This paper introduces part of the content in the association standard,T/CAAM0002–2020 Nomenclature and Location of Acupuncture Points for Laboratory Animals Part 2:Rat.This standard was released by the China Associat...This paper introduces part of the content in the association standard,T/CAAM0002–2020 Nomenclature and Location of Acupuncture Points for Laboratory Animals Part 2:Rat.This standard was released by the China Association of Acupuncture and Moxibustion on May 15,2020,implemented on October 31,2020,and published by Standards Press of China.The standard was drafted by the Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,and the Nanjing University of Chinese Medicine.Principal draftsmen:Xiang-hong JING and Xing-bang HUA.Participating draftsmen:Wan-Zhu BAI,Bin XU,Dong-sheng XU,Yi GUO,Tie-ming MA,Xin-jun WANG,and Sheng-feng LU.展开更多
Objectives: This study aimed to evaluate the prolonged therapeutic effects of a 35 kDa molecular weight hyaluronan fragment (HA35) in alleviating pain associated with myofascial pain syndrome (MPS). Hyaluronan interac...Objectives: This study aimed to evaluate the prolonged therapeutic effects of a 35 kDa molecular weight hyaluronan fragment (HA35) in alleviating pain associated with myofascial pain syndrome (MPS). Hyaluronan interacts with various receptors in the human body, including CD44, LYVE-1, RHAMM, and TLR2, and is well-known for its analgesic effects when used in intra-articular or ultrasound-guided nerve trunk injections. Studies have shown that hyaluronidase cleaves high molecular weight HA to generate HA35, a low molecular weight fragment with enhanced tissue permeability, capable of binding to HA receptors on cell surfaces to produce broad-spectrum analgesic effects. Methods: Ten patients diagnosed with MPS were treated and assessed in this study. HA35 was administered through injection at a dosage of 100 mg daily for 15 days. Patients evaluated their MPS, overall pain levels, and treatment satisfaction using the Numerical Pain Rating Scale (NPRS), the Global Pain Scale (GPS), and the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4). Follow-up evaluations were performed three months post-treatment to assess the duration of therapeutic effects. Results: Significant improvements were observed in NPRS, GPS, and TSQM scores both during and after the treatment period (P Conclusions: HA35 provides effective and sustained relief from pain associated with MPS, demonstrating a prolonged therapeutic benefit.展开更多
This paper introduces part of the content in the association standard,T/CAAM0002–2020 Nomenclature and Location of Acupuncture Points for Laboratory Animals Part 3:Mouse.This standard was released by the China Associ...This paper introduces part of the content in the association standard,T/CAAM0002–2020 Nomenclature and Location of Acupuncture Points for Laboratory Animals Part 3:Mouse.This standard was released by the China Association of Acupuncture and Moxibustion on May 15,2020,implemented on October 31,2020,and published by Standards Press of China.The standard was drafted by the Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,and the Nanjing University of Chinese Medicine.Principal draftsmen:Xiang-hong JING and Xing-bang HUA.Participating draftsmen:Wan-zhu BAI,Bin XU,Dong-sheng XU,Yi GUO,Tie-ming MA,Xin-jun WANG,and Sheng-feng LU.展开更多
The success of robot-assisted pelvic fracture reduction surgery heavily relies on the accuracy of 3D/3D feature-based registration.This process involves extracting anatomical feature points from pre-operative 3D image...The success of robot-assisted pelvic fracture reduction surgery heavily relies on the accuracy of 3D/3D feature-based registration.This process involves extracting anatomical feature points from pre-operative 3D images which can be challenging because of the complex and variable structure of the pelvis.PointMLP_RegNet,a modified PointMLP,was introduced to address this issue.It retains the feature extraction module of PointMLP but replaces the classification layer with a regression layer to predict the coordinates of feature points instead of conducting regular classification.A flowchart for an automatic feature points extraction method was presented,and a series of experiments was conducted on a clinical pelvic dataset to confirm the accuracy and effectiveness of the method.PointMLP_RegNet extracted feature points more accurately,with 8 out of 10 points showing less than 4 mm errors and the remaining two less than 5 mm.Compared to PointNettt and PointNet,it exhibited higher accuracy,robustness and space efficiency.The proposed method will improve the accuracy of anatomical feature points extraction,enhance intra-operative registration precision and facilitate the widespread clinical application of robot-assisted pelvic fracture reduction.展开更多
