Background：A relationship between hyperthyroidism and insulin secretion in type 2 diabetes mellitus （T2DM） has been reported.Therefore,this study explored the use of first-phase insulin secretion in the differentia...Background：A relationship between hyperthyroidism and insulin secretion in type 2 diabetes mellitus （T2DM） has been reported.Therefore,this study explored the use of first-phase insulin secretion in the differential diagnosis of thyroid diabetes （TDM） and T2DM.Methods：In total,101 patients with hyperthyroidism were divided into hyperthyroidism with normal glucose tolerance （TNGT）,hyperthyroidism with impaired glucose regulation （TIGR）,and diabetes （TDM） groups.Furthermore,96 patients without hyperthyroidism were recruited as control groups （normal glucose tolerance [NGT],impaired glucose regulation [IGR],and T2DM）.The following parameters were evaluated：homeostasis model assessment （HOMA）-IR,HOMA-β,modified β-cell function index （MBCI）,peak insulin/fasting insulin （IP/I0）,AUCins-OGTT,and AUCins-OGTr/AUCglu-OGTT from the oral glucose tolerance test （OGTT） insulin release test were utilized to assess the second-phase insulin secretion,while the IP/I0,AIR0＇-10＇,and AUCins-IVGTT from the intravenous glucose tolerance test （IVGTT） insulin release test were used to assess the first-phase insulin secretion.Results：In the OGTT,the HOMA-β values of the TNGT and TDM groups were higher than those of the NGT and T2DM groups （all P 〈 0.05）.In the hyperthyroidism groups,the MBCI of the TDM group was lower than that of the TNGT and TIGR groups （all P 〈 0.05）.Among the control groups,the MBCI values of the IGR and T2DM groups were lower than that of the normal glucose tolerance （NGT） group （all P 〈 0.05）.In the IVGTT,insulin secretion peaked for all groups at 2-4 min,except for the T2DM group,which showed a low plateau and no secretion peak.The IPvalues of the TNGT,TIGR,and TDM groups were higher than those of the NGT,IGR,and T2DM groups （all P 〈 0.05）.The IP/I0,AIR0＇-10＇,and AUCins-IVGTT values of the TDM group were higher than those of the T2DM group but were lower than those of the TNGT,TIGR,NGR,and IGR groups （all P 〈 0.05）.Compared with the other five groups,the IP/I0 AIR0＇-10＇,and AUCins-IVGTT values of the T2DM group were significantly decreased （all P 〈 0.05）.The IP/I0 and AUCins-IVGTT values of the TNGT group were higher than those of the NGT group （all P 〈 0.05）.Conclusions：β-cell function in TDM patients is superior to that in T2DM patients.First-phase insulin secretion could be used as an early diagnostic marker to differentiate TDM and T2DM.展开更多
Background Both repaglinide and gliclazide are insulin secretagogues widely used in the treatment of type 2 diabetes.They stimulate insulin secretion through distinct mechanisms and may benefit patients from different...Background Both repaglinide and gliclazide are insulin secretagogues widely used in the treatment of type 2 diabetes.They stimulate insulin secretion through distinct mechanisms and may benefit patients from different aspects.The present study was to evaluate the effects of repaglinide or gliclazide on glycaemic control,insulin secretion,and lipid profiles in type 2 diabetes patients.Methods A total of 47 newly diagnosed type 2 diabetes patients were randomized 1：1 to receive a 4-week treatment with repaglinide or gliclazide.The standard mixed meal tolerance test was performed before and after the treatment.Plasma glucose （PG）,insulin concentration,and lipid profiles were measured.The area under insulin concentration curve （AUCins） and the early-phase insulin secretion index （△I30/△G3o） were calculated.Results After the trial,fasting and postprandial PG and postprandial insulin improved significantly in both groups （P〈0.05）.The maximum insulin concentration occurred earlier in the repaglinide group than that in the gliclazide group.AUCins increased in both groups （P 〈0.05）,but no significant difference was found between groups.△I30/△G30 increased in both groups （P 〈0.05）,especially in the repaglinide group （P 〈0.05）.Triglyceride and total cholesterol decreased significantly in the repaglinide group in some time points,while no significant change was observed in the gliclazide group.Conclusions Repaglinide and gliclazide had similar effects on glycaemic control and total insulin secretion,while repaglinide had more effects on improvements in β-cell function and lipid metabolism.展开更多
