Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications i...Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications in aquatic and terrestrial ecosystems and assessing China’s standardization progress.It delineates four developmental phases from single-species detection to high-throughput sequencing,and highlights China’s contribution to the development of technical standards.While significant progress has been made,challenges persist in quantitative accuracy,methodological consistency,and large-scale implementation.Future efforts should prioritize enhanced standardization,improved quantification techniques,broader applications,and international collaboration to drive innovation in eDNA technology.展开更多
Hepatocellular carcinoma presents with three distinct immune phenotypes,including immune-desert,immune-excluded,and immune-inflamed,indicating various treatment responses and prognostic outcomes.The clinical applicati...Hepatocellular carcinoma presents with three distinct immune phenotypes,including immune-desert,immune-excluded,and immune-inflamed,indicating various treatment responses and prognostic outcomes.The clinical application of multi-omics parameters is still restricted by the expensive and less accessible assays,although they accurately reflect immune status.A comprehensive evaluation framework based on“easy-to-obtain”multi-model clinical parameters is urgently required,incorporating clinical features to establish baseline patient profiles and disease staging;routine blood tests assessing systemic metabolic and functional status;immune cell subsets quantifying subcluster dynamics;imaging features delineating tumor morphology,spatial configuration,and perilesional anatomical relationships;immunohistochemical markers positioning qualitative and quantitative detection of tumor antigens from the cellular and molecular level.This integrated phenomic approach aims to improve prognostic stratification and clinical decision-making in hepatocellular carcinoma management conveniently and practically.展开更多
Objective:To systematically review the current implementation status of nurses’non-pharmacological prescription authority and analyze the barriers encountered during its implementation in China,providing countermeasu...Objective:To systematically review the current implementation status of nurses’non-pharmacological prescription authority and analyze the barriers encountered during its implementation in China,providing countermeasures and references for promoting the standardized implementation of nurses’non-pharmacological prescription authority.Methods:A secondary analysis of literature was conducted to systematically search for domestic and international literature related to nurses’non-pharmacological prescription authority.Meta-analysis was performed on eligible literature to evaluate the implementation effects.Simultaneously,semi-structured in-depth interviews were conducted with healthcare workers,patients,and policymakers.Content analysis was used to organize the interview data and extract core issues and barriers.Results:A total of 46 international articles were included in the Meta-analysis,which revealed that the implementation of nurses’non-pharmacological prescription authority significantly improved patients’health management outcomes,enhanced healthcare service efficiency,and increased patient satisfaction.Conclusion:The implementation of nurses’non-pharmacological prescription authority has demonstrated significant positive effects.However,China faces multiple barriers in its advancement,necessitating efforts in optimizing policy systems,constructing collaborative models,strengthening professional skills training,and improving social awareness to guide the scientific and rational implementation of nurses’non-pharmacological prescription authority.展开更多
Background Understanding the genetic basis of male reproduction in mammals remains challenging.Commercial pig populations offer a unique model for studying fertility,as semen traits are routinely recorded using high-t...Background Understanding the genetic basis of male reproduction in mammals remains challenging.Commercial pig populations offer a unique model for studying fertility,as semen traits are routinely recorded using high-throughput systems.Results In a large-scale GWAS of 15 semen traits based on 286,314 ejaculates collected from 2,954 boars of a purebred pig line,we identified 10 QTL,including four loci with recessive deleterious alleles.Several lead SNPs affected multiple semen traits.For example,a SNP on SSC6 was significantly associated with distal cytoplasmic droplets and with effects on tail abnormalities and sperm motility in a follow up analysis.The allele frequencies of some loci were different in older boar's,most likely due to culling based on poor semen quality.Using WGS,we identified six missense variants in high linkage disequilibrium(LD)with lead SNPs in genes related to sperm production(e.g.,MEIOB,CFAP74 and UBE2B).Remarkably,the frequency of some alleles with predicted deleterious effects on semen traits increased between 2013 and 2019.Conclusions Our results highlight loci with major effects on semen quality,some of which are linked to functional variants in key genes involved in spermatogenesis.The information from this study can be used to select against deleterious alleles affecting semen characteristics in pigs and provides valuable insight into the genetics of mammalian male fertility.展开更多
Soil fertility and forest structure influence tree carbon stocks.However,it remains unclear how tree mycorrhizal types affect these relationships.This study addressed the question of how aboveground and belowground tr...Soil fertility and forest structure influence tree carbon stocks.However,it remains unclear how tree mycorrhizal types affect these relationships.This study addressed the question of how aboveground and belowground tree carbon stocks in soils with different mycorrhizal types are affected by soil fertility and forest structure.Tree demographic data were used from a 21.12-ha study area collected over a ten-year period(2009-2019),covering 43species of woody plants and more than 50,000 individuals.Relationships between tree carbon stock,soil fertility and forest structure(stand density,diameter variation,species diversity and spatial distribution)were examined,as well as whether these relationships differed between arbuscular mycorrhiza and ectomycorrhizal mycorrhiza groups in a typical temperate conifer and broad-leaved mixed forest.We found that total tree carbon stock was positively impacted by variations in stand density and tree diameter but negatively influenced by soil fertility,tree species diversity and uniform angle index.Soil fertility promoted carbon stock of trees associated with arbuscular mycorrhiza(AM)but inhibited the carbon stock of trees with ectomycorrhizal mycorrhiza fungi(EcM).Carbon stock of AM trees was mainly influenced by soil fertility,while carbon stock of EcM trees was influenced by stand density.Our findings show that mycorrhizae types mediate the impact of stand structure and soil fertility on tree carbon stocks and provides new evidence on how forest tree carbon stocks may be enhanced based on the types of mycorrhizal associations.Tree species with different mycorrhizal types can be managed in different ways.展开更多
To assess the impact of land use on the Andosol fertility, changes in chemical and physical properties affecting soil quality were monitored on Andosols from Mount Bambouto submitted to four different land use and man...To assess the impact of land use on the Andosol fertility, changes in chemical and physical properties affecting soil quality were monitored on Andosols from Mount Bambouto submitted to four different land use and management systems: natural cover, tillage, burning and fallow. In comparison with the natural cover, tillage reduces Andosol OC (6.5 to 4.8%), total N (4.51 to 2.95‰), CEC (22.0 to 20.9 cmol.kg–1) and the abundance of soil macro-aggregates expressed by the water stable aggregates (WSA) varies from 53.8 to 12.0%;and increases the bulk density (0.69 to 1.09 g.cm–3) and the sum of exchangeable cations (3.58 to 4.84 cmol.kg–1). Burning also reduces Andosol OC (6.5 to 0.8%), total N (4.51 to 0.95‰) and CEC (22.0 to 10.2 cmol.kg–1), but increases soil pH (4.62 to 6.54), the sum of exchangeable cations (3.58 to 5.74 cmol.kg–1) and the abundance of soil macroaggregates (WSA: 38.2 to 57.0%). In comparison with tillage, fallow increases Andosol OC (4.8 to 6.5%), total N (2.95 to 5.04‰), CEC (18.0 to 21.6 cmol.kg–1), the sum of exchangeable cations (3.58 to 5.05 cmol.kg–1) and the abundance of soil macroaggregates (WSA: 12.0 to 48.8%). Globally, the tillage management deteriorates Andosol chemical and physical properties affecting fertility, whereas the fallow management restores them. The burning management also improves some Andosol chemical and physical properties affecting quality, but it won’t last long.展开更多
