Patients with acute respiratory distress syndrome (ARDS) are currently treated with a lung protective ventilation strategy and the application of positive end-expiratory pressure (PEEP), sometimes in combination with ...Patients with acute respiratory distress syndrome (ARDS) are currently treated with a lung protective ventilation strategy and the application of positive end-expiratory pressure (PEEP), sometimes in combination with recruitment maneuvers. In this study, the respiratory system elastance and airway resistance of each breath before, during and after a specific recruitment maneuver (PEEP wave maneuver) were analyzed in two patient groups, ARDS and control group. A reduction of elastance after the maneuver was observed in ARDS patients. In addition, only healthy lungs exhibited a reduction of the elastance during the course of the maneuver, while the lungs of ARDS patients didn’t show that reduction of elastance. The capability of PEEP wave maneuvers to improve lung ventilation was shown and the dynamic behavior of the elastance after the maneuver was illustrated. Healthy lungs adapt faster to changes in mechanical ventilation than the lungs of ARDS patients.展开更多
Preisach model is widely used in modeling of smart materials. Although first order reversal curves （FORCs） have often found applications in the fields of physics and geology, they are able to serve to identify Preis...Preisach model is widely used in modeling of smart materials. Although first order reversal curves （FORCs） have often found applications in the fields of physics and geology, they are able to serve to identify Preisach model. In order to clarify the relationship between the Preisach model and the first order reversal curves, this paper is directed towards： （1） giving the reason a first order reversal curve is introduced; （2） presenting, for identifying Preisach model, two discrete methods, which are analytically based on first order reversal curves. Herein also is indicated the solution＇s uniqueness of these two identifying methods. At last, the validity of these two methods is verified by simulating a real smart actuator both methods have been applied to.展开更多
The mathematical model for the thermokinetics of irreversible consecutive first order reactions has been suggested,which was used for the calculation of rate constants and molar enthalpies of the two consecutive steps...The mathematical model for the thermokinetics of irreversible consecutive first order reactions has been suggested,which was used for the calculation of rate constants and molar enthalpies of the two consecutive steps.And its validity has been verified by the ex- perimental results.展开更多
Methane generation in landfills and its inadequate management represent the major avoidable source of anthropogenic methane today. This paper models methane production and the potential resources expected (electrical ...Methane generation in landfills and its inadequate management represent the major avoidable source of anthropogenic methane today. This paper models methane production and the potential resources expected (electrical energy production and potential carbon credits from avoided CH4 emissions) from its proper management in a municipal solid waste landfill located in Ouagadougou, Burkina Faso. The modeling was carried out using two first-order decay (FOD) models (LandGEM V3.02 and SWANA) using parameters evaluated on the basis of the characteristics of the waste admitted to the landfill and weather data for the site. At the same time, production data have been collected since 2016 in order to compare them with the model results. The results obtained from these models were compared to experimental one. For the simulation of methane production, the SWANA model showed better consistency with experimental data, with a coefficient of determination (R²) of 0.59 compared with the LandGEM model, which obtained a coefficient of 0.006. Thus, despite the low correlation values linked to the poor consistency of experimental data, the SWANA model models methane production much better than the LandGEM model. Thus, despite the low correlation values linked to the poor consistency of the experimental data, the SWANA model models methane production much better than the LandGEM V3.02 model. It was noted that the poor consistency of the experimental data justifies these low coefficients, and that they can be improved in the future thanks to ongoing in situ measurements. According to the SWANA model prediction, in 27 years of operation a biogas plant with 33% electrical efficiency using biogas from the Polesgo landfill would avoid 1,340 GgCO2e. Also, the evaluation of revenues due to electricity and carbon credit gave a total revenue derived from methane production of US$27.38 million at a cost of US$10.5/tonne CO2e.展开更多
This work illustrates the application of the “Second Order Comprehensive Adjoint Sensitivity Analysis Methodology” (2<sup>nd</sup>-CASAM) to a mathematical model that can simulate the evolution and/or tr...This work illustrates the application of the “Second Order Comprehensive Adjoint Sensitivity Analysis Methodology” (2<sup>nd</sup>-CASAM) to a mathematical model that can simulate the evolution and/or transmission of particles in a heterogeneous medium. The model response is the value of the model’s state function (particle concentration or particle flux) at a point in phase-space, which would simulate a pointwise measurement of the respective state function. This paradigm model admits exact closed-form expressions for all of the 1<sup>st</sup>- and 2<sup>nd</sup>-order response sensitivities to the model’s uncertain parameters and domain boundaries. These closed-form expressions can be used to verify the numerical results of production and/or commercial software, e.g., particle transport codes. Furthermore, this paradigm model comprises many uncertain parameters which have relative sensitivities of identical magnitudes. Therefore, this paradigm model could serve as a stringent benchmark for inter-comparing the performances of all deterministic and statistical sensitivity analysis methods, including the 2<sup>nd</sup>-CASAM.展开更多
