Some apolar organic solvents is miscible with perfluorous nonene to form fluorous biphase systems.Perfluorous nonene could be used as a green solvent in equimolar esterification of carboxylic acids with alcohols witho...Some apolar organic solvents is miscible with perfluorous nonene to form fluorous biphase systems.Perfluorous nonene could be used as a green solvent in equimolar esterification of carboxylic acids with alcohols without removal of water or ester formed. Perfluorous nonene made the esterification equilibrium to move right and the yields of esterification to enhance in different degrees as compared with that in the absence of perfluorous nonene. After esterification perfluorous nonene is easy to be recovered and recycled.展开更多
A facile, efficient and novel approach to access 2-substituted-N1-carbethoxy-2,3-dihydro-4（1H）-quinazolinones was developed by condensation of substituted N-carbethoxyanthranilamide with alkyl, aromatic or heteroaro...A facile, efficient and novel approach to access 2-substituted-N1-carbethoxy-2,3-dihydro-4（1H）-quinazolinones was developed by condensation of substituted N-carbethoxyanthranilamide with alkyl, aromatic or heteroaromatic aldehydes in the refluxing 2,2,2- trifluoroethanol or hexafluoroisopropanol using p-toluenesulfonic acid as catalyst.展开更多
We herein described the design, synthesis and application of two recyclable benzyl-type fluorous tags with double fluorous chains. The benzyl-type fluorous tags were prepared in 3 steps from a commercially available f...We herein described the design, synthesis and application of two recyclable benzyl-type fluorous tags with double fluorous chains. The benzyl-type fluorous tags were prepared in 3 steps from a commercially available fluorous alcohol. The glycosylation of the benzyl-type tags with imidate donors proceeded smoothly to provide the corresponding fluorous-tagged carbohydrates in good to excellent yields, which were readily purified by fluorous solid-phase extraction（FSPE）. Efficient removal of the tags from tagtethered carbohydrates were conducted under the common catalytic hydrogenation condition and the initial benzyl-type fluorous tags could be regenerated [5_TD$IF]via a 2-step simple procedure in 69%–93% yields.The utility of the new benzyl-fluorous tag was demonstrated [7_TD$IF]via the FSPE-assisted synthesis of oligosaccharides Gb3.展开更多
Methyl methacrylate （MMA） was polymerized by using of benzoyl peroxide （BPO） and N, N-dimethylaniline （DMA） as an redox initiator in fluorous triphasic system at room temperature. The polymerization was occurred...Methyl methacrylate （MMA） was polymerized by using of benzoyl peroxide （BPO） and N, N-dimethylaniline （DMA） as an redox initiator in fluorous triphasic system at room temperature. The polymerization was occurred in both initiator layer and monomer layer in a U-tube. It was found that PMMA obtained from the initiator layer with relatively narrow polydispersity.（PDI = 1.38）展开更多
A convenient method for Morita-Baylis-Hillman reaction of arylaldehydes with methyl acrylate has been developed by using fluorous-tag organocatalyst 1-[4-（perfluorooctyl）phenyl]-3-phenylthiourea and DABCO at room te...A convenient method for Morita-Baylis-Hillman reaction of arylaldehydes with methyl acrylate has been developed by using fluorous-tag organocatalyst 1-[4-（perfluorooctyl）phenyl]-3-phenylthiourea and DABCO at room temperature. The fluorous organocatalyst could be recovered from the reaction mixture by fluorous solid-phase extraction （F-SPE） with excellent purity for direct reuse.展开更多
Thick-film organic solar cells(OSCs)are critical for large-scale manufacturing,yet they face persistent challenges of severe energy loss and complex morphology control.The integration of molecular design and device en...Thick-film organic solar cells(OSCs)are critical for large-scale manufacturing,yet they face persistent challenges of severe energy loss and complex morphology control.The integration of molecular design and device engineering is widely recognized as a promising strategy to address these bottlenecks.Here,we report the synthesis of a fluoropolymer PF8 and its application in combination with fluorous solvent vapor annealing(FSVA)post-treatment to fabricate high-performance thick-film OSCs.The fluorination strategy and FSVA process synergistically enhance the