Qing Fei Xiao Yan Wan had been incorporated into the existing “Chinese Pharmacopoeia”, protected by patents. The manufacturing process of it was scientific and its compatibility was reasonable. It was also shown by ...Qing Fei Xiao Yan Wan had been incorporated into the existing “Chinese Pharmacopoeia”, protected by patents. The manufacturing process of it was scientific and its compatibility was reasonable. It was also shown by clinical trials that the efficacy is exact. Clinical trials and experiment studies had confirmed the efficacy and some mechanism for the treatment of respiratory diseases, which were summaried in this paper. Combined with the experimental results (published in another paper), the other prospect application was further discussed.展开更多
Objective:By data mining,to analyze the characteristics of Professor Han Fei’s medication in the treatment of children with epilepsy,to explore the rules of medication,in order to provide reference for clinical treat...Objective:By data mining,to analyze the characteristics of Professor Han Fei’s medication in the treatment of children with epilepsy,to explore the rules of medication,in order to provide reference for clinical treatment of children with epilepsy by Chinese medicine.Methods:From January 2008 to March 2021,we collected the diagnosis and treatment data of the children with epilepsy who were treated by Professor Han Fei in the outpatient department of Guang’Anmen Hospital of Chinese Academy of Medical Sciences.Using the software of IBM SPSS Statistics 24.0 and IBM SPSS Modeler 18.0,the characteristics and rules of Professor Hanfei’s Chinese materia medica used were summarized through the descriptive analysis,correlation analysis and cluster analysis of drug cumulative frequency,drug flavor,drug channel tropism and efficacy.Results:A total of 224 cases were included in this study,excluding 1 case with other neurological disorders.Finally,223 prescriptions were included,involving 176 kinds of Chinese materia medica and the total medication frequency was 4712.The first 10 highfrequency Chinese materia medica were Chaihu(95.52%),Bombyx batryticatus(94.17%),keels(83.41%),oysters(72.65%),earthworm(72.20%),fructus aurantii(66.37%),Scorpion(64.57%),Gastrodia elata(60.99%),Acorus gramineus(59.19%)and Dannan Xing(58.30%).The main Chinese materia medica used were mainly for suppressing hyperactive liver for calming endogenous wind,relieving exterior syndromes and tranquillizing mind.The medicine properties were mainly to be flat,slight cold,pungent,bitter and willing,and they were mainly for liver,lung and heart meridian tropism.Correlation Analysis:Bupleurum chinense,Bombyx batryticatus,Dragon Bone,oyster as its core medicine group,Semen Ziziphi spinosae and semen platycladi are effective strong correlation medicine pair.Three medicine combinations were obtained by cluster analysis.Conclusion:Hanshi has the characteristics of“calming liver,tranquilizing mind,calming endogenous wind,removing the phlegm and extravasated blood”in treating epilepsy.展开更多
Fei Xiaotong’s(Fei Hsiao-tung)works on rural economies and societies written in the 1940s were deeply affected by British economic historian R.H.Tawney.Through comparison,this article reveals at least two connections...Fei Xiaotong’s(Fei Hsiao-tung)works on rural economies and societies written in the 1940s were deeply affected by British economic historian R.H.Tawney.Through comparison,this article reveals at least two connections between their works.First,Tawney’s analysis of the transition from agricultural modernization to industrial modernization in Britain serves as a reference for Fei’s works on the economic transformation of the Yangtze Valley in Jiangsu and Lucun village in Yunnan.Second,Tawney’s“theory of gentry”also serves as the underlying view for Fei’s theory on the functions of the Chinese gentry.However,Fei does not simply follow Tawney’s steps.Instead,he offers unique insights into the issues of horticulture transformation and gentry types in China.Furthermore,in Fei’s social theory and practice,the role of“state”was considered to be less positive.The interrelations of the community,market,intellectuals and the state construct Fei’s modernization scheme of China.His idea about how China,a slower participant in the world system,can maintain economic autonomy was still valuable today.展开更多
