The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways.Recent advan-cements underscore the critical role of gut microbial homeostasis in...The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways.Recent advan-cements underscore the critical role of gut microbial homeostasis in female health;with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome,endometriosis,breast cancer,cervical cancer,and ovarian cancer etc.Despite this,there has been limited discussion on the underlying mechanisms.This editorial explores the three potential mechanisms through which gut microbiota dysbiosis may impact the development of diseases among women,namely,the immune system,the gut microbiota-estrogen axis,and the metabolite pathway.We focused on approaches for treating diseases in women by addressing gut microbiota imbalances through probiotics,prebiotics supple-mentation,and fecal microbiota transplantation(FMT).Future studies should focus on determining the molecular mechanisms underlying associations between dysbiosis of gut microbiota and female diseases to realize precision medicine,with FMT emerging as a promising intervention.展开更多
Citrus,which has been consumed internationally for a long time,is widely used as a health food.Citrus and its active components exert significant effects on oxidative stress and lipid metabolism,which are closely asso...Citrus,which has been consumed internationally for a long time,is widely used as a health food.Citrus and its active components exert significant effects on oxidative stress and lipid metabolism,which are closely associated with female reproductive health.Studies suggest that citrus-derived compounds may alleviate oxidative stress by activating signaling pathways such as nuclear factor erythroid 2-related factor 2(Nrf2)and Sirtuin 1(SIRT1),and improve lipid metabolism through the activation of pathways such as peroxisome proliferator-activated receptorα(PPARα).This review focuses on the effects of Citrus on oxidative stress and lipid metabolism,aiming to provide new insights for promoting female reproductive health;however,further work is needed to elucidate the mechanisms involved and validate the therapeutic potential of Citrus’s bioactive components in clinical settings.展开更多
BACKGROUND Almost 80 percent of adults in the United States have had cytomegalovirus(CMV)infection by age 40.The number of symptomatic CMV hepatitis cases has been increasing along with non-alcoholic fatty liver disea...BACKGROUND Almost 80 percent of adults in the United States have had cytomegalovirus(CMV)infection by age 40.The number of symptomatic CMV hepatitis cases has been increasing along with non-alcoholic fatty liver disease(NAFLD)cases in the United States that is estimated to be 25 percent of the population.In this paper,we try to link these two entities together.CASE SUMMARY In this case report,we describe a young female who presented with fever,nausea,and vomiting who was found to have NAFLD and CMV hepatitis that was treated supportively.CONCLUSION In this case report,we describe NAFLD as a risk factor for CMV hepatitis and discuss the possible impact on clinical practice.We believe,it is essential to consider NAFLD and it’s disease mechanisms’localized immu-nosuppression,as a risk factor of CMV hepatitis and severe coronavirus disease 2019 infection.展开更多
The microbiome plays a critical role in the process of conception and the outcomes of pregnancy.Disruptions in microbiome homeostasis in women of reproductive age can lead to various pregnancy complications,which sign...The microbiome plays a critical role in the process of conception and the outcomes of pregnancy.Disruptions in microbiome homeostasis in women of reproductive age can lead to various pregnancy complications,which significantly impact maternal and fetal health.Recent studies have associated the microbiome in the female reproductive tract(FRT)with assisted reproductive technology(ART)outcomes,and restoring microbiome balance has been shown to improve fertility in infertile couples.This review provides an overview of the role of the microbiome in female reproductive health,including its implications for pregnancy outcomes and ARTs.Additionally,recent advances in the use of microbial biomarkers as indicators of pregnancy disorders are summarized.A comprehensive understanding of the characteristics of the microbiome before and during pregnancy and its impact on reproductive health will greatly promote maternal and fetal health.Such knowledge can also contribute to the development of ARTs and microbiome-based interventions.展开更多
