The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular processes.In t...The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular processes.In the brain,these processes include neurogenesis,neuronal differentiation,activation and function of microglia,and synaptic plasticity,finally resulting in memory formation.展开更多
In recent years, the threats posed by computer viruses have become increasingly diverse and complex. While classic percolation theory provides a novel perspective for analyzing epidemics and information dissemination,...In recent years, the threats posed by computer viruses have become increasingly diverse and complex. While classic percolation theory provides a novel perspective for analyzing epidemics and information dissemination, it fails to capture the temporal dynamics of these systems and the effects of virus invasion and governmental regulation. Triadic percolation theory, a recent advancement, addresses these limitations. In this paper, we apply this new percolation mechanism to model the diffusion of computer viruses, deriving a precise mathematical formulation of the triadic percolation model and providing an analytical solution of the triadic percolation threshold. Additionally, we investigate the impact of nonlinear transmission probability characteristics on virus propagation. Numerical simulations demonstrate that reducing the network's average degree(or the positive regulation) or increasing regulatory interventions raises the outbreak threshold for computer viruses while decreasing their final size. Moreover, the study reveals that nonlinear transmission probabilities result in an increased number of solutions for the final size of the computer viruses. Our findings contribute new insights into controlling the spread of computer viruses.展开更多
As a reliable additive manufacturing technology,the stereolithography(SLA)ceramic core necessitates a tailored sintering process to achieve optimal performance.This study explored the effects of final sintering temper...As a reliable additive manufacturing technology,the stereolithography(SLA)ceramic core necessitates a tailored sintering process to achieve optimal performance.This study explored the effects of final sintering temperatures(specifically 1,150,1,250,and 1,300°C)on the properties of SLA-fabricated SiO_(2)-based ceramic cores reinforced with nano-ZrO_(2)(at concentrations of 1.0wt.%,1.5wt.%,and 2.0wt.%).The results demonstrate that increasing the final sintering temperature and the incorporation of nano-ZrO_(2)enhance the viscous fiow of quartz glass,resulting in a higher sintering degree.As the final sintering temperature rises,the ceramic samples exhibit increased shrinkage rate,decreased apparent porosity,and increased bulk density.Higher final sintering temperatures also promote greater cristobalite precipitation,promoting an increase in the amount and precipitation rate of quartz during investment casting.The formation of a cristobalite and ZrSiO_4 network at elevated temperatures effectively inhibits the viscous flow of quartz glass,thereby significantly improving high-temperature flexural strength and creep resistance of ceramic cores.When the content of nano-ZrO_(2)is between 1.5wt.%and 2.0wt.%,the final sintering temperature of 1,250°C is the best choice.Under these conditions,the shrinkage rate along the Z direction ranges from 3.35%to 3.68%,the porosity lies between 25.57%and 26.03%,the bulk density varies from 1.612 to 1.645 g·cm^(-3),the room temperature fiexural strength is between 26.79 and 27.85 MPa,and the fiexural strength at high temperatures is within the range of 30.77 to 33.02 MPa.The defiection at high-temperatures is 3.37-5.31 mm,while the surface roughness of the upper surface is 3.26-4.79μm,and the surface roughness of the side surface is 4.97-5.79μm.These findings provide valuable guidance for optimizing the sintering processes of SLA ceramic cores,offering potential for industrial applications.展开更多
In an aircraft final assembly line(AFAL),the rational scheduling of assembly workers to complete tasks in an orderly manner is crucial for enhancing production efficiency.This paper addresses the multi-skilled worker ...In an aircraft final assembly line(AFAL),the rational scheduling of assembly workers to complete tasks in an orderly manner is crucial for enhancing production efficiency.This paper addresses the multi-skilled worker scheduling problem in the AFAL,where the processing time of each task varies due to the assigned workers’skill levels,referred to as variable duration.The objective is to minimize the makespan,i.e.,the total time required for all workers to complete all tasks.A mixed integer linear programming model is formulated under complex constraints including assembly precedence relations,skill requirements,worker skill capabilities,and workspace