polymer’s crystallinity and induce an intrinsic fibrous morphology.As a result,the FSVA-treated PF8:L8BO device with a thickness of 110 nm achieves a power conversion efficiency(PCE)of 18.89%.Notably,even when the film thickness is increased to 300 and 500 nm,the devices maintain high efficiencies of 17.54%and 15.59%,respectively.More importantly,the 300-nm FSVA-treated blend films exhibit enhanced packing order and well-defined fibrillar morphology,leading to suppressed non-radiative recombination and efficient charge transport along the fiber network.This study demonstrates the potential of combining fluoropolymers with fluorous solvent-based device engineering for advanced thick-film optoelectronic applications,providing a viable pathway for scalable OSC manufacturing.展开更多
The similarities in molecular size and physical properties of acetylene(C_(2)H_(2))and carbon dioxide(CO_(2))produce a formidable challenge for their separation.Herein,we report two isoreticular fluorinated metal–org...The similarities in molecular size and physical properties of acetylene(C_(2)H_(2))and carbon dioxide(CO_(2))produce a formidable challenge for their separation.Herein,we report two isoreticular fluorinated metal–organic frameworks(MOFs),labeled as JXNU-11(Fe2M)(M=Ni and Co),featuring unique octahedral cages encapsulated by cuboctahedral cages.JXNU-11(Fe_(2)Ni)shows a record high C_(2)H_(2)-capture amount of 4.8mmol g−1 and a long C_(2)H_(2)/CO_(2)breakthrough interval time of 55 min g^(−1)in an actual breakthrough experiment based on the equimolar C_(2)H_(2)/CO_(2)mixture under ambient conditions,indicating a high-performance material for C_(2)H_(2)capture andC_(2)H_(2)/CO_(2)separation.展开更多
Fluorous gold nanoparticle （Fluo-NP）, i.e. gold nanoparticle covered by fluorous ponytail （C8F17-） was pre- pared and found to self-assemble into supra-structures covered by carbohydrates （named supraF-NP）, due ...Fluorous gold nanoparticle （Fluo-NP）, i.e. gold nanoparticle covered by fluorous ponytail （C8F17-） was pre- pared and found to self-assemble into supra-structures covered by carbohydrates （named supraF-NP）, due to the strong fluorous interaction. More importantly, the re-dispersed supraF-NP （diameter around 200 nm） in water pro- vided an alternative strategy to detect carbohydrate-protein interaction in solution by naked eve.展开更多
We report the development of a small interfering RNA （siRNA） delivery vector based on cationic perfluorocarbon nanoemulsions. We have prepared perfluorodecalin （PFD） emulsions with a positive surface charge provid...We report the development of a small interfering RNA （siRNA） delivery vector based on cationic perfluorocarbon nanoemulsions. We have prepared perfluorodecalin （PFD） emulsions with a positive surface charge provided by a fluorinated poly（ethylenimine） （F-PEI）. The fluorinated emulsion （F-PEI@PFD） reduced cytotoxicity of F-PEI and demonstrated effective binding with siRNAs to form nanosized emulsion polyplexes. The prepared emulsion polyplexes enhanced cellular uptake and improved endosomal escape of the siRNA. In addition to increased reporter gene silencing in multiple cancer cell lines, when compared with control F-PEI and PEI polyplexes, the siR_NA emulsion polyplexes showed an excellent resistance to serum deactivation and maintained high activity, even in high-serum conditions. The F-PEI@PFD emulsion polyplexes carrying an siRNA to silence the expression of Bcl2 gene induced apoptosis and inhibited tumor growth in a melanoma mouse model in vivo and showed potential for in vivo ultrasound imaging. This study demonstrates the potential of F-PEI@PFD emulsions as a multifunctional theranostic nanoplatform for safe siRNA delivery, with integrated ultrasound imaging functionality.展开更多
Bis(1H,1H,2H,2H perfluorooctyl) BINOL and 6,6′ bis(1 H ,1 H ,2 H ,2 H perfluorodecyl) BINOL were synthesized through Suzuki coupling reaction and used in fluorous biphase asymmetric alkylation...Bis(1H,1H,2H,2H perfluorooctyl) BINOL and 6,6′ bis(1 H ,1 H ,2 H ,2 H perfluorodecyl) BINOL were synthesized through Suzuki coupling reaction and used in fluorous biphase asymmetric alkylation of benzaldehyde. Good enantioselectivity was obtained and the catalysts could be recovered by liquid liquid extraction.展开更多
基金Supported by the Natural Science Foundation of Zhejiang Province （Y 405396）.
