We revisit the multi-allelic mutation-fitness balance problem especially when fitnesses are multiplicative. Using ideas arising from quasi-stationary distributions, we analyze the qualitative differences between the f...We revisit the multi-allelic mutation-fitness balance problem especially when fitnesses are multiplicative. Using ideas arising from quasi-stationary distributions, we analyze the qualitative differences between the fitness-first and mutation-first models, under various schemes of the mutation pattern. We give some stochastic domination relations between the equilibrium states resulting from these models.展开更多
Background:Physical fitness is a key indicator of current and future health in children and adolescents.Evidence suggests that fitness levels have declined then stagnated in recent decades,but it remains unclear how t...Background:Physical fitness is a key indicator of current and future health in children and adolescents.Evidence suggests that fitness levels have declined then stagnated in recent decades,but it remains unclear how the coronavirus disease 2019(COVID-19)pandemic has impacted this trend.Methods:We conducted a systematic review and meta-analyses to assess pandemic-related changes in physical fitness among children and adolescents(0-19 years)in the World Health Organization European Region.Seven databases were searched up to February 28,2025 for studies reporting validated pre-and during/post-pandemic fitness measurements.Two reviewers independently performed screening,data extraction,risk-of-bias assessment(Risk Of Bias In Non-randomized Studies-of Exposure)(ROBINS-E),and certainty grading(Grading of Recommendations,Assessment,Development and Evaluation)(GRADE).Random-effects meta-analyses yielded standardized mean differences(SMDs)with 95%confidence intervals(95%CIs).Subgroup analyses examined sex,age,year,and national restriction severity(Oxford Stringency Index).Results:Thirty-two studies comprising 270,179 participants and 1,519,386 fitness measurements from 17 European countries were included.Cardiorespiratory fitness declined significantly during the pandemic,especially in 2021,with reductions in endurance(SMD=-0.43;95%CI:-0.61 to-0.25)and speed(SMD=-0.29;95%CI:-0.61 to 0.03).While speed returned to baseline by 2023,endurance remained below pre-pandemic levels(SMD=-0.10;95%CI:-0.12 to-0.08).Girls and adolescents were disproportionately affected.In contrast to cardiorespiratory fitness,muscular fitness remained largely unchanged.Stricter national regulations were associated with greater declines in cardiorespiratory fitness.Conclusion:COVID-19 pandemic restrictions were associated with a marked decline in cardiorespiratory fitness in European children and adolescents,with levels not recovered by 2023.These findings call for urgent,targeted public health interventions to improve physical fitness and prevent long-term health consequences.展开更多
Background:Midlife lifestyle factors,including physical activity,are associated with late-life brain health,yet the role of aerobic exercise on structural brain health in early and mid-adulthood remains poorly underst...Background:Midlife lifestyle factors,including physical activity,are associated with late-life brain health,yet the role of aerobic exercise on structural brain health in early and mid-adulthood remains poorly understood.This study aimed to examine the effect of aerobic exercise on structural brain age and to explore potential mediators.Methods:In a single-blind,12-month randomized clinical trial,130 healthy participants aged 26-58 years were randomized into a moderate-to-vigorous intensity aerobic exercise group or a usual-care control group.The exercise group attended two supervised 60-min sessions per week in a laboratory setting plus engaged in home-based exercise to achieve 150 min of exercise per week.Brain-predicted age difference(brain-PAD)and cardiorespiratory fitness(CRF)were assessed at baseline and 12 months.Both intention-to-treat(ITT)and completers analyses(including participants who completed post-intervention assessments)were performed.Results:The 130 participants(67.7%female)had an age of 41.28±9.93 years(mean±SD).At baseline,higher CRF(peak oxygen uptake,VO_(2peak))was associated with smaller brain-PAD(β=-0.309,p=0.012).After the intervention,the exercise group showed a decrease in brainPAD(estimated mean difference(EMD)=-0.60;95%confidence interval(95%CI):-1.15 to-0.04;p=0.034)compared to the control group(EMD=0.35;95%CI:-0.21 to 0.92;p=0.217);time×group interaction(between-group difference(BGD)=-0.95;95%CI:-1.72 to-0.17;p=0.019).VO2peak improved in the exercise group(EMD=1.60;95%CI:0.29-2.90;p=0.017)compared to the control group(EMD=-0.78;95%CI:-2.17 to 0.60;p=0.265);time×group interaction(BGD=2.38;95%CI:0.52-4.25;p=0.015).Body composition,blood pressure,and brain-derived neurotrophic factor levels were unaffected.None of the proposed pathways statistically mediated the effect of exercise on brain-PAD.The results from completers were similar.Conclusion:Engaging in 12 months of moderate-to-vigorous exercise reduced brain-PAD in early-to-midlife adults.The pathways by which these effects occur remain unknown.展开更多
Feature selection serves as a critical preprocessing step inmachine learning,focusing on identifying and preserving the most relevant features to improve the efficiency and performance of classification algorithms.Par...Feature selection serves as a critical preprocessing step inmachine learning,focusing on identifying and preserving the most relevant features to improve the efficiency and performance of classification algorithms.Particle Swarm Optimization has demonstrated significant potential in addressing feature selection challenges.However,there are inherent limitations in Particle Swarm Optimization,such as the delicate balance between exploration and exploitation,susceptibility to local optima,and suboptimal convergence rates,hinder its performance.To tackle these issues,this study introduces a novel Leveraged Opposition-Based Learning method within Fitness Landscape Particle Swarm Optimization,tailored for wrapper-based feature selection.The proposed approach integrates:(1)a fitness-landscape adaptive strategy to dynamically balance exploration and exploitation,(2)the lever principle within Opposition-Based Learning to improve search efficiency,and(3)a Local Selection and Re-optimization mechanism combined with random perturbation to expedite convergence and enhance the quality of the optimal feature subset.The effectiveness of is rigorously evaluated on 24 benchmark datasets and compared against 13 advancedmetaheuristic algorithms.Experimental results demonstrate that the proposed method outperforms the compared algorithms in classification accuracy on over half of the datasets,whilst also significantly reducing the number of selected features.These findings demonstrate its effectiveness and robustness in feature selection tasks.展开更多