A good understanding of the levels and distribution patterns of soil properties and/or quality indicators is a prerequisite for developing sustainable agricultural land management programs. Traditional assessments of ...A good understanding of the levels and distribution patterns of soil properties and/or quality indicators is a prerequisite for developing sustainable agricultural land management programs. Traditional assessments of these parameters of soil fertility status are somewhat costly, in both economics and time aspects. Different modelling techniques have been proposed as a useful tool for determination of soil quality indicators and development of soil fertility maps, but to what extent these results are reliable remains under-quantified in many regions worldwide. To address this uncertainty, Fuzzy-Analytical Hierarchy Process(Fuzzy-AHP) and Parametric analyses were conducted to ascertain the soil fertility status of a semiarid region in the Northeast of Iran for some selected crops: alfalfa, corn silage, potato, sugar beet, tomato and wheat. The Fuzzy-AHP and Parametric techniques using soil suitability indices were estimated for each crop and each soil delineation was achieved by Ordinary Kriging. The Technique for Order of Preference by Similarity to Ideal Solution(TOPSIS) was used as a compensatory method to allow tradeoffs among the selected criteria. Our results demonstrated that from the Fuzzy-AHP analysis, the soil fertility indices ranged from moderate to high for production of alfalfa;from low to high for production of corn silage and sugar beet;moderate to high for production of potato and tomato;and from low to moderate for production of wheat. However, the parametric analysis showed soil fertility classes ranging from very low to high for production of all the selected crops. High correlations were also observed between soil fertility indices predicted by both models. Similarly, the capacities of both models to predict soil fertility status for production of the selected crops were also highly correlated. The preference for the cultivation of the selected crops based on the Fuzzy-AHP analysis was sugar beet > corn silage > wheat > alfalfa > tomato > potato. On the other hand, using Parametric techniques, the crops preferences for cultivation ranked as corn silage > wheat > alfalfa > sugar beet > tomato > potato. We concluded that the findings would help to develop sustainable plans of cultivation based on patterns related to soil fertility classes depending on each crop’s requirement.展开更多
With the decline in male fertility in recent years,strategies for male fertility preservation have received increasing attention.In this study,by reviewing current treatments and recent publications,we describe resear...With the decline in male fertility in recent years,strategies for male fertility preservation have received increasing attention.In this study,by reviewing current treatments and recent publications,we describe research progress in and the future directions of stem cell-based therapies for male fertility preservation,focusing on the use of spermatogonial stem cells(SSCs),SSC niches,SSC-based testicular organoids,other stem cell types such as mesenchymal stem cells,and stem cell-derived extracellular vesicles.In conclusion,a more comprehensive understanding of the germ cell microenvironment,stem cell-derived extracellular vesicles,and testicular organoids will play an important role in achieving male fertility preservation.展开更多
Tailings are the residue of mined material after separation of metals such as copper, gold and silver elements. Separation of minerals involves crushing of the host material to fine particles and separation of the met...Tailings are the residue of mined material after separation of metals such as copper, gold and silver elements. Separation of minerals involves crushing of the host material to fine particles and separation of the metals by flotation or other technique. The total amount of tailings produced by Freeport Indonesia from their Grasberg mine is about 230,000 tons/day. These tailings are deposited in a lowland area and are confined by two levees. There are two types of plant growth on inactive tailings according to land use （natural succession area or reclaimed agricultural area）. This study of soil fertility on the mine tailing was required to contribute to information on the management oftailings. Representative sampling locations were chosen based on particle size distribution with soil （0- 5 50 cm depth） being subjected to laboratory analysis. Total N soil is very low （〈 0.02%）, CEC （≤20 me/100 g） low to medium, and organic-C ranges from 0.1-2%. oH is 7-8 resulting in the low availability of some nutrients, but values of extractable Cu may be high （≥ 300 mg/kg）. Nutrient elements are more abundant in soils on fine textured tailings.展开更多
In Cameroon, most farmers rely on their perceptions for fertility evaluation and choice of agricultural land units. However, because of environmental change, this knowledge is mostly disregarded. The use of farmers＇ ...In Cameroon, most farmers rely on their perceptions for fertility evaluation and choice of agricultural land units. However, because of environmental change, this knowledge is mostly disregarded. The use of farmers＇ knowledge is important for the identification of relevant information for the choice of agricultural land units. The objective of this study was to compare farmers＇ perceptions of soil fertility with a conventional scientific approach in two locations of the forest margin zone of Center Cameroon. Through interviews and soil analysis, this study spelled and weighed the relationships between farmers＇ perceptions and soil fertility status. One hundred and twenty households＇ heads were interviewed and 30 soil samples collected. Farmers＇ perceptions were used to assess the topsoil fertility status across the studied areas, while a conventional scientific approach was used to quantify soil fertility status by the means of a soil fertility index （SFI）. Results showed that farmers, for soil differentiation, used color, texture, depth, drainage and vegetation. Soil＇ names delivered key messages for their location. Although the low overall SFI approximated by the conventional approach, farmers＇ perceptions could differentiate fertility levels between soils. This knowledge is relevant for the design of technical innovations in perceived fertility niches.展开更多
Mountainous ecosystem soils are subject to colonization nowadays for agri</span><span style="font-family:Verdana;">cultural purposes due to an increasing population in towns making the</span&g...Mountainous ecosystem soils are subject to colonization nowadays for agri</span><span style="font-family:Verdana;">cultural purposes due to an increasing population in towns making the</span><span style="font-family:Verdana;"> detailed </span><span style="font-family:Verdana;">characterization of such soils indispensable. This work aims to characterize</span><span style="font-family:Verdana;"> the steep slopes soils of the Dschang hills and to evaluate their fertility level for </span><span style="font-family:Verdana;">agricultural valorization. Thus, four soil profiles were dug at various topographic</span><span style="font-family:Verdana;"> positions (summit (SP), shoulder (MP), backslope (BP) and footslope (PP)) following a toposequence. Samples of disturbed and undisturbed soils were taken and analyzed in the laboratory according to standard methods. The Fertility</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Capability</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">Classification (FCC) and simple limitation methods were used to identify major agricultural constraints. The main results show that </span><span style="font-family:Verdana;">profiles thickness is moderate, between 0 and 120 cm, with a high sand</span><span style="font-family:Verdana;"> content </span><span style="font-family:Verdana;">(at least 50%) over the entire toposequence, especially at the surface. The</span><span style="font-family:Verdana;"> study site has four types of soils, namely Eutric</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">Cambisols (ochric) in SP and L</span><span style="font-family:Verdana;">eptic</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Eutric</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Cambisols (Humic) in MP, Eutric</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Cambisols (Humic) in BP</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> and Stagnic</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Oxygleyic</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Dystric</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Gleysols</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">(Humic) in pp. The soils are very acidic at PP, moderately acidic at BP and SP and slightly acidic at MP. Organic matter is higher at the surface than at depth at the topographic segments of MP, BP and PP and low to SP. The C/N ratio is high (>17) in all profiles except P4 </span><span style="font-family:Verdana;">(<10). In addition, the cation exchange capacity (CEC), the sum of</span><span style="font-family:Verdana;"> exchangeable bases, total nitrogen and available phosphorus is low in all profiles. The Ca/</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">Mg/K balance in all the profiles shows a cation imbalance and a relatively </span><span style="font-family:Verdana;">high concentration of exchangeable potassium compared to the ideal</span><span style="font-family:Verdana;"> situation (76% Ca, 18% Mg and 6% K). The major constraints to crop production are: aluminum toxicity (a) and nutrients leaching (e), textural discontinuity (LS), flooding (g), low nutrient reserve (k), sand (S), clay (C) and slope (t). Hence the fertility capacity classes of these soils are CCaegk (PP), SSek (BP), SSte (MP) and LSaek (SP). To improve the yield, it will require off-season crop cultivation, fertilization and liming, and earthworks.展开更多
The processes of nutrient depletion and soil degradation within smallholder farms of central Kenya are spatially heterogeneous, determined by both biophysical and socio-economic factors. A monitoring study involving n...The processes of nutrient depletion and soil degradation within smallholder farms of central Kenya are spatially heterogeneous, determined by both biophysical and socio-economic factors. A monitoring study involving nutrient stocks, flows and balances was conducted in central Kenya to explore between and within-farm variability in soil fertility management and identify spatial niches for targeting soil fertility management strategies. Focus group discussions were conducted and farms grouped into 3 farm types （rich, medium and poor）. Nine case-study farms - three from each of the farm types - were randomly selected from the 50 farms studied, for detailed resource flow mapping. The farms were visited to record movement of nutrients inputs using a monitoring protocol covering soil, crops, livestock, and socio-economic aspects of the farm. Soil in different plots were sampled at a depth of 0-20 cm and analyzed for texture, pH, C, N, available P, exchangeable K＋, Mg2＋ and Ca2＋. Results revealed that wealthy farmers added an average of 51.3 kg/ha N, 37 kg/ha P, and 244 kg/ha K, compared to 25.9 kg/ha N, 14.5 kg/ha P and 50.7 kg/ha K for the poor farmers. In all farm types, home fields received more nutrient inputs compared to the outfields. Consequently, maize grain yields, partial nutrient balances and soil nutrient stocks were significantly higher in wealthy farms and home fields compared to poor farms and outfields, respectively. These results imply that different soil management strategies are required to achieve similar yields on the different field and farm types and avert soil degradation.展开更多
Organic material combined with inorganic fertilizer has been shown to greatly improve crop yield and maintain soil fertility globally. However, it remains unclear if crop yield and soil fertility can be sustained in t...Organic material combined with inorganic fertilizer has been shown to greatly improve crop yield and maintain soil fertility globally. However, it remains unclear if crop yield and soil fertility can be sustained in the long term under the combined application of organic and inorganic fertilizers. Three long-term field trials were conducted to investigate the effects of organic amendments on the grain sustainable yield index(SYI), soil fertility index(SFI)and nutrient balance in maize–wheat cropping systems of central and southern China during 1991–2019. Five treatments were included in the trials: 1) no fertilization(control);2) balanced mineral fertilization(NPK);3) NPK plus manure(NPKM);4) high dose of NPK plus manure(1.5NPKM);and 5) NPK plus crop straw(NPKS). Over time, the grain yields of wheat and maize showed an increasing trend in all four fertilization treatments at the Yangling(YL) and Zhengzhou(ZZ) locations, while they declined at Qiyang(QY). The grain yield in the NPKM and 1.5NPKM treatments gradually exceeded that of the NPK and NPKS treatments at the QY site. The largest SYI was recorded in the NPKM treatment across the three sites, suggesting that inorganic fertilizer combined with manure can effectively improve crop yield sustainability. Higher SYI values were recorded at the YL and ZZ sites than at the QY site, possibly because the soil was more acid at QY. The key factors affecting grain yield were soil available phosphorus(AP) and available potassium(AK) at the YL and ZZ sites, and pH and AP at the QY site.All fertilization treatments resulted in soil N and P surpluses at the three sites, but soil K surpluses were recorded only at the QY site. The SFI was greater in the 1.5NPKM, NPKM and NPKS treatments than in the NPK treatment by 13.3–40.0 and 16.4–63.6% at the YL and ZZ sites, respectively, and was significantly higher in the NPKM and 1.5NPKM treatments than in the NPK and NPKS treatments at the QY site. A significant, positive linear relationship was found between SFI and crop yield, and SYI and nutrient balance, indicating that grain yield and its sustainability significantly increased with increasing soil fertility. The apparent N, P and K balances positively affected SFI.This study suggests that the appropriate amount of manure mixed with mineral NPK fertilizer is beneficial to the development of sustainable agriculture, which effectively increases the crop yield and yield sustainability by improving soil fertility.展开更多
Cyclosporin A fermentation residue(CFR)is a type of organic waste generated during the production of cyclosporin A,which are abundant in nutrients including organic matter,phosphorus,nitrogen and potassium.Inappropria...Cyclosporin A fermentation residue(CFR)is a type of organic waste generated during the production of cyclosporin A,which are abundant in nutrients including organic matter,phosphorus,nitrogen and potassium.Inappropriate handling of CFR not only waste valuable bioresources,but may also lead to the cyclosporin A and associated resistance genes into the natural environment,posing a significant threat to ecological system and human health.Land application was an effective way to resource recovery of CFR after aerobic composting(CAC).This study investigated the impact of CAC on soil fertility and environmental safety.The results indicated that CAC could improve soil nutrient contents and enhance enzyme activities.CAC altered the diversity and community composition of soil bacteria,resulting in an increase in the abundance of relevant bacteria beneficial for organic matter decomposition and cyclosporin A degradation.The introduced cyclosporin A(71.69μg/kg)completely degraded within 20 days due to soil biodegradation.The significantly increased abundance of intIl,mdr3,pgp,TSR and pmra in the soil cultivation early stage were restored to the soil background level within 90 days,indicating a reduced risk of antimicrobial resistance.The results demonstrated that reasonable land application of CAC could improve soil fertility without antimicrobial resistance risk,which is helpful for evaluating the resource utilization value and environmental risks of antibiotic fermentation residue after aerobic composting.展开更多
