Fear memory,a predictive and protective mechanism in potentially hostile environments,elicits defensive behavioral responses that have evolved to help organisms avoid harm and ensure survival.However,excessive fear me...Fear memory,a predictive and protective mechanism in potentially hostile environments,elicits defensive behavioral responses that have evolved to help organisms avoid harm and ensure survival.However,excessive fear memories may contribute to the onset of various psychological disorders,such as panic disorder,phobias,and post-traumatic stress disorder(PTSD).展开更多
The phenomenon of fear memory generalization can be defined as the expansion of an individual's originally specific fear responses to a similar yet genuinely harmless stimulus or situation subsequent to the occurr...The phenomenon of fear memory generalization can be defined as the expansion of an individual's originally specific fear responses to a similar yet genuinely harmless stimulus or situation subsequent to the occurrence of a traumatic event[1].Fear generalization within the normal range represents an adaptive evolutionary mechanism to facilitate prompt reactions to potential threats and to enhance the likelihood of survival.展开更多
Fear memory is crucial for survival and adaptation in complex and dynamically changing environments that enables individuals to avoid or escape from potentially dangerous situations.However,excessive fear memories can...Fear memory is crucial for survival and adaptation in complex and dynamically changing environments that enables individuals to avoid or escape from potentially dangerous situations.However,excessive fear memories can significantly contribute to emotional disabilities and mental disorders,including panic disorder,phobias,social anxiety disorder,and post-traumatic stress disorder(PTSD).展开更多
In the contemporary research landscape of mental illness treatment,fear-related disorders such as post-traumatic stress disorder continue to pose significant challenges.Although exposure therapy remains a fundamental ...In the contemporary research landscape of mental illness treatment,fear-related disorders such as post-traumatic stress disorder continue to pose significant challenges.Although exposure therapy remains a fundamental component of treatment,its efficacy varies considerably among individuals.DNA methylation plays a pivotal role in the extinction of fear memories,providing a promising molecular mechanism that could enhance the success of exposure-based interventions.Extensive studies have consistently demonstrated a substantial association between DNA methylation and neuronal plasticity.While DNA methylation holds potential regulatory effects on the effectiveness of exposure therapy,the bidirectional regulatory relationship between it and neuronal activity necessitates addressing several challenges before its widespread clinical application for mental disorders.First,excessive DNA methylation may suppress neural function,and non-selective enhancement of methylation could be counterproductive.Furthermore,due to potential systemic side effects,the use of methylation-modulating agents might disrupt the physiological balance and functionality of other organs and systems.Despite the dynamic interplay between DNA methylation and neuronal activity offering novel insights into the treatment of mental disorders, the strict consideration of target specificity and an appropriate dosing window requirescautious implementation in clinical practice.展开更多
BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social lives.However,these survivors encounter significant challenges during their...BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social lives.However,these survivors encounter significant challenges during their RTW process.Hence,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC survivors.AIM To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW outcomes.METHODS A cross-sectional investigation was adopted in this study.From September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in Chongqing.The investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and FT.To analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were used.RESULTS A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 days.Cox regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further improvement.Elevated levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC survivors.Health professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.展开更多
Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear memory.Cylindromatosis(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-...Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear memory.Cylindromatosis(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-B pathway.CYLD is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly expressed.Emerging studies have shown involvement of CYLD in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like behaviors.However,the precise role of CYLD in glutamatergic neurons is largely unknown.Here,we first proposed involvement of CYLD in cued fear expression.We next constructed transgenic model mice with specific deletion of Cyld from glutamatergic neurons.Our results show that glutamatergic CYLD deficiency exaggerated the expression of cued fear in only male mice.Further,loss of CYLD in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male mice.Altogether,our study suggests a critical role of glutamatergic CYLD in maintaining normal neuronal,synaptic,and microglial activation.This may contribute,at least in part,to cued fear expression.展开更多
BACKGROUND Fear of childbirth(FoC)is a widespread issue that impacts the health and well-being of mothers and newborns.However,there is inconsistency regarding the prevalence of FoC in the and there is limited researc...BACKGROUND Fear of childbirth(FoC)is a widespread issue that impacts the health and well-being of mothers and newborns.However,there is inconsistency regarding the prevalence of FoC in the and there is limited research on the prevalence of FoC among Australian pregnant women.AIM To investigate the prevalence of FoC,its risk factors and birth outcomes in Aust-ralian multiparous women.METHODS In this prospective cohort quantitative study,212 multiparous women were re-cruited from antenatal clinics at Westmead Hospital in western Sydney from 2019 to 2022.Pregnant women who attended antenatal visits and met the inclusion criteria signed the consent forms and completed several online questionnaires at baseline.After they gave birth,their birth outcomes were collected from the hospital’s medical record database.The data were analyzed using SPSS software and descriptive statistics,χ^(2)test,independent samples t-test,and multivariable logistic regression analysis.RESULTS Out of 212 participants,24%experienced a high level of FoC and 7%experienced severe FoC.Theχ^(2)test results revealed that a family income of≤$100000,no alcohol intake during pregnancy,pre-existing health problems,previous caesarean section(emergency or planned),and previous neutral/traumatic childbirth experiences were significantly associated with higher levels of FoC(P<0.05).Other risk factors included being moderately to very worried and fearful about the upcoming birth,having severe to extremely severe anxiety throughout pregnancy,and expressing low relationship satisfaction.According to multivariable logistic regression,the odds of a high level of FoC were higher in women with anxiety,a history of traumatic childbirth experience,a history of sexual assault during childhood,pre-existing health problems,and lower relationship satisfaction(P<0.05).CONCLUSION High-severe levels of FoC are experienced by pregnant multiparous women and are affected by several demo-graphic factors.However,due to the small sample size in the present study,further studies with larger sample sizes are required to draw a firm conclusion on the prevalence of severe FoC among multiparous women and its associated risk factors and birth outcomes.展开更多