文摘Some apolar organic solvents is miscible with perfluorous nonene to form fluorous biphase systems.Perfluorous nonene could be used as a green solvent in equimolar esterification of carboxylic acids with alcohols without removal of water or ester formed. Perfluorous nonene made the esterification equilibrium to move right and the yields of esterification to enhance in different degrees as compared with that in the absence of perfluorous nonene. After esterification perfluorous nonene is easy to be recovered and recycled.
基金We are grateful to the National Natural Science Foundation of China(No.30672540)the Natural Science Foundation of Beijing(No.7072048)for financial support.
文摘A facile, efficient and novel approach to access 2-substituted-N1-carbethoxy-2,3-dihydro-4（1H）-quinazolinones was developed by condensation of substituted N-carbethoxyanthranilamide with alkyl, aromatic or heteroaromatic aldehydes in the refluxing 2,2,2- trifluoroethanol or hexafluoroisopropanol using p-toluenesulfonic acid as catalyst.
基金supported by the National Natural Science Foundation of China(Nos.21072122,21472119,21302119)Ministry of Science and Technology(No.2012ZX09502-001-001)
文摘We herein described the design, synthesis and application of two recyclable benzyl-type fluorous tags with double fluorous chains. The benzyl-type fluorous tags were prepared in 3 steps from a commercially available fluorous alcohol. The glycosylation of the benzyl-type tags with imidate donors proceeded smoothly to provide the corresponding fluorous-tagged carbohydrates in good to excellent yields, which were readily purified by fluorous solid-phase extraction（FSPE）. Efficient removal of the tags from tagtethered carbohydrates were conducted under the common catalytic hydrogenation condition and the initial benzyl-type fluorous tags could be regenerated [5_TD$IF]via a 2-step simple procedure in 69%–93% yields.The utility of the new benzyl-fluorous tag was demonstrated [7_TD$IF]via the FSPE-assisted synthesis of oligosaccharides Gb3.
文摘Methyl methacrylate （MMA） was polymerized by using of benzoyl peroxide （BPO） and N, N-dimethylaniline （DMA） as an redox initiator in fluorous triphasic system at room temperature. The polymerization was occurred in both initiator layer and monomer layer in a U-tube. It was found that PMMA obtained from the initiator layer with relatively narrow polydispersity.（PDI = 1.38）
基金the project of"Excellence Initiative"and"Zijin Star"in NJUST,"Doctoral Fund of Ministry of Education of China"(No.200802881024)"National Natural Science Foundation of China"(No.20902047) for financial support
文摘A convenient method for Morita-Baylis-Hillman reaction of arylaldehydes with methyl acrylate has been developed by using fluorous-tag organocatalyst 1-[4-（perfluorooctyl）phenyl]-3-phenylthiourea and DABCO at room temperature. The fluorous organocatalyst could be recovered from the reaction mixture by fluorous solid-phase extraction （F-SPE） with excellent purity for direct reuse.
基金supported by the National Natural Science Foundation of China(22379095)the Natural Science Foundation of Shanghai(21ZR1435100)the Oceanic Interdisciplinary Program of Shanghai Jiao Tong University(SL2022MS015).
文摘Thick-film organic solar cells(OSCs)are critical for large-scale manufacturing,yet they face persistent challenges of severe energy loss and complex morphology control.The integration of molecular design and device engineering is widely recognized as a promising strategy to address these bottlenecks.Here,we report the synthesis of a fluoropolymer PF8 and its application in combination with fluorous solvent vapor annealing(FSVA)post-treatment to fabricate high-performance thick-film OSCs.The fluorination strategy and FSVA process synergistically enhance the polymer’s crystallinity and induce an intrinsic fibrous morphology.As a result,the FSVA-treated PF8:L8BO device with a thickness of 110 nm achieves a power conversion efficiency(PCE)of 18.89%.Notably,even when the film thickness is increased to 300 and 500 nm,the devices maintain high efficiencies of 17.54%and 15.59%,respectively.More importantly,the 300-nm FSVA-treated blend films exhibit enhanced packing order and well-defined fibrillar morphology,leading to suppressed non-radiative recombination and efficient charge transport along the fiber network.This study demonstrates the potential of combining fluoropolymers with fluorous solvent-based device engineering for advanced thick-film optoelectronic applications,providing a viable pathway for scalable OSC manufacturing.