Objective Selective estrogen receptor modulators(SERMs)have demonstrated efficacy in the treatment of hypogonadism in males and male factor infertility.Two SERMs,clomiphene citrate and tamoxifen,are now prescribed for...Objective Selective estrogen receptor modulators(SERMs)have demonstrated efficacy in the treatment of hypogonadism in males and male factor infertility.Two SERMs,clomiphene citrate and tamoxifen,are now prescribed for off-label use to treat both conditions in males.However,existing literature compares mixed protocols with active management.We aimed to conduct a meta-analysis to evaluate the effect of clomiphene and tamoxifen versus placebo on natural pregnancy rates.Methods We conducted a comprehensive systematic review of electronic databases:MEDLINE,PubMed/PMC,EMBASE,CINAHL,Cochrane Central Register of Controlled Trials(CENTRAL),Scopus,Google Scholar,and Web of Science.Articles satisfying all selection criteria were analyzed.The primary outcome was the incidence of pregnancy after receiving the treatment.Secondary outcomes included serum follicle-stimulating hormone,luteinizing hormone,and testosterone levels,and sperm count and motility.We calculated the pooled odds ratio,risk ratio,and risk difference to ascertain possible alterations in the direction of the pooled effect size.Results Ten randomized controlled trials were ultimately included and underwent data extraction.Clomiphene citrate and placebo groups had similar pregnancy rates(10.4%and 7.1%,respectively;odds ratio 1.30[95%confidence interval 0.27–6.17];p=0.74).No meta-analysis could be calculated for pregnancy rates in tamoxifen versus placebo groups.Heterogeneity among the studies of both SERMs ranged from low to high.Conclusion Although clomiphene citrate and tamoxifen are often used off-label for the treatment of male infertility secondary to hypogonadism,studies of SERMs in the treatment of idiopathic male factor infertility are limited and heterogenous,preventing this meta-analysis from investigating the efficacy of SERMs on male infertility.The effect of clomiphene citrate or tamoxifen on the pregnancy rate remains uncertain.展开更多
Objective: to investigate the status quo of fertility anxiety in breast cancer patients and analyze its influencing factors. Methods: 214 patients with breast cancer who were treated in Tangshan Peoples Hospital from ...Objective: to investigate the status quo of fertility anxiety in breast cancer patients and analyze its influencing factors. Methods: 214 patients with breast cancer who were treated in Tangshan Peoples Hospital from March 2021 to October 2021 were selected by convenience sampling. The post cancer fertility Anxiety Scale (RCAC), self-efficacy scale (BCSES) and self disclosure scale were used for investigation and analysis. Results: the total score of breast cancer patients fertility worries is (58.78 ± 8.68). Age, education level, monthly income, sex of children, fertility willingness, operation method, whether family members have cancer or not, and self-efficacy are the influencing factors of breast cancer patients fertility worries. Conclusion: breast cancer patients fertility anxiety level is poor, which should be highly valued by medical workers. Effective measures should be taken to help breast cancer patients improve their fertility anxiety level and improve their quality of life.展开更多
BACKGROUND The incidence of malignant tumors in the digestive system is increasing and is a threat to human health.However,the long duration from tumor detection to radical resection,stress responses due to surgical t...BACKGROUND The incidence of malignant tumors in the digestive system is increasing and is a threat to human health.However,the long duration from tumor detection to radical resection,stress responses due to surgical trauma,and insufficient nu-tritional intake increases the risk of malnutrition,immune function reduction,postoperative complications,and intestinal dysfunction among patients.AIM To systematically investigate the association of parenteral nutrition enriched with n-3 polyunsaturated fatty acids(PUFAs)with the nutritional status of patients after gastrointestinal treatment.METHODS Randomized controlled trials associated with PUFA-enriched parenteral nutrition administration in patients with digestive system malignancies were retrieved from online databases such as PubMed,EMBASE,ScienceDirect,Cochrane Li-brary,China Knowledge Network,China VIP,Wanfang,and China Biomedical Literature Database,with the retrieval time from database inception to present.Two researchers independently extracted data.Each article’s bias risk was ass-essed by referring to the Cochrane Handbook version 5.3 criteria and RevMan5.4 was used for data analysis.RESULTS This meta-analysis involved six randomized controlled trials involving a total of 505 cases.Random-effects model analysis indicated remarkably better impro-vements in various inflammatory factors in the study group(P<0.05).Meta-analysis of nutritional indicators revealed that the study group had higher total protein,albumin,and prealbumin levels,as well as lower transferrin levels compared to the control group(P<0.05).Meanwhile,meta-analysis of T-cell subsets revealed no remarkable inter-group difference in post-treatment CD8+cells(P>0.05).Moreover,the meta-analysis identified a notably lower incidence of adverse reactions in the study group(P<0.05).CONCLUSION Administration of PUFAs helps improve the nutritional status of patients with digestive malignancies in the perioperative period.It promotes immune function recovery,reduces the inflammatory response,and decreases the risk of adverse effects.These beneficial effects make it worth investigating and promoting their use in ap-propriate patient populations.However,further validation via high-quality studies with long intervention time and extended follow-up periods is required.展开更多
In this editorial,I comment on the article by Zhang et al.To emphasize the importance of the topic,I discuss the relationship between the use of smart medical devices and mental health.Smart medical services have the ...In this editorial,I comment on the article by Zhang et al.To emphasize the importance of the topic,I discuss the relationship between the use of smart medical devices and mental health.Smart medical services have the potential to positively influence mental health by providing monitoring,insights,and inter-ventions.However,they also come with challenges that need to be addressed.Understanding the primary purpose for which individuals use these smart tech-nologies is essential to tailoring them to specific mental health needs and prefe-rences.展开更多
The use of organic fertilizers can be an opportunity to increase crop yield and improve soil fertility in semi-arid regions,since soils from these regions usually have unfavourable conditions for plant growth.This res...The use of organic fertilizers can be an opportunity to increase crop yield and improve soil fertility in semi-arid regions,since soils from these regions usually have unfavourable conditions for plant growth.This research investigates the effects of organic and mineral fertilization on the impact of soil properties(pH,electrical conductivity and organic matter),availability of macro-(N,P and K),micro-nutrients(Fe,Mn,Cu and Zn)and the accumulation of heavy metals(Pb,Cd,Cr)in soil and potato tubers grown under semiarid conditions.A field experiment was conducted in Raqqa Governorate(Syria)using a randomized complete block design with six treatments:control,mineral fertilizer,fermented cow manure,municipal compost,sewage sludge and olive oil solid waste.At harvest,soil and plant samples were analyzed to assess nutrient dynamics in the soil and potato tubers,including metal uptake.The results showed that the highest yields were obtained with mineral fertilizer(22.87 t ha^(−1))and sewage sludge(22.15 t ha^(−1)).Organic amendments significantly improved soil organic matter,total nitrogen,and the bioavailability of phosphorus,potassium,and micronutrients after harvest.Compost and sewage sludge notably enhanced the soil and plant contents of Mn and Cu.However,these amendments also increased the amounts of Pb and Cd in soils and their uptake by plants,with Cd contents exceeding the Codex Alimentarius limit for potatoes(>0.1 mg kg^(−1)).These findings highlight the potential of treated organic waste as a valuable nutrient input for potato cultivation,especially in resource-limited areas.However,continuous monitoring is required due to the risk of heavy metal accumulation.Integrating organic fertilizers with mineral sources appears to be an effective strategy for improving crop productivity,soil health,and environmental sustainability.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.32160172)the Key Science-Technology Project of Inner Mongolia(2023KYPT0010)+1 种基金the Natural Science Foundation of Inner Mongolia Autonomous Region of China(Grant No.2025QN03006)the 2023 Inner Mongolia Public Institution High-Level Talent Introduction Scientific Research Support Project.