Energy expenditure estimation can be used to measure the exercise load and physical condition of different individuals, such as soldiers, athletes, firemen, etc., during their training and work. Energy expenditure est...Energy expenditure estimation can be used to measure the exercise load and physical condition of different individuals, such as soldiers, athletes, firemen, etc., during their training and work. Energy expenditure estimation methods based on computer vision have rapidly developed in recent years. Compared with sensor-based methods, such methods are capable of monitoring several target persons at the same time, and the subjects do not need to wear different sensor devices that hamper their movement. In this paper, we propose a cross-attention spatial–temporal convolutional neural network to predict the energy expenditure of people under different exercise intensities. The model explores the relationship between changes in the human skeleton and energy expenditure intensity. In addition, a cross-attention correction module is used to reduce the negative effects of individual physical fitness characteristics during energy expenditure estimation. The experimental results show that our proposed method achieves high accuracy for energy expenditure estimation and performs better than existing computer vision-based energy expenditure estimation methods do. The proposed method can be widely used in various physical activity scenarios to measure energy expenditure, increasing the convenience of usage.展开更多
Background:Physicalfitness in childhood and adolescence is associated with a variety of health outcomes and is a powerful marker of current and future health.However,inconsistencies in tests and protocols limit interna...Background:Physicalfitness in childhood and adolescence is associated with a variety of health outcomes and is a powerful marker of current and future health.However,inconsistencies in tests and protocols limit international monitoring and surveillance.The objective of the study was to seek international consensus on a proposed,evidence-informed,Youth Fitness International Test(YFIT)battery and protocols for health monitoring and surveillance in children and adolescents aged 618 years.Methods:We conducted an international modified Delphi study to evaluate the level of agreement with a proposed,evidence-based,YFIT of core health-relatedfitness tests and protocols to be used worldwide in 6-to 18-year-olds.This proposal was based on previous European and North American projects that systematically reviewed the existing evidence to identify the most valid,reliable,health-related,safe,and feasiblefitness tests to be used in children and adolescents aged 618 years.We designed a single-panel modified Delphi study and invited 216 experts from all around the world to answer this Delphi survey,of whom one-third are from low-to-middle income countries and one-third are women.Four experts were involved in the piloting of the survey and did not participate in the main Delphi study to avoid bias.We pre-defined an agreement of 80%among the expert participants to achieve consensus.Results:We obtained a high response rate(78%)with a total of 169fitness experts from 50 countries and territories,including 63 women and 61 experts from low-or middle-income countries/territories.Consensus(>85%agreement)was achieved for all proposed tests and protocols,supporting the YFIT battery,which includes weight and height(to compute body mass index as a proxy of body size/composition),the 20-m shuttle run(cardiorespiratoryfitness),handgrip strength,and standing long jump(muscularfitness).Conclusion:This study contributes to standardizingfitness tests and protocols used for research,monitoring,and surveillance across the world,which will allow for future data pooling and the development of international and regional sex-and age-specific reference values,health-related cut-points,and a global picture offitness among children and adolescents.展开更多
1.Introduction。There is abundant evidence that the amount of habitual physical activity(PA)and the level of cardiorespiratory fitness(CRF)are inversely related to developing chronic diseases,including cardiovascular(...1.Introduction。There is abundant evidence that the amount of habitual physical activity(PA)and the level of cardiorespiratory fitness(CRF)are inversely related to developing chronic diseases,including cardiovascular(CV)disease(CVD).Relative to the CV and all-cause mortality reductions associated with exercise,intensity and duration also appear to be inversely related.For example,the mortality reductions that are associated with a regular 5-min run~a 15-min walk,and a 25-min run~a 105-min walk.1 In addition,at comparable levels of total energy expenditure,vigorous exercise seems to be more effective than moderate-intensity exercise in reducing CV risk.2 Vigorous exercise training is also more effective than moderate intensity training at increasing CRF,expressed as metabolic equivalents or METs,which has been shown to confer a lower risk of mortality.3 Accordingly,the optimal physiologic,clinical,and survival benefits of exercise are most likely to be achieved by progressing from moderate intensity exercise(usually defined as 40%-59%of functional capacity or 55%-69%of the maximal heart rate)to vigorous training regimens,corresponding to≥60%of functional capacity or 70%-89%of the measured maximal heart rate.展开更多
Objectives:Cardiorespiratory fitness(CRF)and skeletal muscle mass(SMM)are both key parameters of intrinsic capacity.To date,the impact of adherence to physical activity guidelines by older adults on these facets is po...Objectives:Cardiorespiratory fitness(CRF)and skeletal muscle mass(SMM)are both key parameters of intrinsic capacity.To date,the impact of adherence to physical activity guidelines by older adults on these facets is poorly understood.Therefore,this study aimed to assess the impact of 4 weeks adherence to UK physical activity guidelines on parameters of intrinsic capacity in older adults,with a secondary aim to determine the utility of a bedside-suitable predictive model of assessing CRF for predicting change in this parameter.Methods:14 older adults(22%female,age:66–80 years)completed a 4-week intervention in which they adhered to UK physical activity guidelines via a combination of supervised and home-based exercise.In addition to assessments of CRF via cardiopulmonary exercise testing and SMM via ultrasonography,whole-body and handgrip strength(HGS)and step-box test(SBT)variables were also measured before and after the intervention.Results:Our intervention resulted in significant increases in CRF(ventilatory threshold(VT):+2.7±0.9 mL/kg/min,p<0.01),vastus lateralis muscle thickness(+9%,p=0.02)and whole body strength(+47%,p<0.01).There was no change in HGS or SBT performance.The bedside-suitable predictive model of CRF was not able to determine change(R^(2)=0.11,p=0.25).Conclusions:Adherence to UK physical activity guidelines for just 4 weeks improves the CRF,SMM and whole-body strength of community-dwelling older adults.Collectively,these findings illustrate that adherence to current guidelines can improve key aspects of intrinsic capacity in older individuals.The impact of such interventions in populations at risk of accelerated physiological decline,warrant further investigation.展开更多
Measuring cardiorespiratory fitness(CRF)is an important predictor of morbidity and mortality in epidemiological studies and clinical settings.1 However,the feasibility of measuring maximal CRF is low due to the time,e...Measuring cardiorespiratory fitness(CRF)is an important predictor of morbidity and mortality in epidemiological studies and clinical settings.1 However,the feasibility of measuring maximal CRF is low due to the time,equipment,and expertise needed to conduct laboratory cardiopulmonary exercise testing(CPET)to determine the maximal rate of oxygen uptake(VO2max)as an objective measure of CRF.Alternatively,indirect estimates of CRF have been applied by measuring maximal duration on treadmill or cycle ergometer tests,2,3 extrapolating maximal CRF from workload or heart rate during submaximal fitness tests,4,5 and using non-exercise algorithms to estimate CRF from an individual’s age,sex,body mass,and physical activity habits.6 It is assumed that objectively measured VO2max is superior to extrapolated and estimated values due to errors associated with the estimated values;7,8 however,until Singh et al.9 newly released article in the Journal of Sport and Health Science,the comparability of these methods in identifying risks for all-cause and cardiovascular disease(CVD)mortality was unknown.展开更多