基金supported by the National Natural Science Foundation of China(nos.22061022 and 21861020)the Foundation for Academic and Technical Leaders of Major Disciplines of Jiangxi Province(no.20204BCJL22043).
文摘The similarities in molecular size and physical properties of acetylene(C_(2)H_(2))and carbon dioxide(CO_(2))produce a formidable challenge for their separation.Herein,we report two isoreticular fluorinated metal–organic frameworks(MOFs),labeled as JXNU-11(Fe2M)(M=Ni and Co),featuring unique octahedral cages encapsulated by cuboctahedral cages.JXNU-11(Fe_(2)Ni)shows a record high C_(2)H_(2)-capture amount of 4.8mmol g−1 and a long C_(2)H_(2)/CO_(2)breakthrough interval time of 55 min g^(−1)in an actual breakthrough experiment based on the equimolar C_(2)H_(2)/CO_(2)mixture under ambient conditions,indicating a high-performance material for C_(2)H_(2)capture andC_(2)H_(2)/CO_(2)separation.
基金The Ministry of Science and Technology of China，the National Natural Science Foundation of China，the Shanghai Rising-Star Program (No.13QA1400600) are acknowledged for their financial supports
文摘Fluorous gold nanoparticle （Fluo-NP）, i.e. gold nanoparticle covered by fluorous ponytail （C8F17-） was pre- pared and found to self-assemble into supra-structures covered by carbohydrates （named supraF-NP）, due to the strong fluorous interaction. More importantly, the re-dispersed supraF-NP （diameter around 200 nm） in water pro- vided an alternative strategy to detect carbohydrate-protein interaction in solution by naked eve.
基金This work was financially supported by the National Science and Technology Major Project （No. 2017YFA0205400）, the Changjiang Scholar program, the National Natural Science Foundation of China （Nos. 81373983 and 81573377）, China Postdoctoral Science Foundation （No. 2016M601923）, and Postgraduate Research ＆ Practice Innovation Program of Jiangsu Province （No. KYCX17_0671）.
文摘We report the development of a small interfering RNA （siRNA） delivery vector based on cationic perfluorocarbon nanoemulsions. We have prepared perfluorodecalin （PFD） emulsions with a positive surface charge provided by a fluorinated poly（ethylenimine） （F-PEI）. The fluorinated emulsion （F-PEI@PFD） reduced cytotoxicity of F-PEI and demonstrated effective binding with siRNAs to form nanosized emulsion polyplexes. The prepared emulsion polyplexes enhanced cellular uptake and improved endosomal escape of the siRNA. In addition to increased reporter gene silencing in multiple cancer cell lines, when compared with control F-PEI and PEI polyplexes, the siR_NA emulsion polyplexes showed an excellent resistance to serum deactivation and maintained high activity, even in high-serum conditions. The F-PEI@PFD emulsion polyplexes carrying an siRNA to silence the expression of Bcl2 gene induced apoptosis and inhibited tumor growth in a melanoma mouse model in vivo and showed potential for in vivo ultrasound imaging. This study demonstrates the potential of F-PEI@PFD emulsions as a multifunctional theranostic nanoplatform for safe siRNA delivery, with integrated ultrasound imaging functionality.
文摘Bis(1H,1H,2H,2H perfluorooctyl) BINOL and 6,6′ bis(1 H ,1 H ,2 H ,2 H perfluorodecyl) BINOL were synthesized through Suzuki coupling reaction and used in fluorous biphase asymmetric alkylation of benzaldehyde. Good enantioselectivity was obtained and the catalysts could be recovered by liquid liquid extraction.