文摘Environmental DNA(eDNA)technology has revolutionized biodiversity monitoring with its non-invasive,sensitive,and cost-efficient approach.This paper systematically reviews eDNA advancements,examining its applications in aquatic and terrestrial ecosystems and assessing China’s standardization progress.It delineates four developmental phases from single-species detection to high-throughput sequencing,and highlights China’s contribution to the development of technical standards.While significant progress has been made,challenges persist in quantitative accuracy,methodological consistency,and large-scale implementation.Future efforts should prioritize enhanced standardization,improved quantification techniques,broader applications,and international collaboration to drive innovation in eDNA technology.
文摘Hepatocellular carcinoma presents with three distinct immune phenotypes,including immune-desert,immune-excluded,and immune-inflamed,indicating various treatment responses and prognostic outcomes.The clinical application of multi-omics parameters is still restricted by the expensive and less accessible assays,although they accurately reflect immune status.A comprehensive evaluation framework based on“easy-to-obtain”multi-model clinical parameters is urgently required,incorporating clinical features to establish baseline patient profiles and disease staging;routine blood tests assessing systemic metabolic and functional status;immune cell subsets quantifying subcluster dynamics;imaging features delineating tumor morphology,spatial configuration,and perilesional anatomical relationships;immunohistochemical markers positioning qualitative and quantitative detection of tumor antigens from the cellular and molecular level.This integrated phenomic approach aims to improve prognostic stratification and clinical decision-making in hepatocellular carcinoma management conveniently and practically.
基金Scientific Research Fund Project of Yunnan Provincial Department of Education(Project No.:2024J2130)。
文摘Objective:To systematically review the current implementation status of nurses’non-pharmacological prescription authority and analyze the barriers encountered during its implementation in China,providing countermeasures and references for promoting the standardized implementation of nurses’non-pharmacological prescription authority.Methods:A secondary analysis of literature was conducted to systematically search for domestic and international literature related to nurses’non-pharmacological prescription authority.Meta-analysis was performed on eligible literature to evaluate the implementation effects.Simultaneously,semi-structured in-depth interviews were conducted with healthcare workers,patients,and policymakers.Content analysis was used to organize the interview data and extract core issues and barriers.Results:A total of 46 international articles were included in the Meta-analysis,which revealed that the implementation of nurses’non-pharmacological prescription authority significantly improved patients’health management outcomes,enhanced healthcare service efficiency,and increased patient satisfaction.Conclusion:The implementation of nurses’non-pharmacological prescription authority has demonstrated significant positive effects.However,China faces multiple barriers in its advancement,necessitating efforts in optimizing policy systems,constructing collaborative models,strengthening professional skills training,and improving social awareness to guide the scientific and rational implementation of nurses’non-pharmacological prescription authority.
基金the GEroNIMO(Genome and Epigenome Enabled Breeding in Monogastics)project.The GEroNIMO project has received funding from the European Union’s Horizon 2020 research and innovation program under Grant Agreement No 101000236。
文摘Background Understanding the genetic basis of male reproduction in mammals remains challenging.Commercial pig populations offer a unique model for studying fertility,as semen traits are routinely recorded using high-throughput systems.Results In a large-scale GWAS of 15 semen traits based on 286,314 ejaculates collected from 2,954 boars of a purebred pig line,we identified 10 QTL,including four loci with recessive deleterious alleles.Several lead SNPs affected multiple semen traits.For example,a SNP on SSC6 was significantly associated with distal cytoplasmic droplets and with effects on tail abnormalities and sperm motility in a follow up analysis.The allele frequencies of some loci were different in older boar's,most likely due to culling based on poor semen quality.Using WGS,we identified six missense variants in high linkage disequilibrium(LD)with lead SNPs in genes related to sperm production(e.g.,MEIOB,CFAP74 and UBE2B).Remarkably,the frequency of some alleles with predicted deleterious effects on semen traits increased between 2013 and 2019.Conclusions Our results highlight loci with major effects on semen quality,some of which are linked to functional variants in key genes involved in spermatogenesis.The information from this study can be used to select against deleterious alleles affecting semen characteristics in pigs and provides valuable insight into the genetics of mammalian male fertility.
基金supported by the Science and Technology Project of the Department of Transportation of Heilongjiang Province(HJK2023B024-3)the National Key R&D Program of China(2023YFF1304001-01)。
文摘Soil fertility and forest structure influence tree carbon stocks.However,it remains unclear how tree mycorrhizal types affect these relationships.This study addressed the question of how aboveground and belowground tree carbon stocks in soils with different mycorrhizal types are affected by soil fertility and forest structure.Tree demographic data were used from a 21.12-ha study area collected over a ten-year period(2009-2019),covering 43species of woody plants and more than 50,000 individuals.Relationships between tree carbon stock,soil fertility and forest structure(stand density,diameter variation,species diversity and spatial distribution)were examined,as well as whether these relationships differed between arbuscular mycorrhiza and ectomycorrhizal mycorrhiza groups in a typical temperate conifer and broad-leaved mixed forest.We found that total tree carbon stock was positively impacted by variations in stand density and tree diameter but negatively influenced by soil fertility,tree species diversity and uniform angle index.Soil fertility promoted carbon stock of trees associated with arbuscular mycorrhiza(AM)but inhibited the carbon stock of trees with ectomycorrhizal mycorrhiza fungi(EcM).Carbon stock of AM trees was mainly influenced by soil fertility,while carbon stock of EcM trees was influenced by stand density.Our findings show that mycorrhizae types mediate the impact of stand structure and soil fertility on tree carbon stocks and provides new evidence on how forest tree carbon stocks may be enhanced based on the types of mycorrhizal associations.Tree species with different mycorrhizal types can be managed in different ways.