Post-traumatic stress disorder(PTSD)is a psychiatric disorder caused by traumatic past experiences,rooted in the neurocircuits of fear memory formation.Memory processes include encoding,storing,and recalling to forget...Post-traumatic stress disorder(PTSD)is a psychiatric disorder caused by traumatic past experiences,rooted in the neurocircuits of fear memory formation.Memory processes include encoding,storing,and recalling to forgetting,suggesting the potential to erase fear memories through timely interventions.Conventional strategies such as medications or electroconvulsive therapy often fail to provide permanent relief and come with significant side-effects.This review explores how fear memory may be erased,particularly focusing on the mnemonic phases of reconsolidation and extinction.Reconsolidation strengthens memory,while extinction weakens it.Interfering with memory reconsolidation could diminish the fear response.Alternatively,the extinction of acquired memory could reduce the fear memory response.This review summarizes experimental animal models of PTSD,examines the nature and epidemiology of reconsolidation to extinction,and discusses current behavioral therapy aimed at transforming fear memories to treat PTSD.In sum,understanding how fear memory updates holds significant promise for PTSD treatment.展开更多
BACKGROUND Fear-related disorders,such as post-traumatic stress disorder(PTSD),significantly impact patients and families.Exposure therapy is a common treatment,but imp-roving its effectiveness remains a key challenge...BACKGROUND Fear-related disorders,such as post-traumatic stress disorder(PTSD),significantly impact patients and families.Exposure therapy is a common treatment,but imp-roving its effectiveness remains a key challenge.Fear conditioning and extinction in animal models offer insights into its mechanisms.Our previous research indi-cates that DNA methyltransferases play a role in fear memory renewal.AIM To investigate the role of DNA methylation in the extinction of fear memory,with the goal of identifying potential strategies to enhance the efficacy of exposure therapy for fear-related disorders.METHODS This study investigated the role of DNA methylation in fear memory extinction in mice.DNA methylation was manipulated using N-phthalyl-L-tryptophan(RG108)to reduce methylation and L-methionine injections to enhance it.Neuronal activity,and dendritic spine density was measured following extinction training.RESULTS RG108 suppressed extinction,reduced spine density,and inhibited neuronal activity.Methionine injections facilitated extinction.CONCLUSION DNA methylation is crucial for fear memory extinction.Enhancing methylation may improve the efficacy of exposure therapy,offering a potential strategy to treat fear-related disorders.展开更多
Objective:This study aimed to explore the effect of aromatherapy combined with emotional release technology on recurrence fear and sleep quality of lung cancer survivors.Methods:114 cases of lung cancer survivors were...Objective:This study aimed to explore the effect of aromatherapy combined with emotional release technology on recurrence fear and sleep quality of lung cancer survivors.Methods:114 cases of lung cancer survivors were divided into routine nursing group,emotional release technology group and aromatherapy combined with emotional release technology group.Routine nursing group received routine nursing;Emotional release technology group implemented emotional release technology for one month on the basis of routine nursing group;Aromatherapy combined with emotional release technology group used lavender aromatherapy on the basis of emotional release technology group.Results:After one month of intervention,there were statistically significant differences in the scores of fear of disease progression and sleep quality among the three groups.Conclusion:Aromatherapy combined with emotional release technology can improve the sleep quality of lung cancer survivors and reduce the economic toxicity of cancer to some extent.展开更多
The nonlinearity and fear hypothesis predicts that highly aroused vocal mammals and birds produce vocalizations(notably alarm calls and screams)which contain a variety of nonlinear phenomena(NLP).Such vocalizations of...The nonlinearity and fear hypothesis predicts that highly aroused vocal mammals and birds produce vocalizations(notably alarm calls and screams)which contain a variety of nonlinear phenomena(NLP).Such vocalizations often sound“noisy”because vocal production systems are over-blown when animals are highly aroused.While much is known about the conditions under which animals produce vocalizations containing NLP and how species respond to them,there is little research about the heritability of such behavioral traits.Using the quantitative genetic animal model,we estimated the genetic basis of“noise”in alarm calls produced by females and found significant heritability in call entropy-our measure of the noisiness.About 9%of the variance in noisiness can be accounted for by genetic differences.Taken together,these findings suggest that the degree to which marmots produce noisy calls is modestly heritable and can be thus subject to further evolution via natural selection.展开更多
Numerous studies on the formation and consolidation of memory have shown that memory processes are characterized by phase-dependent and dynamic regulation.Memory retrieval,as the only representation of memory content ...Numerous studies on the formation and consolidation of memory have shown that memory processes are characterized by phase-dependent and dynamic regulation.Memory retrieval,as the only representation of memory content and an active form of memory processing that induces memory reconsolidation,has attracted increasing attention in recent years.Although the molecular mechanisms specifc to memory retrievalinduced reconsolidation have been gradually revealed,an understanding of the time-dependent regulatory mechanisms of this process is still lacking.In this study,we applied a transcriptome analysis of memory retrieval at diferent time points in the recent memory stage.Diferential expression analysis and Short Time-series Expression Miner(STEM)depicting temporal gene expression patterns indicated that most diferential gene expression occurred at 48 h,and the STEM cluster showing the greatest transcriptional upregulation at 48 h demonstrated the most significant diference.We then screened the diferentially-expressed genes associated with that met the expression patterns of those cluster-identifed genes that have been reported to be involved in learning and memory processes in addition to dipeptidyl peptidase 9(DPP9).Further quantitative polymerase chain reaction verifcation and pharmacological intervention suggested that DPP9 is involved in 48-h fear memory retrieval and viral vector-mediated overexpression of DPP9 countered the 48-h retrieval-induced attenuation of fear memory.Taken together,our fndings suggest that temporal gene expression patterns are induced by recent memory retrieval and provide hitherto undocumented evidence of the role of DPP9 in the retrieval-induced reconsolidation of fear memory.展开更多