Objective To investigate the correlation between serum uric acid(SUA)level and early-phase insulin secretion in subjects with normal glucose regulation(NGR).Methods Totally 367 community NGR residents confirmed by a 7...Objective To investigate the correlation between serum uric acid(SUA)level and early-phase insulin secretion in subjects with normal glucose regulation(NGR).Methods Totally 367 community NGR residents confirmed by a 75g oral glucose tolerance test were enrolled.展开更多
文摘Background：A relationship between hyperthyroidism and insulin secretion in type 2 diabetes mellitus （T2DM） has been reported.Therefore,this study explored the use of first-phase insulin secretion in the differential diagnosis of thyroid diabetes （TDM） and T2DM.Methods：In total,101 patients with hyperthyroidism were divided into hyperthyroidism with normal glucose tolerance （TNGT）,hyperthyroidism with impaired glucose regulation （TIGR）,and diabetes （TDM） groups.Furthermore,96 patients without hyperthyroidism were recruited as control groups （normal glucose tolerance [NGT],impaired glucose regulation [IGR],and T2DM）.The following parameters were evaluated：homeostasis model assessment （HOMA）-IR,HOMA-β,modified β-cell function index （MBCI）,peak insulin/fasting insulin （IP/I0）,AUCins-OGTT,and AUCins-OGTr/AUCglu-OGTT from the oral glucose tolerance test （OGTT） insulin release test were utilized to assess the second-phase insulin secretion,while the IP/I0,AIR0＇-10＇,and AUCins-IVGTT from the intravenous glucose tolerance test （IVGTT） insulin release test were used to assess the first-phase insulin secretion.Results：In the OGTT,the HOMA-β values of the TNGT and TDM groups were higher than those of the NGT and T2DM groups （all P 〈 0.05）.In the hyperthyroidism groups,the MBCI of the TDM group was lower than that of the TNGT and TIGR groups （all P 〈 0.05）.Among the control groups,the MBCI values of the IGR and T2DM groups were lower than that of the normal glucose tolerance （NGT） group （all P 〈 0.05）.In the IVGTT,insulin secretion peaked for all groups at 2-4 min,except for the T2DM group,which showed a low plateau and no secretion peak.The IPvalues of the TNGT,TIGR,and TDM groups were higher than those of the NGT,IGR,and T2DM groups （all P 〈 0.05）.The IP/I0,AIR0＇-10＇,and AUCins-IVGTT values of the TDM group were higher than those of the T2DM group but were lower than those of the TNGT,TIGR,NGR,and IGR groups （all P 〈 0.05）.Compared with the other five groups,the IP/I0 AIR0＇-10＇,and AUCins-IVGTT values of the T2DM group were significantly decreased （all P 〈 0.05）.The IP/I0 and AUCins-IVGTT values of the TNGT group were higher than those of the NGT group （all P 〈 0.05）.Conclusions：β-cell function in TDM patients is superior to that in T2DM patients.First-phase insulin secretion could be used as an early diagnostic marker to differentiate TDM and T2DM.
文摘Background Both repaglinide and gliclazide are insulin secretagogues widely used in the treatment of type 2 diabetes.They stimulate insulin secretion through distinct mechanisms and may benefit patients from different aspects.The present study was to evaluate the effects of repaglinide or gliclazide on glycaemic control,insulin secretion,and lipid profiles in type 2 diabetes patients.Methods A total of 47 newly diagnosed type 2 diabetes patients were randomized 1：1 to receive a 4-week treatment with repaglinide or gliclazide.The standard mixed meal tolerance test was performed before and after the treatment.Plasma glucose （PG）,insulin concentration,and lipid profiles were measured.The area under insulin concentration curve （AUCins） and the early-phase insulin secretion index （△I30/△G3o） were calculated.Results After the trial,fasting and postprandial PG and postprandial insulin improved significantly in both groups （P〈0.05）.The maximum insulin concentration occurred earlier in the repaglinide group than that in the gliclazide group.AUCins increased in both groups （P 〈0.05）,but no significant difference was found between groups.△I30/△G30 increased in both groups （P 〈0.05）,especially in the repaglinide group （P 〈0.05）.Triglyceride and total cholesterol decreased significantly in the repaglinide group in some time points,while no significant change was observed in the gliclazide group.Conclusions Repaglinide and gliclazide had similar effects on glycaemic control and total insulin secretion,while repaglinide had more effects on improvements in β-cell function and lipid metabolism.
文摘Objective To investigate the correlation between serum uric acid(SUA)level and early-phase insulin secretion in subjects with normal glucose regulation(NGR).Methods Totally 367 community NGR residents confirmed by a 75g oral glucose tolerance test were enrolled.