文摘To assess the impact of land use on the Andosol fertility, changes in chemical and physical properties affecting soil quality were monitored on Andosols from Mount Bambouto submitted to four different land use and management systems: natural cover, tillage, burning and fallow. In comparison with the natural cover, tillage reduces Andosol OC (6.5 to 4.8%), total N (4.51 to 2.95‰), CEC (22.0 to 20.9 cmol.kg–1) and the abundance of soil macro-aggregates expressed by the water stable aggregates (WSA) varies from 53.8 to 12.0%;and increases the bulk density (0.69 to 1.09 g.cm–3) and the sum of exchangeable cations (3.58 to 4.84 cmol.kg–1). Burning also reduces Andosol OC (6.5 to 0.8%), total N (4.51 to 0.95‰) and CEC (22.0 to 10.2 cmol.kg–1), but increases soil pH (4.62 to 6.54), the sum of exchangeable cations (3.58 to 5.74 cmol.kg–1) and the abundance of soil macroaggregates (WSA: 38.2 to 57.0%). In comparison with tillage, fallow increases Andosol OC (4.8 to 6.5%), total N (2.95 to 5.04‰), CEC (18.0 to 21.6 cmol.kg–1), the sum of exchangeable cations (3.58 to 5.05 cmol.kg–1) and the abundance of soil macroaggregates (WSA: 12.0 to 48.8%). Globally, the tillage management deteriorates Andosol chemical and physical properties affecting fertility, whereas the fallow management restores them. The burning management also improves some Andosol chemical and physical properties affecting quality, but it won’t last long.
基金partially supported by the Department of Soil Science,University of Tehran,Iran。
文摘A good understanding of the levels and distribution patterns of soil properties and/or quality indicators is a prerequisite for developing sustainable agricultural land management programs. Traditional assessments of these parameters of soil fertility status are somewhat costly, in both economics and time aspects. Different modelling techniques have been proposed as a useful tool for determination of soil quality indicators and development of soil fertility maps, but to what extent these results are reliable remains under-quantified in many regions worldwide. To address this uncertainty, Fuzzy-Analytical Hierarchy Process(Fuzzy-AHP) and Parametric analyses were conducted to ascertain the soil fertility status of a semiarid region in the Northeast of Iran for some selected crops: alfalfa, corn silage, potato, sugar beet, tomato and wheat. The Fuzzy-AHP and Parametric techniques using soil suitability indices were estimated for each crop and each soil delineation was achieved by Ordinary Kriging. The Technique for Order of Preference by Similarity to Ideal Solution(TOPSIS) was used as a compensatory method to allow tradeoffs among the selected criteria. Our results demonstrated that from the Fuzzy-AHP analysis, the soil fertility indices ranged from moderate to high for production of alfalfa;from low to high for production of corn silage and sugar beet;moderate to high for production of potato and tomato;and from low to moderate for production of wheat. However, the parametric analysis showed soil fertility classes ranging from very low to high for production of all the selected crops. High correlations were also observed between soil fertility indices predicted by both models. Similarly, the capacities of both models to predict soil fertility status for production of the selected crops were also highly correlated. The preference for the cultivation of the selected crops based on the Fuzzy-AHP analysis was sugar beet > corn silage > wheat > alfalfa > tomato > potato. On the other hand, using Parametric techniques, the crops preferences for cultivation ranked as corn silage > wheat > alfalfa > sugar beet > tomato > potato. We concluded that the findings would help to develop sustainable plans of cultivation based on patterns related to soil fertility classes depending on each crop’s requirement.
文摘With the decline in male fertility in recent years,strategies for male fertility preservation have received increasing attention.In this study,by reviewing current treatments and recent publications,we describe research progress in and the future directions of stem cell-based therapies for male fertility preservation,focusing on the use of spermatogonial stem cells(SSCs),SSC niches,SSC-based testicular organoids,other stem cell types such as mesenchymal stem cells,and stem cell-derived extracellular vesicles.In conclusion,a more comprehensive understanding of the germ cell microenvironment,stem cell-derived extracellular vesicles,and testicular organoids will play an important role in achieving male fertility preservation.
文摘Tailings are the residue of mined material after separation of metals such as copper, gold and silver elements. Separation of minerals involves crushing of the host material to fine particles and separation of the metals by flotation or other technique. The total amount of tailings produced by Freeport Indonesia from their Grasberg mine is about 230,000 tons/day. These tailings are deposited in a lowland area and are confined by two levees. There are two types of plant growth on inactive tailings according to land use （natural succession area or reclaimed agricultural area）. This study of soil fertility on the mine tailing was required to contribute to information on the management oftailings. Representative sampling locations were chosen based on particle size distribution with soil （0- 5 50 cm depth） being subjected to laboratory analysis. Total N soil is very low （〈 0.02%）, CEC （≤20 me/100 g） low to medium, and organic-C ranges from 0.1-2%. oH is 7-8 resulting in the low availability of some nutrients, but values of extractable Cu may be high （≥ 300 mg/kg）. Nutrient elements are more abundant in soils on fine textured tailings.
文摘In Cameroon, most farmers rely on their perceptions for fertility evaluation and choice of agricultural land units. However, because of environmental change, this knowledge is mostly disregarded. The use of farmers＇ knowledge is important for the identification of relevant information for the choice of agricultural land units. The objective of this study was to compare farmers＇ perceptions of soil fertility with a conventional scientific approach in two locations of the forest margin zone of Center Cameroon. Through interviews and soil analysis, this study spelled and weighed the relationships between farmers＇ perceptions and soil fertility status. One hundred and twenty households＇ heads were interviewed and 30 soil samples collected. Farmers＇ perceptions were used to assess the topsoil fertility status across the studied areas, while a conventional scientific approach was used to quantify soil fertility status by the means of a soil fertility index （SFI）. Results showed that farmers, for soil differentiation, used color, texture, depth, drainage and vegetation. Soil＇ names delivered key messages for their location. Although the low overall SFI approximated by the conventional approach, farmers＇ perceptions could differentiate fertility levels between soils. This knowledge is relevant for the design of technical innovations in perceived fertility niches.