capacities.To solve the model effectively,a multi-pass priority rule-based heuristic(MPRH)algorithm is proposed.This algorithm integrates 14 activity priority rules and nine worker priority rules with worker weights.Extensive experiments iteratively the best-performing priority rules,and the most effective rule subsets are integrated through a lightweight multi-pass mechanism to enhance its efficiency.The computational results demonstrate that the MPRH can find high-quality solutions effectively within very short central processing unit central processing unit(CPU)time compared to GUROBI.A case study based on real data obtained from an AFAL confirms the necessity and the feasibility of the approach in practical applications.Sensitivity analyses provide valuable insights to real production scenarios.展开更多
纯粹驾驶乐趣始终深植于宝马品牌的基因血脉之中。宝马Z4正是这一理念的完美化身——以敞篷跑车的极致魅力诠释无与伦比的驾驭激情。自2002年初代车型问世以来,这款双座敞篷跑车便凭借独树一帜的设计美学、纯粹至臻的驾驶体验和运动性...纯粹驾驶乐趣始终深植于宝马品牌的基因血脉之中。宝马Z4正是这一理念的完美化身——以敞篷跑车的极致魅力诠释无与伦比的驾驭激情。自2002年初代车型问世以来,这款双座敞篷跑车便凭借独树一帜的设计美学、纯粹至臻的驾驶体验和运动性能的完美平衡,持续征服全球车迷。即将推出的宝马Z4 Final Edition将为爱好者开启限时珍藏通道,提供订购这款特别版车型的专属机遇——它的限量身份和专属或将使它成为车坛的不朽经典。该版本配备了独特的配置元素,在外观和内饰方面均营造出个性化的亮点。同时,Final Edition也象征着这款标志性双座跑车迎来了其巅峰荣耀。宝马Z4的生产将于2026年3月正式结束。展开更多
With the continuous adjustment of the energy structure,photovoltaic(PV)power generation projects are increasing,playing a crucial role in promoting the application of clean energy.However,the current audit of complete...With the continuous adjustment of the energy structure,photovoltaic(PV)power generation projects are increasing,playing a crucial role in promoting the application of clean energy.However,the current audit of completed final accounts for photovoltaic power generation projects faces many challenges,such as incomplete institutional processes,scattered archive management materials,inadequate digital intelligence systems,and insufficient analysis of final account amounts.Based on this,this article aims to deeply analyze these issues and propose targeted audit suggestions to standardize the construction and audit work of photovoltaic power generation projects and promote the sustainable and healthy development of the photovoltaic power generation business.展开更多
An opposite combined vertical linear electromagnetic stirring(CV-LEMS)was proposed,which is applied in the final solidification zone of bloom continuous casting.The melt flow,heat transfer,and solidification under CV-...An opposite combined vertical linear electromagnetic stirring(CV-LEMS)was proposed,which is applied in the final solidification zone of bloom continuous casting.The melt flow,heat transfer,and solidification under CV-LEMS were investigated by establishing a three-dimensional numerical simulation model and a pilot continuous casting simulation experiment and compared with the conventional rotary electromagnetic stirring(REMS).The results show that a longitudinally symmetric linear magnetic field is formed in the liquid core of the bloom by applying CV-LEMS,which induces a strong longitudinal circulation flow both on the inner arc side and the outer arc side in the liquid core of the bloom.The height of the melt longitudinal effective mixing range under CV-LEMS reaches 0.9 m,which is greater than that of the REMS and makes up for the deficiency of REMS sensitivity to the position of the final solidification zone.CV-LEMS strongly promotes the mixing of upper melt with high temperature and the lower part melt with low temperature in the liquid core,improves the uniformity of melt temperature distribution and significantly increases the melt temperature near the solidification front,and the width of the liquid core increases by 4.2 mm at maximum.This shows that the appliction of CV-LEMS is more helpful to strengthen the feeding effect of the upper melt to the solidification shrinkage of the lower melt than the conventional REMS and inhibits the formation of porosity,shrinkage cavity and crack defects in the center of the bloom.展开更多
The novel copper(Ⅱ) complex with α-hydroxyphenylacetic acid (H2PHAc) and pyridine (py) ligands, [Cu(HPHAc)2(py)2], has been synthesized and characterized by elemental analysis and IR spectroscopy. Its crystal struct...The novel copper(Ⅱ) complex with α-hydroxyphenylacetic acid (H2PHAc) and pyridine (py) ligands, [Cu(HPHAc)2(py)2], has been synthesized and characterized by elemental analysis and IR spectroscopy. Its crystal structure was determined by single crystal X-ray diffraction techniques. The crystal belongs to monoclinic with space group C2/c. The cell parameters are: a=1.712 5(3) nm, b=1.533 2(2) nm, c=0.963 42(14) nm, β=111.866(2)°, V=2.347 6(6) nm3, and Dc=1.483 Mg·m-3, Z=4, F(000)=1 084. The structure was refined to final R1=0.071 4, wR2=0.166 1. The complex has a six-coordinated distorted octahedral geometry, in which copper(Ⅱ) ion coordinates with two carboxylic oxygen atoms and two hydroxyl oxygen atoms from the two α-hydroxyphenylacetic acid ligands, two nitrogen atoms from the two pyridine ligands. The analysis of the crystal structure indicates that the complex has a one-dimensional chain structure, which is formed by intermolecular hydrogen bonds. CCDC: 255346.展开更多
