Stephen Fitzpatrick是此次夏季房展会上参展商中为数不多的"老外开发商"。当海外地产在今年的夏展上成为夺人眼球的"亮点"时,不少海外楼盘的推介人还是选择了国内的代理商或公司中国区负责人出席。Stephen告诉记者...Stephen Fitzpatrick是此次夏季房展会上参展商中为数不多的"老外开发商"。当海外地产在今年的夏展上成为夺人眼球的"亮点"时,不少海外楼盘的推介人还是选择了国内的代理商或公司中国区负责人出席。Stephen告诉记者,尽管Kinsale资产投资集团与北京澳达天成投资有限公司合作的很愉快,但是,Stephen仍然选择了"亲自来这个广阔的市场看看"。展开更多
In this paper,the authors first apply the Fitzpatrick algorithm to multivariate vectorvalued osculatory rational interpolation.Then based on the Fitzpatrick algorithm and the properties of an Hermite interpolation bas...In this paper,the authors first apply the Fitzpatrick algorithm to multivariate vectorvalued osculatory rational interpolation.Then based on the Fitzpatrick algorithm and the properties of an Hermite interpolation basis,the authors present a Fitzpatrick-Neville-type algorithm for multivariate vector-valued osculatory rational interpolation.It may be used to compute the values of multivariate vector-valued osculatory rational interpolants at some points directly without computing the interpolation function explicitly.展开更多
目的：测定贵阳地区正常人群长波紫外线（UVA）、中波紫外线（UVB）的最小红斑量（MED）。方法：以SUV-l000型日光紫外线模拟器作为照射光源,测定190例健康志愿者腹部正常皮肤UVA-MED及UVB-MED,比较不同皮肤类型、性别、年龄及季节受试...目的：测定贵阳地区正常人群长波紫外线（UVA）、中波紫外线（UVB）的最小红斑量（MED）。方法：以SUV-l000型日光紫外线模拟器作为照射光源,测定190例健康志愿者腹部正常皮肤UVA-MED及UVB-MED,比较不同皮肤类型、性别、年龄及季节受试者UVA-MED及UVB-MED。结果：190例志愿者UVA-MED中位数为48.25 J/cm2,UVB-MED为35.24 m J/cm2,男性UVA-MED和UVB-MED中位数均高于女性（P〈0.01）,Ⅳ型皮肤MED中位数亦均显著高于Ⅲ型皮肤（P〈0.01）;男性10～29岁组及30～49岁组UVA-MED明显高于≥50岁组（P〈0.01）,10～29岁组UVB-MED高于30～49岁组及≥50岁组（P〈0.05）;男性夏季UVA-MED显著低于春、秋两季（P〈0.01）,女性夏季UVA-MED亦显著低于春、冬两季（P〈0.01）;男、女性夏季UVB-MED低于春、秋、冬季（P〈0.05）。结论：皮肤日光反应类型、性别、年龄及季节是影响贵阳地区人群MED的重要因素。展开更多
Objective： To investigate cutaneous aging patterns of residents in Hangzhou, Zhejiang, China, and their contributing factors. Methods： Eight hundred and forty-eight Hangzhou residents received the survey between Mar...Objective： To investigate cutaneous aging patterns of residents in Hangzhou, Zhejiang, China, and their contributing factors. Methods： Eight hundred and forty-eight Hangzhou residents received the survey between March 2004 and September 2004. Results： Facial wrinkling first occurred at 21 years of age and skin elasticity began to lose at 22 years of age. In middle-aged and old people, facial wrinkling and looseness escalated with the increase of ultraviolet （UV）-exposure time, indicating the accelerating effect of a higher accumulative dose of UV radiation on skin aging. Only Fitzpatrick types Ⅱ, Ⅲ and Ⅳ were found in the skin phototypes of residents in Hangzhou area, and Fitzpatrick type Ⅱ seemed to be much more subject to severe wrinkling, elasticity destruction and skin tumors than types Ⅲ and Ⅳ. The oily skin was more protected against wrinkling and facial looseness than dry skin. However, as to concomitant cutaneous diseases, no difference was found among different skin types. Conclusion： Age, solar-exposure time, Fitzpatrick type and skin type are the associated forces in promoting skin aging, and emotional factor seems to be another independent risk factor. The age of 49 years and 2 h/d of solar-exposure time seem to be the turning points responsible for dramatic changes of cutaneous appearance in the process of skin aging in Southeast China.展开更多
Background:Wound healing can result in various outcomes,including hypertrophic scar(HTS).Pigs serve as models to study wound healing as their skin shares physi-ologic similarity with humans.Yorkshire(Yk)and Duroc(Dc)p...Background:Wound healing can result in various outcomes,including hypertrophic scar(HTS).Pigs serve as models to study wound healing as their skin shares physi-ologic similarity with humans.Yorkshire(Yk)and Duroc(Dc)pigs have been used to mimic normal and abnormal wound healing,respectively.The reason behind this differential healing phenotype was explored here.Methods:Excisional wounds were made on Dc and Yk pigs and were sampled and imaged for 98 days.PCR arrays were used to determine differential gene expression.Vancouver Scar Scale(VSS)scores were given.Re-epithelialization was analyzed.H&E,Mason's trichrome,and immunostains were used to determine cellularity,col-lagen content,and blood vessel density,respectively.Results:Yk wounds heal to a“port wine”HTS,resembling scarring in Fitzpatrick skin types(FST)I-III.Dc wounds heal to a dyspigmented,non-pliable HTS,resembling scarring in FST IV-VI.Gene expression during wound healing was differentially regulated versus uninjured skin in 40/80 genes,15 of which differed between breeds.Yk scars had a higher VSS score at all time points.Yk and Dc wounds had equivalent re-epithelialization,collagen disorganization,and blood vessel density.Conclusions:Our findings demonstrate that Dc and Yk pigs can produce HTS.Wound creation and healing were consistent among breeds,and differences in gene expression were not sufficient to explain differences in resulting scar phenotype.Both pig breeds should be used in animal models to investigate novel therapeutics to provide insight into a treatment's effectiveness on various skin types.展开更多
基金supported by the National Science Foundation of China under Grant No.11171133the Open Fund of Automated Reasoning and Cognition Key Laboratory of Chongqing under Grant No.CARC2014001
文摘In this paper,the authors first apply the Fitzpatrick algorithm to multivariate vectorvalued osculatory rational interpolation.Then based on the Fitzpatrick algorithm and the properties of an Hermite interpolation basis,the authors present a Fitzpatrick-Neville-type algorithm for multivariate vector-valued osculatory rational interpolation.It may be used to compute the values of multivariate vector-valued osculatory rational interpolants at some points directly without computing the interpolation function explicitly.