In this paper, we investigate the effect of exceptional points(EPs) on the violation of Leggett–Garg inequality(LGI) and no-signaling-in-time(NSIT) conditions and compare the different effects between the Hamiltonian...In this paper, we investigate the effect of exceptional points(EPs) on the violation of Leggett–Garg inequality(LGI) and no-signaling-in-time(NSIT) conditions and compare the different effects between the Hamiltonian EP(HEP) and Liouvillian EP(LEP) on those violations. We consider an open system consisting of two coupled qubits and each qubit is contacted with a thermal bath at a different temperature. In the case of omitting quantum jumps, we find that the system exhibits a second-order HEP, which separates the parameter space into an overdamped regime and an underdamped regime. In this situation, the LGI and NSIT conditions can be violated in both regimes and not violated at the HEP. In the case of without omitting quantum jumps, we find that the system exhibits a third-order LEP, which also separates the parameter space into an overdamped regime and an underdamped regime. In this situation, the LGI can only be violated in the underdamped regime with large coupling strength between the qubits.Conversely, the NSIT conditions can be violated in both regimes, as well as at the LEP, except in the overdamped regime with small coupling strength between the qubits. Comparing the violations of the LGI and NSIT conditions with HEP and LEP, we find that the quantum jumps would reduce the generation of coherence, enhance the decoherence, and lead to narrower parameter regimes that the LGI and NSIT conditions can be violated. Furthermore, in both cases,the NSIT conditions can be violated in a wider parameter regime than the LGI.展开更多
Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewa...Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewable,and clinical demand is increasingly difficult to meet,leading to a proliferation of counterfeit products.During prolonged geological burial,static pressure from the surrounding strata severely compromises the microstructural integrity of osteons in Os Draconis,but Os Draconis still largely retains the structural features of mammalian bone.Methods:Using verified authentic Os Draconis samples over 10,000 years old as a baseline,this study summarizes the ultrastructural characteristics of genuine Os Draconis.Employing electron probe microanalysis and optical polarized light microscopy,we examined 28 batches of authentic Os Draconis and 31 batches of counterfeits to identify their ultrastructural differences.Key points for ultrastructural identification of Os Draconis were compiled,and a new identification approach was proposed based on these differences.Results:Authentic Os Draconis exhibited distinct ultrastructural markers:irregularly shaped osteons with traversing fissures,deformed/displaced Haversian canals,and secondary mineral infill(predominantly calcium carbonate).Counterfeits showed regular osteon arrangements,absent traversal fissures,and homogeneous hydroxyapatite composition.Lab-simulated samples lacked structural degradation features.EPMA confirmed calcium carbonate infill in fossilized Haversian canals,while elemental profiles differentiated lacunae types(void vs.mineral-packed).Conclusion:The study established ultrastructural criteria for authentic Os Draconis identification:osteon deformation,geological fissures penetrating bone units,and heterogenous mineral deposition.These features,unattainable in counterfeits or modern processed bones,provide a cost-effective,accurate identification method.This approach bridges gaps in TCM material standardization and supports quality control for clinical applications.展开更多
Leaf turgor loss point has been recognized as an important plant physiological trait explaining a species’drought tolerance( π_(tlp)).Less is known about the variation of π_(tlp) in time and how seasonal or interan...Leaf turgor loss point has been recognized as an important plant physiological trait explaining a species’drought tolerance( π_(tlp)).Less is known about the variation of π_(tlp) in time and how seasonal or interannual differences in water availability are affecting π_(tlp) as a static trait.I monitored the seasonal variation of π_(tlp) during a drought year starting in early spring with juvenile leaves and assessed the interannual variation in π_(tlp) of fully matured leaves among years with diverting water availability for three temperate broad-leaved tree species.The largest seasonal changes in π_(tlp) occurred during leaf unfolding until leaves were fully developed and matured.After leaves matured,no significant changes occurred for the rest of the vegetation period.Interannual variation that could be related to water availability was only present in one of the three tree species.The results suggest that the investigated species have a rapid period of osmotic adjustment early in the growing season followed by a period of relative stability,when π_(tlp) can be considered as a static trait.展开更多
