This paper tries to build a multi-functional downhole nuclear magnetic resonance （NMR） fluid analysis laboratory that can evaluate fluid information in real time at reservoir conditions at a depth of several thousan...This paper tries to build a multi-functional downhole nuclear magnetic resonance （NMR） fluid analysis laboratory that can evaluate fluid information in real time at reservoir conditions at a depth of several thousand meters. The aim is to monitor the pollution of the formation fluids and quantitatively evaluate NMR characteristics of the fluids. It focuses on the design of the structure and parameters of a sensor with zero stray fields. Two separate coils are designed to measure NMR characteristics of flowing or static fluids. A method is proposed to use the Bloch equation, to guide the optimization of the NMR sensor. Finally, the measured results confirm that the design is reasonable. There is a homogeneous static field （perpendicular to the axial direction） in the center of the sensor, and there are no stray external fields. The novel design of pre-polarization magnet improves the signal to noise ratio, while shortening the sensor length.展开更多
·AIM:To evaluate visual outcomes and changes in fluid after administering monthly anti-vascular endothelial growth factor(VEGF)injections to treat neovascular agerelated macular degeneration(n AMD)with subretinal...·AIM:To evaluate visual outcomes and changes in fluid after administering monthly anti-vascular endothelial growth factor(VEGF)injections to treat neovascular agerelated macular degeneration(n AMD)with subretinal fluid(SRF)and pigment epithelial detachment(PED).·METHODS:This prospective study included eyes with n AMD previously treated with as-needed anti-VEGF injections.The patients were treated with six monthly intravitreal injections of ranibizumab.Quantitative volumetric segmentation analyses of the SRF and PED were performed.The main outcome measures included best-corrected visual acuity(BCVA),and SRF and PED volumes.·RESULTS:Twenty eyes of 20 patients were included in this study.At the 6-month follow-up,BCVA and PED volume did not change significantly(P=0.110 and 0.999,respectively)but the mean SRF volume decreased from 0.53±0.82 mm3 at baseline to 0.08±0.23 mm3(P=0.002).The absorption rate of the SRF volume was negatively correlated with the duration of previous antiVEGF treatment(P=0.029).Seven of the 20 eyes(35%)showed a fluid-free macula and significant improvement in BCVA(P=0.036)by month 6.·CONCLUSION:Quantifying the SRF can precisely determine the patient’s responsiveness to anti-VEGF treatment of n AMD.展开更多
The surrogate model technology has a good performance in solving black-box optimization problems,which is widely used in multi-domain engineering optimization problems.The adaptive surrogate model is the mainstream re...The surrogate model technology has a good performance in solving black-box optimization problems,which is widely used in multi-domain engineering optimization problems.The adaptive surrogate model is the mainstream research direction of surrogate model technology,which can realize model fitting and global optimization of engineering problems by infilling criteria.Based on the idea of the adaptive surrogate model,this paper proposes an efficient global optimization algorithm based on the local remodeling method(EGO-LR),which aims at improving the accuracy and optimization efficiency of the model.The proposed algorithm firstly constructs the expectation improvement(EI)function in the local area and optimizes it to get the update points.Secondly,the obtained update points are added to the global region until the global accuracy of the model meets the requirements.Then the differential evolution algorithm is used for global optimization.Sixteen benchmark functions are used to compare the EGO-LR algorithm with the existing algorithms.The results show that the EGO-LR algorithm can quickly converge to the accuracy requirements of the model and find the optimal value efficiently when facing complex problems with many local extrema and large variable spaces.The proposed algorithm is applied to the optimization design of the structural parameter of the impeller,and the outflow field analysis of the impeller is realized through finite element analysis.The optimization with the maximum fluid pressure(MP value)of the impeller as the objective function is completed,which effectively reduces the pressure value of the impeller under load.展开更多
<strong>Background: </strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Semen analysis has rema...<strong>Background: </strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Semen analysis has remained an objective, inexpensive and readil</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">y available means of assessing male factor infertility. </span><b><span style="font-family:Verdana;">Aim and Objective: </span></b><span style="font-family:Verdana;">This study aims to determine the prevalence of male infertility, the type</span><span style="font-family:Verdana;">s and</span><span style="font-family:Verdana;"> semen quality among infertile couples attending infertility clinic at UDUTH, Sokoto. </span><b><span style="font-family:Verdana;">Materials and Method:</span></b><span style="font-family:Verdana;"> This is a retrospective study carried out bet</span><span style="font-family:Verdana;">ween January, 2012 to December, 2016. All case notes of infertile pat</span><span style="font-family:Verdana;">ients </span><span style="font-family:Verdana;">managed were retrieved The data obtained was analysed using SPSS version 20 </span><span style="font-family:Verdana;">and the results were presented in text, tables and charts. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">Eight hundred and seventy-six out of 11,938 total gynaecological consultations over the </span><span style="font-family:Verdana;">study period were due to infertility, giving a prevalence of 7.3%. Among the</span><span style="font-family:Verdana;">m, 34.4% (320) accounted for male factor infertility. The age ranged between 22 to 75 years with a mean of 37.44 years ± 7.44. Majority, 50.2% were within the </span><span style="font-family:Verdana;">ages of 35 - 44 years and up to 73.8% of them had at least secondary education</span><span style="font-family:Verdana;"> and were mostly, 39.7% civil servants. Up to 75.4% had sperm abnormalities, among which 65% (196/301) had primary infertility while, 35% (105/301) had secondary infertility. About half of them (47.5% (153/301)) had Azoospermia, 22.3% (67/301) Oligospermia and only 30.3% (91/301) had a normal sperm </span><span style="font-family:Verdana;">count. More than half of them, 121/227 (53.3% had multiple abnormaliti</span><span style="font-family:Verdana;">es). </span><b><span style="font-family:Verdana;">Conclusion: </span></b><span style="font-family:Verdana;">Male factor infertility contributes significantly to the bur</span><span style="font-family:Verdana;">den of </span><span><span style="font-family:Verdana;">infertility in</span><b> </b><span style="font-family:Verdana;">our</span><b> </b><span style="font-family:Verdana;">environment. Therefore, there is the need to create awarenes</span></span><span style="font-family:Verdana;">s so that males fully participate in the evaluation, as the blames are mainly on the females.</span></span></span></span>展开更多
