Objective To observe the effect of Xiaoer Feire Kechuan oral solution on the extrapulmonary injury induced by Mycoplasma pneumoniae in infant Wistar rats. Methods Infant Wistar rats were infected intranasally with M. ...Objective To observe the effect of Xiaoer Feire Kechuan oral solution on the extrapulmonary injury induced by Mycoplasma pneumoniae in infant Wistar rats. Methods Infant Wistar rats were infected intranasally with M. pneumoniae once a day for four days. In the treatment groups, Xiaoer Feire Kechuan oral solution was administered daily for four days beginning from the day of infection. On day 5, blood of the rats was collected, and blood routine and biochemistry indexes were measured. All rats were sacrificed, and the weight of brain, heart, liver, and kidney was measured to calculate the organ indexes. The GM1 and GALC-Ab content in brain tissue was determined by ELISA. Pathological changes in the brain, heart, liver, kidney, and cerebellum were observed by HE staining. Results Blood routine indexes fluctuated within the normal range in the infection control group and in three of the Xiaoer Feire Kechuan oral solution groups. The serum LDH, CK, and CRE in all three Xiaoer Feire Kechuan oral solution groups were distinctly lower than those in the infection control group (P < 0.01, P < 0.05). Rat brain index and GALC-Ab content in the brain tissue showed an increase in infection control group. In the Xiaoer Feire Kechuan oral solution groups, the GALC-Ab content in brain tissue was decreased significantly. The heart, liver, and kidney tissues showed mild pathological changes in the infection group, which were reversed by Xiaoer Feire Kechuan oral solution treatment. Conclusions The extrapulmonary injury induced by M. pneumoniae in infant Wistar rats was significantly inhibited by Xiaoer Feire Kechuan oral solution.展开更多
Ir is recognized as efficient catalyst for hydrogen evolution reaction(HER).The high price,however,has hindered its application in the production of hydrogen.In this work,we prepared the self-supported FeIr alloy nano...Ir is recognized as efficient catalyst for hydrogen evolution reaction(HER).The high price,however,has hindered its application in the production of hydrogen.In this work,we prepared the self-supported FeIr alloy nanoparticles,taking advantage of solid-state synthesis method.The as-prepared FeIr alloy possesses a novel morphology of pollen,which is consist of smaller FeIr nanoparticles.DFT calculations reveal that the change of the free Gibbs for Ir is negative after the adsorption of active H,while it is positive for the case of Fe.Thus,the alloying of Fe and Ir not only effectively reduces the cost,but also can achieve more adequate adsorption of active H species.Benefitting from this,the as-prepared FeIr alloy nanoparticle exhibits superior HER performance with an overpotential of 19 m V at a current density of 10 m V/cm^(2)and a Tafel slope of 32 m V/dec,when tested in 0.5 M H_(2)SO_(4),better than pure Ir and Pt/C.This work paves the way to the exploration of efficient alloy electrocatalysts for HER.展开更多
文摘Objective To observe the effect of Xiaoer Feire Kechuan oral solution on the extrapulmonary injury induced by Mycoplasma pneumoniae in infant Wistar rats. Methods Infant Wistar rats were infected intranasally with M. pneumoniae once a day for four days. In the treatment groups, Xiaoer Feire Kechuan oral solution was administered daily for four days beginning from the day of infection. On day 5, blood of the rats was collected, and blood routine and biochemistry indexes were measured. All rats were sacrificed, and the weight of brain, heart, liver, and kidney was measured to calculate the organ indexes. The GM1 and GALC-Ab content in brain tissue was determined by ELISA. Pathological changes in the brain, heart, liver, kidney, and cerebellum were observed by HE staining. Results Blood routine indexes fluctuated within the normal range in the infection control group and in three of the Xiaoer Feire Kechuan oral solution groups. The serum LDH, CK, and CRE in all three Xiaoer Feire Kechuan oral solution groups were distinctly lower than those in the infection control group (P < 0.01, P < 0.05). Rat brain index and GALC-Ab content in the brain tissue showed an increase in infection control group. In the Xiaoer Feire Kechuan oral solution groups, the GALC-Ab content in brain tissue was decreased significantly. The heart, liver, and kidney tissues showed mild pathological changes in the infection group, which were reversed by Xiaoer Feire Kechuan oral solution treatment. Conclusions The extrapulmonary injury induced by M. pneumoniae in infant Wistar rats was significantly inhibited by Xiaoer Feire Kechuan oral solution.
基金supported by the National Natural Science Foundation of China(Grant No.52072255)the Natural Science Foundation of Zhejiang Province(Grant Nos.LTY20E020001,LY21E020001)。
文摘Ir is recognized as efficient catalyst for hydrogen evolution reaction(HER).The high price,however,has hindered its application in the production of hydrogen.In this work,we prepared the self-supported FeIr alloy nanoparticles,taking advantage of solid-state synthesis method.The as-prepared FeIr alloy possesses a novel morphology of pollen,which is consist of smaller FeIr nanoparticles.DFT calculations reveal that the change of the free Gibbs for Ir is negative after the adsorption of active H,while it is positive for the case of Fe.Thus,the alloying of Fe and Ir not only effectively reduces the cost,but also can achieve more adequate adsorption of active H species.Benefitting from this,the as-prepared FeIr alloy nanoparticle exhibits superior HER performance with an overpotential of 19 m V at a current density of 10 m V/cm^(2)and a Tafel slope of 32 m V/dec,when tested in 0.5 M H_(2)SO_(4),better than pure Ir and Pt/C.This work paves the way to the exploration of efficient alloy electrocatalysts for HER.