BACKGROUND The prevalence of metabolic syndrome(MetS)in adolescents is rising,correlating with the global increase in obesity and physical inactivity.AIM To examine the individual and combined associations of fitness,...BACKGROUND The prevalence of metabolic syndrome(MetS)in adolescents is rising,correlating with the global increase in obesity and physical inactivity.AIM To examine the individual and combined associations of fitness,fatness,visceral adiposity index(VAI),and lipid ratios with MetS risk in Nigerian adolescents.METHODS This cross-sectional study included a sample of 403 adolescents(201 girls and 202 boys)aged 11-19 years.Participants were assessed for cardiorespiratory fitness,body mass index(BMI),VAI,triglyceride-to-high-density lipoprotein cholesterol ratio(TG/HDL-C),and total cholesterol-to-high-density lipoprotein cholesterol ratio(TC/HDL-C).Regression models adjusted for age and sexual maturity were used to determine the associations between these health markers and MetS risk.RESULTS Among the 177 high-risk adolescents,56.6%were at risk of central obesity,49.1%had low fitness,33.3%had dyslipidemia,and 11.7%were obese.After controlling for confounding variables,all health markers were independently and jointly associated with MetS risk,with VAI displaying the strongest explanatory power(girls:β=1.308,P<0.001;boys:β=2.300,P<0.001).Unfit girls were 5.1%more likely to be at risk of MetS,while the odds of unfit boys being at risk of MetS is 3.6.Boys with elevated VAI were 22.3 times more likely to be at risk of MetS,while the likelihood of girls with elevated VAI developing MetS risk is 2.78.CONCLUSION Health markers were independently and jointly associated with MetS risk in adolescents,with VAI and dyslip-idemia contributing most significantly.Promoting healthy eating and also aerobic activities among adolescents is crucial for improving metabolic health.展开更多
Objective To study the increasing use of sports and fitness APPs against the background of national fitness and post-epidemic era,and to provide some suggestions for the development of sports and fitness APPs.Methods ...Objective To study the increasing use of sports and fitness APPs against the background of national fitness and post-epidemic era,and to provide some suggestions for the development of sports and fitness APPs.Methods Literature survey and mathematical statistics were used to define the concept of sports and fitness APPs,and their characteristics and advantages were investigated.Then,their problems were pointed out.Results and Conclusion The existing problems include some APPs favoring female users,single function,and slightly backward profit model.Some countermeasures such as enriching course types,taking into account all categories of users,expanding more functions,improving service quality,broadening profit channels,and improving marketing level are put forward.This can provide theoretical basis for the operation of sports and fitness APPs and better popularize the culture of national fitness.展开更多
Blooms of the toxic dinoflagellate Alexandrium spp.,which produce paralytic shellfish toxins(PSTs),have threatened marine ecosystems for decades.However,their impacts on benthic copepods remain underexplored.Here,we i...Blooms of the toxic dinoflagellate Alexandrium spp.,which produce paralytic shellfish toxins(PSTs),have threatened marine ecosystems for decades.However,their impacts on benthic copepods remain underexplored.Here,we investigated the physiological and biochemical responses of marine benthic copepod Tigriopus japonicus to Alexandrium pacificum.Adult female showed no mortality within 24 h and maintained high survival(>80%)across all A.pacificum concentrations over 96 h,with no significant difference from non-toxic controls.Ingestion rates on A.pacificum and non-toxic controls were similar,when algal prey concentrations were lower than about 2500µgC/L.However,above this threshold,feeding of T.japonicus was significantly depressed by A.pacificum.Six-day exposure induced oxidative stress,marked by elevated level of reactive oxygen species,malondialdehyde,total antioxidant capacity and superoxide dismutase activity,while catalase activity showed a non-significant increase.Moreover,concentration-dependent increase was observed in acetylcholinesterase activity,and its positive correlation with oxidative biomarkers suggests additional roles in coping with stress.Chronic exposure over three generations did not consistently affect development,except for complete development failure in F2 and F3 at the highest concentration.However,moderate-to-high concentrations of A.pacificum significantly impaired reproduction,reducing egg production by 9.66%–96.07%and clutch numbers by 33.33%–55.56%.Our findings indicate that Alexandrium blooms can adversely impact benthic copepod feeding and population recruitment through neurotoxicity and oxidative stress,highlighting the ecological risks of prolonged algal blooms in benthic habitats.展开更多
Mounting evidence suggests that male sperm may be gradually depleted after consecutive matings,resulting in the decline of female reproductive output in insect species.It is predicted that females may employ adaptive ...Mounting evidence suggests that male sperm may be gradually depleted after consecutive matings,resulting in the decline of female reproductive output in insect species.It is predicted that females may employ adaptive strategies to avoid the sperm-depleted males,such as mating multiply with different males and/or discriminating against previously mated males(MMs).Similarly,males may exhibit adaptive behaviors toward females varying in mating status.However,in spiders with males lacking primary copulatory organs and their pedipalps modified to transfer sperm,there are few studies on male mating potential and previous mating experience on their subsequent mate choice.In this study,we used a polyandrous crab spider,Ebrechtella tricuspidata,a sit-and-wait predator with female-biased sex ratio as a model system to ascertain whether 1)male mating experiences influence female reproductive fitness;2)females respond differently to males varying in mating status;and 3)males respond differently to females varying in mating status.Our results showed that female fecundity was independent of male mating experiences,but female fertility markedly declined with the increase of male previous mating experiences in the first eggsac.Counter to our predictions,females preferred to choose and mate with the larger males,regardless of their mating status.In contrast,male mating status influenced their mating preference toward females.Virgin males did not show any preference between virgin and mated females;however,MMs were more likely to prefer the virgin females over the mated ones.Overall,our results indicated that female choice depended primarily on male relative size rather than male mating status,whereas male choice depended on female mating status,Depending on the investigation of reproductive dynamics and mate choice in E.tricuspidata,the study will provide valuable insights into the adaptive behaviors of both males and females exhibiting toward mates varying inmating status.展开更多