Multicent ricreticulohistiocytosis (MRH) is a rare systemic disease of unclear etiology characterized by destructive, deforming arthritis, nodules in the skin, mucous membrane and internal organs and can be associated...Multicent ricreticulohistiocytosis (MRH) is a rare systemic disease of unclear etiology characterized by destructive, deforming arthritis, nodules in the skin, mucous membrane and internal organs and can be associated with malignancy. The tenosynovial fluid and tenosynovium histologic findings have not been reported in any case reports of MRH in the literature. To our knowledge, this is the first case report of tenosynovial fluid and tenosynovium demonstrating the classic histologic findings of histiocytes with a foamy eosinophilic cytoplasm. This case also demonstrates a non-deforming arthritis.展开更多
Ascites is the pathologic accumulation of fluid within the peritoneal cavity.Because many diseases can cause ascites,in particular cirrhosis,samples of ascitic fluid are commonly analyzed in order to develop a differe...Ascites is the pathologic accumulation of fluid within the peritoneal cavity.Because many diseases can cause ascites,in particular cirrhosis,samples of ascitic fluid are commonly analyzed in order to develop a differential diagnosis.The concept of transudate versus exudate,as determined by total protein measurements,is outdated and the use of serumascites albumin gradient as an indicator of portal hypertension is more accurate.Lactate dehydrogenase (LDH),vascular endothelial growth factor (VEGF),and other tumor markers can be helpful in distinguishing between malignant and benign conditions.Glucose and adenosine deaminase levels may support a diagnosis of tuberculous disease,and amylase level may indicate a diagnosis of pancreatitis.Given the specificity and sensitivity of laboratory results,accurate diagnosis should be based on both laboratory data and clinical iudgment.展开更多
The transport of fluid, nutrients, and signaling molecules in the bone lacunar-canalicular system （LCS） is critical for osteocyte survival and function. We have applied the fluorescence recovery after photobleaching...The transport of fluid, nutrients, and signaling molecules in the bone lacunar-canalicular system （LCS） is critical for osteocyte survival and function. We have applied the fluorescence recovery after photobleaching （FRAP） approach to quantify load-induced fluid and solute transport in the LCS in situ, but the measurements were limited to cortical regions 30-50 μm underneath the periosteum due to the constrains of laser penetration. With this work, we aimed to expand our understanding of load-induced fluid and solute transport in both trabecular and cortical bone using a multiscaled image-based finite element analysis （FEA） approach. An intact murine tibia was first re-constructed from microCT images into a three-dimensional （3D） linear elastic FEA model, and the matrix deformations at various locations were calculated under axial loading. A segment of the above 3D model was then imported to the biphasic poroelasticity analysis platform （FEBio） to predict load-induced fluid pressure fields, and interstitial solute/fluid flows through LCS in both cortical and trabecular regions. Further, secondary flow effects such as the shear stress and/or drag force acting on osteocytes, the presumed mechano-sensors in bone, were derived using the previously developed ultrastructural model of Brinkman flow in the canaliculi. The material properties assumed in the FEA models were validated against previously obtained strain and FRAP transport data measured on the cortical cortex. Our results demonstrated the feasibility of this computational approach in estimating the fluid flux in the LCS and the cellular stimulation forces （shear and drag forces） for osteocytes in any cortical and trabecular bone locations, allowing further studies of how the activation of osteocytes correlates with in vivo functional bone formation. The study provides a promising platform to reveal potential cellular mechanisms underlying the anabolic power of exercises and physical activities in treating patients with skeletal deficiencies.展开更多
BACKGROUND： Guillain-Barre syndrome （GBS） is an autoimmune disease which is characterized by demyelination of peripheral nerve and nerve root, and inflammatory reaction of lymphocyte and macrophage. Neuroelectrophy...BACKGROUND： Guillain-Barre syndrome （GBS） is an autoimmune disease which is characterized by demyelination of peripheral nerve and nerve root, and inflammatory reaction of lymphocyte and macrophage. Neuroelectrophysiological examination and cerebrospinal fluid （CSF） analysis are of significance for its diagnosis. OBJECTIVE： To study the association of neuroelectrophysiology and cerebrospinal fluid immunoglobulin （CSF-lg） with pathogenetic conditions of patients with GBS. DESIGN： Case control study SETTING： Department of Neurology, Shenzhen Municipal Shekou Group Hospital; Department of Neuroelectrophysiology, People＇s Hospital of Guangdong Province. PARTICIPANTS： A total of 32 GBS patients including 18 males and 14 females who aged from 17 to 72 years were selected as experimental group from the Department of Neurology, People＇s Hospital of Guang- dong Province from January 2004 to December 2005. All cases conformed with GBS diagnostic criteria established by Asbury in 1990 and they were divided into three types according to neurological criteria established by Chinese Neurology and Psychology Journal in 1993： mild, moderate and severe types. Another 30 patients with vascular headache were selected as control group from the same hospital including 14 males and 16 females who aged from 17 to 79 years. METHODS： ① Neuroelectrophysiological examination： Multiple-functional electromyography device provided by Nicolet Company, USA