Background:As the digital age progresses,fear of missing out(FoMO)is becoming increasingly common,and the impact factor of FOMO needs to be further investigated.This study aims to explore the relationship between psyc...Background:As the digital age progresses,fear of missing out(FoMO)is becoming increasingly common,and the impact factor of FOMO needs to be further investigated.This study aims to explore the relationship between psychological security(PS)and FoMO by analyzing the mediating role of social networking addiction(SNA)and the moderating role of social self-efficacy(SSE).Methods:We collected a sample of 1181 college students(with a mean age of 19.671.38 years)from five universities in a province of China's Mainland through cluster sampling.Data±were gathered using the psychological security questionnaire(PSQ),the FoMO scale,the SNA scale,and the perceived social self-efficacy(PSSE)scale.Data analysis employed independent-sample t-tests,one-way analysis of variance(ANOVA),Harman’s single-factor test,confirmatory factor analysis,and moderated mediation analysis.Results:The results of the mediation model and moderated mediation model analyses showed the following key findings:(1)PS is significantly negatively correlated with FoMO;(2)SNA mediates the relationship between PS and FoMO;(3)SSE positively moderates the relationship between PS and FoMO;and(4)SSE also positively moderates the relationship between PS and SNA.Conclusion:University students’PS not only directly impacts FoMO but also indirectly influences it through SNA.Additionally,SSE positively moderates both the direct path and the first half of the mediation path,indicating that enhancing students’PS and SSE can help alleviate their SNA and FoMO,promoting their psychological and behavioral well-being.展开更多
Background:To understand the current situation of loneliness and dementia fear among elderly people in the community;Analyze the influencing factors and clarify the correlation between the two.Methods:Through convenie...Background:To understand the current situation of loneliness and dementia fear among elderly people in the community;Analyze the influencing factors and clarify the correlation between the two.Methods:Through convenience sampling,228 elderly people were selected as the research subjects,and the general demographic characteristics questionnaire,elderly loneliness scale,dementia fear scale,and simplified intelligence status check scale were used for investigation.SPSS 28.0 statistical software was used for data analysis.Results:The total score of loneliness was 96.21±21.83 points,and the total score of dementia fear was 59.34±13.50 points.There were statistically significant differences in dementia fear scores among elderly people in the community in terms of age,gender,marital status,family history of dementia,and number of chronic diseases(P<0.05).Person correlation analysis showed a positive correlation between the total score of dementia fear and loneliness in elderly people in the community(r=0.162,P<0.05).Conclusion:The level of loneliness and dementia fear among elderly people in the community is at a moderate level.Age,gender,marital status,family history of dementia,and number of chronic diseases are important influencing factors of dementia fear among elderly people in the community.The sense of loneliness among elderly people in the community is positively correlated with dementia fear,meaning that the greater the degree of loneliness,the higher the degree of dementia fear among elderly people in the community.展开更多
BACKGROUND Uncertainty in illness(UI)and fear of progression(FoP)are significant psycho-logical challenges for lung cancer patients.Coping styles and social support are critical mediators,influencing patients'abil...BACKGROUND Uncertainty in illness(UI)and fear of progression(FoP)are significant psycho-logical challenges for lung cancer patients.Coping styles and social support are critical mediators,influencing patients'ability to manage the emotional and psy-chological burden of UI and FoP.However,limited research has explored the chain mediation effect of these factors on the relationship between UI and FoP,particularly among Chinese lung cancer patients.Convenience sampling was used to recruit inpatients diagnosed with lung cancer at a tertiary hospital in Changde City between November and December 2023.A total of 320 participants completed the Mishel Uncertainty in Illness Scale,Simp-lified Coping Style Questionnaire,Mandarin Chinese Version of the Medical Outcomes Study Social Support Survey,and Fear of Progression Questionnaire-Short Form.The chain mediation analysis was performed using the PROCESS macro to examine the relationships between the variables.RESULTS The results revealed that UI had a significant direct effect on FoP(effect=0.224,95%CI:0.136-0.408).Additionally,three indirect pathways were identified:(1)Social support(effect=0.128,95%CI:0.045-0.153);(2)Coping style(effect=0.115,95%CI:0.048-0.157);and(3)Chain mediators involving social support and coping style(effect=0.072,95%CI:0.045-0.120).The total indirect effect of the three mediation paths is 31.5%.These results confirm that social support and coping style significantly mediate the relationship between UI and FoP.CONCLUSION Based on cross-sectional data and a chain mediation model,this study explored the mechanisms between UI,social support,coping style,and FOP.Patients with lung cancer have higher levels of FOP,and the results of this study revealed a correlation between these four factors.Social support and coping style partially mediated the effects of UI on FOP,and there was a chain-mediating effect between UI and FOP.Programs designed to strengthen social support networks should also incorporate training to develop adaptive coping strategies,ultimately reducing FOP and improving overall quality of life.展开更多
BACKGROUND Fear of cancer recurrence(FCR)is a common psychological problem among patients with cancer,especially elderly patients.For patients with gastric cancer(GC)who have undergone treatments such as surgery,FCR m...BACKGROUND Fear of cancer recurrence(FCR)is a common psychological problem among patients with cancer,especially elderly patients.For patients with gastric cancer(GC)who have undergone treatments such as surgery,FCR may seriously affect their quality of life and psychological well-being.AIM To evaluate the FCR in elderly patients with GC undergoing laparoscopic radical surgery in Hefei City and to explore its related influencing factors.METHODS In this study 264 elderly patients with GC who underwent laparoscopic radical surgery in four hospital districts of The First Affiliated Hospital of Anhui Medical University from June 2021 to January 2024 were recruited.Information on basic characteristics,disease characteristics,psychological status,and social support was collected by a questionnaire.In statistical analysis,the t-test andχ^(2) test were used to analyze the differences between groups.The influencing factors of FCR were analyzed by logistic regression.Based on these influencing factors,a nomogram model was initially constructed to identify patients with GC with high FCR risk.RESULTS Elderly patients with GC generally faced higher FCR levels after laparoscopic radical surgery.Among the 264 patients,168 had clinical symptoms of FCR,and the prevalence rate was 63.64%.Further analysis showed that older age,high mental resilience,and sufficient social support were favorable factors for reducing FCR level,while heavier self-perceived burden,low education level,shorter duration of disease,larger tumor diameter,and more complications were associated with a higher FCR level.CONCLUSION This study demonstrated the significance of psychological interventions and social support strategies in reducing FCR among elderly patients with GC.In the future treatment protocols should be further optimized,and psychological and social support should be enhanced to improve the quality of life for this patient population.展开更多