Background:Cardiorespiratory fitness(CRF)is a powerful health marker recommended by the American Heart Association as a clinical vital sign.Comparing the predictive validity of objectively measured CRF(the"gold s...Background:Cardiorespiratory fitness(CRF)is a powerful health marker recommended by the American Heart Association as a clinical vital sign.Comparing the predictive validity of objectively measured CRF(the"gold standara")and estimated CRF is clinically relevant because estimated CRF is more feasible.Our objective was to meta-analyze cohort studies to compare the associations of objectively measured,exerciseestimated,and non-exercise-estimated CRF with all-cause and cardiovascular disease(CVD)mortality in adults.Methods:Systematic searches were conducted in 9 databases(MEDLINE,SPORTDiscus,Embase,Scopus,PsycINFO,Web of Science,PubMed,CINAHL,and the Cochrane Library)up to April 11,2024.We included full-text refereed cohort studies published in English that quantified the association(using risk estimates with 95%confidence intervals(95%CIs))of objectively measured,exercise-estimated,and non-exercise-estimated CRF with all-cause and CVD mortality in adults.CRF was expressed as metabolic equivalents(METs)of task.Pooled relative risks(RR)for all-cause and CVD mortality per 1-MET(3.5 mL/kg/min)higher level of CRF were quantified using random-effects models.Results:Forty-two studies representing 35 cohorts and 3,813,484 observations(81%male)(362,771 all-cause and 56,471 CVD deaths)were included.The pooled RRs for all-cause and CVD mortality per higher MET were 0.86(95%CI:0.83-0.88)and 0.84(95%CI:0.80-0.87),respectively.For both all-cause and CVD mortality,there were no statistically significant differences in RR per higher MET between objectively measured(RR range:0.86-0.90)and maximal exercise-estimated(RR range:0.85-0.86),submaximal exercise-estimated(RR range:0.91-0.94),and non-exercise-estimated CRF(RR range:0.81-0.85).Conclusion:Objectively measured and estimated CRF showed similar dose-response associations for all-cause and CVD mortality in adults.Estimated CRF could provide a practical and robust alternative to objectively measured CRF for assessing mortality risk across diverse populations.Our findings underscore the health-related benefits of higher CRF and advocate for its integration into clinical practice to enhance risk stratification.展开更多
BACKGROUND Hypertension(HTN)is a significant global health concern due to its rising prevalence and associated risks of cardiovascular disease,chronic kidney disease,and other comorbidities.The increasing rates of HTN...BACKGROUND Hypertension(HTN)is a significant global health concern due to its rising prevalence and associated risks of cardiovascular disease,chronic kidney disease,and other comorbidities.The increasing rates of HTN among youth have been partly attributed to the global rise in childhood obesity,lipid abnormalities,and sedentary lifestyles.AIM To investigate the independent associations of aerobic fitness(AF),the triglyceride-to-high-density lipoprotein cholesterol(TG/HDL-C)ratio,visceral adiposity index(VAI),and resting blood pressure(BP)in Nigerian adolescents.METHODS A multistage sampling technique was used to select 403 in-school adolescents aged 11-19 years in Kogi East,Nigeria.Participants were assessed for AF,TG/HDL-C ratio,VAI,systolic BP(SBP),and diastolic BP(DBP).The associations between the independent variables and the risk of systolic and diastolic HTN were examined using multivariate regression models,controlling for age and maturity status.Receiver operating characteristics curve(ROC)and area under the curve(AUC)were employed to determine the predictive capacities of the independent variables.RESULTS The overall prevalence of systolic HTN was 5.5%(girls:7%;boys:4%)while diastolic HTN was 12.7%(girls:16.9%;boys:8.4%).Among girls,all independent variables showed significant associations with SBP,including fitness(P<0.001),TG/HDL-C(P<0.001),and VAI(P<0.001),with VAI showing the strongest association.In boys,all independent variables except VAI(P=0.063)were significantly associated with SBP,with fitness showing the stronger predictive power(Fitness,P<0.001;TG/HDL-C,P=0.029).For DBP,all independent variables,except fitness in girls(P=0.099),were significantly associated(P<0.001)in both sexes.Unfit boys were 1.1 times more likely to develop systolic HTN(95%CI:1.01–1.15,P=0.018)and had 1.1 times higher odds of developing diastolic HTN(95%CI:1.03–1.13,P=0.001).Only the ROC for DBP turned up significant(P<0.001)AUCs for TG/HDL-C and VAI in girls only,with 0.6 and 1.0 thresholds respectively.CONCLUSION AF,dyslipidemia,and visceral adipose tissue dysfunction were independently associated with the risk of HTN in Nigerian adolescents.These findings highlight the importance of promoting a healthy diet and encouraging aerobic physical activity among adolescents to reduce the risk of HTN.展开更多
The Internet of Things(IoT)technology offers significant advancements in fitness trackers and AI-driven health management systems and presents practical applications for monitoring health and performance.New energy co...The Internet of Things(IoT)technology offers significant advancements in fitness trackers and AI-driven health management systems and presents practical applications for monitoring health and performance.New energy composites,which improve the performance of traditional metals,have been widely used in automotive manufacturing but have limited application in the sports industry.To bridge this gap,the study proposes integrating these advanced composites into sports equipment and facilities,utilizing IoT technology as the foundation for intelligent health monitoring.The research explores how IoT technology can enhance the promotional impact of fitness equipment within the sports industry.Additionally,the communication process for data assessment is conducted using the Priority-based Congestion-avoidance Routing Protocol(PCRP)to ensure efficient data transmission.The analysis of sports activities is performed by utilizing the data transferred through PCRP.Experimental results show that the proposed mechanism outperforms conventional models,achieving an energy efficiency of 0.502 joules(J),a delay of 0.407 seconds(s),and a throughput of 0.620.These results demonstrate the potential of combining IoT technology and new energy composites to revolutionize sports equipment and enhance fitness monitoring systems.These findings highlight the potential of combining IoT and advanced composite materials to revolutionize sports equipment,improve fitness monitoring,and contribute to the growth of the sports industry through enhanced data management and energy-efficient technologies.展开更多
文摘We revisit the multi-allelic mutation-fitness balance problem especially when fitnesses are multiplicative. Using ideas arising from quasi-stationary distributions, we analyze the qualitative differences between the fitness-first and mutation-first models, under various schemes of the mutation pattern. We give some stochastic domination relations between the equilibrium states resulting from these models.