Han Fei presented a thought-provoking perspective on human nature and its implications for governance.Departing from traditional moral doctrines,Han Fei’s“non-moralistic”philosophy posited that human nature is inhe...Han Fei presented a thought-provoking perspective on human nature and its implications for governance.Departing from traditional moral doctrines,Han Fei’s“non-moralistic”philosophy posited that human nature is inherently self-interested and driven by personal gain.In this paper,we explore Han Fei’s keen insights into human nature and its practical application in political governance.His emphasis on aligning political strategies with human inclinations,rather than relying solely on moral preaching,highlights the complexity and pragmatism of his approach.However,we also examine the limitations of his philosophy,particularly in disregarding individual differences and idealism.By striking a balance between political expediency and moral considerations,Han Fei’s ideas continue to resonate with contemporary discussions on governance and human behavior.This study calls for a reflective and cautious assessment of the implications of Han Fei’s“non-moralistic”thought in today’s society.展开更多
Cui Fei was born in 1970 in Jinan,Shandong Province.After graduating from the China Academy of Fine Arts,Hangzhou,she moved to the United States in 1996 and has been resident there ever since.Although painting was the...Cui Fei was born in 1970 in Jinan,Shandong Province.After graduating from the China Academy of Fine Arts,Hangzhou,she moved to the United States in 1996 and has been resident there ever since.Although painting was the primary focus in the first展开更多
As a national cultural property,General Zhang Fei’s Temple is the largest ancient architectural complex in the Three Gorges of the Yangtze River.It was built in the Han Dynasty and has a long history of nearly 2,000 ...As a national cultural property,General Zhang Fei’s Temple is the largest ancient architectural complex in the Three Gorges of the Yangtze River.It was built in the Han Dynasty and has a long history of nearly 2,000 years.In 1994,the Chinese government launched the Three Gorges Dam project at the Yangtze River and implemented the largest relocation project for the General Zhang Fei Temple to prevent it from being submerged.The temple was relocated 32 kilometers upstream along with the local people of Yunyang County,and the historic environment was rebuilt on the opposite side of the migrant city of New Yunyang County.The temple was restored successfully and the tradition of offering sacrifices to General Zhang Fei continued in the local community.The relocation project lasted for 8 years and became the largest cultural heritage conservation project of the People’s Republic of China at the end of the 20th century.This paper comprehensively summarizes and reviews the project goals,implementation process,and project highlights of this relocation,so as to provide an important case reference for heritage conservation projects in the future.展开更多
Objective:To observe the clinical effect and safety of Lu'e Biyan Formula(LBF)combined with loratadine in the treatment of moderate to severe allergic rhinitis(AR)patients with Fei(Lung)-qi deficiencycoldness(FQDC...Objective:To observe the clinical effect and safety of Lu'e Biyan Formula(LBF)combined with loratadine in the treatment of moderate to severe allergic rhinitis(AR)patients with Fei(Lung)-qi deficiencycoldness(FQDC)syndrome.Methods:From September 2023 to December 2024,moderate to severe AR patients with FQDC syndrome were recruited from the Outpatient Department of Integrated Traditional Chinese and Western Medicine for Pulmonary Diseases Part 1,China-Japan Friendship Hospital.Participants were randomly assigned to a test group and a control group by using a random number table at a ratio of 1:1.Both groups received oral loratadine tablets(10 mg,once daily)for 2 weeks.In addition,the test group received oral LBF(30 mL,twice daily),and the control group received a placebo of LBF.Changes in the Total Nasal Symptom Score(TNSS),Total Non-nasal Symptom Score(TNNSS),Visual Analog Scale(VAS),Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ),and Chinese medicine(CM)syndrome scores before and after treatment were compared between groups.Moreover,the total effective rates and disease recurrence rates were compared.Adverse events(AEs)during the study period were also recorded.Results:Totally 109 participants were recruited,and the full analysis set included 105 cases,54 in the test group and 51 in the control group.Compared with the pre-treatment values,the scores of sneezing,runny nose,nasal obstruction,nasal itching,TNSS,TNNSS,VAS,RQLQ,and CM syndrome were significantly reduced in both groups at 1 and 2 weeks post-treatment and 12 weeks postdrug withdrawal(P<0.01).After treatment,the aforementioned scores in the test group were all markedly lower than those in the control group(P<0.01).Moreover,the total effective rate in the test group was higher than that in the control group(98.15%vs.70.59%,P<0.01).After 12 weeks of drug withdrawal,there was no significant difference in the recurrence rate between groups(13.21%vs.22.22%,P>0.05).No obvious AEs were observed in either group following treatment.Conclusions:The combination of LBF with loratadine can effectively alleviate the symptoms of moderate to severe AR patients with FQDC syndrome,thereby improving their quality of life.This therapy demonstrated both precise effect and high safety.(Trial registration No.ITMCTR2025000589)展开更多