was used to measure nerve conduction velocity （NCV）, including motor nerve conduction velocity （MCV） and sensory nerve conduction velocity （SCV）; meanwhile, electromyologram （EMG）, somatosensory evoked potential （SEP） and electroencephalogram （EEG） were also measured. ② Detection of CSF-lg： Concentrations of IgG, IgA and IgM were measured with immunofixation electrophoresis. ③Follow-up： Among 32 GBS patients, 14 cases received follow-up after treatment and the longest fol- low-up time was 1 year after onset. Among them, 8 cases were reexaminined with neuroelectrophysiological and CSF examinations. MAIN OUTCOME MEASURES： Results of NCV, EMG, SEP and EEG; comparison of CSF-lg content; results of follow-up examinations. RESULTS： All 32 GBS cases and 30 patients with vascular headache were involved in the final analysis. ① Abnormal rate of neuroelectrophysiological test： 75% of NCV, 88% of F-wave, 53% of MCV, 25% of SEP, 47% of EMG and 31% of EEG. There were no significant differences among various types （P 〉 0.05）. ② Results of CSF-lg test： There were no significant differences among various types （P 〉 0.05）; however, abnormalities in experimental group was higher than those in control group （P 〈 0.01）. CONCLUSION ： Results of follow-up study suggest that improvement of clinical symptom is earlier than neuroelectrophysiological recovery; MCV and EMG recoveries are faster than that of NCV; the earlier the abnormality of EMG, the poorer the recovery. CSF4g recovers normally along improvement of clinical symptoms. It is of significance for neuroelectrophysiology and abnormality of CSF-Ig to determine degree of peripheral nerve demyelination and prognosis.展开更多
A high-performance liquid chromatographic method for the simultaneous determination of KR-008 and its metabolite in biological fluids was developed The samples were injected directly without further treatment,the comp...A high-performance liquid chromatographic method for the simultaneous determination of KR-008 and its metabolite in biological fluids was developed The samples were injected directly without further treatment,the compounds were separated and analysed on a reversed- phase column under isocratic conditions,including ion pairing.Concentrations in urine and bile were determined by an external standard method.The detection limit was 0.8μg/ml in urine.Preliminary data showed that,following i.p.administration(120mg/kg)of KR-008 to rats,approximately 2.8% of the dose was excreted in urine as unchanged compound and more than 8.9% was as a metabolite;in bile it was 0.73% excreted as unchanged form and above 0.29% as the metabolite.The peak biliary concentration of KR-008 was 0.39mg/ml at 20min after dosing.展开更多
In this paper, a new finite element method for the flow analysis of the viscous incompressible power-law fluid is proposed by the use of penalty-hybrid/mixed finite element formulation and by the introduction of an al...In this paper, a new finite element method for the flow analysis of the viscous incompressible power-law fluid is proposed by the use of penalty-hybrid/mixed finite element formulation and by the introduction of an alternative perturbation, which is weighted by viscosity, of the continuity equation. A numerical example is presented to exhibit the efficiency of the method.展开更多
Torquigener albomaculosus,also known as the white-spotted pufferfish,is known for creating circular nests in the underwater sand as part of the mating ritual.The nests are built by the males to attract females through...Torquigener albomaculosus,also known as the white-spotted pufferfish,is known for creating circular nests in the underwater sand as part of the mating ritual.The nests are built by the males to attract females through the nest’s impressive design and related ability to gather fine sand particles.As the fluid-dynamic processes associated with these unique nests are still almost completely unknown,in the present study,an analysis has been conducted to investigate how the geometric parameters related to the nest design influence the fluid velocity in its center.For this reason,a geometric model of the nest consisting of 24 channels,where each unit channel can be described by three strips of broken lines,has been introduced,and a multivariate analysis has been implemented to determine the relative weight of each considered parameter.In particular,the“optimal”combination of parameters has been obtained by means of an orthogonal design approach.We show that these bio-nest structures also display a potential for significant application in marine litter collection,or for use as a buffer against the waves in offshore areas.展开更多
Fluid flow analysis, such as gas flow analysis, water flow analysis, etc., is a fundamental problem in integrated energy systems (IES). Datasets are significant for researchers to test their proposed models and algori...Fluid flow analysis, such as gas flow analysis, water flow analysis, etc., is a fundamental problem in integrated energy systems (IES). Datasets are significant for researchers to test their proposed models and algorithms for fluid flow analysis. In this paper, we provide multiple benchmark datasets of fluid systems with detailed topology and operation information, such as data of fluid supply, fluid demand, pipes, valves, compressors/pumps, physical operation limits, etc. The provided benchmark datasets have synthetic and practical fluid systems of different scales, including gas systems with numbers of nodes ranging from 11 to 4197 and water systems with numbers of nodes ranging from 7 to 1894. Then, the data format of the datasets is described. Finally, fluid flow results on different benchmark systems under several typical scenarios are analyzed.展开更多
A fluid–structure interaction method combining a nonlinear finite element algorithm with a preconditioning finite volume method is proposed in this paper to simulate parachute transient dynamics. This method uses a t...A fluid–structure interaction method combining a nonlinear finite element algorithm with a preconditioning finite volume method is proposed in this paper to simulate parachute transient dynamics. This method uses a three-dimensional membrane–cable fabric model to represent a parachute system at a highly folded configuration. The large shape change during parachute inflation is computed by the nonlinear Newton–Raphson iteration and the linear system equation is solved by the generalized minimal residual（GMRES） method. A membrane wrinkling algorithm is also utilized to evaluate the special uniaxial tension state of membrane elements on the parachute canopy. In order to avoid large time expenses during structural nonlinear iteration, the implicit Hilber–Hughes–Taylor（HHT） time integration method is employed. For the fluid dynamic simulations, the Roe and HLLC（Harten–Lax–van Leer contact） scheme has been modified and extended to compute flow problems at all speeds. The lower–upper symmetric Gauss–Seidel（LUSGS） approximate factorization is applied to accelerate the numerical convergence speed. Finally,the test model of a highly folded C-9 parachute is simulated at a prescribed speed and the results show similar characteristics compared with experimental results and previous literature.展开更多
