method or collocation method or finite difference method to solve quasi-periodic solutions with multiple base frequencies.For this purpose,a method of alternating U and S domain is also developed to efficiently evaluate the nonlinear force terms.Furthermore,a new robust phase condition is presented for all of the three methods to make them track the quasi-periodic solutions with prior unknown multiple base frequencies,while the stability of the quasi-periodic solutions is assessed by mean of Lyapunov exponents.The feasibility of the constructed methods under the above framework is verified by application to three nonlinear systems.
文摘This year,concerts have become immensely popular in China and brought sizable economic benefits to host cities.Going to another city to see a concert has become a new fashion among young people.A recent example is pop singer Jay Chou's four-day concerts in early September in Tianjin Municipality in north China,which attracted an audience of 185,000,of whom 62 percent were from other cities.The concerts generated 3 billion yuan($411 million)of consumption in the city.
文摘China is coming into line with international practice in terms of the standards and regulations of the safety and emissions of motor vehicles. However, the sector of fuel economy has been a blank sheet. Along with the ever increasing of vehicle population in China, the reality of petroleum energy shortage urges people to pay attention to vehicle fuel economy. Recently, the first standard on the consumption of fuels in China,
文摘With the approval of the State Council,the Ministry of Environmental Protection,the National Development and Reform Commission,the Ministry of Water Conservancy and the Ministry of Real Estate and Municipal Construction have recently formulated the"Program for the Water Pollution Control in Major River Reaches such as the Huai River,
文摘In 1999,China released its first edition of the“Guidelines for the Prevention and Treatment of Hypertension”,which was subsequently updated in 2005,2010,and 2018,establishing a diagnostic,assessment,grading,stratification,prevention,intervention,and management framework for hypertension tailored to the unique characteristics of the Chinese population.Over the past two decades,these guidelines have been widely implemented in clinical practice across China and have played a significant role in the management of hypertension and chronic diseases,the development of grassroots guidelines,the formulation of clinical pathways,and the implementation of health insurance policies.
基金Supported by National Science and Technology Major Project,No.2024ZD0521002The Innovation Team Project of Traditional Chinese Medicine of Liaoning Province,No.LNZYYCXTD-CCCX-003+1 种基金General Program of the National Natural Science Foundation of China,No.82074296Construction Project of Inheritance Studios of Famous Chinese Medicine Experts in China,No.[2022]No.75.
文摘Peptic ulcer(PU)is characterized by inflammation,necrosis,and erosion of the gastrointestinal mucosa caused by various pathogenic factors,leading to ulcer formation.The stomach and duodenum are the most commonly affected sites.Bletilla striata,a traditional Chinese medicinal herb,contains diverse chemical constituents and exhibits multiple pharmacological effects.As a key component in various traditional Chinese medicine compound formulations,it has demonstrated notable clinical efficacy.Moreover,it has a solid research foundation and broad application prospects in the treatment of gastrointestinal diseases.This paper systematically elaborates on the clinical efficacy and mechanisms of action of Bletilla striata in the treatment of PUs,drawing from ancient medical literature and traditional formula applications to provide support for clinical use.