N-(m-ferrocenylphenyl)-formamide has been synthesized by the reaction of m-ferrocenyl-aniline with DMF, and characterized by elements analysis, IR, 1H NMR, and X-ray structure determination. The crystallized was in th...N-(m-ferrocenylphenyl)-formamide has been synthesized by the reaction of m-ferrocenyl-aniline with DMF, and characterized by elements analysis, IR, 1H NMR, and X-ray structure determination. The crystallized was in the monoclinic, P21/c space group, with a=0.140 94(3) nm, b=0.102 87(2) nm, c=0.100 26(2) nm, β=104.85(3)° and final R indices [I>2σ(I)] R1=0.072 7, wR2=0.184 5. An infinite one-dimensional chain is formed by intermolecular hydrogen bonding N-H...O. Cyclic voltammetry was studied comparing with the parent compound (m-ferrocenylaniline). CCDC: 243511.展开更多
视频公开课节目制作要求使用多机位进行拍摄制作,传统多机位制作多是用现场切换进行一次性录制制作,这种制作方式有前期工作量大,后期编辑不方便等缺点,本文结合具体案例,介绍了视频公开课多机位制作的流程,以及苹果公司后期制作软件Fin...视频公开课节目制作要求使用多机位进行拍摄制作,传统多机位制作多是用现场切换进行一次性录制制作,这种制作方式有前期工作量大,后期编辑不方便等缺点,本文结合具体案例,介绍了视频公开课多机位制作的流程,以及苹果公司后期制作软件Final Cut Pro X的多机位编辑技术。展开更多
The experiments of primary and secondary instabilities with controlled excitation are carried out on a swept flat plate to study the process leading to the final breakdown of laminar flow. Two types of high frequency ...The experiments of primary and secondary instabilities with controlled excitation are carried out on a swept flat plate to study the process leading to the final breakdown of laminar flow. Two types of high frequency secondary instabilities are identified. The most amplified mode is centered about the inflection point of the crosswise profile of the boundary layer and is interpreted as inflectional instability, the other occurs in the one third of the boundary layer from the wall. The high frequency disturbances are highly amplified but they also saturate similarly to the primary and nonlinearly generated disturbances. Their main effect in the final breakdown seems interact with the disturbances is developed and thus widens the frequency spectrum to turbulent state.展开更多
Through concluding landscape form and its development process,the paper analyzed the value of landscape form and proposed that the study on landscape form should be conducted from the perspective of final cause,effici...Through concluding landscape form and its development process,the paper analyzed the value of landscape form and proposed that the study on landscape form should be conducted from the perspective of final cause,efficient cause and material cause.Finally,it discussed the fashion trend of modern landscape design and put forward the tendency and strategies of correction of landscape form.展开更多
文摘The second messengers 3',5'-cyclic adenosine monophosphate(cAMP)and 3',5'-cyclic guanosine monophosphate(cGMP)modulate molecular pathways that are involved in a large variety of cellular processes.In the brain,these processes include neurogenesis,neuronal differentiation,activation and function of microglia,and synaptic plasticity,finally resulting in memory formation.
基金Project supported by the National Natural Science Foundation of China (Grant Nos. 12101573 and 12022113)the Fundamental Research Program of Shanxi Province,China (Grant Nos. 20210302124381,202203021211213,and 20210302123018)。
文摘In recent years, the threats posed by computer viruses have become increasingly diverse and complex. While classic percolation theory provides a novel perspective for analyzing epidemics and information dissemination, it fails to capture the temporal dynamics of these systems and the effects of virus invasion and governmental regulation. Triadic percolation theory, a recent advancement, addresses these limitations. In this paper, we apply this new percolation mechanism to model the diffusion of computer viruses, deriving a precise mathematical formulation of the triadic percolation model and providing an analytical solution of the triadic percolation threshold. Additionally, we investigate the impact of nonlinear transmission probability characteristics on virus propagation. Numerical simulations demonstrate that reducing the network's average degree(or the positive regulation) or increasing regulatory interventions raises the outbreak threshold for computer viruses while decreasing their final size. Moreover, the study reveals that nonlinear transmission probabilities result in an increased number of solutions for the final size of the computer viruses. Our findings contribute new insights into controlling the spread of computer viruses.