文摘Background:Physical fitness is a key indicator of current and future health in children and adolescents.Evidence suggests that fitness levels have declined then stagnated in recent decades,but it remains unclear how the coronavirus disease 2019(COVID-19)pandemic has impacted this trend.Methods:We conducted a systematic review and meta-analyses to assess pandemic-related changes in physical fitness among children and adolescents(0-19 years)in the World Health Organization European Region.Seven databases were searched up to February 28,2025 for studies reporting validated pre-and during/post-pandemic fitness measurements.Two reviewers independently performed screening,data extraction,risk-of-bias assessment(Risk Of Bias In Non-randomized Studies-of Exposure)(ROBINS-E),and certainty grading(Grading of Recommendations,Assessment,Development and Evaluation)(GRADE).Random-effects meta-analyses yielded standardized mean differences(SMDs)with 95%confidence intervals(95%CIs).Subgroup analyses examined sex,age,year,and national restriction severity(Oxford Stringency Index).Results:Thirty-two studies comprising 270,179 participants and 1,519,386 fitness measurements from 17 European countries were included.Cardiorespiratory fitness declined significantly during the pandemic,especially in 2021,with reductions in endurance(SMD=-0.43;95%CI:-0.61 to-0.25)and speed(SMD=-0.29;95%CI:-0.61 to 0.03).While speed returned to baseline by 2023,endurance remained below pre-pandemic levels(SMD=-0.10;95%CI:-0.12 to-0.08).Girls and adolescents were disproportionately affected.In contrast to cardiorespiratory fitness,muscular fitness remained largely unchanged.Stricter national regulations were associated with greater declines in cardiorespiratory fitness.Conclusion:COVID-19 pandemic restrictions were associated with a marked decline in cardiorespiratory fitness in European children and adolescents,with levels not recovered by 2023.These findings call for urgent,targeted public health interventions to improve physical fitness and prevent long-term health consequences.
基金funded by the National Institutes of Health and the National Heart,Lung,and Blood Institute(P01HL040962)。
文摘Background:Midlife lifestyle factors,including physical activity,are associated with late-life brain health,yet the role of aerobic exercise on structural brain health in early and mid-adulthood remains poorly understood.This study aimed to examine the effect of aerobic exercise on structural brain age and to explore potential mediators.Methods:In a single-blind,12-month randomized clinical trial,130 healthy participants aged 26-58 years were randomized into a moderate-to-vigorous intensity aerobic exercise group or a usual-care control group.The exercise group attended two supervised 60-min sessions per week in a laboratory setting plus engaged in home-based exercise to achieve 150 min of exercise per week.Brain-predicted age difference(brain-PAD)and cardiorespiratory fitness(CRF)were assessed at baseline and 12 months.Both intention-to-treat(ITT)and completers analyses(including participants who completed post-intervention assessments)were performed.Results:The 130 participants(67.7%female)had an age of 41.28±9.93 years(mean±SD).At baseline,higher CRF(peak oxygen uptake,VO_(2peak))was associated with smaller brain-PAD(β=-0.309,p=0.012).After the intervention,the exercise group showed a decrease in brainPAD(estimated mean difference(EMD)=-0.60;95%confidence interval(95%CI):-1.15 to-0.04;p=0.034)compared to the control group(EMD=0.35;95%CI:-0.21 to 0.92;p=0.217);time×group interaction(between-group difference(BGD)=-0.95;95%CI:-1.72 to-0.17;p=0.019).VO2peak improved in the exercise group(EMD=1.60;95%CI:0.29-2.90;p=0.017)compared to the control group(EMD=-0.78;95%CI:-2.17 to 0.60;p=0.265);time×group interaction(BGD=2.38;95%CI:0.52-4.25;p=0.015).Body composition,blood pressure,and brain-derived neurotrophic factor levels were unaffected.None of the proposed pathways statistically mediated the effect of exercise on brain-PAD.The results from completers were similar.Conclusion:Engaging in 12 months of moderate-to-vigorous exercise reduced brain-PAD in early-to-midlife adults.The pathways by which these effects occur remain unknown.
基金supported by National Natural Science Foundation of China(62106092)Natural Science Foundation of Fujian Province(2024J01822,2024J01820,2022J01916)Natural Science Foundation of Zhangzhou City(ZZ2024J28).
文摘Feature selection serves as a critical preprocessing step inmachine learning,focusing on identifying and preserving the most relevant features to improve the efficiency and performance of classification algorithms.Particle Swarm Optimization has demonstrated significant potential in addressing feature selection challenges.However,there are inherent limitations in Particle Swarm Optimization,such as the delicate balance between exploration and exploitation,susceptibility to local optima,and suboptimal convergence rates,hinder its performance.To tackle these issues,this study introduces a novel Leveraged Opposition-Based Learning method within Fitness Landscape Particle Swarm Optimization,tailored for wrapper-based feature selection.The proposed approach integrates:(1)a fitness-landscape adaptive strategy to dynamically balance exploration and exploitation,(2)the lever principle within Opposition-Based Learning to improve search efficiency,and(3)a Local Selection and Re-optimization mechanism combined with random perturbation to expedite convergence and enhance the quality of the optimal feature subset.The effectiveness of is rigorously evaluated on 24 benchmark datasets and compared against 13 advancedmetaheuristic algorithms.Experimental results demonstrate that the proposed method outperforms the compared algorithms in classification accuracy on over half of the datasets,whilst also significantly reducing the number of selected features.These findings demonstrate its effectiveness and robustness in feature selection tasks.