This study aims to understand the current status of fear of disease progression(FoP)in patients with coronary heart disease(CHD)following percutaneous coronary intervention(PCI),and to explore the relationship between...This study aims to understand the current status of fear of disease progression(FoP)in patients with coronary heart disease(CHD)following percutaneous coronary intervention(PCI),and to explore the relationship between FoP levels,perceived control,and medical coping strategies in these patients.A total of 360 CHD patients who underwent PCI at Xijing Hospital in Shaanxi Province between June and November 2024 were selected using a convenience sampling method.Surveys included a general information questionnaire,the Fear of Progression Questionnaire-Short Form(FoP-Q-SF),the revised Control Attitudes Scale(CAS-R),and the Medical Coping Modes Questionnaire(MCMQ).Pearson correlation analysis was used to examine the relationships between disease perception,positive coping strategies,and FoP.A total of 360 patients completed the study.The average score for FoP in patients with CHD after PCI was 31.64±4.61.FoP was negatively correlated with perceived control(r=-0.106,P<0.01)and medical coping(r=-0.194,P<0.01).Multivariate regression analysis showed that the type of intervention,family history of CHD,smoking status,perceived control,and total medical coping score were significant factors influencing FoP(P<0.01).Enhancing perceived control and identifying positive coping strategies can improve FoP levels in patients with CHD after PCI.Therefore,clinicians should focus on perceived control and medical coping levels in patients and develop targeted interventions to alleviate negative emotions related to FoP.展开更多
Background:Restrained eating,often motivated by the desire to control weight,is prevalent among young female college students and is considered a risk factor for eating disorders.Negative evaluation fear,exacerbated b...Background:Restrained eating,often motivated by the desire to control weight,is prevalent among young female college students and is considered a risk factor for eating disorders.Negative evaluation fear,exacerbated by social pressure,peer comparison,and academic stress,has been identified as a potential contributor to restrained eating behavior.However,research exploring the relationship between negative evaluation fear and restrained eating,particularly in the context of self-esteem and physical appearance perfectionism,remains limited.This study aims to investigate these relationships and design an intervention program to reduce restrained eating behaviors in female college students.Methods:Study 1 involved 617 female college students,using the Physical Appearance Perfectionism Scale,Rosenberg Self-Esteem Scale,Fear of Negative Evaluation Scale,and Dutch Eating Behavior Questionnaire to measure key variables.We examined the relationships between physical appearance perfectionism,self-esteem,fear of negative evaluation,and restrained eating.In Study 2,a 4-week group psychological intervention based on Acceptance and Commitment Therapy(ACT)was implemented with 45 students,divided into experimental,control,and placebo groups.The intervention’s effectiveness was assessed in reducing restrained eating and negative evaluation fear.Results:The study found that fear of negative evaluation significantly predicted restrained eating and physical appearance perfectionism.Physical appearance perfectionism,in turn,positively predicted restrained eating and partially mediated the relationship between negative evaluation fear and restrained eating.Self-esteem moderated this mediation effect.Additionally,the ACT-based intervention significantly reduced fear of negative evaluation and restrained eating behavior in the experimental group.Conclusion:This study identifies fear of negative evaluation and physical appearance perfectionism as key predictors of restrained eating in female college students.Fear of negative evaluation significantly predicted restrained eating,with physical appearance perfectionism partially mediating this relationship.The ACT-based intervention effectively reduced both fear of negative evaluation and restrained eating.These findings highlight the importance of addressing negative evaluation fear and appearance perfectionism in interventions for restrained eating.展开更多
Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement,allowing the organism to re-adapt to ever-changing situations.Based on the behavioral hypothesis that...Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement,allowing the organism to re-adapt to ever-changing situations.Based on the behavioral hypothesis that extinction is new learning and forms an extinction memory,this new memory is more readily forgettable than the original fear memory.The brain’s cellular and synaptic traces underpinning this inherently fragile yet reinforceable extinction memory remain unclear.Intriguing questions are about the whereabouts of the engram neurons that emerged during extinction learning and how they constitute a dynamically evolving functional construct that works in concert to store and express the extinction memory.In this review,we discuss recent advances in the engram circuits and their neural connectivity plasticity for fear extinction,aiming to establish a conceptual framework for understanding the dynamic competition between fear and extinction memories in adaptive control of conditioned fear responses.展开更多
BACKGROUND The mental well-being of individuals with coronary heart disease(CHD)during the intensive care unit(ICU)transition period is a multifaceted and significant concern.In this phase,the individuals might encoun...BACKGROUND The mental well-being of individuals with coronary heart disease(CHD)during the intensive care unit(ICU)transition period is a multifaceted and significant concern.In this phase,the individuals might encounter psychological challenges like anxiety and depression,which can impede their recuperation and potentially have lasting effects on their health.AIM To investigate the correlation among psychological factors in CHD patients in the ICU transition period.METHODS A questionnaire survey was conducted with 119 patients admitted to the ICU after coronary artery bypass grafting between March and December 2023.Variations in Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD),Fear of Progression Questionnaire-Short Form(Fop-Q-SF),and Social Support Rating Scale(SSRS)were collected and analyzed among diverse populations.We used Pearson’s correlation analysis to examine the correlation.Multiple linear regression analysis was used to explore whether these indicators influenced depression and anxiety in the patients.RESULTS The total scores for anxiety,depression,fear of disease progression,and social support were(7.50±1.41)points,(8.38±1.62)points,(35.19±8.14)points,and(36.34±7.08)points,respectively(P<0.05).Multivariate regression analysis showed that both the level of disease progression and social support affected the level of postoperative depression and anxiety in patients.CONCLUSION The anxiety and depression levels were positively related to each dimension of phobia disease progression and negatively related to each dimension of social support among patients with CHD.展开更多
基金supported by the National Natural Science Foundation of China(82104138)the Zhejiang Provincial Natural Science Foundation of China(LY24H310003).
