Our aim was to study the effect of depression and social support on the risk of type 2 diabetes in female population aged 25-64 in Russia/Siberia.Under the screening surveys random representative samples of women aged...Our aim was to study the effect of depression and social support on the risk of type 2 diabetes in female population aged 25-64 in Russia/Siberia.Under the screening surveys random representative samples of women aged 25-64 years were examined in 1994 and 2005.Depression assessment was performed using the MONICA-MOPSY test.Social support was measured using the Berkman-Sim test.From 1994 to 2018 in a cohort of women new-onset cases of diabetes mellitus were detected.The risk of T2DM in persons with depression was 1.844(p<0.01).After adjusting for sociodemographic variables,the risk decreased by 6%but remained significantly significant(p<0.05).The impact of a low level of social relations showed a significant effect on the risk of diabetes mellitus,including the multivariate model adjusted for the social gradient(HR=1.833,p<0.05).The presence of psychosocial factors decreases the protective effect of education in diabetes incidence.The incidence of T2D was higher in the group of manual labor and in executives.Depression and low social support increase the risk of T2DM by 80%.The frequencies of T2DM are determined by the social gradient and are associated with the role conflict“family-work”.展开更多
As a living fossil, the endangered Chinese sturgeon(Acipenser sinensis) has been considered a national treasure in China. Here,the famous Gezhouba Dam and Three Gorges Dam on the Yangtze River were built in 1988 and 2...As a living fossil, the endangered Chinese sturgeon(Acipenser sinensis) has been considered a national treasure in China. Here,the famous Gezhouba Dam and Three Gorges Dam on the Yangtze River were built in 1988 and 2006, for economic purposes.The natural population of Chinese sturgeon has declined since then, as these dams block its migratory route to the original spawning grounds in the middle reaches of the Yangtze River. In 2013 and 2014, there was an absence of spawning where it typically happened near the Gezhouba Dam. Nevertheless, from April to June in 2015, over 1,000 larvae with different body lengths(10–35 cm) were detected along the Shanghai Yangtze Estuary; but only little is currently known about the population genetic structure of the Chinese sturgeon. Herein, we inferred population genetic parameters from 462 available Chinese sturgeon specimens based on a 421-bp fragment of the mitochondrial DNA(mtDNA) D-loop region and 1,481,620 SNPs(singlenucleotide polymorphisms) generated by restriction site-associated DNA sequencing(RAD-seq). For the D-loop dataset, 15 haplotypes were determined. Randomly picked 23 individuals, representing the 15 D-loop haplotype groups, were subsequently used for further RAD-seq validation. The average nucleotide diversity calculated from the mtDNA and RAD datasets was 0.0086 and 0.000478, respectively. The overall effective female population size was calculated to be 1,255 to 2,607, and the long-term effective population size was estimated to range from 11,950 to 119,500. We observed that the genetic variability and the effective female population size of the current population in the Yangtze River are severely low, which are similar to the data reported over 10 years ago. The deduced relatively small effective population of female fish, limiting the genetic connectivity among Chinese sturgeon, should be considered a serious threat to this endangered species.展开更多
文摘Our aim was to study the effect of depression and social support on the risk of type 2 diabetes in female population aged 25-64 in Russia/Siberia.Under the screening surveys random representative samples of women aged 25-64 years were examined in 1994 and 2005.Depression assessment was performed using the MONICA-MOPSY test.Social support was measured using the Berkman-Sim test.From 1994 to 2018 in a cohort of women new-onset cases of diabetes mellitus were detected.The risk of T2DM in persons with depression was 1.844(p<0.01).After adjusting for sociodemographic variables,the risk decreased by 6%but remained significantly significant(p<0.05).The impact of a low level of social relations showed a significant effect on the risk of diabetes mellitus,including the multivariate model adjusted for the social gradient(HR=1.833,p<0.05).The presence of psychosocial factors decreases the protective effect of education in diabetes incidence.The incidence of T2D was higher in the group of manual labor and in executives.Depression and low social support increase the risk of T2DM by 80%.The frequencies of T2DM are determined by the social gradient and are associated with the role conflict“family-work”.
基金supported by National Natural Science Foundation of China (31370047, U1301252)Shenzhen Scientific R & D Grant (GJHS20160331150703934)+1 种基金Shenzhen Dapeng Special Program for Industrial Development (KY20160102)Zhenjiang Leading Talent Program for Innovation and Entrepreneurship
文摘As a living fossil, the endangered Chinese sturgeon(Acipenser sinensis) has been considered a national treasure in China. Here,the famous Gezhouba Dam and Three Gorges Dam on the Yangtze River were built in 1988 and 2006, for economic purposes.The natural population of Chinese sturgeon has declined since then, as these dams block its migratory route to the original spawning grounds in the middle reaches of the Yangtze River. In 2013 and 2014, there was an absence of spawning where it typically happened near the Gezhouba Dam. Nevertheless, from April to June in 2015, over 1,000 larvae with different body lengths(10–35 cm) were detected along the Shanghai Yangtze Estuary; but only little is currently known about the population genetic structure of the Chinese sturgeon. Herein, we inferred population genetic parameters from 462 available Chinese sturgeon specimens based on a 421-bp fragment of the mitochondrial DNA(mtDNA) D-loop region and 1,481,620 SNPs(singlenucleotide polymorphisms) generated by restriction site-associated DNA sequencing(RAD-seq). For the D-loop dataset, 15 haplotypes were determined. Randomly picked 23 individuals, representing the 15 D-loop haplotype groups, were subsequently used for further RAD-seq validation. The average nucleotide diversity calculated from the mtDNA and RAD datasets was 0.0086 and 0.000478, respectively. The overall effective female population size was calculated to be 1,255 to 2,607, and the long-term effective population size was estimated to range from 11,950 to 119,500. We observed that the genetic variability and the effective female population size of the current population in the Yangtze River are severely low, which are similar to the data reported over 10 years ago. The deduced relatively small effective population of female fish, limiting the genetic connectivity among Chinese sturgeon, should be considered a serious threat to this endangered species.