基金supported by the National Key Research and Development Program of China (Grant No.2022YFC3600403)Emerging Interdisciplinary Platform for Medicine and Engineering in Sports (EIPMES),Beijing,China。
文摘Energy expenditure estimation can be used to measure the exercise load and physical condition of different individuals, such as soldiers, athletes, firemen, etc., during their training and work. Energy expenditure estimation methods based on computer vision have rapidly developed in recent years. Compared with sensor-based methods, such methods are capable of monitoring several target persons at the same time, and the subjects do not need to wear different sensor devices that hamper their movement. In this paper, we propose a cross-attention spatial–temporal convolutional neural network to predict the energy expenditure of people under different exercise intensities. The model explores the relationship between changes in the human skeleton and energy expenditure intensity. In addition, a cross-attention correction module is used to reduce the negative effects of individual physical fitness characteristics during energy expenditure estimation. The experimental results show that our proposed method achieves high accuracy for energy expenditure estimation and performs better than existing computer vision-based energy expenditure estimation methods do. The proposed method can be widely used in various physical activity scenarios to measure energy expenditure, increasing the convenience of usage.
基金supported by the Grant PID2020-120249RB-I00PID2023-148404OB-100funded by MCIN/AEI/10.13039/501100011033+4 种基金by the Andalusian Government(Junta de Andalucía,Plan Andaluz de Investigación,ref.P20_00124)by the Erasmus+Sport Programme of the European Union within the project FitBack4Literacy(No.101089829)Additional support is provided by the University of Granada,Plan Propio de Inves-tigación,Units of ExcellenceUnit of Excellence on Exercise,Nutrition and Health(UCEENS)by theCIBERobn Physiopa-thology of Obesity and Nutrition,and by the Spanish Network in Exercise and Health,EXERNET Network(RED2022-134800-Tand EXP_99828).
文摘Background:Physicalfitness in childhood and adolescence is associated with a variety of health outcomes and is a powerful marker of current and future health.However,inconsistencies in tests and protocols limit international monitoring and surveillance.The objective of the study was to seek international consensus on a proposed,evidence-informed,Youth Fitness International Test(YFIT)battery and protocols for health monitoring and surveillance in children and adolescents aged 618 years.Methods:We conducted an international modified Delphi study to evaluate the level of agreement with a proposed,evidence-based,YFIT of core health-relatedfitness tests and protocols to be used worldwide in 6-to 18-year-olds.This proposal was based on previous European and North American projects that systematically reviewed the existing evidence to identify the most valid,reliable,health-related,safe,and feasiblefitness tests to be used in children and adolescents aged 618 years.We designed a single-panel modified Delphi study and invited 216 experts from all around the world to answer this Delphi survey,of whom one-third are from low-to-middle income countries and one-third are women.Four experts were involved in the piloting of the survey and did not participate in the main Delphi study to avoid bias.We pre-defined an agreement of 80%among the expert participants to achieve consensus.Results:We obtained a high response rate(78%)with a total of 169fitness experts from 50 countries and territories,including 63 women and 61 experts from low-or middle-income countries/territories.Consensus(>85%agreement)was achieved for all proposed tests and protocols,supporting the YFIT battery,which includes weight and height(to compute body mass index as a proxy of body size/composition),the 20-m shuttle run(cardiorespiratoryfitness),handgrip strength,and standing long jump(muscularfitness).Conclusion:This study contributes to standardizingfitness tests and protocols used for research,monitoring,and surveillance across the world,which will allow for future data pooling and the development of international and regional sex-and age-specific reference values,health-related cut-points,and a global picture offitness among children and adolescents.
文摘1.Introduction。There is abundant evidence that the amount of habitual physical activity(PA)and the level of cardiorespiratory fitness(CRF)are inversely related to developing chronic diseases,including cardiovascular(CV)disease(CVD).Relative to the CV and all-cause mortality reductions associated with exercise,intensity and duration also appear to be inversely related.For example,the mortality reductions that are associated with a regular 5-min run~a 15-min walk,and a 25-min run~a 105-min walk.1 In addition,at comparable levels of total energy expenditure,vigorous exercise seems to be more effective than moderate-intensity exercise in reducing CV risk.2 Vigorous exercise training is also more effective than moderate intensity training at increasing CRF,expressed as metabolic equivalents or METs,which has been shown to confer a lower risk of mortality.3 Accordingly,the optimal physiologic,clinical,and survival benefits of exercise are most likely to be achieved by progressing from moderate intensity exercise(usually defined as 40%-59%of functional capacity or 55%-69%of the maximal heart rate)to vigorous training regimens,corresponding to≥60%of functional capacity or 70%-89%of the measured maximal heart rate.
基金funded through a Biotechnology and Biosciences Research Council(BBSRC)grant awarded to BE Phillips(BB/R010358/1)a Medical Research Council(MRC),United Kingdom grant awarded to BE Phillips(MR/X005240/1)+1 种基金through the MRC(grant no.MR/P021220/1)as part of the MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research awarded to the Universities of Nottingham and Birminghamsupported by the National Institute for Health Research,United Kingdom,Nottingham Biomedical Research Centre。
文摘Objectives:Cardiorespiratory fitness(CRF)and skeletal muscle mass(SMM)are both key parameters of intrinsic capacity.To date,the impact of adherence to physical activity guidelines by older adults on these facets is poorly understood.Therefore,this study aimed to assess the impact of 4 weeks adherence to UK physical activity guidelines on parameters of intrinsic capacity in older adults,with a secondary aim to determine the utility of a bedside-suitable predictive model of assessing CRF for predicting change in this parameter.Methods:14 older adults(22%female,age:66–80 years)completed a 4-week intervention in which they adhered to UK physical activity guidelines via a combination of supervised and home-based exercise.In addition to assessments of CRF via cardiopulmonary exercise testing and SMM via ultrasonography,whole-body and handgrip strength(HGS)and step-box test(SBT)variables were also measured before and after the intervention.Results:Our intervention resulted in significant increases in CRF(ventilatory threshold(VT):+2.7±0.9 mL/kg/min,p<0.01),vastus lateralis muscle thickness(+9%,p=0.02)and whole body strength(+47%,p<0.01).There was no change in HGS or SBT performance.The bedside-suitable predictive model of CRF was not able to determine change(R^(2)=0.11,p=0.25).Conclusions:Adherence to UK physical activity guidelines for just 4 weeks improves the CRF,SMM and whole-body strength of community-dwelling older adults.Collectively,these findings illustrate that adherence to current guidelines can improve key aspects of intrinsic capacity in older individuals.The impact of such interventions in populations at risk of accelerated physiological decline,warrant further investigation.