This work continues the illustrative application of the “Second Order Comprehensive Adjoint Sensitivity Analysis Methodology” (2<sup>nd</sup>-CASAM) to a benchmark mathematical model that can simulate th...This work continues the illustrative application of the “Second Order Comprehensive Adjoint Sensitivity Analysis Methodology” (2<sup>nd</sup>-CASAM) to a benchmark mathematical model that can simulate the evolution and/or transmission of particles in a heterogeneous medium. The model response considered in this work is a reaction-rate detector response, which provides the average interactions of particles with the respective detector or, alternatively, the time-average of the concentration of a mixture of substances in a medium. The definition of this model response includes both uncertain boundary points of the benchmark, thereby providing both direct and indirect contributions to the response sensitivities stemming from the boundaries. The exact expressions for the 1<sup>st</sup>- and 2<sup>nd</sup>-order response sensitivities to the boundary and model parameters obtained in this work can serve as stringent benchmarks for inter-comparing the performances of all (deterministic and statistical) sensitivity analysis methods.展开更多
Acute Respiratory Distress Syndrome (ARDS) is a major cause of morbidity and has a high rate of mortality. ARDS patients in the intensive care unit (ICU) require mechan-ical ventilation (MV) for breathing support, but...Acute Respiratory Distress Syndrome (ARDS) is a major cause of morbidity and has a high rate of mortality. ARDS patients in the intensive care unit (ICU) require mechan-ical ventilation (MV) for breathing support, but inappropriate settings of MV can lead to ventilator induced lung injury (VILI). Those complications may be avoided by carefully optimizing ventilation parameters through model-based approaches. In this study we introduced a new model of lung mechanics (mNARX) which is a variation of the NARX model by Langdon et al. A multivariate process was undertaken to deter-mine the optimal parameters of the mNARX model and hence, the final structure of the model fit 25 patient data sets and successfully described all parts of the breathing cycle. The model was highly successful in predicting missing data and showed minimal error. Thus, this model can be used by the clinicians to find the optimal patient specific ventilator settings.展开更多
In this paper, the equilibrium entrainment into a shear-free, linearly stratified atmosphere is discussed under the framework of bulk models, namely, the zero-order jump model （ZOM） and the first-order jump model （...In this paper, the equilibrium entrainment into a shear-free, linearly stratified atmosphere is discussed under the framework of bulk models, namely, the zero-order jump model （ZOM） and the first-order jump model （FOM）. The parameterizations for the dimensionless entrainment rate versus the convective Richard- son number in the two models are compared. Based on the assumption that the parameterized entrainment rates in ZOM and FOM should be the same, the inherent relationships among the entrainment parameters in the bulk models are revealed. These relationships are supported by tank experiments and large-eddy sim- ulations. The validity of these inherent relationships indicates that, for a convective boundary layer growing into a linearly stratified free atmosphere, the only dominant factors of the growth rate are the turbulent buoyancy in the mixed layer and the stratification in the free atmosphere. In the point of the similarity view, the former is characterized by turbulent temperature and mixing length scales （mixed layer depth）, and the latter is characterized by the lapse rate of potential temperature in the free atmosphere. Thus, the commonly-used Richardson number scheme for the parameterization of the entrainment rate is just as an equivalent description. The variability of the total entrainment flux ratio in FOM, which is connected with the entrainment zone thickness, can implicitly describe the effect of the stratification in the free atmosphere, but the entrainment zone thickness is not an independent parameter. These results demonstrate the validity of the hypothesis that there exists a similarity limit in which the mixed layer depth is the only lengthscale.展开更多
In this paper, by means of combining non-probabilistic convex modeling with perturbation theory, an improvement is made on the first order approximate solution in convex models of uncertainties. Convex modeling is ext...In this paper, by means of combining non-probabilistic convex modeling with perturbation theory, an improvement is made on the first order approximate solution in convex models of uncertainties. Convex modeling is extended to largely uncertain and non-convex sets of uncertainties and the combinational convex modeling is developed. The presented method not only extends applications of convex modeling, but also improves its accuracy in uncertain problems and computational efficiency. The numerical example illustrates the efficiency of the proposed method.展开更多