Objective:Qu Du Qiang Fei 1 Hao Fang(QDQF1)is a novel Chinese herbal medicine formula used to treat coronavirus disease 2019(COVID-19).However,the pharmacological mechanisms of action of QDQF1 remain unclear.The objec...Objective:Qu Du Qiang Fei 1 Hao Fang(QDQF1)is a novel Chinese herbal medicine formula used to treat coronavirus disease 2019(COVID-19).However,the pharmacological mechanisms of action of QDQF1 remain unclear.The objective of this study was to identify the effective ingredients and biological targets of QDQF1 for COVID-19 treatment.Materials and Methods:The effective ingredients and mechanisms of action of QDQF1 were analyzed by using network pharmacology methods,which included an analysis of the effective ingredients and corresponding targets,COVID-19-related target acquisition,compound-target network analyses,protein-protein interaction network analysis,Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene Ontology(GO)enrichment analyses,and molecular docking studies.Results:In total,288 effective QDQF1 ingredients were identified.We identified 51 core targets from the 148 targets through an overlap between putative QDQF1 targets and COVID-19-related targets.Six key components,including formononetin,kaempferol,luteolin,naringenin,quercetin,and wogonin were identified through component-target network analyses.GO functional enrichment analysis of the core targets revealed 1296 items,while KEGG pathway enrichment analysis identified 148 signaling pathways.Nine central targets(CCL2,CXCL8,IL1B,IL6,MAPK1,MAPK3,MAPK8,STAT3,and TNF)related to the COVID-19 pathway were identified in the KEGG pathway enrichment analysis.Furthermore,molecular docking analysis suggested that the docking scores of the six key components to the nine central targets were better than those to remdesivir.Conclusions:QDQF1 may regulate multiple immune-and inflammation-related targets to inhibit the progression of severe acute respiratory syndrome coronavirus 2,and thus,may be suitable for the treatment of COVID-19.展开更多
Ethnic corridor(minzu zoulang民族走廊)is a research orientation that Fei Xiaotong first proposed and continuously explained in the early stage of reform and opening up.From a long-term perspective of academic history,...Ethnic corridor(minzu zoulang民族走廊)is a research orientation that Fei Xiaotong first proposed and continuously explained in the early stage of reform and opening up.From a long-term perspective of academic history,its academic origin is closely related to the formation of Fei Xiaotong's early academic thoughts and self-academic reflections,and also stemmed from ethnic historical turn and ethnic investigation since the 1950s.Fei Xiaotong initially proposed the corridor perspective in order to solve the remaining problem of ethnic identification,and advocated the identification of a single ethnic group from the ethnic relationship in the regional history.However,the phenomenon of multi-ethnic cultural integration in the corridor area has pushed Fei Xiaotong's breaking away from the shackles of single-ethnic research,and promoted his corridor research to the exploratory level about the formation and pattern of Chinese nation.The academic path of Fei Xiaotong's corridor idea indicates ethnic corridor research should pay more attention to the interpretation of historical process and ethnographic fieldwork of multi-ethnic relation.展开更多
The ISO Central Secretariat and the ISO/TC 314,Ageing societies,awarded Hou Fei,Cao Lili,and Wang Qi from CNIS for their contributions to ISO 25556:2025,Ageing societies-General requirements and guidelines for ageing-...The ISO Central Secretariat and the ISO/TC 314,Ageing societies,awarded Hou Fei,Cao Lili,and Wang Qi from CNIS for their contributions to ISO 25556:2025,Ageing societies-General requirements and guidelines for ageing-inclusive digital economy.展开更多
文摘Qing Fei Xiao Yan Wan had been incorporated into the existing “Chinese Pharmacopoeia”, protected by patents. The manufacturing process of it was scientific and its compatibility was reasonable. It was also shown by clinical trials that the efficacy is exact. Clinical trials and experiment studies had confirmed the efficacy and some mechanism for the treatment of respiratory diseases, which were summaried in this paper. Combined with the experimental results (published in another paper), the other prospect application was further discussed.