文摘Measuring cardiorespiratory fitness(CRF)is an important predictor of morbidity and mortality in epidemiological studies and clinical settings.1 However,the feasibility of measuring maximal CRF is low due to the time,equipment,and expertise needed to conduct laboratory cardiopulmonary exercise testing(CPET)to determine the maximal rate of oxygen uptake(VO2max)as an objective measure of CRF.Alternatively,indirect estimates of CRF have been applied by measuring maximal duration on treadmill or cycle ergometer tests,2,3 extrapolating maximal CRF from workload or heart rate during submaximal fitness tests,4,5 and using non-exercise algorithms to estimate CRF from an individual’s age,sex,body mass,and physical activity habits.6 It is assumed that objectively measured VO2max is superior to extrapolated and estimated values due to errors associated with the estimated values;7,8 however,until Singh et al.9 newly released article in the Journal of Sport and Health Science,the comparability of these methods in identifying risks for all-cause and cardiovascular disease(CVD)mortality was unknown.
文摘BACKGROUND The prevalence of metabolic syndrome(MetS)in adolescents is rising,correlating with the global increase in obesity and physical inactivity.AIM To examine the individual and combined associations of fitness,fatness,visceral adiposity index(VAI),and lipid ratios with MetS risk in Nigerian adolescents.METHODS This cross-sectional study included a sample of 403 adolescents(201 girls and 202 boys)aged 11-19 years.Participants were assessed for cardiorespiratory fitness,body mass index(BMI),VAI,triglyceride-to-high-density lipoprotein cholesterol ratio(TG/HDL-C),and total cholesterol-to-high-density lipoprotein cholesterol ratio(TC/HDL-C).Regression models adjusted for age and sexual maturity were used to determine the associations between these health markers and MetS risk.RESULTS Among the 177 high-risk adolescents,56.6%were at risk of central obesity,49.1%had low fitness,33.3%had dyslipidemia,and 11.7%were obese.After controlling for confounding variables,all health markers were independently and jointly associated with MetS risk,with VAI displaying the strongest explanatory power(girls:β=1.308,P<0.001;boys:β=2.300,P<0.001).Unfit girls were 5.1%more likely to be at risk of MetS,while the odds of unfit boys being at risk of MetS is 3.6.Boys with elevated VAI were 22.3 times more likely to be at risk of MetS,while the likelihood of girls with elevated VAI developing MetS risk is 2.78.CONCLUSION Health markers were independently and jointly associated with MetS risk in adolescents,with VAI and dyslip-idemia contributing most significantly.Promoting healthy eating and also aerobic activities among adolescents is crucial for improving metabolic health.
基金Liaoning Provincial Social Science Planning Fund Office(2019)(L19BGL034).
文摘Objective To study the increasing use of sports and fitness APPs against the background of national fitness and post-epidemic era,and to provide some suggestions for the development of sports and fitness APPs.Methods Literature survey and mathematical statistics were used to define the concept of sports and fitness APPs,and their characteristics and advantages were investigated.Then,their problems were pointed out.Results and Conclusion The existing problems include some APPs favoring female users,single function,and slightly backward profit model.Some countermeasures such as enriching course types,taking into account all categories of users,expanding more functions,improving service quality,broadening profit channels,and improving marketing level are put forward.This can provide theoretical basis for the operation of sports and fitness APPs and better popularize the culture of national fitness.
基金the Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology(Qingdao)(No.LSKJ202203206)the Fundamental Research Funds for the Central Universities(No.202161069)。
文摘Blooms of the toxic dinoflagellate Alexandrium spp.,which produce paralytic shellfish toxins(PSTs),have threatened marine ecosystems for decades.However,their impacts on benthic copepods remain underexplored.Here,we investigated the physiological and biochemical responses of marine benthic copepod Tigriopus japonicus to Alexandrium pacificum.Adult female showed no mortality within 24 h and maintained high survival(>80%)across all A.pacificum concentrations over 96 h,with no significant difference from non-toxic controls.Ingestion rates on A.pacificum and non-toxic controls were similar,when algal prey concentrations were lower than about 2500µgC/L.However,above this threshold,feeding of T.japonicus was significantly depressed by A.pacificum.Six-day exposure induced oxidative stress,marked by elevated level of reactive oxygen species,malondialdehyde,total antioxidant capacity and superoxide dismutase activity,while catalase activity showed a non-significant increase.Moreover,concentration-dependent increase was observed in acetylcholinesterase activity,and its positive correlation with oxidative biomarkers suggests additional roles in coping with stress.Chronic exposure over three generations did not consistently affect development,except for complete development failure in F2 and F3 at the highest concentration.However,moderate-to-high concentrations of A.pacificum significantly impaired reproduction,reducing egg production by 9.66%–96.07%and clutch numbers by 33.33%–55.56%.Our findings indicate that Alexandrium blooms can adversely impact benthic copepod feeding and population recruitment through neurotoxicity and oxidative stress,highlighting the ecological risks of prolonged algal blooms in benthic habitats.
基金the National Natural Science Foundation of China(30800121).
文摘Mounting evidence suggests that male sperm may be gradually depleted after consecutive matings,resulting in the decline of female reproductive output in insect species.It is predicted that females may employ adaptive strategies to avoid the sperm-depleted males,such as mating multiply with different males and/or discriminating against previously mated males(MMs).Similarly,males may exhibit adaptive behaviors toward females varying in mating status.However,in spiders with males lacking primary copulatory organs and their pedipalps modified to transfer sperm,there are few studies on male mating potential and previous mating experience on their subsequent mate choice.In this study,we used a polyandrous crab spider,Ebrechtella tricuspidata,a sit-and-wait predator with female-biased sex ratio as a model system to ascertain whether 1)male mating experiences influence female reproductive fitness;2)females respond differently to males varying in mating status;and 3)males respond differently to females varying in mating status.Our results showed that female fecundity was independent of male mating experiences,but female fertility markedly declined with the increase of male previous mating experiences in the first eggsac.Counter to our predictions,females preferred to choose and mate with the larger males,regardless of their mating status.In contrast,male mating status influenced their mating preference toward females.Virgin males did not show any preference between virgin and mated females;however,MMs were more likely to prefer the virgin females over the mated ones.Overall,our results indicated that female choice depended primarily on male relative size rather than male mating status,whereas male choice depended on female mating status,Depending on the investigation of reproductive dynamics and mate choice in E.tricuspidata,the study will provide valuable insights into the adaptive behaviors of both males and females exhibiting toward mates varying inmating status.