Ovarian aging poses significant challenges to female fertility and overall health.While whole-grain black rice diet(BRD)has emerged as a promising anti-aging intervention,its translational potential for ovarian health...Ovarian aging poses significant challenges to female fertility and overall health.While whole-grain black rice diet(BRD)has emerged as a promising anti-aging intervention,its translational potential for ovarian health remains underexplored.This study systematically evaluated BRD's effects on ovarian functional decline through single-cell profiling and phenotypic validation.We demonstrated that BRD intervention effectively delays ovarian aging by preserving the ovarian reserve and maintaining hormonal balance,with granulosa cells(GCs)exhibiting the most pronounced responsiveness.Notably,BRD counteracts age-associated reductions in the GCs population and restores ovarian functional capacity.These findings highlight BRD's ability to rejuvenate the ovarian cellular landscape and stabilize aging-related transcriptional profiles.Our study provides actionable insights for developing BRD-based nutritional strategies to combat female reproductive aging,paving the way for clinically translatable dietary interventions and functional food innovations targeting the extension of women's healthspan.展开更多
Objective:We aimed to evaluate an integrated screening program for female migrants to Taiwan.Method:We performed a mixed methodological evaluation of a public health nurse(PHN)-led intervention to promote an integrate...Objective:We aimed to evaluate an integrated screening program for female migrants to Taiwan.Method:We performed a mixed methodological evaluation of a public health nurse(PHN)-led intervention to promote an integrated screening program for female migrants to Taiwan.The clini-cal case yield was determined by an audit,and staff/client questionnaires were used for the evalua-tion.Screening comprised surveillance for four untreated chronic diseases(hypertension,diabetes mellitus,tuberculosis,and liver disease),four cancers(mouth,bowel,liver,and cervix),parasitic infection,and hyperlipidemia.Results:Three hundred and thirty-six PHNs and 4751 immigrant women-with an average age of 29.2 years,most of whom were from Vietnam(44%)or China's Mainland(41%)-took part in the programme.Two thirds of screened women had no abnormalities.Further investigation was required in 1523 women,of whom 1220 were found to have significant disease.The majority of 280 PHNs(85%)found the content,processes,and waiting time to be‘highly acceptable’and thought the program was worthwhile and could be incorporated into standard care.Conclusions:The Taipei County Comprehensive Health Screening Programme provided an accessible,free-of-charge,and preventative intervention for female migrants to Taiwan and had a good clinical case yield.展开更多
Ovarian aging profoundly impacts female reproductive health,driven primarily by key factors like oxidative stress.Non-human primates(monkeys)serve as vital models because they,like humans,can not synthesize their own ...Ovarian aging profoundly impacts female reproductive health,driven primarily by key factors like oxidative stress.Non-human primates(monkeys)serve as vital models because they,like humans,can not synthesize their own Vitamin C(VC).Researchers,including those from the Institute of Zoology,Chinese Academy of Sciences,and the China National Center for Bioinformation and Beijing Institute of Genomics,Chinese Academy of Sciences,investigated the use of oral VC supplementation to mitigate this biological decline.展开更多
基金Supported by Science and Technology Plan of Liaoning Province,No.2022JH2/101500063.
文摘The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways.Recent advan-cements underscore the critical role of gut microbial homeostasis in female health;with dysbiosis potentially leading to diseases among women such as polycystic ovarian syndrome,endometriosis,breast cancer,cervical cancer,and ovarian cancer etc.Despite this,there has been limited discussion on the underlying mechanisms.This editorial explores the three potential mechanisms through which gut microbiota dysbiosis may impact the development of diseases among women,namely,the immune system,the gut microbiota-estrogen axis,and the metabolite pathway.We focused on approaches for treating diseases in women by addressing gut microbiota imbalances through probiotics,prebiotics supple-mentation,and fecal microbiota transplantation(FMT).Future studies should focus on determining the molecular mechanisms underlying associations between dysbiosis of gut microbiota and female diseases to realize precision medicine,with FMT emerging as a promising intervention.
基金supported by the National Natural Science Foundation of China(No.82374510)the General Scientific Research Project of the Education Department of Zhejiang Province(No.Y202455593),China.
文摘Citrus,which has been consumed internationally for a long time,is widely used as a health food.Citrus and its active components exert significant effects on oxidative stress and lipid metabolism,which are closely associated with female reproductive health.Studies suggest that citrus-derived compounds may alleviate oxidative stress by activating signaling pathways such as nuclear factor erythroid 2-related factor 2(Nrf2)and Sirtuin 1(SIRT1),and improve lipid metabolism through the activation of pathways such as peroxisome proliferator-activated receptorα(PPARα).This review focuses on the effects of Citrus on oxidative stress and lipid metabolism,aiming to provide new insights for promoting female reproductive health;however,further work is needed to elucidate the mechanisms involved and validate the therapeutic potential of Citrus’s bioactive components in clinical settings.