基金Special Fund Support for Basic Scientific Research Business Fee of Central Level Public Welfare Research Institute(No.ZZ13-024-05,ZZ15-XY-PT-03)。
文摘Objective:By data mining,to analyze the characteristics of Professor Han Fei’s medication in the treatment of children with epilepsy,to explore the rules of medication,in order to provide reference for clinical treatment of children with epilepsy by Chinese medicine.Methods:From January 2008 to March 2021,we collected the diagnosis and treatment data of the children with epilepsy who were treated by Professor Han Fei in the outpatient department of Guang’Anmen Hospital of Chinese Academy of Medical Sciences.Using the software of IBM SPSS Statistics 24.0 and IBM SPSS Modeler 18.0,the characteristics and rules of Professor Hanfei’s Chinese materia medica used were summarized through the descriptive analysis,correlation analysis and cluster analysis of drug cumulative frequency,drug flavor,drug channel tropism and efficacy.Results:A total of 224 cases were included in this study,excluding 1 case with other neurological disorders.Finally,223 prescriptions were included,involving 176 kinds of Chinese materia medica and the total medication frequency was 4712.The first 10 highfrequency Chinese materia medica were Chaihu(95.52%),Bombyx batryticatus(94.17%),keels(83.41%),oysters(72.65%),earthworm(72.20%),fructus aurantii(66.37%),Scorpion(64.57%),Gastrodia elata(60.99%),Acorus gramineus(59.19%)and Dannan Xing(58.30%).The main Chinese materia medica used were mainly for suppressing hyperactive liver for calming endogenous wind,relieving exterior syndromes and tranquillizing mind.The medicine properties were mainly to be flat,slight cold,pungent,bitter and willing,and they were mainly for liver,lung and heart meridian tropism.Correlation Analysis:Bupleurum chinense,Bombyx batryticatus,Dragon Bone,oyster as its core medicine group,Semen Ziziphi spinosae and semen platycladi are effective strong correlation medicine pair.Three medicine combinations were obtained by cluster analysis.Conclusion:Hanshi has the characteristics of“calming liver,tranquilizing mind,calming endogenous wind,removing the phlegm and extravasated blood”in treating epilepsy.
基金The paper was the research result of the“Study on the Theory and Methodology of the Rural Social Transformation by the Yanching School”(18BSH001)a general project under the National Social Science Foundation of China.Thoughts on the paper were initially formed in the“Shiheng Excellent Lecture”sponsored by Yunnan Shiheng Education Foundation in the summer of 2016.
文摘Fei Xiaotong’s(Fei Hsiao-tung)works on rural economies and societies written in the 1940s were deeply affected by British economic historian R.H.Tawney.Through comparison,this article reveals at least two connections between their works.First,Tawney’s analysis of the transition from agricultural modernization to industrial modernization in Britain serves as a reference for Fei’s works on the economic transformation of the Yangtze Valley in Jiangsu and Lucun village in Yunnan.Second,Tawney’s“theory of gentry”also serves as the underlying view for Fei’s theory on the functions of the Chinese gentry.However,Fei does not simply follow Tawney’s steps.Instead,he offers unique insights into the issues of horticulture transformation and gentry types in China.Furthermore,in Fei’s social theory and practice,the role of“state”was considered to be less positive.The interrelations of the community,market,intellectuals and the state construct Fei’s modernization scheme of China.His idea about how China,a slower participant in the world system,can maintain economic autonomy was still valuable today.
