Objective:This study aimed to investigate the influence of lung function on the relationship between allergies and hypertension,thereby elucidating significant potential mechanisms from a genetic standpoint.We investi...Objective:This study aimed to investigate the influence of lung function on the relationship between allergies and hypertension,thereby elucidating significant potential mechanisms from a genetic standpoint.We investigated the causal relationship between childhood allergies(age<16 years)and essential hypertension and identified and quantified the role of lung function(forced vital capacity[FVC]and forced expiratory volume in the first second/forced vital capacity[FEV1/FVC])as potential mediators.Methods:Using data from a genome-wide association study and the Fenn Genn consortium,a two-sample Mendelian randomization(MR)analysis of genetically predicted childhood allergies(7128 cases and 211,703 controls)and essential hypertension(116,714 cases and 1,032,659 controls)was performed.Furthermore,we used two-step MR to quantify the effect of lung function-mediated childhood allergies on essential hypertension.The FVC and FEV1/FV sample size was 371,898.Results:Childhood allergies were associated with increased odds of developing essential hypertension(odds ratio[OR]=1.0900,95%confidence interval[CI]=1.0034–1.1842,P=0.0414).No strong evidence that genetically predicted essential hypertension affected childhood allergy risk was identified(OR=1.0631,95%CI=0.9829–1.1498,P=0.1264).The proportion of genetically predicted childhood allergies mediated only by FVC was 5.67%(95%CI,5.13%–5.73%).Conclusion:A causal relationship between childhood allergies and essential hypertension was identified,with a proportion of the effect mediated by FVC.Therefore,implementing early interventions in children with allergies is imperative to mitigate the long-term risk of developing hypertension.Further research is required to identify additional risk factors as potential mediators.展开更多
基金supported by the National Key Research and Development Program of China(2021YFC2700701,2022YFC2703803,and 2022YFC2703001)the National Natural Science Foundation of China(82088102,82071731,82171613,8227034,and 81601238)+9 种基金Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2019-I2M-5-064)the Science and Technology Commission of Shanghai Municipality(21Y11907600)Shanghai Municipal Commission of Health and Family Planning(20215Y0216)Collaborative Innovation Program of Shanghai Municipal Health Commission(2020CXJQ01)Clinical Research Plan of Shanghai Hospital Development Center(SHDC2020CR1008A)Shanghai Clinical Research Center for Gynecological Diseases(22MC1940200)Shanghai Urogenital System Diseases Research Center(2022ZZ01012)Shanghai Frontiers Science Research Base of Reproduction and Development,The Science and Technology Commission of Quzhou Municipality(2022K54)Open Fund Project of Key Laboratory of Reproductive Genetics,Ministry of Education,Zhejiang University(KY2022035)Open Fund Project of Guangdong Academy of Medical Sciences(YKY-KF202202).
文摘Objective:This study aimed to investigate the influence of lung function on the relationship between allergies and hypertension,thereby elucidating significant potential mechanisms from a genetic standpoint.We investigated the causal relationship between childhood allergies(age<16 years)and essential hypertension and identified and quantified the role of lung function(forced vital capacity[FVC]and forced expiratory volume in the first second/forced vital capacity[FEV1/FVC])as potential mediators.Methods:Using data from a genome-wide association study and the Fenn Genn consortium,a two-sample Mendelian randomization(MR)analysis of genetically predicted childhood allergies(7128 cases and 211,703 controls)and essential hypertension(116,714 cases and 1,032,659 controls)was performed.Furthermore,we used two-step MR to quantify the effect of lung function-mediated childhood allergies on essential hypertension.The FVC and FEV1/FV sample size was 371,898.Results:Childhood allergies were associated with increased odds of developing essential hypertension(odds ratio[OR]=1.0900,95%confidence interval[CI]=1.0034–1.1842,P=0.0414).No strong evidence that genetically predicted essential hypertension affected childhood allergy risk was identified(OR=1.0631,95%CI=0.9829–1.1498,P=0.1264).The proportion of genetically predicted childhood allergies mediated only by FVC was 5.67%(95%CI,5.13%–5.73%).Conclusion:A causal relationship between childhood allergies and essential hypertension was identified,with a proportion of the effect mediated by FVC.Therefore,implementing early interventions in children with allergies is imperative to mitigate the long-term risk of developing hypertension.Further research is required to identify additional risk factors as potential mediators.