In the multilayer film-substrate system,thermal stress concentration and stress mutations cause film buckling,delamination and cracking,leading to device failure.In this paper,we investigated a multilayer film system ...In the multilayer film-substrate system,thermal stress concentration and stress mutations cause film buckling,delamination and cracking,leading to device failure.In this paper,we investigated a multilayer film system composed of a substrate and three film layers.The thermal stress distribution inside the structure was calculated by the finite element method,revealing significant thermal stress differences between the layers.This is mainly due to the mismatch of the coefficient of thermal expansion between materials.Different materials respond differently to changes in external temperature,leading to compression between layers.There are obvious thermal stress concentration points at the corners of the base layer and the transition layer,which is due to the sudden change of the shape at the geometric section of the structure,resulting in a sudden increase in local stress.To address this issue,we chamfered the substrate and added an intermediate layer between the substrate and the transition layer to assess whether these modifications could reduce or eliminate the thermal stress concentration points and extend the service life of the multilayer structure.The results indicate that chamfering and adding the intermediate layer effectively reduce stress discontinuities and mitigate thermal stress concentration points,thereby improving interlayer bonding strength.展开更多
Dysphagia caused by true bulbar paralysis after stroke is a common and serious complication that severely affects patients’eating ability and quality of life,and significantly increases the risk of complications such...Dysphagia caused by true bulbar paralysis after stroke is a common and serious complication that severely affects patients’eating ability and quality of life,and significantly increases the risk of complications such as pneumonia and malnutrition.Electroacupuncture at swallowing points stimulates Swallowing 1 and Swallowing 2 acupoints,acting on key areas such as the glossopharyngeal nerve and vagus nerve,stimulating the reconstruction of nerve reflex arcs and the recovery of swallowing function.Therefore,this article analyzes the mechanism and clinical efficacy of electroacupuncture at swallowing points for the treatment of dysphagia caused by true bulbar paralysis after stroke,aiming to provide theoretical support and practical basis for clinical application.展开更多
Fractional discrete systems can enable the modeling and control of the complicated processes more adaptable through the concept of versatility by providing systemdynamics’descriptions withmore degrees of freedom.Nume...Fractional discrete systems can enable the modeling and control of the complicated processes more adaptable through the concept of versatility by providing systemdynamics’descriptions withmore degrees of freedom.Numerical approaches have become necessary and sufficient to be addressed and employed for benefiting from the adaptability of such systems for varied applications.A variety of fractional Layla and Majnun model(LMM)system kinds has been proposed in the current work where some of these systems’key behaviors are addressed.In addition,the necessary and sufficient conditions for the stability and asymptotic stability of the fractional dynamic systems are investigated,as a result of which,the necessary requirements of the LMM to achieve constant and asymptotically steady zero resolutions are provided.As a special case,when Layla and Majnun have equal feelings,we propose an analysis of the system in view of its equilibrium and fixed point sets.Considering that the system has marginal stability if its eigenvalues have both negative and zero real portions,it is demonstrated that the system neither converges nor diverges to a steady trajectory or equilibrium point.It,rather,continues to hover along the line separating stability and instability based on the fractional LMM system.展开更多
In 2004 and 2014,two monographs on hypobaric storage(LP)were published by Stanley P.Burg.Based on his theoretical framework and technological advancements,as well as the research and development of equipment conducted...In 2004 and 2014,two monographs on hypobaric storage(LP)were published by Stanley P.Burg.Based on his theoretical framework and technological advancements,as well as the research and development of equipment conducted under his guidance,alongside customer practices and reflections on various scientific literature both domestically and internationally,it is posited that,as articulated in the monograph,misconceptions regarding his theory and technology in Western scientific literature prior to 1985 continue to persist.This ongoing dissemination of misunderstandings has resulted in a near stagnation of research and has adversely impacted the Chinese academic community as well.Consequently,it is essential to delineate the characteristics and main points of its theory and technology,with the aim of offering guidance to individuals seeking to comprehend its foundational purpose.LP technology is a dynamic physical technology that continuously and uninterruptedly extracts air from a closed container and simultaneously introduces fresh,low-pressure moist air from the external environment,while maintaining specific levels of humidity and/or temperature within the container and upholding a predetermined pressure value.Preservation technology is the collective term for the set of various technical parameters associated with preservation,including pressure,relative humidity,and other relevant factors,to which LP equipment is specifically designed.The theory of LP is characterized by the enhanced diffusion of gases and vapors that enter and exit the commodity in a dynamic manner under low pressure conditions.The theoretical points involve equipment performance,low pressure,the impact of trace