文摘Mountainous ecosystem soils are subject to colonization nowadays for agri</span><span style="font-family:Verdana;">cultural purposes due to an increasing population in towns making the</span><span style="font-family:Verdana;"> detailed </span><span style="font-family:Verdana;">characterization of such soils indispensable. This work aims to characterize</span><span style="font-family:Verdana;"> the steep slopes soils of the Dschang hills and to evaluate their fertility level for </span><span style="font-family:Verdana;">agricultural valorization. Thus, four soil profiles were dug at various topographic</span><span style="font-family:Verdana;"> positions (summit (SP), shoulder (MP), backslope (BP) and footslope (PP)) following a toposequence. Samples of disturbed and undisturbed soils were taken and analyzed in the laboratory according to standard methods. The Fertility</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Capability</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">Classification (FCC) and simple limitation methods were used to identify major agricultural constraints. The main results show that </span><span style="font-family:Verdana;">profiles thickness is moderate, between 0 and 120 cm, with a high sand</span><span style="font-family:Verdana;"> content </span><span style="font-family:Verdana;">(at least 50%) over the entire toposequence, especially at the surface. The</span><span style="font-family:Verdana;"> study site has four types of soils, namely Eutric</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">Cambisols (ochric) in SP and L</span><span style="font-family:Verdana;">eptic</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Eutric</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Cambisols (Humic) in MP, Eutric</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Cambisols (Humic) in BP</span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;"> and Stagnic</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Oxygleyic</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Dystric</span></span></span><span><span><span style="font-family:""> </span></span></span><span style="font-family:Verdana;"><span style="font-family:Verdana;"><span style="font-family:Verdana;">Gleysols</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">(Humic) in pp. The soils are very acidic at PP, moderately acidic at BP and SP and slightly acidic at MP. Organic matter is higher at the surface than at depth at the topographic segments of MP, BP and PP and low to SP. The C/N ratio is high (>17) in all profiles except P4 </span><span style="font-family:Verdana;">(<10). In addition, the cation exchange capacity (CEC), the sum of</span><span style="font-family:Verdana;"> exchangeable bases, total nitrogen and available phosphorus is low in all profiles. The Ca/</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:""><span style="font-family:Verdana;">Mg/K balance in all the profiles shows a cation imbalance and a relatively </span><span style="font-family:Verdana;">high concentration of exchangeable potassium compared to the ideal</span><span style="font-family:Verdana;"> situation (76% Ca, 18% Mg and 6% K). The major constraints to crop production are: aluminum toxicity (a) and nutrients leaching (e), textural discontinuity (LS), flooding (g), low nutrient reserve (k), sand (S), clay (C) and slope (t). Hence the fertility capacity classes of these soils are CCaegk (PP), SSek (BP), SSte (MP) and LSaek (SP). To improve the yield, it will require off-season crop cultivation, fertilization and liming, and earthworks.
文摘The processes of nutrient depletion and soil degradation within smallholder farms of central Kenya are spatially heterogeneous, determined by both biophysical and socio-economic factors. A monitoring study involving nutrient stocks, flows and balances was conducted in central Kenya to explore between and within-farm variability in soil fertility management and identify spatial niches for targeting soil fertility management strategies. Focus group discussions were conducted and farms grouped into 3 farm types （rich, medium and poor）. Nine case-study farms - three from each of the farm types - were randomly selected from the 50 farms studied, for detailed resource flow mapping. The farms were visited to record movement of nutrients inputs using a monitoring protocol covering soil, crops, livestock, and socio-economic aspects of the farm. Soil in different plots were sampled at a depth of 0-20 cm and analyzed for texture, pH, C, N, available P, exchangeable K＋, Mg2＋ and Ca2＋. Results revealed that wealthy farmers added an average of 51.3 kg/ha N, 37 kg/ha P, and 244 kg/ha K, compared to 25.9 kg/ha N, 14.5 kg/ha P and 50.7 kg/ha K for the poor farmers. In all farm types, home fields received more nutrient inputs compared to the outfields. Consequently, maize grain yields, partial nutrient balances and soil nutrient stocks were significantly higher in wealthy farms and home fields compared to poor farms and outfields, respectively. These results imply that different soil management strategies are required to achieve similar yields on the different field and farm types and avert soil degradation.
基金supported by the National Natural Science Foundation of China(42177341)the Natural Science Basic Research Program of Shanxi,China(202203021222138).
文摘Organic material combined with inorganic fertilizer has been shown to greatly improve crop yield and maintain soil fertility globally. However, it remains unclear if crop yield and soil fertility can be sustained in the long term under the combined application of organic and inorganic fertilizers. Three long-term field trials were conducted to investigate the effects of organic amendments on the grain sustainable yield index(SYI), soil fertility index(SFI)and nutrient balance in maize–wheat cropping systems of central and southern China during 1991–2019. Five treatments were included in the trials: 1) no fertilization(control);2) balanced mineral fertilization(NPK);3) NPK plus manure(NPKM);4) high dose of NPK plus manure(1.5NPKM);and 5) NPK plus crop straw(NPKS). Over time, the grain yields of wheat and maize showed an increasing trend in all four fertilization treatments at the Yangling(YL) and Zhengzhou(ZZ) locations, while they declined at Qiyang(QY). The grain yield in the NPKM and 1.5NPKM treatments gradually exceeded that of the NPK and NPKS treatments at the QY site. The largest SYI was recorded in the NPKM treatment across the three sites, suggesting that inorganic fertilizer combined with manure can effectively improve crop yield sustainability. Higher SYI values were recorded at the YL and ZZ sites than at the QY site, possibly because the soil was more acid at QY. The key factors affecting grain yield were soil available phosphorus(AP) and available potassium(AK) at the YL and ZZ sites, and pH and AP at the QY site.All fertilization treatments resulted in soil N and P surpluses at the three sites, but soil K surpluses were recorded only at the QY site. The SFI was greater in the 1.5NPKM, NPKM and NPKS treatments than in the NPK treatment by 13.3–40.0 and 16.4–63.6% at the YL and ZZ sites, respectively, and was significantly higher in the NPKM and 1.5NPKM treatments than in the NPK and NPKS treatments at the QY site. A significant, positive linear relationship was found between SFI and crop yield, and SYI and nutrient balance, indicating that grain yield and its sustainability significantly increased with increasing soil fertility. The apparent N, P and K balances positively affected SFI.This study suggests that the appropriate amount of manure mixed with mineral NPK fertilizer is beneficial to the development of sustainable agriculture, which effectively increases the crop yield and yield sustainability by improving soil fertility.
基金supported by the National Natural Science Foundation of China(No.52170138)the National Key Research and Development Program of China(No.2023YFD1900305)+3 种基金Qingdao Agricultural University Doctoral Start-Up Fund(No.6631122003)the Project of Talent IntroductionEducation Program of Youth Innovation Teams in Universities of Shandong Province(2021–05)Shandong Provincial College Youth Innovation Team Program(No.2023KJ169).
文摘Cyclosporin A fermentation residue(CFR)is a type of organic waste generated during the production of cyclosporin A,which are abundant in nutrients including organic matter,phosphorus,nitrogen and potassium.Inappropriate handling of CFR not only waste valuable bioresources,but may also lead to the cyclosporin A and associated resistance genes into the natural environment,posing a significant threat to ecological system and human health.Land application was an effective way to resource recovery of CFR after aerobic composting(CAC).This study investigated the impact of CAC on soil fertility and environmental safety.The results indicated that CAC could improve soil nutrient contents and enhance enzyme activities.CAC altered the diversity and community composition of soil bacteria,resulting in an increase in the abundance of relevant bacteria beneficial for organic matter decomposition and cyclosporin A degradation.The introduced cyclosporin A(71.69μg/kg)completely degraded within 20 days due to soil biodegradation.The significantly increased abundance of intIl,mdr3,pgp,TSR and pmra in the soil cultivation early stage were restored to the soil background level within 90 days,indicating a reduced risk of antimicrobial resistance.The results demonstrated that reasonable land application of CAC could improve soil fertility without antimicrobial resistance risk,which is helpful for evaluating the resource utilization value and environmental risks of antibiotic fermentation residue after aerobic composting.