The fast-growing demand of computational fluid dynamics（CFD） application for computing resources stimulates the development of high performance computing（HPC） and meanwhile raises new requirements for the technolo...The fast-growing demand of computational fluid dynamics（CFD） application for computing resources stimulates the development of high performance computing（HPC） and meanwhile raises new requirements for the technology of parallel application performance monitor and analysis.In response to large-scale and long-time running for the application of CFD,online and scalable performance analysis technology is required to optimize the parallel programs as well as to improve their operational efficiency.As a result,this research implements a scalable infrastructure for online performance analysis on CFD application with homogeneous or heterogeneous system.The infrastructure is part of the parallel application performance monitor and analysis system（PAPMAS） and is composed of two modules which are scalable data transmission module and data storage module.The paper analyzes and elaborates this infrastructure in detail with respect to its design and implementation.Furthermore,some experiments are carried out to verify the rationality and high efficiency of this infrastructure that could be adopted to meet the practical needs.展开更多
Objective: This study aims to explore the differences in cerebrospinal fluid oligoclonal band (CSF-OCB) expression among different age groups in viral encephalitis and its reference value for diagnosis. Methods: Forty...Objective: This study aims to explore the differences in cerebrospinal fluid oligoclonal band (CSF-OCB) expression among different age groups in viral encephalitis and its reference value for diagnosis. Methods: Forty-two patients with viral encephalitis were divided into two groups: 25 adults and 17 children. The presence of oligoclonal bands in the cerebrospinal fluid (CSF) was detected using polyacrylamide gel electrophoresis, and CSF routine analysis was conducted for comparative analysis. Results: The CSF-OCB positivity rate was higher in the adult group (48%) compared with the pediatric group (11.76%), with a statistically significant difference (P Conclusion: 1) The expression of CSF-OCB positivity in patients with viral encephalitis is age-related, with higher positivity rates observed in adults compared to children. 2) Although CSF oligoclonal band detection is not a specific diagnostic marker for viral encephalitis in adults, it still holds certain reference value.展开更多
Physical analysis of the pancreatic cystic lesions(PCLs)fluid as expressed by the rheological behavior(“string sign”)can improve the diagnostic yield and should be integrated in every multimodal PCLs workup.
BACKGROUND Hydatid cyst disease(HCD)is common in certain locations.Surgery is associated with postoperative biliary fistula(POBF)and recurrence.The primary aim of this study was to identify whether occult cysto-biliar...BACKGROUND Hydatid cyst disease(HCD)is common in certain locations.Surgery is associated with postoperative biliary fistula(POBF)and recurrence.The primary aim of this study was to identify whether occult cysto-biliary communication(CBC)can predict recurrent HCD.The secondary aim was to assess the role of cystic fluid bilirubin and alkaline phosphatase(ALP)levels in predicting POBF and recurrent HCD.AIM To identify whether occult CBC can predict recurrent HCD.The secondary aim was to assess the role of cystic fluid bilirubin and ALP levels in predicting POBF and recurrent HCD.METHODS From September 2010 to September 2016,a prospective multicenter study was undertaken involving 244 patients with solitary primary superficial stage cystic echinococcosis 2 and cystic echinococcosis 3b HCD who underwent laparoscopic partial cystectomy with omentoplasty.Univariable logistic regression analysis assessed independent factors determining biliary complications and recurrence.RESULTS There was a highly statistically significant association(P≤0.001)between cystic fluid biochemical indices and the development of biliary complications(of 16 patients with POBF,15 patients had high cyst fluid bilirubin and ALP levels),where patients with high bilirubin-ALP levels were 3405 times more likely to have biliary complications.There was a highly statistically significant association(P≤0.001)between biliary complications,biochemical indices,and the occurrence of recurrent HCD(of 30 patients with recurrent HCD,15 patients had high cyst fluid bilirubin and ALP;all 16 patients who had POBF later developed recurrent HCD),where patients who developed biliary complications and high bilirubin-ALP were 244.6 and 214 times more likely to have recurrent hydatid cysts,respectively.CONCLUSION Occult CBC can predict recurrent HCD.Elevated cyst fluid bilirubin and ALP levels predicted POBF and recurrent HCD.展开更多
Pancreatic cystic neoplasms present a complex diagnostic scenario encompassing low-and high-grade malignancies.Their prevalence varies widely,notably increasing with age,reaching 75%in individuals older than 80 years....Pancreatic cystic neoplasms present a complex diagnostic scenario encompassing low-and high-grade malignancies.Their prevalence varies widely,notably increasing with age,reaching 75%in individuals older than 80 years.Accurate diagnosis is crucial,as errors occur in approximately one-third of resected cysts discovered incidentally.Various imaging modalities such as computed tomography,magnetic resonance imaging,and endoscopic techniques are available to address this challenge.However,risk stratification remains problematic,with guideline inconsistencies and diagnostic accuracy varying according to cyst type.This review proposed a stepwisemanagement approach,considering patient factors,imaging results,and specific features.This patient-centered model offers a structured framework for optimizing the care of individuals with pancreatic cystic neoplasms.展开更多