concentrations of gases such as O_(2),CO_(2) and C_(2)H_(4) that naturally occur at low pressure,diffusive mass transfer,heat transfer,and impacts on the activity of enzymes associated with maturation and senescence.The technology is characterized by dynamic low pressure,and the range of commodities preserved is comparable to that of refrigeration.However,certain commodities exiting the hypobaric environment possess subsequent preservation advantages that are not available through refrigeration.The main points of the technology encompass an extended sotrage life,a postponement of quality degradation,minimized water loss,the suppression of pathogen growth,and the killing of both internal and external insects of the commodity under dynamic low pressure conditions.The core advantage of LP technology lies in its ability to significantly reduce water loss,inhibit respiration and C_(2)H_(4) action,and pathogen growth,killing insects and modulate the activity of enzymes associated with maturation and senescence in post-harvest fresh horticultural products.Consequently,this technology plays a crucial role in prolonging the post-harvest lifespan of these commodities and mitigating quality degradation.Over the past decade,researchers in China have developed a hypobaric short period treatment technology,grounded in LP theory and technical practice,which is commonly referred to as hypobaric treatment.This method has garnered significant attention,leading to an increase in both domestic and international research.A growing body of literature categorizes LP as hypobaric treatment,while some studies also consider vacuum packaging and modified atmosphere packaging(MAP)as LP or hypobaric treatment.Misunderstandings are exacerbated by confusion surrounding nomenclature,which,in conjunction with pre-existing misconceptions,represents a significant barrier to both the research and practical application of the technology.The successful commercial implementation of a vacuum cold fresh chain,centered on LP or hypobaric treatment technology,may be the sole solution to the prevailing misunderstandings associated with LP.展开更多
OBJECTIVE:To observe the effects of electroacupuncture at Neiguan(PC6)at different time points on reperfusion arrhythmia(RA)after myocardial ischemia and reperfusion in rats,and to investigate the correlation of this ...OBJECTIVE:To observe the effects of electroacupuncture at Neiguan(PC6)at different time points on reperfusion arrhythmia(RA)after myocardial ischemia and reperfusion in rats,and to investigate the correlation of this protective effect with nerve growth factor(NGF),tyrosine kinase A(Trk A),tyrosine hydroxylase(TH),and norepinephrine(NE).METHODS:A total of 72 Sprague-Dawley male rats were randomly divided into six groups(n=12 rats/group):normal group(Norm),sham operation group(Sham),ischemia reperfusion group(I/R),pre-ischemic electroacupuncture group(EAI),pre-reperfusion electroacupuncture group(EAII),post-reperfusion electroacupuncture group(EAIII).The myocardial ischemia-reperfusion injury(MIRI)model was induced by occlusion of left anterior descending coronary artery for 20 min followed by reperfusion for 40 min in rats.With no intervention in the Norm group and only threading without ligation in the Sham group.Electroacupuncture pretreatment at 20 min/d for 7 d before ligation in the EAⅠgroup,20 min of electroacupuncture before reperfusion in the EAII group and 20 min of electroacupuncture after reperfusion in the EAIII group.The electrocardiogram(ECG)of each group was recorded throughout the whole process,and the success of the MIRI model was determined based on the changs of J-point and T-wave in the ECG.The arrhythmia score was used to record premature ventricular contractions,ventricular tachycardia and ventricular fibrillation during the reperfusion period to assess the reperfusion induced arrhythmias.The expression levels of NGF,Trk A,TH protein were measured by Western blot.Moreover,the expression levels of plasma and myocardial NE levels were detected by enzyme linked immunosorbent assay.RESULTS:The differences between Norm group and Sham group were not statistically significant in all indexes.Arrhythmia score,myocardial NGF,Trk A,TH,and NE expression were significantly higher in the I/R group compared with the Sham group.Arrhythmia score,myocardial NGF,Trk A,TH,and NE expression were significantly lower in each EA group compared with the I/R group.CONCLUSION:Electroacupuncture at Neiguan(PC6)at different time points can reduce the incidence and severity of reperfusion arrhythmias in rats.This protective effect is related to electroacupuncture regulating NGF,Trk A,TH,NE expression and reducing sympathetic hyperactivation.展开更多
针对菇房内杏鲍菇表型参数测量任务中,由于扫描设备视角受限,扫描的杏鲍菇点云出现残缺问题,基于AdaPoinTr(Adaptive geometry-aware point transformers)提出了改进的SwinPoinTr模型,实现了对残缺杏鲍菇点云的准确补全和杏鲍菇表型参...针对菇房内杏鲍菇表型参数测量任务中,由于扫描设备视角受限,扫描的杏鲍菇点云出现残缺问题,基于AdaPoinTr(Adaptive geometry-aware point transformers)提出了改进的SwinPoinTr模型,实现了对残缺杏鲍菇点云的准确补全和杏鲍菇表型参数的测量。该方法在使用提出的特征重塑模块的基础上,构建具有几何感知能力的层次化Transformer编码模块,提高了模型对输入点云的利用率和模型捕捉点云细节特征的能力。然后基于泊松重建方法完成了补全点云表面重建,并测量到杏鲍菇表型参数。实验结果表明,本文所提算法在残缺杏鲍菇点云补全任务中,模型倒角距离为1.316×10^(-4),地球移动距离为21.3282,F1分数为87.87%。在表型参数估测任务中,模型对杏鲍菇菌高、体积、表面积估测结果的决定系数分别为0.9582、0.9596、0.9605,均方根误差分别为4.4213 mm、10.8185 cm^(3)、7.5778 cm^(2)。结果证实了该研究方法可以有效地补全残缺的杏鲍菇点云,可以为菇房内杏鲍菇表型参数测量提供基础。展开更多