文摘Fear memory,a predictive and protective mechanism in potentially hostile environments,elicits defensive behavioral responses that have evolved to help organisms avoid harm and ensure survival.However,excessive fear memories may contribute to the onset of various psychological disorders,such as panic disorder,phobias,and post-traumatic stress disorder(PTSD).
基金supported by the Shandong Provincial Natural Science Foundation(ZR2022QH144).
文摘The phenomenon of fear memory generalization can be defined as the expansion of an individual's originally specific fear responses to a similar yet genuinely harmless stimulus or situation subsequent to the occurrence of a traumatic event[1].Fear generalization within the normal range represents an adaptive evolutionary mechanism to facilitate prompt reactions to potential threats and to enhance the likelihood of survival.
文摘Fear memory is crucial for survival and adaptation in complex and dynamically changing environments that enables individuals to avoid or escape from potentially dangerous situations.However,excessive fear memories can significantly contribute to emotional disabilities and mental disorders,including panic disorder,phobias,social anxiety disorder,and post-traumatic stress disorder(PTSD).
基金Supported by the General Program of the Joint Fund Project Under the Liaoning Provincial Science and Technology Plan,No.2024-MSLH-104Research Project Plan of the Qingpu Branch of Zhongshan Hospital,No.QYT2023-02Research Topic of the Shanghai Qingpu District Health Commission,No.QWJ2024-10.
文摘In the contemporary research landscape of mental illness treatment,fear-related disorders such as post-traumatic stress disorder continue to pose significant challenges.Although exposure therapy remains a fundamental component of treatment,its efficacy varies considerably among individuals.DNA methylation plays a pivotal role in the extinction of fear memories,providing a promising molecular mechanism that could enhance the success of exposure-based interventions.Extensive studies have consistently demonstrated a substantial association between DNA methylation and neuronal plasticity.While DNA methylation holds potential regulatory effects on the effectiveness of exposure therapy,the bidirectional regulatory relationship between it and neuronal activity necessitates addressing several challenges before its widespread clinical application for mental disorders.First,excessive DNA methylation may suppress neural function,and non-selective enhancement of methylation could be counterproductive.Furthermore,due to potential systemic side effects,the use of methylation-modulating agents might disrupt the physiological balance and functionality of other organs and systems.Despite the dynamic interplay between DNA methylation and neuronal activity offering novel insights into the treatment of mental disorders, the strict consideration of target specificity and an appropriate dosing window requirescautious implementation in clinical practice.
基金Supported by the Chongqing Medical University Program for Youth Innovation in Future Medicine,No.W0019Chongqing Municipal Education Commission’s 14th Five-Year Key Discipline Support Project,No.20240101 and No.20240102。
文摘BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social lives.However,these survivors encounter significant challenges during their RTW process.Hence,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC survivors.AIM To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW outcomes.METHODS A cross-sectional investigation was adopted in this study.From September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in Chongqing.The investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and FT.To analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were used.RESULTS A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 days.Cox regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further improvement.Elevated levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC survivors.Health professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.
基金supported by the National Natural Science Foundation of China,Nos.32371065(to CL)and 32170950(to LY)the Natural Science Foundation of the Guangdong Province,No.2023A1515010899(to CL)the Science and Technology Projects in Guangzhou,Nos.2023A4J0578 and 2024A03J0180(to CW)。
文摘Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear memory.Cylindromatosis(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-B pathway.CYLD is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly expressed.Emerging studies have shown involvement of CYLD in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like behaviors.However,the precise role of CYLD in glutamatergic neurons is largely unknown.Here,we first proposed involvement of CYLD in cued fear expression.We next constructed transgenic model mice with specific deletion of Cyld from glutamatergic neurons.Our results show that glutamatergic CYLD deficiency exaggerated the expression of cued fear in only male mice.Further,loss of CYLD in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male mice.Altogether,our study suggests a critical role of glutamatergic CYLD in maintaining normal neuronal,synaptic,and microglial activation.This may contribute,at least in part,to cued fear expression.
文摘BACKGROUND Fear of childbirth(FoC)is a widespread issue that impacts the health and well-being of mothers and newborns.However,there is inconsistency regarding the prevalence of FoC in the and there is limited research on the prevalence of FoC among Australian pregnant women.AIM To investigate the prevalence of FoC,its risk factors and birth outcomes in Aust-ralian multiparous women.METHODS In this prospective cohort quantitative study,212 multiparous women were re-cruited from antenatal clinics at Westmead Hospital in western Sydney from 2019 to 2022.Pregnant women who attended antenatal visits and met the inclusion criteria signed the consent forms and completed several online questionnaires at baseline.After they gave birth,their birth outcomes were collected from the hospital’s medical record database.The data were analyzed using SPSS software and descriptive statistics,χ^(2)test,independent samples t-test,and multivariable logistic regression analysis.RESULTS Out of 212 participants,24%experienced a high level of FoC and 7%experienced severe FoC.Theχ^(2)test results revealed that a family income of≤$100000,no alcohol intake during pregnancy,pre-existing health problems,previous caesarean section(emergency or planned),and previous neutral/traumatic childbirth experiences were significantly associated with higher levels of FoC(P<0.05).Other risk factors included being moderately to very worried and fearful about the upcoming birth,having severe to extremely severe anxiety throughout pregnancy,and expressing low relationship satisfaction.According to multivariable logistic regression,the odds of a high level of FoC were higher in women with anxiety,a history of traumatic childbirth experience,a history of sexual assault during childhood,pre-existing health problems,and lower relationship satisfaction(P<0.05).CONCLUSION High-severe levels of FoC are experienced by pregnant multiparous women and are affected by several demo-graphic factors.However,due to the small sample size in the present study,further studies with larger sample sizes are required to draw a firm conclusion on the prevalence of severe FoC among multiparous women and its associated risk factors and birth outcomes.