By using thin section identification, cathodoluminescence, major and trace elements and fluid inclusion tests and authigenic illite dating, based on observation of core cracks, combined with the microscopic characteri...By using thin section identification, cathodoluminescence, major and trace elements and fluid inclusion tests and authigenic illite dating, based on observation of core cracks, combined with the microscopic characteristics and imaging logging characteristics of fractures, the stages of the fractures in the Huagang Formation of the central reversal tectonic belt of the Xihu Sag in the East China Sea, and the matching relationship between the fracture development stages and the oil and gas charging stages are clarified. There are diagenetic fractures and tectonic fractures in the reservoirs of the Huagang Formation in the study area. The diagenetic fractures developed during the diagenetic stage of the reservoirs and have less effect on oil and gas migration and transport. The tectonic fractures are divided into three stages based on tectonic movements controlling the fractures and their relationships with hydrocarbon charging: The first stage of fractures was generated in the early stage of the Himalayan Movement–Longjing Movement(12–13 Ma ago), when the tectonic stress caused the sutures and shale strips to twist, deform, and break. Tectonic microfractures generated in this period had short extension, narrow width, and poor effectiveness, and had little effect on oil and gas migration and transport. The second stage of fractures came up during the middle-late period of Himalayan Movement–Longjing Movement(9–12 Ma ago), when tectonic movements caused the development of tectonic fractures in the central reversal tectonic belt, these fractures are of large scale, long extension, and good effectiveness, and matched with the first stage of large scale oil and gas charging(9–12 Ma ago), so they play an important role in oil and gas migration, transportation, and accumulation. The third stage of fractures were created from Himalayan Movement–Okinawa Trough movement to the present day(0–3 Ma ago), the fractures are tectonic ones developing successively;matching with the second stage(0–3 Ma ago) of large-scale oil and gas charging, they created conditions for continuous natural gas migration and transportation. All these prove that the development of reservoir fractures in the Huagang Formation of Xihu Sag can provide seepage space and continuous and effective channels for efficient migration and accumulation of oil and gas.展开更多
基金Financial support from the National Science Foundation of China (Grant No. 41074102)the China International Science and Technology Cooperation (Grant No.2009DFA61030)
文摘This paper tries to build a multi-functional downhole nuclear magnetic resonance （NMR） fluid analysis laboratory that can evaluate fluid information in real time at reservoir conditions at a depth of several thousand meters. The aim is to monitor the pollution of the formation fluids and quantitatively evaluate NMR characteristics of the fluids. It focuses on the design of the structure and parameters of a sensor with zero stray fields. Two separate coils are designed to measure NMR characteristics of flowing or static fluids. A method is proposed to use the Bloch equation, to guide the optimization of the NMR sensor. Finally, the measured results confirm that the design is reasonable. There is a homogeneous static field （perpendicular to the axial direction） in the center of the sensor, and there are no stray external fields. The novel design of pre-polarization magnet improves the signal to noise ratio, while shortening the sensor length.
文摘·AIM:To evaluate visual outcomes and changes in fluid after administering monthly anti-vascular endothelial growth factor(VEGF)injections to treat neovascular agerelated macular degeneration(n AMD)with subretinal fluid(SRF)and pigment epithelial detachment(PED).·METHODS:This prospective study included eyes with n AMD previously treated with as-needed anti-VEGF injections.The patients were treated with six monthly intravitreal injections of ranibizumab.Quantitative volumetric segmentation analyses of the SRF and PED were performed.The main outcome measures included best-corrected visual acuity(BCVA),and SRF and PED volumes.·RESULTS:Twenty eyes of 20 patients were included in this study.At the 6-month follow-up,BCVA and PED volume did not change significantly(P=0.110 and 0.999,respectively)but the mean SRF volume decreased from 0.53±0.82 mm3 at baseline to 0.08±0.23 mm3(P=0.002).The absorption rate of the SRF volume was negatively correlated with the duration of previous antiVEGF treatment(P=0.029).Seven of the 20 eyes(35%)showed a fluid-free macula and significant improvement in BCVA(P=0.036)by month 6.·CONCLUSION:Quantifying the SRF can precisely determine the patient’s responsiveness to anti-VEGF treatment of n AMD.
基金supported by the National Natural Science Foundation of China under the Contract No.51975106.
文摘The surrogate model technology has a good performance in solving black-box optimization problems,which is widely used in multi-domain engineering optimization problems.The adaptive surrogate model is the mainstream research direction of surrogate model technology,which can realize model fitting and global optimization of engineering problems by infilling criteria.Based on the idea of the adaptive surrogate model,this paper proposes an efficient global optimization algorithm based on the local remodeling method(EGO-LR),which aims at improving the accuracy and optimization efficiency of the model.The proposed algorithm firstly constructs the expectation improvement(EI)function in the local area and optimizes it to get the update points.Secondly,the obtained update points are added to the global region until the global accuracy of the model meets the requirements.Then the differential evolution algorithm is used for global optimization.Sixteen benchmark functions are used to compare the EGO-LR algorithm with the existing algorithms.The results show that the EGO-LR algorithm can quickly converge to the accuracy requirements of the model and find the optimal value efficiently when facing complex problems with many local extrema and large variable spaces.The proposed algorithm is applied to the optimization design of the structural parameter of the impeller,and the outflow field analysis of the impeller is realized through finite element analysis.The optimization with the maximum fluid pressure(MP value)of the impeller as the objective function is completed,which effectively reduces the pressure value of the impeller under load.