Using angle-resolved photoemission spectroscopy and density functional theory calculations methods,we investigate the electronic structures and topological properties of ternary tellurides NbIrTe_(4),a candidate for t...Using angle-resolved photoemission spectroscopy and density functional theory calculations methods,we investigate the electronic structures and topological properties of ternary tellurides NbIrTe_(4),a candidate for type-II Weyl semimetal.We demonstrate the presence of several Fermi arcs connecting their corresponding Weyl points on both termination surfaces of the topological material.Our analysis reveals the existence of Dirac points,in addition to Weyl points,giving both theoretical and experimental evidences of the coexistence of Dirac and Weyl points in a single material.These findings not only confirm NbIrTe_(4) as a unique topological semimetal but also open avenues for exploring novel electronic devices based on its coexisting Dirac and Weyl fermions.展开更多
文摘This paper introduces part of the content in the association standard,T/CAAM0002–2020 Nomenclature and Location of Acupuncture Points for Laboratory Animals Part 2:Rat.This standard was released by the China Association of Acupuncture and Moxibustion on May 15,2020,implemented on October 31,2020,and published by Standards Press of China.The standard was drafted by the Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,and the Nanjing University of Chinese Medicine.Principal draftsmen:Xiang-hong JING and Xing-bang HUA.Participating draftsmen:Wan-Zhu BAI,Bin XU,Dong-sheng XU,Yi GUO,Tie-ming MA,Xin-jun WANG,and Sheng-feng LU.
文摘Objectives: This study aimed to evaluate the prolonged therapeutic effects of a 35 kDa molecular weight hyaluronan fragment (HA35) in alleviating pain associated with myofascial pain syndrome (MPS). Hyaluronan interacts with various receptors in the human body, including CD44, LYVE-1, RHAMM, and TLR2, and is well-known for its analgesic effects when used in intra-articular or ultrasound-guided nerve trunk injections. Studies have shown that hyaluronidase cleaves high molecular weight HA to generate HA35, a low molecular weight fragment with enhanced tissue permeability, capable of binding to HA receptors on cell surfaces to produce broad-spectrum analgesic effects. Methods: Ten patients diagnosed with MPS were treated and assessed in this study. HA35 was administered through injection at a dosage of 100 mg daily for 15 days. Patients evaluated their MPS, overall pain levels, and treatment satisfaction using the Numerical Pain Rating Scale (NPRS), the Global Pain Scale (GPS), and the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4). Follow-up evaluations were performed three months post-treatment to assess the duration of therapeutic effects. Results: Significant improvements were observed in NPRS, GPS, and TSQM scores both during and after the treatment period (P Conclusions: HA35 provides effective and sustained relief from pain associated with MPS, demonstrating a prolonged therapeutic benefit.
文摘This paper introduces part of the content in the association standard,T/CAAM0002–2020 Nomenclature and Location of Acupuncture Points for Laboratory Animals Part 3:Mouse.This standard was released by the China Association of Acupuncture and Moxibustion on May 15,2020,implemented on October 31,2020,and published by Standards Press of China.The standard was drafted by the Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,and the Nanjing University of Chinese Medicine.Principal draftsmen:Xiang-hong JING and Xing-bang HUA.Participating draftsmen:Wan-zhu BAI,Bin XU,Dong-sheng XU,Yi GUO,Tie-ming MA,Xin-jun WANG,and Sheng-feng LU.
基金supported by the National Key Research and Development Program of China(Grant No.2020YFB1313800)the National Science Foundation of China(Grant No.NSFC62373259)+1 种基金the Natural Science Foundation of Top Talent of SZTU(Grant No.GDRC202303)the Education Promotion Foundation of Guangdong Province(Grant No.2022ZDJS115).
文摘The success of robot-assisted pelvic fracture reduction surgery heavily relies on the accuracy of 3D/3D feature-based registration.This process involves extracting anatomical feature points from pre-operative 3D images which can be challenging because of the complex and variable structure of the pelvis.PointMLP_RegNet,a modified PointMLP,was introduced to address this issue.It retains the feature extraction module of PointMLP but replaces the classification layer with a regression layer to predict the coordinates of feature points instead of conducting regular classification.A flowchart for an automatic feature points extraction method was presented,and a series of experiments was conducted on a clinical pelvic dataset to confirm the accuracy and effectiveness of the method.PointMLP_RegNet extracted feature points more accurately,with 8 out of 10 points showing less than 4 mm errors and the remaining two less than 5 mm.Compared to PointNettt and PointNet,it exhibited higher accuracy,robustness and space efficiency.The proposed method will improve the accuracy of anatomical feature points extraction,enhance intra-operative registration precision and facilitate the widespread clinical application of robot-assisted pelvic fracture reduction.