Monte Carlo simulation of two dimensional 4 state Potts model has been carried out in microcanonical ensemble. The simulations were done on a 30 × 30 system with periodic boundary conditions. The temperature depe...Monte Carlo simulation of two dimensional 4 state Potts model has been carried out in microcanonical ensemble. The simulations were done on a 30 × 30 system with periodic boundary conditions. The temperature dependence of energy and order parameter has been calculated. The transition in 4-state Potts model is concluded to be first-order in nature. The transition temperature and latent heat of the first-order transition have been found to be 0.92 and 0.18, respectively.展开更多
The first order reliability method (FORM) is widely adopted for structural reliability evaluation due to its numerical efficiency. Concerning the issue of FORM often failing to converge when the limit state function (...The first order reliability method (FORM) is widely adopted for structural reliability evaluation due to its numerical efficiency. Concerning the issue of FORM often failing to converge when the limit state function (LSF) behaves high nonlinearity, a new iteration scheme called "rotated gradient algorithm (RGA)" is proposed and combined with Kriging model to evaluate the reliability of implicit performance function. In this paper, the Kriging model is applied to approximate the real LSF first. Then the scheme of RGA, constructed in terms of gradient information of two adjacent design points obtained during the process of calculation, is used to calculate the reliability index. Numerical examples show the validity in convergence and accuracy of the proposed methodfor arbitrary nonlinear performance function.展开更多
Environmental load is the primary factor in the design of offshore engineering structures and ocean current is the principal environmental load that causes underwater structural failure. In computational analysis, the...Environmental load is the primary factor in the design of offshore engineering structures and ocean current is the principal environmental load that causes underwater structural failure. In computational analysis, the calculation of current load is mainly based on the current profile. The current profile model, which is based on a structural failure criterion, is conducive to decreasing the uncertainty of the current load. In this study, we used prototype monitoring data and the empirical orthogonal function(EOF) method to investigate the current profile in the South China Sea and its correlation with the design of underwater structural strength and the dynamic design of fatigue. The underwater structural strength design takes into account the size of the structure and the service water depth. We propose profiles for the overall and local designs using the inverse first-order reliability method(IFORM). We extracted the characteristic profile current(CPC) of the monitored sea area to solve dynamic design problems such as vortex-induced vibration(VIV). We used random sampling to verify the feasibility of using the EOF method to calculate the CPC from the current data and identified the main problems associated with using the CPC, which deserve close attention in VIV design. Our research conclusions provide direct references for determining current load in this sea area. This analysis method can also be used in the analysis of other sea areas or field variables.展开更多
基金Partial support by the EU-Project-“eTime”-ID:“FP7-PEOPLE-2012-IRSES”is gratefully acknowledged.
文摘Patients with acute respiratory distress syndrome (ARDS) are currently treated with a lung protective ventilation strategy and the application of positive end-expiratory pressure (PEEP), sometimes in combination with recruitment maneuvers. In this study, the respiratory system elastance and airway resistance of each breath before, during and after a specific recruitment maneuver (PEEP wave maneuver) were analyzed in two patient groups, ARDS and control group. A reduction of elastance after the maneuver was observed in ARDS patients. In addition, only healthy lungs exhibited a reduction of the elastance during the course of the maneuver, while the lungs of ARDS patients didn’t show that reduction of elastance. The capability of PEEP wave maneuvers to improve lung ventilation was shown and the dynamic behavior of the elastance after the maneuver was illustrated. Healthy lungs adapt faster to changes in mechanical ventilation than the lungs of ARDS patients.
基金National Natural Science Foundation of China (50674005)
文摘Preisach model is widely used in modeling of smart materials. Although first order reversal curves （FORCs） have often found applications in the fields of physics and geology, they are able to serve to identify Preisach model. In order to clarify the relationship between the Preisach model and the first order reversal curves, this paper is directed towards： （1） giving the reason a first order reversal curve is introduced; （2） presenting, for identifying Preisach model, two discrete methods, which are analytically based on first order reversal curves. Herein also is indicated the solution＇s uniqueness of these two identifying methods. At last, the validity of these two methods is verified by simulating a real smart actuator both methods have been applied to.