文摘<strong>Background: </strong><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Semen analysis has remained an objective, inexpensive and readil</span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">y available means of assessing male factor infertility. </span><b><span style="font-family:Verdana;">Aim and Objective: </span></b><span style="font-family:Verdana;">This study aims to determine the prevalence of male infertility, the type</span><span style="font-family:Verdana;">s and</span><span style="font-family:Verdana;"> semen quality among infertile couples attending infertility clinic at UDUTH, Sokoto. </span><b><span style="font-family:Verdana;">Materials and Method:</span></b><span style="font-family:Verdana;"> This is a retrospective study carried out bet</span><span style="font-family:Verdana;">ween January, 2012 to December, 2016. All case notes of infertile pat</span><span style="font-family:Verdana;">ients </span><span style="font-family:Verdana;">managed were retrieved The data obtained was analysed using SPSS version 20 </span><span style="font-family:Verdana;">and the results were presented in text, tables and charts. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">Eight hundred and seventy-six out of 11,938 total gynaecological consultations over the </span><span style="font-family:Verdana;">study period were due to infertility, giving a prevalence of 7.3%. Among the</span><span style="font-family:Verdana;">m, 34.4% (320) accounted for male factor infertility. The age ranged between 22 to 75 years with a mean of 37.44 years ± 7.44. Majority, 50.2% were within the </span><span style="font-family:Verdana;">ages of 35 - 44 years and up to 73.8% of them had at least secondary education</span><span style="font-family:Verdana;"> and were mostly, 39.7% civil servants. Up to 75.4% had sperm abnormalities, among which 65% (196/301) had primary infertility while, 35% (105/301) had secondary infertility. About half of them (47.5% (153/301)) had Azoospermia, 22.3% (67/301) Oligospermia and only 30.3% (91/301) had a normal sperm </span><span style="font-family:Verdana;">count. More than half of them, 121/227 (53.3% had multiple abnormaliti</span><span style="font-family:Verdana;">es). </span><b><span style="font-family:Verdana;">Conclusion: </span></b><span style="font-family:Verdana;">Male factor infertility contributes significantly to the bur</span><span style="font-family:Verdana;">den of </span><span><span style="font-family:Verdana;">infertility in</span><b> </b><span style="font-family:Verdana;">our</span><b> </b><span style="font-family:Verdana;">environment. Therefore, there is the need to create awarenes</span></span><span style="font-family:Verdana;">s so that males fully participate in the evaluation, as the blames are mainly on the females.</span></span></span></span>
文摘Multicent ricreticulohistiocytosis (MRH) is a rare systemic disease of unclear etiology characterized by destructive, deforming arthritis, nodules in the skin, mucous membrane and internal organs and can be associated with malignancy. The tenosynovial fluid and tenosynovium histologic findings have not been reported in any case reports of MRH in the literature. To our knowledge, this is the first case report of tenosynovial fluid and tenosynovium demonstrating the classic histologic findings of histiocytes with a foamy eosinophilic cytoplasm. This case also demonstrates a non-deforming arthritis.
基金This project was sponsored in part by grants from the National Natural Science Foundation of China(#81072044)the Guangdong Natural Science Foundation(#S2011010004653)
文摘Ascites is the pathologic accumulation of fluid within the peritoneal cavity.Because many diseases can cause ascites,in particular cirrhosis,samples of ascitic fluid are commonly analyzed in order to develop a differential diagnosis.The concept of transudate versus exudate,as determined by total protein measurements,is outdated and the use of serumascites albumin gradient as an indicator of portal hypertension is more accurate.Lactate dehydrogenase (LDH),vascular endothelial growth factor (VEGF),and other tumor markers can be helpful in distinguishing between malignant and benign conditions.Glucose and adenosine deaminase levels may support a diagnosis of tuberculous disease,and amylase level may indicate a diagnosis of pancreatitis.Given the specificity and sensitivity of laboratory results,accurate diagnosis should be based on both laboratory data and clinical iudgment.
基金supported by grants from NIH (P30GM103333 and RO1AR054385 to LW)China CSC fellowship (to LF)DOD W81XWH-13-1-0148 (to XLL)
文摘The transport of fluid, nutrients, and signaling molecules in the bone lacunar-canalicular system （LCS） is critical for osteocyte survival and function. We have applied the fluorescence recovery after photobleaching （FRAP） approach to quantify load-induced fluid and solute transport in the LCS in situ, but the measurements were limited to cortical regions 30-50 μm underneath the periosteum due to the constrains of laser penetration. With this work, we aimed to expand our understanding of load-induced fluid and solute transport in both trabecular and cortical bone using a multiscaled image-based finite element analysis （FEA） approach. An intact murine tibia was first re-constructed from microCT images into a three-dimensional （3D） linear elastic FEA model, and the matrix deformations at various locations were calculated under axial loading. A segment of the above 3D model was then imported to the biphasic poroelasticity analysis platform （FEBio） to predict load-induced fluid pressure fields, and interstitial solute/fluid flows through LCS in both cortical and trabecular regions. Further, secondary flow effects such as the shear stress and/or drag force acting on osteocytes, the presumed mechano-sensors in bone, were derived using the previously developed ultrastructural model of Brinkman flow in the canaliculi. The material properties assumed in the FEA models were validated against previously obtained strain and FRAP transport data measured on the cortical cortex. Our results demonstrated the feasibility of this computational approach in estimating the fluid flux in the LCS and the cellular stimulation forces （shear and drag forces） for osteocytes in any cortical and trabecular bone locations, allowing further studies of how the activation of osteocytes correlates with in vivo functional bone formation. The study provides a promising platform to reveal potential cellular mechanisms underlying the anabolic power of exercises and physical activities in treating patients with skeletal deficiencies.
