Postaurical injection of therapeutics was recently applied in clinical practice to treat inner ear diseases based on supposed existence of a direct channel from the postaurical area to the inner ear. Doubting on the a...Postaurical injection of therapeutics was recently applied in clinical practice to treat inner ear diseases based on supposed existence of a direct channel from the postaurical area to the inner ear. Doubting on the associated reports and aiming to provide evidence on the inner ear uptake mechanism, the present study tracked the dynamic distribution of gadolinium-tetra-azacyclo-dodecane-tetra-acetic acid (Gd-DOTA) in rat inner ears after postaurical injection using MRI. A targeted tympanic medial wall delivery was utilized as control. The results showed that, at the early time points after postaurical injection, Gd-DOTA distributed mainly in tissues surrounding the bulla, temporal bone and skull and neck space. In the inner ear, there was gradual uptake of Gd-DOTA on both the ipsilateral and contralateral sides with equal signal intensities. There was no sign of direct channel carrying the agent from the postaurical area to the inner ear. Targeted tympanic medial wall delivery induced significantly greater uptake of Gd-DOTA in the inner ear than did postaurical injection. At 30 min post-administration, targeted tympanic medial wall delivery yielded 4.6-folds higher signal intensity than did postaurical injection. The total dose of Gd-DOTA delivered by the targeted tympanic medial wall approach was only 0.1% of that delivered by postaurical injection. In conclusion, postaurical injection is a systemic administration, which is similar to hypodermic injection, rather than a focal delivery method. By contraries, targeted tympanic medial wall delivery induces fast and abundant uptake of Gd-DOTA in the ipsilateral inner ear without significant distribution in unwanted areas.展开更多
The spatial damage distribution of August 16, 2003, Inner Mongolia, China, MS=5.9 earthquake is summarized through field investigation. The moment tensor solution and focal mechanism are inverted using the digital lon...The spatial damage distribution of August 16, 2003, Inner Mongolia, China, MS=5.9 earthquake is summarized through field investigation. The moment tensor solution and focal mechanism are inverted using the digital long-period waveform records of China Digital Seismograph Network (CDSN). The relation between the spatial damage distribution and focal mechanism is analyzed according to the focal mechanism, the aftershock distribution and the spatial damage distribution. The possible relation between the characteristics of ground motion and the tectonic background of the source region is discussed in terms of the global ground motion records, historical earthquake documents and the damage distribution. Investigation reveals that the meizoseismal region is in east-west direction, which is consistent with the nodal plane of focal mechanism inversion. The meizoseismal area is relatively large and the damage of single-story adobe houses or masonry houses is more severe. This may have relations with local seismotectonic environment.展开更多
We selected the 103 M_L≥2. 5 earthquake waveform data from the Inner Mongolia-Ningxia border during 2009-2015,which was recorded by the Inner Mongolia Digital Seismic Networks and used the simplex method, Hyposat met...We selected the 103 M_L≥2. 5 earthquake waveform data from the Inner Mongolia-Ningxia border during 2009-2015,which was recorded by the Inner Mongolia Digital Seismic Networks and used the simplex method, Hyposat method, double difference location method,and deterministic method (PTD) for the determination of focal depth,and compared the results. The CAP moment tensor inversion method is used to determine the focal depths of the Alxa Left Banner M5. 8 and M4. 2 earthquakes. The final results of the focal depth by the deterministic method (PTD) and the double difference location method fit well with the tectonic characteristics of the Inner Mongolia-Ningxia border area,but those of the simplex method and the Hyposat method do not. The average depth of the Inner Mongolia-Ningxia border seismic tectonic zone is 13. 32 ± 8 km.展开更多
基金supported by the 1255 project of Changhai HospitalSecond Military Medical University,Shanghai,China
文摘Postaurical injection of therapeutics was recently applied in clinical practice to treat inner ear diseases based on supposed existence of a direct channel from the postaurical area to the inner ear. Doubting on the associated reports and aiming to provide evidence on the inner ear uptake mechanism, the present study tracked the dynamic distribution of gadolinium-tetra-azacyclo-dodecane-tetra-acetic acid (Gd-DOTA) in rat inner ears after postaurical injection using MRI. A targeted tympanic medial wall delivery was utilized as control. The results showed that, at the early time points after postaurical injection, Gd-DOTA distributed mainly in tissues surrounding the bulla, temporal bone and skull and neck space. In the inner ear, there was gradual uptake of Gd-DOTA on both the ipsilateral and contralateral sides with equal signal intensities. There was no sign of direct channel carrying the agent from the postaurical area to the inner ear. Targeted tympanic medial wall delivery induced significantly greater uptake of Gd-DOTA in the inner ear than did postaurical injection. At 30 min post-administration, targeted tympanic medial wall delivery yielded 4.6-folds higher signal intensity than did postaurical injection. The total dose of Gd-DOTA delivered by the targeted tympanic medial wall approach was only 0.1% of that delivered by postaurical injection. In conclusion, postaurical injection is a systemic administration, which is similar to hypodermic injection, rather than a focal delivery method. By contraries, targeted tympanic medial wall delivery induces fast and abundant uptake of Gd-DOTA in the ipsilateral inner ear without significant distribution in unwanted areas.
基金The Special Funds for Major State Basic Research Project (2002CB412706).
文摘The spatial damage distribution of August 16, 2003, Inner Mongolia, China, MS=5.9 earthquake is summarized through field investigation. The moment tensor solution and focal mechanism are inverted using the digital long-period waveform records of China Digital Seismograph Network (CDSN). The relation between the spatial damage distribution and focal mechanism is analyzed according to the focal mechanism, the aftershock distribution and the spatial damage distribution. The possible relation between the characteristics of ground motion and the tectonic background of the source region is discussed in terms of the global ground motion records, historical earthquake documents and the damage distribution. Investigation reveals that the meizoseismal region is in east-west direction, which is consistent with the nodal plane of focal mechanism inversion. The meizoseismal area is relatively large and the damage of single-story adobe houses or masonry houses is more severe. This may have relations with local seismotectonic environment.
基金sponsored by the “Major Scientific and Technical Project of Science and Technology Department of Inner Mongolia in 2016 (Strong Earthquake Track in the Short Stage and Integration Innovation of Stereoscopic Observation Technology in Space and Ground)”
文摘We selected the 103 M_L≥2. 5 earthquake waveform data from the Inner Mongolia-Ningxia border during 2009-2015,which was recorded by the Inner Mongolia Digital Seismic Networks and used the simplex method, Hyposat method, double difference location method,and deterministic method (PTD) for the determination of focal depth,and compared the results. The CAP moment tensor inversion method is used to determine the focal depths of the Alxa Left Banner M5. 8 and M4. 2 earthquakes. The final results of the focal depth by the deterministic method (PTD) and the double difference location method fit well with the tectonic characteristics of the Inner Mongolia-Ningxia border area,but those of the simplex method and the Hyposat method do not. The average depth of the Inner Mongolia-Ningxia border seismic tectonic zone is 13. 32 ± 8 km.