基金supported by the National Key Research and Development Project of China(2021ZD0202800)the National Natural Science Foundation of China(U21A20418,82003727).
文摘Post-traumatic stress disorder(PTSD)is a psychiatric disorder caused by traumatic past experiences,rooted in the neurocircuits of fear memory formation.Memory processes include encoding,storing,and recalling to forgetting,suggesting the potential to erase fear memories through timely interventions.Conventional strategies such as medications or electroconvulsive therapy often fail to provide permanent relief and come with significant side-effects.This review explores how fear memory may be erased,particularly focusing on the mnemonic phases of reconsolidation and extinction.Reconsolidation strengthens memory,while extinction weakens it.Interfering with memory reconsolidation could diminish the fear response.Alternatively,the extinction of acquired memory could reduce the fear memory response.This review summarizes experimental animal models of PTSD,examines the nature and epidemiology of reconsolidation to extinction,and discusses current behavioral therapy aimed at transforming fear memories to treat PTSD.In sum,understanding how fear memory updates holds significant promise for PTSD treatment.
基金Supported by National Natural Science Foundation of China,No.82360231Yunnan Basic Research Program General Project,No.202401AT070075+1 种基金Dali Basic Research Program Key Project,No.202301A020021Youth Special Project for Basic Research of Local Universities in Yunnan Province,No.202301BA070001-127.
文摘BACKGROUND Fear-related disorders,such as post-traumatic stress disorder(PTSD),significantly impact patients and families.Exposure therapy is a common treatment,but imp-roving its effectiveness remains a key challenge.Fear conditioning and extinction in animal models offer insights into its mechanisms.Our previous research indi-cates that DNA methyltransferases play a role in fear memory renewal.AIM To investigate the role of DNA methylation in the extinction of fear memory,with the goal of identifying potential strategies to enhance the efficacy of exposure therapy for fear-related disorders.METHODS This study investigated the role of DNA methylation in fear memory extinction in mice.DNA methylation was manipulated using N-phthalyl-L-tryptophan(RG108)to reduce methylation and L-methionine injections to enhance it.Neuronal activity,and dendritic spine density was measured following extinction training.RESULTS RG108 suppressed extinction,reduced spine density,and inhibited neuronal activity.Methionine injections facilitated extinction.CONCLUSION DNA methylation is crucial for fear memory extinction.Enhancing methylation may improve the efficacy of exposure therapy,offering a potential strategy to treat fear-related disorders.
基金Guiding Science and Technology Program Project of Yichang City in 2024(Project No.:B24-2-002)。
文摘Objective:This study aimed to explore the effect of aromatherapy combined with emotional release technology on recurrence fear and sleep quality of lung cancer survivors.Methods:114 cases of lung cancer survivors were divided into routine nursing group,emotional release technology group and aromatherapy combined with emotional release technology group.Routine nursing group received routine nursing;Emotional release technology group implemented emotional release technology for one month on the basis of routine nursing group;Aromatherapy combined with emotional release technology group used lavender aromatherapy on the basis of emotional release technology group.Results:After one month of intervention,there were statistically significant differences in the scores of fear of disease progression and sleep quality among the three groups.Conclusion:Aromatherapy combined with emotional release technology can improve the sleep quality of lung cancer survivors and reduce the economic toxicity of cancer to some extent.
基金supported by the National Geographic Society,the University of California Los Angeles(Faculty Senate and Division of Life Sciences)an RMBL research fellowship and the U.S.National Science Foundation(NSF IDBR-0754247 and DEB-1119660 and 1557130 to D.T.B.,as well as DBI 0242960,07211346 and 1226713 to RMBL).
文摘The nonlinearity and fear hypothesis predicts that highly aroused vocal mammals and birds produce vocalizations(notably alarm calls and screams)which contain a variety of nonlinear phenomena(NLP).Such vocalizations often sound“noisy”because vocal production systems are over-blown when animals are highly aroused.While much is known about the conditions under which animals produce vocalizations containing NLP and how species respond to them,there is little research about the heritability of such behavioral traits.Using the quantitative genetic animal model,we estimated the genetic basis of“noise”in alarm calls produced by females and found significant heritability in call entropy-our measure of the noisiness.About 9%of the variance in noisiness can be accounted for by genetic differences.Taken together,these findings suggest that the degree to which marmots produce noisy calls is modestly heritable and can be thus subject to further evolution via natural selection.
基金supported by the STI2030-Major Projects(2022ZD0204900)the National Natural Science Foundation of China(32071029 and 32271080)+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32020200)the Yunnan Provincial Science and Technology Department(202402AA310014).
文摘Numerous studies on the formation and consolidation of memory have shown that memory processes are characterized by phase-dependent and dynamic regulation.Memory retrieval,as the only representation of memory content and an active form of memory processing that induces memory reconsolidation,has attracted increasing attention in recent years.Although the molecular mechanisms specifc to memory retrievalinduced reconsolidation have been gradually revealed,an understanding of the time-dependent regulatory mechanisms of this process is still lacking.In this study,we applied a transcriptome analysis of memory retrieval at diferent time points in the recent memory stage.Diferential expression analysis and Short Time-series Expression Miner(STEM)depicting temporal gene expression patterns indicated that most diferential gene expression occurred at 48 h,and the STEM cluster showing the greatest transcriptional upregulation at 48 h demonstrated the most significant diference.We then screened the diferentially-expressed genes associated with that met the expression patterns of those cluster-identifed genes that have been reported to be involved in learning and memory processes in addition to dipeptidyl peptidase 9(DPP9).Further quantitative polymerase chain reaction verifcation and pharmacological intervention suggested that DPP9 is involved in 48-h fear memory retrieval and viral vector-mediated overexpression of DPP9 countered the 48-h retrieval-induced attenuation of fear memory.Taken together,our fndings suggest that temporal gene expression patterns are induced by recent memory retrieval and provide hitherto undocumented evidence of the role of DPP9 in the retrieval-induced reconsolidation of fear memory.