基金supported by the Natural Science Foundation of Shanghai(No.23ZR1421500)the National Natural Science Foundation of China(Nos.52474412,52127807,52271035)+3 种基金the Shanghai Municipal Commission of Economy and Informatization(No.GYOJ2022-2-02)the United Innovation Program of Shanghai Commercial Aircraft Engine(No.AR966)the SPMI Project from Shanghai Academy of Spaceflight Technology(No.SPMI2022-06)the Ningbo International Science and Technology Cooperation Program(No.2023H004)。
文摘As a reliable additive manufacturing technology,the stereolithography(SLA)ceramic core necessitates a tailored sintering process to achieve optimal performance.This study explored the effects of final sintering temperatures(specifically 1,150,1,250,and 1,300°C)on the properties of SLA-fabricated SiO_(2)-based ceramic cores reinforced with nano-ZrO_(2)(at concentrations of 1.0wt.%,1.5wt.%,and 2.0wt.%).The results demonstrate that increasing the final sintering temperature and the incorporation of nano-ZrO_(2)enhance the viscous fiow of quartz glass,resulting in a higher sintering degree.As the final sintering temperature rises,the ceramic samples exhibit increased shrinkage rate,decreased apparent porosity,and increased bulk density.Higher final sintering temperatures also promote greater cristobalite precipitation,promoting an increase in the amount and precipitation rate of quartz during investment casting.The formation of a cristobalite and ZrSiO_4 network at elevated temperatures effectively inhibits the viscous flow of quartz glass,thereby significantly improving high-temperature flexural strength and creep resistance of ceramic cores.When the content of nano-ZrO_(2)is between 1.5wt.%and 2.0wt.%,the final sintering temperature of 1,250°C is the best choice.Under these conditions,the shrinkage rate along the Z direction ranges from 3.35%to 3.68%,the porosity lies between 25.57%and 26.03%,the bulk density varies from 1.612 to 1.645 g·cm^(-3),the room temperature fiexural strength is between 26.79 and 27.85 MPa,and the fiexural strength at high temperatures is within the range of 30.77 to 33.02 MPa.The defiection at high-temperatures is 3.37-5.31 mm,while the surface roughness of the upper surface is 3.26-4.79μm,and the surface roughness of the side surface is 4.97-5.79μm.These findings provide valuable guidance for optimizing the sintering processes of SLA ceramic cores,offering potential for industrial applications.
基金supported by the National Natural Science Foundation of China(52175475).
文摘In an aircraft final assembly line(AFAL),the rational scheduling of assembly workers to complete tasks in an orderly manner is crucial for enhancing production efficiency.This paper addresses the multi-skilled worker scheduling problem in the AFAL,where the processing time of each task varies due to the assigned workers’skill levels,referred to as variable duration.The objective is to minimize the makespan,i.e.,the total time required for all workers to complete all tasks.A mixed integer linear programming model is formulated under complex constraints including assembly precedence relations,skill requirements,worker skill capabilities,and workspace capacities.To solve the model effectively,a multi-pass priority rule-based heuristic(MPRH)algorithm is proposed.This algorithm integrates 14 activity priority rules and nine worker priority rules with worker weights.Extensive experiments iteratively the best-performing priority rules,and the most effective rule subsets are integrated through a lightweight multi-pass mechanism to enhance its efficiency.The computational results demonstrate that the MPRH can find high-quality solutions effectively within very short central processing unit central processing unit(CPU)time compared to GUROBI.A case study based on real data obtained from an AFAL confirms the necessity and the feasibility of the approach in practical applications.Sensitivity analyses provide valuable insights to real production scenarios.
文摘纯粹驾驶乐趣始终深植于宝马品牌的基因血脉之中。宝马Z4正是这一理念的完美化身——以敞篷跑车的极致魅力诠释无与伦比的驾驭激情。自2002年初代车型问世以来,这款双座敞篷跑车便凭借独树一帜的设计美学、纯粹至臻的驾驶体验和运动性能的完美平衡,持续征服全球车迷。即将推出的宝马Z4 Final Edition将为爱好者开启限时珍藏通道,提供订购这款特别版车型的专属机遇——它的限量身份和专属或将使它成为车坛的不朽经典。该版本配备了独特的配置元素,在外观和内饰方面均营造出个性化的亮点。同时,Final Edition也象征着这款标志性双座跑车迎来了其巅峰荣耀。宝马Z4的生产将于2026年3月正式结束。
文摘With the continuous adjustment of the energy structure,photovoltaic(PV)power generation projects are increasing,playing a crucial role in promoting the application of clean energy.However,the current audit of completed final accounts for photovoltaic power generation projects faces many challenges,such as incomplete institutional processes,scattered archive management materials,inadequate digital intelligence systems,and insufficient analysis of final account amounts.Based on this,this article aims to deeply analyze these issues and propose targeted audit suggestions to standardize the construction and audit work of photovoltaic power generation projects and promote the sustainable and healthy development of the photovoltaic power generation business.