文摘The mathematical model for the thermokinetics of irreversible consecutive first order reactions has been suggested,which was used for the calculation of rate constants and molar enthalpies of the two consecutive steps.And its validity has been verified by the ex- perimental results.
文摘Methane generation in landfills and its inadequate management represent the major avoidable source of anthropogenic methane today. This paper models methane production and the potential resources expected (electrical energy production and potential carbon credits from avoided CH4 emissions) from its proper management in a municipal solid waste landfill located in Ouagadougou, Burkina Faso. The modeling was carried out using two first-order decay (FOD) models (LandGEM V3.02 and SWANA) using parameters evaluated on the basis of the characteristics of the waste admitted to the landfill and weather data for the site. At the same time, production data have been collected since 2016 in order to compare them with the model results. The results obtained from these models were compared to experimental one. For the simulation of methane production, the SWANA model showed better consistency with experimental data, with a coefficient of determination (R²) of 0.59 compared with the LandGEM model, which obtained a coefficient of 0.006. Thus, despite the low correlation values linked to the poor consistency of experimental data, the SWANA model models methane production much better than the LandGEM model. Thus, despite the low correlation values linked to the poor consistency of the experimental data, the SWANA model models methane production much better than the LandGEM V3.02 model. It was noted that the poor consistency of the experimental data justifies these low coefficients, and that they can be improved in the future thanks to ongoing in situ measurements. According to the SWANA model prediction, in 27 years of operation a biogas plant with 33% electrical efficiency using biogas from the Polesgo landfill would avoid 1,340 GgCO2e. Also, the evaluation of revenues due to electricity and carbon credit gave a total revenue derived from methane production of US$27.38 million at a cost of US$10.5/tonne CO2e.
文摘This work illustrates the application of the “Second Order Comprehensive Adjoint Sensitivity Analysis Methodology” (2<sup>nd</sup>-CASAM) to a mathematical model that can simulate the evolution and/or transmission of particles in a heterogeneous medium. The model response is the value of the model’s state function (particle concentration or particle flux) at a point in phase-space, which would simulate a pointwise measurement of the respective state function. This paradigm model admits exact closed-form expressions for all of the 1<sup>st</sup>- and 2<sup>nd</sup>-order response sensitivities to the model’s uncertain parameters and domain boundaries. These closed-form expressions can be used to verify the numerical results of production and/or commercial software, e.g., particle transport codes. Furthermore, this paradigm model comprises many uncertain parameters which have relative sensitivities of identical magnitudes. Therefore, this paradigm model could serve as a stringent benchmark for inter-comparing the performances of all deterministic and statistical sensitivity analysis methods, including the 2<sup>nd</sup>-CASAM.
文摘This work continues the illustrative application of the “Second Order Comprehensive Adjoint Sensitivity Analysis Methodology” (2<sup>nd</sup>-CASAM) to a benchmark mathematical model that can simulate the evolution and/or transmission of particles in a heterogeneous medium. The model response considered in this work is a reaction-rate detector response, which provides the average interactions of particles with the respective detector or, alternatively, the time-average of the concentration of a mixture of substances in a medium. The definition of this model response includes both uncertain boundary points of the benchmark, thereby providing both direct and indirect contributions to the response sensitivities stemming from the boundaries. The exact expressions for the 1<sup>st</sup>- and 2<sup>nd</sup>-order response sensitivities to the boundary and model parameters obtained in this work can serve as stringent benchmarks for inter-comparing the performances of all (deterministic and statistical) sensitivity analysis methods.
文摘Acute Respiratory Distress Syndrome (ARDS) is a major cause of morbidity and has a high rate of mortality. ARDS patients in the intensive care unit (ICU) require mechan-ical ventilation (MV) for breathing support, but inappropriate settings of MV can lead to ventilator induced lung injury (VILI). Those complications may be avoided by carefully optimizing ventilation parameters through model-based approaches. In this study we introduced a new model of lung mechanics (mNARX) which is a variation of the NARX model by Langdon et al. A multivariate process was undertaken to deter-mine the optimal parameters of the mNARX model and hence, the final structure of the model fit 25 patient data sets and successfully described all parts of the breathing cycle. The model was highly successful in predicting missing data and showed minimal error. Thus, this model can be used by the clinicians to find the optimal patient specific ventilator settings.
