This article delves into the research conducted by Liu DW et al on the integration of mindfulness-based stress reduction training(MSRT)and flavored Jinshui Liujun decoction(FJLD)with conventional chemotherapy(CC)in th...This article delves into the research conducted by Liu DW et al on the integration of mindfulness-based stress reduction training(MSRT)and flavored Jinshui Liujun decoction(FJLD)with conventional chemotherapy(CC)in the treatment of non-small cell lung cancer.The study investigates the impact of this combined approach on immune function and emotional well-being of non-small cell lung cancer patients.Patients were divided into a control group(CG)receiving CC alone and a treatment group(TG)receiving MSRT+FJLD alongside CC.The primary outcomes were progression-free survival and overall survival,with secondary outcomes including Karnofsky performance status scores,clinical efficacy,immune function markers,and emotional state assessments.The findings underscore significant improvements in median progression-free survival(20.50 months in TG vs 13.10 months in CG,P<0.05),Karnofsky performance status scores(60 in TG vs 50 in CG,P<0.05),and immune cell ratios,along with reductions in negative emotions(self-rating anxiety scale and self-rating depression scale scores significantly lower in TG,P<0.05)among patients receiving MSRT+FJLD in conjunction with CC.This article highlights the potential of combining traditional Chinese medicine and modern psychological interventions to enhance the efficacy of conventional cancer treatments and improve patient outcomes.展开更多
BACKGROUND Conventional chemotherapy(CC)administered to patients with non-small cell lung cancer(NSCLC)often causes adverse effects,such as cardiopulmonary dysfunction and immune system imbalance.Patients may experien...BACKGROUND Conventional chemotherapy(CC)administered to patients with non-small cell lung cancer(NSCLC)often causes adverse effects,such as cardiopulmonary dysfunction and immune system imbalance.Patients may experience anxiety and depression during the perioperative period due to various factors,such as treatment costs and cancer recurrence risks,thereby compromising the overall quality of life.Consequently,we hypothesized that integrating mindfulness-based stress reduction training(MSRT)with Jinshui Liujun decoction may mitigate negative emotions and promote recovery in patients with NSCLC.AIM To explore the effects of MSRT and Jinshui Liujun decoction on the immune function and emotional state of NSCLC patients.METHODS A retrospective clinical study was conducted involving 92 patients with stage IIIb-IV NSCLC;35 patients in the control group(CG)received CC therapy(combination of pemetrexed and carboplatin),and 57 patients in the treatment group(TG)received MSRT-assisted flavored Jinshui Liujun decoction(FJLD)in addition to CC.We evaluated the survival time,Karnofsky performance status,treatment efficacy,traditional Chinese medicine syndrome score,immune function,negative emotional level,and adverse reactions of the CG and TG.RESULTS Median progression-free survival,Karnofsky performance status,and clinical efficacy of the TG were superior to those of the CG(P<0.05).Symptoms of cough,weakness,bloody sputum,shortness of breath,and chest pain significantly decreased in the TG compared to that in the CG(P<0.05).In the TG,MSRT+FJLD treatment increased the numbers of CD3^(+)and CD4^(+)immune cells,effectively reduced the number of CD8^(+)cells,and enhanced the CD4^(+)/CD8^(+)ratio,thereby restoring the immune function of patients.In the TG,the self-rating anxiety scale and self-rating depression scale scores decreased significantly.There was no statistically significant difference in the incidence of adverse reactions between the CG and TG(P>0.05).CONCLUSION MSRT+FJLD proved to be an effective treatment for patients with NSCLC.展开更多
基金Supported by the Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education,No.RS-2023-00237287。
文摘This article delves into the research conducted by Liu DW et al on the integration of mindfulness-based stress reduction training(MSRT)and flavored Jinshui Liujun decoction(FJLD)with conventional chemotherapy(CC)in the treatment of non-small cell lung cancer.The study investigates the impact of this combined approach on immune function and emotional well-being of non-small cell lung cancer patients.Patients were divided into a control group(CG)receiving CC alone and a treatment group(TG)receiving MSRT+FJLD alongside CC.The primary outcomes were progression-free survival and overall survival,with secondary outcomes including Karnofsky performance status scores,clinical efficacy,immune function markers,and emotional state assessments.The findings underscore significant improvements in median progression-free survival(20.50 months in TG vs 13.10 months in CG,P<0.05),Karnofsky performance status scores(60 in TG vs 50 in CG,P<0.05),and immune cell ratios,along with reductions in negative emotions(self-rating anxiety scale and self-rating depression scale scores significantly lower in TG,P<0.05)among patients receiving MSRT+FJLD in conjunction with CC.This article highlights the potential of combining traditional Chinese medicine and modern psychological interventions to enhance the efficacy of conventional cancer treatments and improve patient outcomes.
基金Supported by Zhangjiakou Science and Technology Plan Project,No.2021127HScientific Research Program Project of Hebei Provincial Administration of Traditional Chinese Medicine,No.2022146.
文摘BACKGROUND Conventional chemotherapy(CC)administered to patients with non-small cell lung cancer(NSCLC)often causes adverse effects,such as cardiopulmonary dysfunction and immune system imbalance.Patients may experience anxiety and depression during the perioperative period due to various factors,such as treatment costs and cancer recurrence risks,thereby compromising the overall quality of life.Consequently,we hypothesized that integrating mindfulness-based stress reduction training(MSRT)with Jinshui Liujun decoction may mitigate negative emotions and promote recovery in patients with NSCLC.AIM To explore the effects of MSRT and Jinshui Liujun decoction on the immune function and emotional state of NSCLC patients.METHODS A retrospective clinical study was conducted involving 92 patients with stage IIIb-IV NSCLC;35 patients in the control group(CG)received CC therapy(combination of pemetrexed and carboplatin),and 57 patients in the treatment group(TG)received MSRT-assisted flavored Jinshui Liujun decoction(FJLD)in addition to CC.We evaluated the survival time,Karnofsky performance status,treatment efficacy,traditional Chinese medicine syndrome score,immune function,negative emotional level,and adverse reactions of the CG and TG.RESULTS Median progression-free survival,Karnofsky performance status,and clinical efficacy of the TG were superior to those of the CG(P<0.05).Symptoms of cough,weakness,bloody sputum,shortness of breath,and chest pain significantly decreased in the TG compared to that in the CG(P<0.05).In the TG,MSRT+FJLD treatment increased the numbers of CD3^(+)and CD4^(+)immune cells,effectively reduced the number of CD8^(+)cells,and enhanced the CD4^(+)/CD8^(+)ratio,thereby restoring the immune function of patients.In the TG,the self-rating anxiety scale and self-rating depression scale scores decreased significantly.There was no statistically significant difference in the incidence of adverse reactions between the CG and TG(P>0.05).CONCLUSION MSRT+FJLD proved to be an effective treatment for patients with NSCLC.