文摘BACKGROUND： Guillain-Barre syndrome （GBS） is an autoimmune disease which is characterized by demyelination of peripheral nerve and nerve root, and inflammatory reaction of lymphocyte and macrophage. Neuroelectrophysiological examination and cerebrospinal fluid （CSF） analysis are of significance for its diagnosis. OBJECTIVE： To study the association of neuroelectrophysiology and cerebrospinal fluid immunoglobulin （CSF-lg） with pathogenetic conditions of patients with GBS. DESIGN： Case control study SETTING： Department of Neurology, Shenzhen Municipal Shekou Group Hospital; Department of Neuroelectrophysiology, People＇s Hospital of Guangdong Province. PARTICIPANTS： A total of 32 GBS patients including 18 males and 14 females who aged from 17 to 72 years were selected as experimental group from the Department of Neurology, People＇s Hospital of Guang- dong Province from January 2004 to December 2005. All cases conformed with GBS diagnostic criteria established by Asbury in 1990 and they were divided into three types according to neurological criteria established by Chinese Neurology and Psychology Journal in 1993： mild, moderate and severe types. Another 30 patients with vascular headache were selected as control group from the same hospital including 14 males and 16 females who aged from 17 to 79 years. METHODS： ① Neuroelectrophysiological examination： Multiple-functional electromyography device provided by Nicolet Company, USA was used to measure nerve conduction velocity （NCV）, including motor nerve conduction velocity （MCV） and sensory nerve conduction velocity （SCV）; meanwhile, electromyologram （EMG）, somatosensory evoked potential （SEP） and electroencephalogram （EEG） were also measured. ② Detection of CSF-lg： Concentrations of IgG, IgA and IgM were measured with immunofixation electrophoresis. ③Follow-up： Among 32 GBS patients, 14 cases received follow-up after treatment and the longest fol- low-up time was 1 year after onset. Among them, 8 cases were reexaminined with neuroelectrophysiological and CSF examinations. MAIN OUTCOME MEASURES： Results of NCV, EMG, SEP and EEG; comparison of CSF-lg content; results of follow-up examinations. RESULTS： All 32 GBS cases and 30 patients with vascular headache were involved in the final analysis. ① Abnormal rate of neuroelectrophysiological test： 75% of NCV, 88% of F-wave, 53% of MCV, 25% of SEP, 47% of EMG and 31% of EEG. There were no significant differences among various types （P 〉 0.05）. ② Results of CSF-lg test： There were no significant differences among various types （P 〉 0.05）; however, abnormalities in experimental group was higher than those in control group （P 〈 0.01）. CONCLUSION ： Results of follow-up study suggest that improvement of clinical symptom is earlier than neuroelectrophysiological recovery; MCV and EMG recoveries are faster than that of NCV; the earlier the abnormality of EMG, the poorer the recovery. CSF4g recovers normally along improvement of clinical symptoms. It is of significance for neuroelectrophysiology and abnormality of CSF-Ig to determine degree of peripheral nerve demyelination and prognosis.
文摘A high-performance liquid chromatographic method for the simultaneous determination of KR-008 and its metabolite in biological fluids was developed The samples were injected directly without further treatment,the compounds were separated and analysed on a reversed- phase column under isocratic conditions,including ion pairing.Concentrations in urine and bile were determined by an external standard method.The detection limit was 0.8μg/ml in urine.Preliminary data showed that,following i.p.administration(120mg/kg)of KR-008 to rats,approximately 2.8% of the dose was excreted in urine as unchanged compound and more than 8.9% was as a metabolite;in bile it was 0.73% excreted as unchanged form and above 0.29% as the metabolite.The peak biliary concentration of KR-008 was 0.39mg/ml at 20min after dosing.
文摘In this paper, a new finite element method for the flow analysis of the viscous incompressible power-law fluid is proposed by the use of penalty-hybrid/mixed finite element formulation and by the introduction of an alternative perturbation, which is weighted by viscosity, of the continuity equation. A numerical example is presented to exhibit the efficiency of the method.
基金This work is supported by the Henan Provincial Science and Technology Research Project(222102220068).
文摘Torquigener albomaculosus,also known as the white-spotted pufferfish,is known for creating circular nests in the underwater sand as part of the mating ritual.The nests are built by the males to attract females through the nest’s impressive design and related ability to gather fine sand particles.As the fluid-dynamic processes associated with these unique nests are still almost completely unknown,in the present study,an analysis has been conducted to investigate how the geometric parameters related to the nest design influence the fluid velocity in its center.For this reason,a geometric model of the nest consisting of 24 channels,where each unit channel can be described by three strips of broken lines,has been introduced,and a multivariate analysis has been implemented to determine the relative weight of each considered parameter.In particular,the“optimal”combination of parameters has been obtained by means of an orthogonal design approach.We show that these bio-nest structures also display a potential for significant application in marine litter collection,or for use as a buffer against the waves in offshore areas.
基金supported by the Science and Technology Project of State Grid Corporation of China(5400-202199524A-O-5-ZN).
文摘Fluid flow analysis, such as gas flow analysis, water flow analysis, etc., is a fundamental problem in integrated energy systems (IES). Datasets are significant for researchers to test their proposed models and algorithms for fluid flow analysis. In this paper, we provide multiple benchmark datasets of fluid systems with detailed topology and operation information, such as data of fluid supply, fluid demand, pipes, valves, compressors/pumps, physical operation limits, etc. The provided benchmark datasets have synthetic and practical fluid systems of different scales, including gas systems with numbers of nodes ranging from 11 to 4197 and water systems with numbers of nodes ranging from 7 to 1894. Then, the data format of the datasets is described. Finally, fluid flow results on different benchmark systems under several typical scenarios are analyzed.
文摘A fluid–structure interaction method combining a nonlinear finite element algorithm with a preconditioning finite volume method is proposed in this paper to simulate parachute transient dynamics. This method uses a three-dimensional membrane–cable fabric model to represent a parachute system at a highly folded configuration. The large shape change during parachute inflation is computed by the nonlinear Newton–Raphson iteration and the linear system equation is solved by the generalized minimal residual（GMRES） method. A membrane wrinkling algorithm is also utilized to evaluate the special uniaxial tension state of membrane elements on the parachute canopy. In order to avoid large time expenses during structural nonlinear iteration, the implicit Hilber–Hughes–Taylor（HHT） time integration method is employed. For the fluid dynamic simulations, the Roe and HLLC（Harten–Lax–van Leer contact） scheme has been modified and extended to compute flow problems at all speeds. The lower–upper symmetric Gauss–Seidel（LUSGS） approximate factorization is applied to accelerate the numerical convergence speed. Finally,the test model of a highly folded C-9 parachute is simulated at a prescribed speed and the results show similar characteristics compared with experimental results and previous literature.
基金Aeronautical Science Foundation of China(2010ZA04001)National Natural Science Foundation of China (61073013,90818024)
文摘The fast-growing demand of computational fluid dynamics（CFD） application for computing resources stimulates the development of high performance computing（HPC） and meanwhile raises new requirements for the technology of parallel application performance monitor and analysis.In response to large-scale and long-time running for the application of CFD,online and scalable performance analysis technology is required to optimize the parallel programs as well as to improve their operational efficiency.As a result,this research implements a scalable infrastructure for online performance analysis on CFD application with homogeneous or heterogeneous system.The infrastructure is part of the parallel application performance monitor and analysis system（PAPMAS） and is composed of two modules which are scalable data transmission module and data storage module.The paper analyzes and elaborates this infrastructure in detail with respect to its design and implementation.Furthermore,some experiments are carried out to verify the rationality and high efficiency of this infrastructure that could be adopted to meet the practical needs.