文摘BACKGROUND Almost 80 percent of adults in the United States have had cytomegalovirus(CMV)infection by age 40.The number of symptomatic CMV hepatitis cases has been increasing along with non-alcoholic fatty liver disease(NAFLD)cases in the United States that is estimated to be 25 percent of the population.In this paper,we try to link these two entities together.CASE SUMMARY In this case report,we describe a young female who presented with fever,nausea,and vomiting who was found to have NAFLD and CMV hepatitis that was treated supportively.CONCLUSION In this case report,we describe NAFLD as a risk factor for CMV hepatitis and discuss the possible impact on clinical practice.We believe,it is essential to consider NAFLD and it’s disease mechanisms’localized immu-nosuppression,as a risk factor of CMV hepatitis and severe coronavirus disease 2019 infection.
基金supported by grants from the National Key R&D Program of China(Grant Nos.2022YFA1303900,2021YFA1301000,and 2022YFC2704702)the National Natural Science Foundation of China(Grant Nos.32001082 and 32025009)the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB38020300).
文摘The microbiome plays a critical role in the process of conception and the outcomes of pregnancy.Disruptions in microbiome homeostasis in women of reproductive age can lead to various pregnancy complications,which significantly impact maternal and fetal health.Recent studies have associated the microbiome in the female reproductive tract(FRT)with assisted reproductive technology(ART)outcomes,and restoring microbiome balance has been shown to improve fertility in infertile couples.This review provides an overview of the role of the microbiome in female reproductive health,including its implications for pregnancy outcomes and ARTs.Additionally,recent advances in the use of microbial biomarkers as indicators of pregnancy disorders are summarized.A comprehensive understanding of the characteristics of the microbiome before and during pregnancy and its impact on reproductive health will greatly promote maternal and fetal health.Such knowledge can also contribute to the development of ARTs and microbiome-based interventions.
基金supported by the National Natural Science Foundation of China(32470711,82271672)the National Key Research and Development Program of China(2023YFC2705700)+2 种基金the Foundation of Hubei Hongshan Laboratory(2021hszd012,2022hszd024,2022hszd028)the Postdoctoral Fellowship Program of CPSF(GZC20240559)the Postdoctor Project of Hubei Province(2024HBBHCXA043)。
文摘Ovarian aging poses significant challenges to female fertility and overall health.While whole-grain black rice diet(BRD)has emerged as a promising anti-aging intervention,its translational potential for ovarian health remains underexplored.This study systematically evaluated BRD's effects on ovarian functional decline through single-cell profiling and phenotypic validation.We demonstrated that BRD intervention effectively delays ovarian aging by preserving the ovarian reserve and maintaining hormonal balance,with granulosa cells(GCs)exhibiting the most pronounced responsiveness.Notably,BRD counteracts age-associated reductions in the GCs population and restores ovarian functional capacity.These findings highlight BRD's ability to rejuvenate the ovarian cellular landscape and stabilize aging-related transcriptional profiles.Our study provides actionable insights for developing BRD-based nutritional strategies to combat female reproductive aging,paving the way for clinically translatable dietary interventions and functional food innovations targeting the extension of women's healthspan.
文摘Objective:We aimed to evaluate an integrated screening program for female migrants to Taiwan.Method:We performed a mixed methodological evaluation of a public health nurse(PHN)-led intervention to promote an integrated screening program for female migrants to Taiwan.The clini-cal case yield was determined by an audit,and staff/client questionnaires were used for the evalua-tion.Screening comprised surveillance for four untreated chronic diseases(hypertension,diabetes mellitus,tuberculosis,and liver disease),four cancers(mouth,bowel,liver,and cervix),parasitic infection,and hyperlipidemia.Results:Three hundred and thirty-six PHNs and 4751 immigrant women-with an average age of 29.2 years,most of whom were from Vietnam(44%)or China's Mainland(41%)-took part in the programme.Two thirds of screened women had no abnormalities.Further investigation was required in 1523 women,of whom 1220 were found to have significant disease.The majority of 280 PHNs(85%)found the content,processes,and waiting time to be‘highly acceptable’and thought the program was worthwhile and could be incorporated into standard care.Conclusions:The Taipei County Comprehensive Health Screening Programme provided an accessible,free-of-charge,and preventative intervention for female migrants to Taiwan and had a good clinical case yield.
文摘Ovarian aging profoundly impacts female reproductive health,driven primarily by key factors like oxidative stress.Non-human primates(monkeys)serve as vital models because they,like humans,can not synthesize their own Vitamin C(VC).Researchers,including those from the Institute of Zoology,Chinese Academy of Sciences,and the China National Center for Bioinformation and Beijing Institute of Genomics,Chinese Academy of Sciences,investigated the use of oral VC supplementation to mitigate this biological decline.