文摘Han Fei presented a thought-provoking perspective on human nature and its implications for governance.Departing from traditional moral doctrines,Han Fei’s“non-moralistic”philosophy posited that human nature is inherently self-interested and driven by personal gain.In this paper,we explore Han Fei’s keen insights into human nature and its practical application in political governance.His emphasis on aligning political strategies with human inclinations,rather than relying solely on moral preaching,highlights the complexity and pragmatism of his approach.However,we also examine the limitations of his philosophy,particularly in disregarding individual differences and idealism.By striking a balance between political expediency and moral considerations,Han Fei’s ideas continue to resonate with contemporary discussions on governance and human behavior.This study calls for a reflective and cautious assessment of the implications of Han Fei’s“non-moralistic”thought in today’s society.
文摘Cui Fei was born in 1970 in Jinan,Shandong Province.After graduating from the China Academy of Fine Arts,Hangzhou,she moved to the United States in 1996 and has been resident there ever since.Although painting was the primary focus in the first
文摘As a national cultural property,General Zhang Fei’s Temple is the largest ancient architectural complex in the Three Gorges of the Yangtze River.It was built in the Han Dynasty and has a long history of nearly 2,000 years.In 1994,the Chinese government launched the Three Gorges Dam project at the Yangtze River and implemented the largest relocation project for the General Zhang Fei Temple to prevent it from being submerged.The temple was relocated 32 kilometers upstream along with the local people of Yunyang County,and the historic environment was rebuilt on the opposite side of the migrant city of New Yunyang County.The temple was restored successfully and the tradition of offering sacrifices to General Zhang Fei continued in the local community.The relocation project lasted for 8 years and became the largest cultural heritage conservation project of the People’s Republic of China at the end of the 20th century.This paper comprehensively summarizes and reviews the project goals,implementation process,and project highlights of this relocation,so as to provide an important case reference for heritage conservation projects in the future.
基金Supported by the National Natural Science Foundation of China(No.82104760)Chinese Association of Chinese Medicine Youth Realistic Project(No.2022-QNQSDEP-09)+1 种基金Funding Project for Clinical Research Business Expenses at Central High-Level Hospitals(No.2022-NHLHCRF-LX-01-0308)the Second Group of the Elite Plan Backbone Talent Project at China-Japan Friendship Hospital(No.ZRJY2023-GG05)。
文摘Objective:To observe the clinical effect and safety of Lu'e Biyan Formula(LBF)combined with loratadine in the treatment of moderate to severe allergic rhinitis(AR)patients with Fei(Lung)-qi deficiencycoldness(FQDC)syndrome.Methods:From September 2023 to December 2024,moderate to severe AR patients with FQDC syndrome were recruited from the Outpatient Department of Integrated Traditional Chinese and Western Medicine for Pulmonary Diseases Part 1,China-Japan Friendship Hospital.Participants were randomly assigned to a test group and a control group by using a random number table at a ratio of 1:1.Both groups received oral loratadine tablets(10 mg,once daily)for 2 weeks.In addition,the test group received oral LBF(30 mL,twice daily),and the control group received a placebo of LBF.Changes in the Total Nasal Symptom Score(TNSS),Total Non-nasal Symptom Score(TNNSS),Visual Analog Scale(VAS),Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ),and Chinese medicine(CM)syndrome scores before and after treatment were compared between groups.Moreover,the total effective rates and disease recurrence rates were compared.Adverse events(AEs)during the study period were also recorded.Results:Totally 109 participants were recruited,and the full analysis set included 105 cases,54 in the test group and 51 in the control group.Compared with the pre-treatment values,the scores of sneezing,runny nose,nasal obstruction,nasal