基金supported by a grant from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska Curie(Grant agreement No.101028929)supported by an Investigator Grant from the Medical Research Future Fund(MRF1193862)supported by an Australian Government Research Training Program Scholarship.
文摘Background:Cardiorespiratory fitness(CRF)is a powerful health marker recommended by the American Heart Association as a clinical vital sign.Comparing the predictive validity of objectively measured CRF(the"gold standara")and estimated CRF is clinically relevant because estimated CRF is more feasible.Our objective was to meta-analyze cohort studies to compare the associations of objectively measured,exerciseestimated,and non-exercise-estimated CRF with all-cause and cardiovascular disease(CVD)mortality in adults.Methods:Systematic searches were conducted in 9 databases(MEDLINE,SPORTDiscus,Embase,Scopus,PsycINFO,Web of Science,PubMed,CINAHL,and the Cochrane Library)up to April 11,2024.We included full-text refereed cohort studies published in English that quantified the association(using risk estimates with 95%confidence intervals(95%CIs))of objectively measured,exercise-estimated,and non-exercise-estimated CRF with all-cause and CVD mortality in adults.CRF was expressed as metabolic equivalents(METs)of task.Pooled relative risks(RR)for all-cause and CVD mortality per 1-MET(3.5 mL/kg/min)higher level of CRF were quantified using random-effects models.Results:Forty-two studies representing 35 cohorts and 3,813,484 observations(81%male)(362,771 all-cause and 56,471 CVD deaths)were included.The pooled RRs for all-cause and CVD mortality per higher MET were 0.86(95%CI:0.83-0.88)and 0.84(95%CI:0.80-0.87),respectively.For both all-cause and CVD mortality,there were no statistically significant differences in RR per higher MET between objectively measured(RR range:0.86-0.90)and maximal exercise-estimated(RR range:0.85-0.86),submaximal exercise-estimated(RR range:0.91-0.94),and non-exercise-estimated CRF(RR range:0.81-0.85).Conclusion:Objectively measured and estimated CRF showed similar dose-response associations for all-cause and CVD mortality in adults.Estimated CRF could provide a practical and robust alternative to objectively measured CRF for assessing mortality risk across diverse populations.Our findings underscore the health-related benefits of higher CRF and advocate for its integration into clinical practice to enhance risk stratification.
文摘BACKGROUND Hypertension(HTN)is a significant global health concern due to its rising prevalence and associated risks of cardiovascular disease,chronic kidney disease,and other comorbidities.The increasing rates of HTN among youth have been partly attributed to the global rise in childhood obesity,lipid abnormalities,and sedentary lifestyles.AIM To investigate the independent associations of aerobic fitness(AF),the triglyceride-to-high-density lipoprotein cholesterol(TG/HDL-C)ratio,visceral adiposity index(VAI),and resting blood pressure(BP)in Nigerian adolescents.METHODS A multistage sampling technique was used to select 403 in-school adolescents aged 11-19 years in Kogi East,Nigeria.Participants were assessed for AF,TG/HDL-C ratio,VAI,systolic BP(SBP),and diastolic BP(DBP).The associations between the independent variables and the risk of systolic and diastolic HTN were examined using multivariate regression models,controlling for age and maturity status.Receiver operating characteristics curve(ROC)and area under the curve(AUC)were employed to determine the predictive capacities of the independent variables.RESULTS The overall prevalence of systolic HTN was 5.5%(girls:7%;boys:4%)while diastolic HTN was 12.7%(girls:16.9%;boys:8.4%).Among girls,all independent variables showed significant associations with SBP,including fitness(P<0.001),TG/HDL-C(P<0.001),and VAI(P<0.001),with VAI showing the strongest association.In boys,all independent variables except VAI(P=0.063)were significantly associated with SBP,with fitness showing the stronger predictive power(Fitness,P<0.001;TG/HDL-C,P=0.029).For DBP,all independent variables,except fitness in girls(P=0.099),were significantly associated(P<0.001)in both sexes.Unfit boys were 1.1 times more likely to develop systolic HTN(95%CI:1.01–1.15,P=0.018)and had 1.1 times higher odds of developing diastolic HTN(95%CI:1.03–1.13,P=0.001).Only the ROC for DBP turned up significant(P<0.001)AUCs for TG/HDL-C and VAI in girls only,with 0.6 and 1.0 thresholds respectively.CONCLUSION AF,dyslipidemia,and visceral adipose tissue dysfunction were independently associated with the risk of HTN in Nigerian adolescents.These findings highlight the importance of promoting a healthy diet and encouraging aerobic physical activity among adolescents to reduce the risk of HTN.
基金supported by the Scientific Research and Innovation Team of Xi’an Eurasia University’Urban Sports Intellectualization Research Team’grant number[2021XJTD08]the Shaanxi Province Sports Bureau Research Project’Research on the Integration of the Whole Industry Chain of Sports Industry’grant number[2023317].
文摘The Internet of Things(IoT)technology offers significant advancements in fitness trackers and AI-driven health management systems and presents practical applications for monitoring health and performance.New energy composites,which improve the performance of traditional metals,have been widely used in automotive manufacturing but have limited application in the sports industry.To bridge this gap,the study proposes integrating these advanced composites into sports equipment and facilities,utilizing IoT technology as the foundation for intelligent health monitoring.The research explores how IoT technology can enhance the promotional impact of fitness equipment within the sports industry.Additionally,the communication process for data assessment is conducted using the Priority-based Congestion-avoidance Routing Protocol(PCRP)to ensure efficient data transmission.The analysis of sports activities is performed by utilizing the data transferred through PCRP.Experimental results show that the proposed mechanism outperforms conventional models,achieving an energy efficiency of 0.502 joules(J),a delay of 0.407 seconds(s),and a throughput of 0.620.These results demonstrate the potential of combining IoT technology and new energy composites to revolutionize sports equipment and enhance fitness monitoring systems.These findings highlight the potential of combining IoT and advanced composite materials to revolutionize sports equipment,improve fitness monitoring,and contribute to the growth of the sports industry through enhanced data management and energy-efficient technologies.