基金financially supported by the National Natural Science Foundation of China (Grants Nos. 11775019 and 11875086)。
文摘In this paper, we investigate the effect of exceptional points(EPs) on the violation of Leggett–Garg inequality(LGI) and no-signaling-in-time(NSIT) conditions and compare the different effects between the Hamiltonian EP(HEP) and Liouvillian EP(LEP) on those violations. We consider an open system consisting of two coupled qubits and each qubit is contacted with a thermal bath at a different temperature. In the case of omitting quantum jumps, we find that the system exhibits a second-order HEP, which separates the parameter space into an overdamped regime and an underdamped regime. In this situation, the LGI and NSIT conditions can be violated in both regimes and not violated at the HEP. In the case of without omitting quantum jumps, we find that the system exhibits a third-order LEP, which also separates the parameter space into an overdamped regime and an underdamped regime. In this situation, the LGI can only be violated in the underdamped regime with large coupling strength between the qubits.Conversely, the NSIT conditions can be violated in both regimes, as well as at the LEP, except in the overdamped regime with small coupling strength between the qubits. Comparing the violations of the LGI and NSIT conditions with HEP and LEP, we find that the quantum jumps would reduce the generation of coherence, enhance the decoherence, and lead to narrower parameter regimes that the LGI and NSIT conditions can be violated. Furthermore, in both cases,the NSIT conditions can be violated in a wider parameter regime than the LGI.
基金supported by the Scientific and Technological Innovation Project of the China Academy of Chinese Medical Sciences(CI2021A04013)the National Natural Science Foundation of China(82204610)+1 种基金the Qihang Talent Program(L2022046)the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ15-YQ-041 and L2021029).
文摘Background:The medicinal material known as Os Draconis(Longgu)originates from fossilized remains of ancient mammals and is widely used in treating emotional and mental conditions.However,fossil resources are nonrenewable,and clinical demand is increasingly difficult to meet,leading to a proliferation of counterfeit products.During prolonged geological burial,static pressure from the surrounding strata severely compromises the microstructural integrity of osteons in Os Draconis,but Os Draconis still largely retains the structural features of mammalian bone.Methods:Using verified authentic Os Draconis samples over 10,000 years old as a baseline,this study summarizes the ultrastructural characteristics of genuine Os Draconis.Employing electron probe microanalysis and optical polarized light microscopy,we examined 28 batches of authentic Os Draconis and 31 batches of counterfeits to identify their ultrastructural differences.Key points for ultrastructural identification of Os Draconis were compiled,and a new identification approach was proposed based on these differences.Results:Authentic Os Draconis exhibited distinct ultrastructural markers:irregularly shaped osteons with traversing fissures,deformed/displaced Haversian canals,and secondary mineral infill(predominantly calcium carbonate).Counterfeits showed regular osteon arrangements,absent traversal fissures,and homogeneous hydroxyapatite composition.Lab-simulated samples lacked structural degradation features.EPMA confirmed calcium carbonate infill in fossilized Haversian canals,while elemental profiles differentiated lacunae types(void vs.mineral-packed).Conclusion:The study established ultrastructural criteria for authentic Os Draconis identification:osteon deformation,geological fissures penetrating bone units,and heterogenous mineral deposition.These features,unattainable in counterfeits or modern processed bones,provide a cost-effective,accurate identification method.This approach bridges gaps in TCM material standardization and supports quality control for clinical applications.
基金supported by the European Union as a mobility grant
文摘Leaf turgor loss point has been recognized as an important plant physiological trait explaining a species’drought tolerance( π_(tlp)).Less is known about the variation of π_(tlp) in time and how seasonal or interannual differences in water availability are affecting π_(tlp) as a static trait.I monitored the seasonal variation of π_(tlp) during a drought year starting in early spring with juvenile leaves and assessed the interannual variation in π_(tlp) of fully matured leaves among years with diverting water availability for three temperate broad-leaved tree species.The largest seasonal changes in π_(tlp) occurred during leaf unfolding until leaves were fully developed and matured.After leaves matured,no significant changes occurred for the rest of the vegetation period.Interannual variation that could be related to water availability was only present in one of the three tree species.The results suggest that the investigated species have a rapid period of osmotic adjustment early in the growing season followed by a period of relative stability,when π_(tlp) can be considered as a static trait.