itching,TNSS,TNNSS,VAS,RQLQ,and CM syndrome were significantly reduced in both groups at 1 and 2 weeks post-treatment and 12 weeks postdrug withdrawal(P<0.01).After treatment,the aforementioned scores in the test group were all markedly lower than those in the control group(P<0.01).Moreover,the total effective rate in the test group was higher than that in the control group(98.15%vs.70.59%,P<0.01).After 12 weeks of drug withdrawal,there was no significant difference in the recurrence rate between groups(13.21%vs.22.22%,P>0.05).No obvious AEs were observed in either group following treatment.Conclusions:The combination of LBF with loratadine can effectively alleviate the symptoms of moderate to severe AR patients with FQDC syndrome,thereby improving their quality of life.This therapy demonstrated both precise effect and high safety.(Trial registration No.ITMCTR2025000589)
基金funded by the National Natural Science Foundation of China(81973543)the Shanghai Sailing Program(No.22YF1449800),China。
文摘Objective:Qu Du Qiang Fei 1 Hao Fang(QDQF1)is a novel Chinese herbal medicine formula used to treat coronavirus disease 2019(COVID-19).However,the pharmacological mechanisms of action of QDQF1 remain unclear.The objective of this study was to identify the effective ingredients and biological targets of QDQF1 for COVID-19 treatment.Materials and Methods:The effective ingredients and mechanisms of action of QDQF1 were analyzed by using network pharmacology methods,which included an analysis of the effective ingredients and corresponding targets,COVID-19-related target acquisition,compound-target network analyses,protein-protein interaction network analysis,Kyoto Encyclopedia of Genes and Genomes(KEGG)and Gene Ontology(GO)enrichment analyses,and molecular docking studies.Results:In total,288 effective QDQF1 ingredients were identified.We identified 51 core targets from the 148 targets through an overlap between putative QDQF1 targets and COVID-19-related targets.Six key components,including formononetin,kaempferol,luteolin,naringenin,quercetin,and wogonin were identified through component-target network analyses.GO functional enrichment analysis of the core targets revealed 1296 items,while KEGG pathway enrichment analysis identified 148 signaling pathways.Nine central targets(CCL2,CXCL8,IL1B,IL6,MAPK1,MAPK3,MAPK8,STAT3,and TNF)related to the COVID-19 pathway were identified in the KEGG pathway enrichment analysis.Furthermore,molecular docking analysis suggested that the docking scores of the six key components to the nine central targets were better than those to remdesivir.Conclusions:QDQF1 may regulate multiple immune-and inflammation-related targets to inhibit the progression of severe acute respiratory syndrome coronavirus 2,and thus,may be suitable for the treatment of COVID-19.
文摘Ethnic corridor(minzu zoulang民族走廊)is a research orientation that Fei Xiaotong first proposed and continuously explained in the early stage of reform and opening up.From a long-term perspective of academic history,its academic origin is closely related to the formation of Fei Xiaotong's early academic thoughts and self-academic reflections,and also stemmed from ethnic historical turn and ethnic investigation since the 1950s.Fei Xiaotong initially proposed the corridor perspective in order to solve the remaining problem of ethnic identification,and advocated the identification of a single ethnic group from the ethnic relationship in the regional history.However,the phenomenon of multi-ethnic cultural integration in the corridor area has pushed Fei Xiaotong's breaking away from the shackles of single-ethnic research,and promoted his corridor research to the exploratory level about the formation and pattern of Chinese nation.The academic path of Fei Xiaotong's corridor idea indicates ethnic corridor research should pay more attention to the interpretation of historical process and ethnographic fieldwork of multi-ethnic relation.
文摘The ISO Central Secretariat and the ISO/TC 314,Ageing societies,awarded Hou Fei,Cao Lili,and Wang Qi from CNIS for their contributions to ISO 25556:2025,Ageing societies-General requirements and guidelines for ageing-inclusive digital economy.