基金the National Natural Science Foundation of China(Grant No.U1760206 and Grant No.51574083)the 111 Project(2.0)of China(No.BP0719037)for the financial support。
文摘An opposite combined vertical linear electromagnetic stirring(CV-LEMS)was proposed,which is applied in the final solidification zone of bloom continuous casting.The melt flow,heat transfer,and solidification under CV-LEMS were investigated by establishing a three-dimensional numerical simulation model and a pilot continuous casting simulation experiment and compared with the conventional rotary electromagnetic stirring(REMS).The results show that a longitudinally symmetric linear magnetic field is formed in the liquid core of the bloom by applying CV-LEMS,which induces a strong longitudinal circulation flow both on the inner arc side and the outer arc side in the liquid core of the bloom.The height of the melt longitudinal effective mixing range under CV-LEMS reaches 0.9 m,which is greater than that of the REMS and makes up for the deficiency of REMS sensitivity to the position of the final solidification zone.CV-LEMS strongly promotes the mixing of upper melt with high temperature and the lower part melt with low temperature in the liquid core,improves the uniformity of melt temperature distribution and significantly increases the melt temperature near the solidification front,and the width of the liquid core increases by 4.2 mm at maximum.This shows that the appliction of CV-LEMS is more helpful to strengthen the feeding effect of the upper melt to the solidification shrinkage of the lower melt than the conventional REMS and inhibits the formation of porosity,shrinkage cavity and crack defects in the center of the bloom.
文摘The novel copper(Ⅱ) complex with α-hydroxyphenylacetic acid (H2PHAc) and pyridine (py) ligands, [Cu(HPHAc)2(py)2], has been synthesized and characterized by elemental analysis and IR spectroscopy. Its crystal structure was determined by single crystal X-ray diffraction techniques. The crystal belongs to monoclinic with space group C2/c. The cell parameters are: a=1.712 5(3) nm, b=1.533 2(2) nm, c=0.963 42(14) nm, β=111.866(2)°, V=2.347 6(6) nm3, and Dc=1.483 Mg·m-3, Z=4, F(000)=1 084. The structure was refined to final R1=0.071 4, wR2=0.166 1. The complex has a six-coordinated distorted octahedral geometry, in which copper(Ⅱ) ion coordinates with two carboxylic oxygen atoms and two hydroxyl oxygen atoms from the two α-hydroxyphenylacetic acid ligands, two nitrogen atoms from the two pyridine ligands. The analysis of the crystal structure indicates that the complex has a one-dimensional chain structure, which is formed by intermolecular hydrogen bonds. CCDC: 255346.
文摘N-(m-ferrocenylphenyl)-formamide has been synthesized by the reaction of m-ferrocenyl-aniline with DMF, and characterized by elements analysis, IR, 1H NMR, and X-ray structure determination. The crystallized was in the monoclinic, P21/c space group, with a=0.140 94(3) nm, b=0.102 87(2) nm, c=0.100 26(2) nm, β=104.85(3)° and final R indices [I>2σ(I)] R1=0.072 7, wR2=0.184 5. An infinite one-dimensional chain is formed by intermolecular hydrogen bonding N-H...O. Cyclic voltammetry was studied comparing with the parent compound (m-ferrocenylaniline). CCDC: 243511.
文摘The experiments of primary and secondary instabilities with controlled excitation are carried out on a swept flat plate to study the process leading to the final breakdown of laminar flow. Two types of high frequency secondary instabilities are identified. The most amplified mode is centered about the inflection point of the crosswise profile of the boundary layer and is interpreted as inflectional instability, the other occurs in the one third of the boundary layer from the wall. The high frequency disturbances are highly amplified but they also saturate similarly to the primary and nonlinearly generated disturbances. Their main effect in the final breakdown seems interact with the disturbances is developed and thus widens the frequency spectrum to turbulent state.
文摘Through concluding landscape form and its development process,the paper analyzed the value of landscape form and proposed that the study on landscape form should be conducted from the perspective of final cause,efficient cause and material cause.Finally,it discussed the fashion trend of modern landscape design and put forward the tendency and strategies of correction of landscape form.