文摘Objective Selective estrogen receptor modulators(SERMs)have demonstrated efficacy in the treatment of hypogonadism in males and male factor infertility.Two SERMs,clomiphene citrate and tamoxifen,are now prescribed for off-label use to treat both conditions in males.However,existing literature compares mixed protocols with active management.We aimed to conduct a meta-analysis to evaluate the effect of clomiphene and tamoxifen versus placebo on natural pregnancy rates.Methods We conducted a comprehensive systematic review of electronic databases:MEDLINE,PubMed/PMC,EMBASE,CINAHL,Cochrane Central Register of Controlled Trials(CENTRAL),Scopus,Google Scholar,and Web of Science.Articles satisfying all selection criteria were analyzed.The primary outcome was the incidence of pregnancy after receiving the treatment.Secondary outcomes included serum follicle-stimulating hormone,luteinizing hormone,and testosterone levels,and sperm count and motility.We calculated the pooled odds ratio,risk ratio,and risk difference to ascertain possible alterations in the direction of the pooled effect size.Results Ten randomized controlled trials were ultimately included and underwent data extraction.Clomiphene citrate and placebo groups had similar pregnancy rates(10.4%and 7.1%,respectively;odds ratio 1.30[95%confidence interval 0.27–6.17];p=0.74).No meta-analysis could be calculated for pregnancy rates in tamoxifen versus placebo groups.Heterogeneity among the studies of both SERMs ranged from low to high.Conclusion Although clomiphene citrate and tamoxifen are often used off-label for the treatment of male infertility secondary to hypogonadism,studies of SERMs in the treatment of idiopathic male factor infertility are limited and heterogenous,preventing this meta-analysis from investigating the efficacy of SERMs on male infertility.The effect of clomiphene citrate or tamoxifen on the pregnancy rate remains uncertain.
文摘Objective: to investigate the status quo of fertility anxiety in breast cancer patients and analyze its influencing factors. Methods: 214 patients with breast cancer who were treated in Tangshan Peoples Hospital from March 2021 to October 2021 were selected by convenience sampling. The post cancer fertility Anxiety Scale (RCAC), self-efficacy scale (BCSES) and self disclosure scale were used for investigation and analysis. Results: the total score of breast cancer patients fertility worries is (58.78 ± 8.68). Age, education level, monthly income, sex of children, fertility willingness, operation method, whether family members have cancer or not, and self-efficacy are the influencing factors of breast cancer patients fertility worries. Conclusion: breast cancer patients fertility anxiety level is poor, which should be highly valued by medical workers. Effective measures should be taken to help breast cancer patients improve their fertility anxiety level and improve their quality of life.
基金Supported by the Guangxi Medical and Health Key(Cultivation)Discipline Construction ProjectGuilin Scientific Research and Technology Development Program Project,No.20210227-7-8.
文摘BACKGROUND The incidence of malignant tumors in the digestive system is increasing and is a threat to human health.However,the long duration from tumor detection to radical resection,stress responses due to surgical trauma,and insufficient nu-tritional intake increases the risk of malnutrition,immune function reduction,postoperative complications,and intestinal dysfunction among patients.AIM To systematically investigate the association of parenteral nutrition enriched with n-3 polyunsaturated fatty acids(PUFAs)with the nutritional status of patients after gastrointestinal treatment.METHODS Randomized controlled trials associated with PUFA-enriched parenteral nutrition administration in patients with digestive system malignancies were retrieved from online databases such as PubMed,EMBASE,ScienceDirect,Cochrane Li-brary,China Knowledge Network,China VIP,Wanfang,and China Biomedical Literature Database,with the retrieval time from database inception to present.Two researchers independently extracted data.Each article’s bias risk was ass-essed by referring to the Cochrane Handbook version 5.3 criteria and RevMan5.4 was used for data analysis.RESULTS This meta-analysis involved six randomized controlled trials involving a total of 505 cases.Random-effects model analysis indicated remarkably better impro-vements in various inflammatory factors in the study group(P<0.05).Meta-analysis of nutritional indicators revealed that the study group had higher total protein,albumin,and prealbumin levels,as well as lower transferrin levels compared to the control group(P<0.05).Meanwhile,meta-analysis of T-cell subsets revealed no remarkable inter-group difference in post-treatment CD8+cells(P>0.05).Moreover,the meta-analysis identified a notably lower incidence of adverse reactions in the study group(P<0.05).CONCLUSION Administration of PUFAs helps improve the nutritional status of patients with digestive malignancies in the perioperative period.It promotes immune function recovery,reduces the inflammatory response,and decreases the risk of adverse effects.These beneficial effects make it worth investigating and promoting their use in ap-propriate patient populations.However,further validation via high-quality studies with long intervention time and extended follow-up periods is required.
文摘In this editorial,I comment on the article by Zhang et al.To emphasize the importance of the topic,I discuss the relationship between the use of smart medical devices and mental health.Smart medical services have the potential to positively influence mental health by providing monitoring,insights,and inter-ventions.However,they also come with challenges that need to be addressed.Understanding the primary purpose for which individuals use these smart tech-nologies is essential to tailoring them to specific mental health needs and prefe-rences.
基金ARS would like to acknowledge their JdCi research contract(IJC2020-044197-I)funded by MICIU/AEI/10.13039/501100011033 and European Union EU/PRTR。
文摘The use of organic fertilizers can be an opportunity to increase crop yield and improve soil fertility in semi-arid regions,since soils from these regions usually have unfavourable conditions for plant growth.This research investigates the effects of organic and mineral fertilization on the impact of soil properties(pH,electrical conductivity and organic matter),availability of macro-(N,P and K),micro-nutrients(Fe,Mn,Cu and Zn)and the accumulation of heavy metals(Pb,Cd,Cr)in soil and potato tubers grown under semiarid conditions.A field experiment was conducted in Raqqa Governorate(Syria)using a randomized complete block design with six treatments:control,mineral fertilizer,fermented cow manure,municipal compost,sewage sludge and olive oil solid waste.At harvest,soil and plant samples were analyzed to assess nutrient dynamics in the soil and potato tubers,including metal uptake.The results showed that the highest yields were obtained with mineral fertilizer(22.87 t ha^(−1))and sewage sludge(22.15 t ha^(−1)).Organic amendments significantly improved soil organic matter,total nitrogen,and the bioavailability of phosphorus,potassium,and micronutrients after harvest.Compost and sewage sludge notably enhanced the soil and plant contents of Mn and Cu.However,these amendments also increased the amounts of Pb and Cd in soils and their uptake by plants,with Cd contents exceeding the Codex Alimentarius limit for potatoes(>0.1 mg kg^(−1)).These findings highlight the potential of treated organic waste as a valuable nutrient input for potato cultivation,especially in resource-limited areas.However,continuous monitoring is required due to the risk of heavy metal accumulation.Integrating organic fertilizers with mineral sources appears to be an effective strategy for improving crop productivity,soil health,and environmental sustainability.