基金supported by the Jiangxi Province Think Tank Research Project(ZK202406)the 2023 Jiangxi Provincial Health Commission Research Project(52524010)。
文摘Background:As the digital age progresses,fear of missing out(FoMO)is becoming increasingly common,and the impact factor of FOMO needs to be further investigated.This study aims to explore the relationship between psychological security(PS)and FoMO by analyzing the mediating role of social networking addiction(SNA)and the moderating role of social self-efficacy(SSE).Methods:We collected a sample of 1181 college students(with a mean age of 19.671.38 years)from five universities in a province of China's Mainland through cluster sampling.Data±were gathered using the psychological security questionnaire(PSQ),the FoMO scale,the SNA scale,and the perceived social self-efficacy(PSSE)scale.Data analysis employed independent-sample t-tests,one-way analysis of variance(ANOVA),Harman’s single-factor test,confirmatory factor analysis,and moderated mediation analysis.Results:The results of the mediation model and moderated mediation model analyses showed the following key findings:(1)PS is significantly negatively correlated with FoMO;(2)SNA mediates the relationship between PS and FoMO;(3)SSE positively moderates the relationship between PS and FoMO;and(4)SSE also positively moderates the relationship between PS and SNA.Conclusion:University students’PS not only directly impacts FoMO but also indirectly influences it through SNA.Additionally,SSE positively moderates both the direct path and the first half of the mediation path,indicating that enhancing students’PS and SSE can help alleviate their SNA and FoMO,promoting their psychological and behavioral well-being.
文摘Background:To understand the current situation of loneliness and dementia fear among elderly people in the community;Analyze the influencing factors and clarify the correlation between the two.Methods:Through convenience sampling,228 elderly people were selected as the research subjects,and the general demographic characteristics questionnaire,elderly loneliness scale,dementia fear scale,and simplified intelligence status check scale were used for investigation.SPSS 28.0 statistical software was used for data analysis.Results:The total score of loneliness was 96.21±21.83 points,and the total score of dementia fear was 59.34±13.50 points.There were statistically significant differences in dementia fear scores among elderly people in the community in terms of age,gender,marital status,family history of dementia,and number of chronic diseases(P<0.05).Person correlation analysis showed a positive correlation between the total score of dementia fear and loneliness in elderly people in the community(r=0.162,P<0.05).Conclusion:The level of loneliness and dementia fear among elderly people in the community is at a moderate level.Age,gender,marital status,family history of dementia,and number of chronic diseases are important influencing factors of dementia fear among elderly people in the community.The sense of loneliness among elderly people in the community is positively correlated with dementia fear,meaning that the greater the degree of loneliness,the higher the degree of dementia fear among elderly people in the community.
基金Supported by Hunan Provincial Natural Science Foundation of China,No.2024JJ9579 and No.2025JJ80410The Science and Technology Innovation Program of Changde City,No.2023YD23.
文摘BACKGROUND Uncertainty in illness(UI)and fear of progression(FoP)are significant psycho-logical challenges for lung cancer patients.Coping styles and social support are critical mediators,influencing patients'ability to manage the emotional and psy-chological burden of UI and FoP.However,limited research has explored the chain mediation effect of these factors on the relationship between UI and FoP,particularly among Chinese lung cancer patients.Convenience sampling was used to recruit inpatients diagnosed with lung cancer at a tertiary hospital in Changde City between November and December 2023.A total of 320 participants completed the Mishel Uncertainty in Illness Scale,Simp-lified Coping Style Questionnaire,Mandarin Chinese Version of the Medical Outcomes Study Social Support Survey,and Fear of Progression Questionnaire-Short Form.The chain mediation analysis was performed using the PROCESS macro to examine the relationships between the variables.RESULTS The results revealed that UI had a significant direct effect on FoP(effect=0.224,95%CI:0.136-0.408).Additionally,three indirect pathways were identified:(1)Social support(effect=0.128,95%CI:0.045-0.153);(2)Coping style(effect=0.115,95%CI:0.048-0.157);and(3)Chain mediators involving social support and coping style(effect=0.072,95%CI:0.045-0.120).The total indirect effect of the three mediation paths is 31.5%.These results confirm that social support and coping style significantly mediate the relationship between UI and FoP.CONCLUSION Based on cross-sectional data and a chain mediation model,this study explored the mechanisms between UI,social support,coping style,and FOP.Patients with lung cancer have higher levels of FOP,and the results of this study revealed a correlation between these four factors.Social support and coping style partially mediated the effects of UI on FOP,and there was a chain-mediating effect between UI and FOP.Programs designed to strengthen social support networks should also incorporate training to develop adaptive coping strategies,ultimately reducing FOP and improving overall quality of life.
文摘BACKGROUND Fear of cancer recurrence(FCR)is a common psychological problem among patients with cancer,especially elderly patients.For patients with gastric cancer(GC)who have undergone treatments such as surgery,FCR may seriously affect their quality of life and psychological well-being.AIM To evaluate the FCR in elderly patients with GC undergoing laparoscopic radical surgery in Hefei City and to explore its related influencing factors.METHODS In this study 264 elderly patients with GC who underwent laparoscopic radical surgery in four hospital districts of The First Affiliated Hospital of Anhui Medical University from June 2021 to January 2024 were recruited.Information on basic characteristics,disease characteristics,psychological status,and social support was collected by a questionnaire.In statistical analysis,the t-test andχ^(2) test were used to analyze the differences between groups.The influencing factors of FCR were analyzed by logistic regression.Based on these influencing factors,a nomogram model was initially constructed to identify patients with GC with high FCR risk.RESULTS Elderly patients with GC generally faced higher FCR levels after laparoscopic radical surgery.Among the 264 patients,168 had clinical symptoms of FCR,and the prevalence rate was 63.64%.Further analysis showed that older age,high mental resilience,and sufficient social support were favorable factors for reducing FCR level,while heavier self-perceived burden,low education level,shorter duration of disease,larger tumor diameter,and more complications were associated with a higher FCR level.CONCLUSION This study demonstrated the significance of psychological interventions and social support strategies in reducing FCR among elderly patients with GC.In the future treatment protocols should be further optimized,and psychological and social support should be enhanced to improve the quality of life for this patient population.