基金supported by the National Natural Science Foundation of China underGrant No. 40475009
文摘In this paper, the equilibrium entrainment into a shear-free, linearly stratified atmosphere is discussed under the framework of bulk models, namely, the zero-order jump model （ZOM） and the first-order jump model （FOM）. The parameterizations for the dimensionless entrainment rate versus the convective Richard- son number in the two models are compared. Based on the assumption that the parameterized entrainment rates in ZOM and FOM should be the same, the inherent relationships among the entrainment parameters in the bulk models are revealed. These relationships are supported by tank experiments and large-eddy sim- ulations. The validity of these inherent relationships indicates that, for a convective boundary layer growing into a linearly stratified free atmosphere, the only dominant factors of the growth rate are the turbulent buoyancy in the mixed layer and the stratification in the free atmosphere. In the point of the similarity view, the former is characterized by turbulent temperature and mixing length scales （mixed layer depth）, and the latter is characterized by the lapse rate of potential temperature in the free atmosphere. Thus, the commonly-used Richardson number scheme for the parameterization of the entrainment rate is just as an equivalent description. The variability of the total entrainment flux ratio in FOM, which is connected with the entrainment zone thickness, can implicitly describe the effect of the stratification in the free atmosphere, but the entrainment zone thickness is not an independent parameter. These results demonstrate the validity of the hypothesis that there exists a similarity limit in which the mixed layer depth is the only lengthscale.
基金supported by the National Natural Science Foundation of China(61304004,61503205)the Foundation of China Scholarship Council(201406715056)+1 种基金the Foundation of Changzhou Key Laboratory of Special Robot and Intelligent Technology(CZSR2014005)the Changzhou Science and Technology Program(CJ20160013)
基金The project supported by the National Outstanding Youth Science Foundation of China the National Post Doctor Science Foundation of China
文摘In this paper, by means of combining non-probabilistic convex modeling with perturbation theory, an improvement is made on the first order approximate solution in convex models of uncertainties. Convex modeling is extended to largely uncertain and non-convex sets of uncertainties and the combinational convex modeling is developed. The presented method not only extends applications of convex modeling, but also improves its accuracy in uncertain problems and computational efficiency. The numerical example illustrates the efficiency of the proposed method.
文摘Monte Carlo simulation of two dimensional 4 state Potts model has been carried out in microcanonical ensemble. The simulations were done on a 30 × 30 system with periodic boundary conditions. The temperature dependence of energy and order parameter has been calculated. The transition in 4-state Potts model is concluded to be first-order in nature. The transition temperature and latent heat of the first-order transition have been found to be 0.92 and 0.18, respectively.
文摘The first order reliability method (FORM) is widely adopted for structural reliability evaluation due to its numerical efficiency. Concerning the issue of FORM often failing to converge when the limit state function (LSF) behaves high nonlinearity, a new iteration scheme called "rotated gradient algorithm (RGA)" is proposed and combined with Kriging model to evaluate the reliability of implicit performance function. In this paper, the Kriging model is applied to approximate the real LSF first. Then the scheme of RGA, constructed in terms of gradient information of two adjacent design points obtained during the process of calculation, is used to calculate the reliability index. Numerical examples show the validity in convergence and accuracy of the proposed methodfor arbitrary nonlinear performance function.
基金support for this work by the National Natural Science Foundation of China (No. 15572072)the National Key Basic Research and Development Program (No. 2016ZX05028-002-005)
文摘Environmental load is the primary factor in the design of offshore engineering structures and ocean current is the principal environmental load that causes underwater structural failure. In computational analysis, the calculation of current load is mainly based on the current profile. The current profile model, which is based on a structural failure criterion, is conducive to decreasing the uncertainty of the current load. In this study, we used prototype monitoring data and the empirical orthogonal function(EOF) method to investigate the current profile in the South China Sea and its correlation with the design of underwater structural strength and the dynamic design of fatigue. The underwater structural strength design takes into account the size of the structure and the service water depth. We propose profiles for the overall and local designs using the inverse first-order reliability method(IFORM). We extracted the characteristic profile current(CPC) of the monitored sea area to solve dynamic design problems such as vortex-induced vibration(VIV). We used random sampling to verify the feasibility of using the EOF method to calculate the CPC from the current data and identified the main problems associated with using the CPC, which deserve close attention in VIV design. Our research conclusions provide direct references for determining current load in this sea area. This analysis method can also be used in the analysis of other sea areas or field variables.