基金the support of the National Natural Science Foundation of China(Grant Nos.51606158,11604311 and 12074151)the Guangxi Science and Technology Base and Talent Special Project(Grant No.AD21075009)+2 种基金the Sichuan Science and Technology Program(Grant No.2021JDRC0022)the Open Fund of the Key Laboratory for Metallurgical Equipment and Control Technology of Ministry of Education in Wuhan University of Science and Technology,People's Republic of China(Grant Nos.MECOF2022B01 and MECOF2023B04)the Guangxi Key Laboratory of Precision Navigation Technology and Application,Guilin University of Electronic Technology(Grant No.DH202321)。
文摘In the multilayer film-substrate system,thermal stress concentration and stress mutations cause film buckling,delamination and cracking,leading to device failure.In this paper,we investigated a multilayer film system composed of a substrate and three film layers.The thermal stress distribution inside the structure was calculated by the finite element method,revealing significant thermal stress differences between the layers.This is mainly due to the mismatch of the coefficient of thermal expansion between materials.Different materials respond differently to changes in external temperature,leading to compression between layers.There are obvious thermal stress concentration points at the corners of the base layer and the transition layer,which is due to the sudden change of the shape at the geometric section of the structure,resulting in a sudden increase in local stress.To address this issue,we chamfered the substrate and added an intermediate layer between the substrate and the transition layer to assess whether these modifications could reduce or eliminate the thermal stress concentration points and extend the service life of the multilayer structure.The results indicate that chamfering and adding the intermediate layer effectively reduce stress discontinuities and mitigate thermal stress concentration points,thereby improving interlayer bonding strength.
文摘Dysphagia caused by true bulbar paralysis after stroke is a common and serious complication that severely affects patients’eating ability and quality of life,and significantly increases the risk of complications such as pneumonia and malnutrition.Electroacupuncture at swallowing points stimulates Swallowing 1 and Swallowing 2 acupoints,acting on key areas such as the glossopharyngeal nerve and vagus nerve,stimulating the reconstruction of nerve reflex arcs and the recovery of swallowing function.Therefore,this article analyzes the mechanism and clinical efficacy of electroacupuncture at swallowing points for the treatment of dysphagia caused by true bulbar paralysis after stroke,aiming to provide theoretical support and practical basis for clinical application.
基金supported by Ajman University Internal Research Grant No.(DRGS Ref.2024-IRGHBS-3).
文摘Fractional discrete systems can enable the modeling and control of the complicated processes more adaptable through the concept of versatility by providing systemdynamics’descriptions withmore degrees of freedom.Numerical approaches have become necessary and sufficient to be addressed and employed for benefiting from the adaptability of such systems for varied applications.A variety of fractional Layla and Majnun model(LMM)system kinds has been proposed in the current work where some of these systems’key behaviors are addressed.In addition,the necessary and sufficient conditions for the stability and asymptotic stability of the fractional dynamic systems are investigated,as a result of which,the necessary requirements of the LMM to achieve constant and asymptotically steady zero resolutions are provided.As a special case,when Layla and Majnun have equal feelings,we propose an analysis of the system in view of its equilibrium and fixed point sets.Considering that the system has marginal stability if its eigenvalues have both negative and zero real portions,it is demonstrated that the system neither converges nor diverges to a steady trajectory or equilibrium point.It,rather,continues to hover along the line separating stability and instability based on the fractional LMM system.
文摘In 2004 and 2014,two monographs on hypobaric storage(LP)were published by Stanley P.Burg.Based on his theoretical framework and technological advancements,as well as the research and development of equipment conducted under his guidance,alongside customer practices and reflections on various scientific literature both domestically and internationally,it is posited that,as articulated in the monograph,misconceptions regarding his theory and technology in Western scientific literature prior to 1985 continue to persist.This ongoing dissemination of misunderstandings has resulted in a near stagnation of research and has adversely impacted the Chinese academic community as well.Consequently,it is essential to delineate the characteristics and main points of its theory and technology,with the aim of offering guidance to individuals seeking to comprehend its foundational purpose.LP technology is a dynamic physical technology that continuously and uninterruptedly extracts air from a closed container and simultaneously introduces fresh,low-pressure moist air from the external environment,while maintaining specific levels of humidity and/or temperature within the container and upholding a predetermined pressure value.Preservation technology is the collective term for the set of various technical parameters associated with preservation,including pressure,relative humidity,and other relevant factors,to which LP equipment is specifically designed.The theory of LP is characterized by the enhanced diffusion of gases and vapors that enter and exit the commodity in a dynamic manner under low pressure conditions.The theoretical points involve equipment performance,low pressure,the impact of trace concentrations of gases such as O_(2),CO_(2) and C_(2)H_(4) that naturally occur at low pressure,diffusive mass transfer,heat transfer,and impacts on the activity of enzymes associated with maturation and senescence.The technology is characterized by dynamic low pressure,and the range of commodities preserved is comparable to that of refrigeration.However,certain commodities exiting the hypobaric environment possess subsequent preservation advantages that are not available through refrigeration.The main points of the technology encompass an extended sotrage life,a postponement of quality degradation,minimized water loss,the suppression of pathogen growth,and the killing of both internal and external insects of the commodity under dynamic low pressure conditions.The core advantage of LP technology lies in its ability to significantly reduce water loss,inhibit respiration and C_(2)H_(4) action,and pathogen growth,killing insects and modulate the activity of enzymes associated with maturation and senescence in post-harvest fresh horticultural products.Consequently,this technology plays a crucial role in prolonging the post-harvest lifespan of these commodities and mitigating quality degradation.Over the past decade,researchers in China have developed a hypobaric short period treatment technology,grounded in LP theory and technical practice,which is commonly referred to as hypobaric treatment.This method has garnered significant attention,leading to an increase in both domestic and international research.A growing body of literature categorizes LP as hypobaric treatment,while some studies also consider vacuum packaging and modified atmosphere packaging(MAP)as LP or hypobaric treatment.Misunderstandings are exacerbated by confusion surrounding nomenclature,which,in conjunction with pre-existing misconceptions,represents a significant barrier to both the research and practical application of the technology.The successful commercial implementation of a vacuum cold fresh chain,centered on LP or hypobaric treatment technology,may be the sole solution to the prevailing misunderstandings associated with LP.