文摘This study aims to understand the current status of fear of disease progression(FoP)in patients with coronary heart disease(CHD)following percutaneous coronary intervention(PCI),and to explore the relationship between FoP levels,perceived control,and medical coping strategies in these patients.A total of 360 CHD patients who underwent PCI at Xijing Hospital in Shaanxi Province between June and November 2024 were selected using a convenience sampling method.Surveys included a general information questionnaire,the Fear of Progression Questionnaire-Short Form(FoP-Q-SF),the revised Control Attitudes Scale(CAS-R),and the Medical Coping Modes Questionnaire(MCMQ).Pearson correlation analysis was used to examine the relationships between disease perception,positive coping strategies,and FoP.A total of 360 patients completed the study.The average score for FoP in patients with CHD after PCI was 31.64±4.61.FoP was negatively correlated with perceived control(r=-0.106,P<0.01)and medical coping(r=-0.194,P<0.01).Multivariate regression analysis showed that the type of intervention,family history of CHD,smoking status,perceived control,and total medical coping score were significant factors influencing FoP(P<0.01).Enhancing perceived control and identifying positive coping strategies can improve FoP levels in patients with CHD after PCI.Therefore,clinicians should focus on perceived control and medical coping levels in patients and develop targeted interventions to alleviate negative emotions related to FoP.
文摘Background:Restrained eating,often motivated by the desire to control weight,is prevalent among young female college students and is considered a risk factor for eating disorders.Negative evaluation fear,exacerbated by social pressure,peer comparison,and academic stress,has been identified as a potential contributor to restrained eating behavior.However,research exploring the relationship between negative evaluation fear and restrained eating,particularly in the context of self-esteem and physical appearance perfectionism,remains limited.This study aims to investigate these relationships and design an intervention program to reduce restrained eating behaviors in female college students.Methods:Study 1 involved 617 female college students,using the Physical Appearance Perfectionism Scale,Rosenberg Self-Esteem Scale,Fear of Negative Evaluation Scale,and Dutch Eating Behavior Questionnaire to measure key variables.We examined the relationships between physical appearance perfectionism,self-esteem,fear of negative evaluation,and restrained eating.In Study 2,a 4-week group psychological intervention based on Acceptance and Commitment Therapy(ACT)was implemented with 45 students,divided into experimental,control,and placebo groups.The intervention’s effectiveness was assessed in reducing restrained eating and negative evaluation fear.Results:The study found that fear of negative evaluation significantly predicted restrained eating and physical appearance perfectionism.Physical appearance perfectionism,in turn,positively predicted restrained eating and partially mediated the relationship between negative evaluation fear and restrained eating.Self-esteem moderated this mediation effect.Additionally,the ACT-based intervention significantly reduced fear of negative evaluation and restrained eating behavior in the experimental group.Conclusion:This study identifies fear of negative evaluation and physical appearance perfectionism as key predictors of restrained eating in female college students.Fear of negative evaluation significantly predicted restrained eating,with physical appearance perfectionism partially mediating this relationship.The ACT-based intervention effectively reduced both fear of negative evaluation and restrained eating.These findings highlight the importance of addressing negative evaluation fear and appearance perfectionism in interventions for restrained eating.
基金supported by grants from the STI2030-Major Projects(2021ZD0202800)the National Natural Science Foundation of China(32071023 and 32371078)+2 种基金the Program of Shanghai Academic/Technology Research Leader(22XD1420700)the Shanghai Municipal Health Commission(2022XD046)Innovative Research Team of High-Level Local Universities in Shanghai.
文摘Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement,allowing the organism to re-adapt to ever-changing situations.Based on the behavioral hypothesis that extinction is new learning and forms an extinction memory,this new memory is more readily forgettable than the original fear memory.The brain’s cellular and synaptic traces underpinning this inherently fragile yet reinforceable extinction memory remain unclear.Intriguing questions are about the whereabouts of the engram neurons that emerged during extinction learning and how they constitute a dynamically evolving functional construct that works in concert to store and express the extinction memory.In this review,we discuss recent advances in the engram circuits and their neural connectivity plasticity for fear extinction,aiming to establish a conceptual framework for understanding the dynamic competition between fear and extinction memories in adaptive control of conditioned fear responses.
文摘BACKGROUND The mental well-being of individuals with coronary heart disease(CHD)during the intensive care unit(ICU)transition period is a multifaceted and significant concern.In this phase,the individuals might encounter psychological challenges like anxiety and depression,which can impede their recuperation and potentially have lasting effects on their health.AIM To investigate the correlation among psychological factors in CHD patients in the ICU transition period.METHODS A questionnaire survey was conducted with 119 patients admitted to the ICU after coronary artery bypass grafting between March and December 2023.Variations in Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD),Fear of Progression Questionnaire-Short Form(Fop-Q-SF),and Social Support Rating Scale(SSRS)were collected and analyzed among diverse populations.We used Pearson’s correlation analysis to examine the correlation.Multiple linear regression analysis was used to explore whether these indicators influenced depression and anxiety in the patients.RESULTS The total scores for anxiety,depression,fear of disease progression,and social support were(7.50±1.41)points,(8.38±1.62)points,(35.19±8.14)points,and(36.34±7.08)points,respectively(P<0.05).Multivariate regression analysis showed that both the level of disease progression and social support affected the level of postoperative depression and anxiety in patients.CONCLUSION The anxiety and depression levels were positively related to each dimension of phobia disease progression and negatively related to each dimension of social support among patients with CHD.
