Stroke is an acute cerebrovascular event characterized by focal neurological deficits resulting from the interruption of cerebral blood flow.As the second leading cause of death globally,stroke is responsible for appr...Stroke is an acute cerebrovascular event characterized by focal neurological deficits resulting from the interruption of cerebral blood flow.As the second leading cause of death globally,stroke is responsible for approximately 6.5 million deaths annually,with a disability rate as high as 50%.Survivors often experience long-term motor,cognitive,and psychological impairments,placing substantial burdens on families and healthcare systems.Stroke is classified into two primary types:ischemic stroke,caused by cerebral artery embolism or thrombosis,and hemorrhagic stroke,resulting from blood vessel rupture.Clinically,it manifests as the sudden onset of neurological dysfunction,with typical symptoms including hemiparesis,dysarthria,sensory disturbances,aphasia,and visual impairments.展开更多
Introduction: Herpes simplex virus is the most common etiology for life-threatening sporadic encephalitis worldwide. Antiviral therapy with acyclovir has been shown to reduce mortality and should be started promptly i...Introduction: Herpes simplex virus is the most common etiology for life-threatening sporadic encephalitis worldwide. Antiviral therapy with acyclovir has been shown to reduce mortality and should be started promptly in patients with clinically suspected viral encephalitis before serological confirmation of the diagnosis. Despite antiviral treatment, it is associated with significant mortality and a wide range of neurologic sequelae or neuropsychiatric disorders. Clinical presentation includes fever, headache, altered mental status, and focal or generalized seizures. In some cases, it can present with focal neurological deficits, such as an acute stroke. The aim of this study is to identify rare complications of HSVE. Presentation: We present a case of a 71-year-old female patient with herpes virus encephalitis and an ischemic cerebral accident. The findings of CT scan of the brain revealed an extensive right temporal hypodensity. CSF findings include an elevated protein level, normal glucose level and pleocytosis with lymphocyte predominance. The lumbar tap confirmed the presence of herpes simplex virus type 1 with polymerase chain reaction (PCR) in the CSF. Neurological manifestations include focal neurological deficit with left-sided hemiparesis and coma. After 40 days of complex therapy, an improvement in the mental state was observed. Conclusion: There are varying degrees of neurologic sequelae among survivors in children and adults despite the antiviral treatment. Herpes simplex encephalitis has significant morbidity and high mortality due to the lack of prophylactic treatment and preventable strategies.展开更多
基金supported by grants from the National Natural Science Foundation of China(82071331)National Key Research and Development Program of China(2018YFC1312200)Canadian Institutes of Health Research(VWY).
文摘Stroke is an acute cerebrovascular event characterized by focal neurological deficits resulting from the interruption of cerebral blood flow.As the second leading cause of death globally,stroke is responsible for approximately 6.5 million deaths annually,with a disability rate as high as 50%.Survivors often experience long-term motor,cognitive,and psychological impairments,placing substantial burdens on families and healthcare systems.Stroke is classified into two primary types:ischemic stroke,caused by cerebral artery embolism or thrombosis,and hemorrhagic stroke,resulting from blood vessel rupture.Clinically,it manifests as the sudden onset of neurological dysfunction,with typical symptoms including hemiparesis,dysarthria,sensory disturbances,aphasia,and visual impairments.
文摘Introduction: Herpes simplex virus is the most common etiology for life-threatening sporadic encephalitis worldwide. Antiviral therapy with acyclovir has been shown to reduce mortality and should be started promptly in patients with clinically suspected viral encephalitis before serological confirmation of the diagnosis. Despite antiviral treatment, it is associated with significant mortality and a wide range of neurologic sequelae or neuropsychiatric disorders. Clinical presentation includes fever, headache, altered mental status, and focal or generalized seizures. In some cases, it can present with focal neurological deficits, such as an acute stroke. The aim of this study is to identify rare complications of HSVE. Presentation: We present a case of a 71-year-old female patient with herpes virus encephalitis and an ischemic cerebral accident. The findings of CT scan of the brain revealed an extensive right temporal hypodensity. CSF findings include an elevated protein level, normal glucose level and pleocytosis with lymphocyte predominance. The lumbar tap confirmed the presence of herpes simplex virus type 1 with polymerase chain reaction (PCR) in the CSF. Neurological manifestations include focal neurological deficit with left-sided hemiparesis and coma. After 40 days of complex therapy, an improvement in the mental state was observed. Conclusion: There are varying degrees of neurologic sequelae among survivors in children and adults despite the antiviral treatment. Herpes simplex encephalitis has significant morbidity and high mortality due to the lack of prophylactic treatment and preventable strategies.