基金Transversal Project:Scenario-based Application of Wearable Devices for the Treatment of Cardiac Arrhythmias with Superficial Stimulation at the Neiguan(PC6)Point Research(BUCM-2022-JS-FW-003)。
文摘OBJECTIVE:To observe the effects of electroacupuncture at Neiguan(PC6)at different time points on reperfusion arrhythmia(RA)after myocardial ischemia and reperfusion in rats,and to investigate the correlation of this protective effect with nerve growth factor(NGF),tyrosine kinase A(Trk A),tyrosine hydroxylase(TH),and norepinephrine(NE).METHODS:A total of 72 Sprague-Dawley male rats were randomly divided into six groups(n=12 rats/group):normal group(Norm),sham operation group(Sham),ischemia reperfusion group(I/R),pre-ischemic electroacupuncture group(EAI),pre-reperfusion electroacupuncture group(EAII),post-reperfusion electroacupuncture group(EAIII).The myocardial ischemia-reperfusion injury(MIRI)model was induced by occlusion of left anterior descending coronary artery for 20 min followed by reperfusion for 40 min in rats.With no intervention in the Norm group and only threading without ligation in the Sham group.Electroacupuncture pretreatment at 20 min/d for 7 d before ligation in the EAⅠgroup,20 min of electroacupuncture before reperfusion in the EAII group and 20 min of electroacupuncture after reperfusion in the EAIII group.The electrocardiogram(ECG)of each group was recorded throughout the whole process,and the success of the MIRI model was determined based on the changs of J-point and T-wave in the ECG.The arrhythmia score was used to record premature ventricular contractions,ventricular tachycardia and ventricular fibrillation during the reperfusion period to assess the reperfusion induced arrhythmias.The expression levels of NGF,Trk A,TH protein were measured by Western blot.Moreover,the expression levels of plasma and myocardial NE levels were detected by enzyme linked immunosorbent assay.RESULTS:The differences between Norm group and Sham group were not statistically significant in all indexes.Arrhythmia score,myocardial NGF,Trk A,TH,and NE expression were significantly higher in the I/R group compared with the Sham group.Arrhythmia score,myocardial NGF,Trk A,TH,and NE expression were significantly lower in each EA group compared with the I/R group.CONCLUSION:Electroacupuncture at Neiguan(PC6)at different time points can reduce the incidence and severity of reperfusion arrhythmias in rats.This protective effect is related to electroacupuncture regulating NGF,Trk A,TH,NE expression and reducing sympathetic hyperactivation.
基金Project supported by the National Natural Science Foundation of China (Grant Nos.12274455,12274459,and 12204533)the National Key R&D Program of China (Grant No.2022YFA1403800)the Beijing Natural Science Foundation (Grant No.Z200005)。
文摘Using angle-resolved photoemission spectroscopy and density functional theory calculations methods,we investigate the electronic structures and topological properties of ternary tellurides NbIrTe_(4),a candidate for type-II Weyl semimetal.We demonstrate the presence of several Fermi arcs connecting their corresponding Weyl points on both termination surfaces of the topological material.Our analysis reveals the existence of Dirac points,in addition to Weyl points,giving both theoretical and experimental evidences of the coexistence of Dirac and Weyl points in a single material.These findings not only confirm NbIrTe_(4) as a unique topological semimetal but also open avenues for exploring novel electronic devices based on its coexisting Dirac and Weyl fermions.