文摘Objective: This study aims to explore the differences in cerebrospinal fluid oligoclonal band (CSF-OCB) expression among different age groups in viral encephalitis and its reference value for diagnosis. Methods: Forty-two patients with viral encephalitis were divided into two groups: 25 adults and 17 children. The presence of oligoclonal bands in the cerebrospinal fluid (CSF) was detected using polyacrylamide gel electrophoresis, and CSF routine analysis was conducted for comparative analysis. Results: The CSF-OCB positivity rate was higher in the adult group (48%) compared with the pediatric group (11.76%), with a statistically significant difference (P Conclusion: 1) The expression of CSF-OCB positivity in patients with viral encephalitis is age-related, with higher positivity rates observed in adults compared to children. 2) Although CSF oligoclonal band detection is not a specific diagnostic marker for viral encephalitis in adults, it still holds certain reference value.
文摘Physical analysis of the pancreatic cystic lesions(PCLs)fluid as expressed by the rheological behavior(“string sign”)can improve the diagnostic yield and should be integrated in every multimodal PCLs workup.
文摘BACKGROUND Hydatid cyst disease(HCD)is common in certain locations.Surgery is associated with postoperative biliary fistula(POBF)and recurrence.The primary aim of this study was to identify whether occult cysto-biliary communication(CBC)can predict recurrent HCD.The secondary aim was to assess the role of cystic fluid bilirubin and alkaline phosphatase(ALP)levels in predicting POBF and recurrent HCD.AIM To identify whether occult CBC can predict recurrent HCD.The secondary aim was to assess the role of cystic fluid bilirubin and ALP levels in predicting POBF and recurrent HCD.METHODS From September 2010 to September 2016,a prospective multicenter study was undertaken involving 244 patients with solitary primary superficial stage cystic echinococcosis 2 and cystic echinococcosis 3b HCD who underwent laparoscopic partial cystectomy with omentoplasty.Univariable logistic regression analysis assessed independent factors determining biliary complications and recurrence.RESULTS There was a highly statistically significant association(P≤0.001)between cystic fluid biochemical indices and the development of biliary complications(of 16 patients with POBF,15 patients had high cyst fluid bilirubin and ALP levels),where patients with high bilirubin-ALP levels were 3405 times more likely to have biliary complications.There was a highly statistically significant association(P≤0.001)between biliary complications,biochemical indices,and the occurrence of recurrent HCD(of 30 patients with recurrent HCD,15 patients had high cyst fluid bilirubin and ALP;all 16 patients who had POBF later developed recurrent HCD),where patients who developed biliary complications and high bilirubin-ALP were 244.6 and 214 times more likely to have recurrent hydatid cysts,respectively.CONCLUSION Occult CBC can predict recurrent HCD.Elevated cyst fluid bilirubin and ALP levels predicted POBF and recurrent HCD.
文摘Pancreatic cystic neoplasms present a complex diagnostic scenario encompassing low-and high-grade malignancies.Their prevalence varies widely,notably increasing with age,reaching 75%in individuals older than 80 years.Accurate diagnosis is crucial,as errors occur in approximately one-third of resected cysts discovered incidentally.Various imaging modalities such as computed tomography,magnetic resonance imaging,and endoscopic techniques are available to address this challenge.However,risk stratification remains problematic,with guideline inconsistencies and diagnostic accuracy varying according to cyst type.This review proposed a stepwisemanagement approach,considering patient factors,imaging results,and specific features.This patient-centered model offers a structured framework for optimizing the care of individuals with pancreatic cystic neoplasms.
基金Supported by the China National Science and Technology Major Project(2016ZX05027,2016ZX05027-002-006)
文摘By using thin section identification, cathodoluminescence, major and trace elements and fluid inclusion tests and authigenic illite dating, based on observation of core cracks, combined with the microscopic characteristics and imaging logging characteristics of fractures, the stages of the fractures in the Huagang Formation of the central reversal tectonic belt of the Xihu Sag in the East China Sea, and the matching relationship between the fracture development stages and the oil and gas charging stages are clarified. There are diagenetic fractures and tectonic fractures in the reservoirs of the Huagang Formation in the study area. The diagenetic fractures developed during the diagenetic stage of the reservoirs and have less effect on oil and gas migration and transport. The tectonic fractures are divided into three stages based on tectonic movements controlling the fractures and their relationships with hydrocarbon charging: The first stage of fractures was generated in the early stage of the Himalayan Movement–Longjing Movement(12–13 Ma ago), when the tectonic stress caused the sutures and shale strips to twist, deform, and break. Tectonic microfractures generated in this period had short extension, narrow width, and poor effectiveness, and had little effect on oil and gas migration and transport. The second stage of fractures came up during the middle-late period of Himalayan Movement–Longjing Movement(9–12 Ma ago), when tectonic movements caused the development of tectonic fractures in the central reversal tectonic belt, these fractures are of large scale, long extension, and good effectiveness, and matched with the first stage of large scale oil and gas charging(9–12 Ma ago), so they play an important role in oil and gas migration, transportation, and accumulation. The third stage of fractures were created from Himalayan Movement–Okinawa Trough movement to the present day(0–3 Ma ago), the fractures are tectonic ones developing successively;matching with the second stage(0–3 Ma ago) of large-scale oil and gas charging, they created conditions for continuous natural gas migration and transportation. All these prove that the development of reservoir fractures in the Huagang Formation of Xihu Sag can provide seepage space and continuous and effective channels for efficient migration and accumulation of oil and gas.