文摘目的：测定贵阳地区正常人群长波紫外线（UVA）、中波紫外线（UVB）的最小红斑量（MED）。方法：以SUV-l000型日光紫外线模拟器作为照射光源,测定190例健康志愿者腹部正常皮肤UVA-MED及UVB-MED,比较不同皮肤类型、性别、年龄及季节受试者UVA-MED及UVB-MED。结果：190例志愿者UVA-MED中位数为48.25 J/cm2,UVB-MED为35.24 m J/cm2,男性UVA-MED和UVB-MED中位数均高于女性（P〈0.01）,Ⅳ型皮肤MED中位数亦均显著高于Ⅲ型皮肤（P〈0.01）;男性10～29岁组及30～49岁组UVA-MED明显高于≥50岁组（P〈0.01）,10～29岁组UVB-MED高于30～49岁组及≥50岁组（P〈0.05）;男性夏季UVA-MED显著低于春、秋两季（P〈0.01）,女性夏季UVA-MED亦显著低于春、冬两季（P〈0.01）;男、女性夏季UVB-MED低于春、秋、冬季（P〈0.05）。结论：皮肤日光反应类型、性别、年龄及季节是影响贵阳地区人群MED的重要因素。
基金Project supported by the Skin Grant Program (2004) of L'Oreal-Chinese Medical Association (CMA), China
文摘Objective： To investigate cutaneous aging patterns of residents in Hangzhou, Zhejiang, China, and their contributing factors. Methods： Eight hundred and forty-eight Hangzhou residents received the survey between March 2004 and September 2004. Results： Facial wrinkling first occurred at 21 years of age and skin elasticity began to lose at 22 years of age. In middle-aged and old people, facial wrinkling and looseness escalated with the increase of ultraviolet （UV）-exposure time, indicating the accelerating effect of a higher accumulative dose of UV radiation on skin aging. Only Fitzpatrick types Ⅱ, Ⅲ and Ⅳ were found in the skin phototypes of residents in Hangzhou area, and Fitzpatrick type Ⅱ seemed to be much more subject to severe wrinkling, elasticity destruction and skin tumors than types Ⅲ and Ⅳ. The oily skin was more protected against wrinkling and facial looseness than dry skin. However, as to concomitant cutaneous diseases, no difference was found among different skin types. Conclusion： Age, solar-exposure time, Fitzpatrick type and skin type are the associated forces in promoting skin aging, and emotional factor seems to be another independent risk factor. The age of 49 years and 2 h/d of solar-exposure time seem to be the turning points responsible for dramatic changes of cutaneous appearance in the process of skin aging in Southeast China.
基金This work was funded in part by R01 AR070851-01A1.
文摘Background:Wound healing can result in various outcomes,including hypertrophic scar(HTS).Pigs serve as models to study wound healing as their skin shares physi-ologic similarity with humans.Yorkshire(Yk)and Duroc(Dc)pigs have been used to mimic normal and abnormal wound healing,respectively.The reason behind this differential healing phenotype was explored here.Methods:Excisional wounds were made on Dc and Yk pigs and were sampled and imaged for 98 days.PCR arrays were used to determine differential gene expression.Vancouver Scar Scale(VSS)scores were given.Re-epithelialization was analyzed.H&E,Mason's trichrome,and immunostains were used to determine cellularity,col-lagen content,and blood vessel density,respectively.Results:Yk wounds heal to a“port wine”HTS,resembling scarring in Fitzpatrick skin types(FST)I-III.Dc wounds heal to a dyspigmented,non-pliable HTS,resembling scarring in FST IV-VI.Gene expression during wound healing was differentially regulated versus uninjured skin in 40/80 genes,15 of which differed between breeds.Yk scars had a higher VSS score at all time points.Yk and Dc wounds had equivalent re-epithelialization,collagen disorganization,and blood vessel density.Conclusions:Our findings demonstrate that Dc and Yk pigs can produce HTS.Wound creation and healing were consistent among breeds,and differences in gene expression were not sufficient to explain differences in resulting scar phenotype.Both pig breeds should be used in animal models to investigate novel therapeutics to provide insight into a treatment's effectiveness on various skin types.
