本文阐述了应用FastMap算法研究类风湿病通路基因在1号染色体上的连锁特性的方法和结果。结果发现,在FGF Signaling in Rheumatoid Arthritis通路中,CTSB、PRKC、ACAT2和MAPK1出现了相似的连锁特性。在IFN Signaling in Rheumatoid Arth...本文阐述了应用FastMap算法研究类风湿病通路基因在1号染色体上的连锁特性的方法和结果。结果发现,在FGF Signaling in Rheumatoid Arthritis通路中,CTSB、PRKC、ACAT2和MAPK1出现了相似的连锁特性。在IFN Signaling in Rheumatoid Arthritis通路中,IL15、HLA-DR和HLA-DQA1出现了相似的连锁特性。在IL10 Signaling in Rheumatoid Arthritis通路中,HLA-DR和TGFB1,CXCR4和CD86出现了相似的连锁特性。该结果说明同一通路中的基因存在相似的连锁特性,这些基因可能具有潜在的相似功能。展开更多
Many database applications currently deal with objects in a metric space.Examples of such objects include unstructured multimedia objects and points of interest(POIs)in a road network.The M-tree is a dynamic index str...Many database applications currently deal with objects in a metric space.Examples of such objects include unstructured multimedia objects and points of interest(POIs)in a road network.The M-tree is a dynamic index structure that facilitates an efficient search for objects in a metric space.Studies have been conducted on the bulk loading of large datasets in an M-tree.However,because previous algorithms involve excessive distance computations and disk accesses,they perform poorly in terms of their index construction and search capability.This study proposes two efficient M-tree bulk loading algorithms.Our algorithms minimize the number of distance computations and disk accesses using FastMap and a space-filling curve,thereby significantly improving the index construction and search performance.Our second algorithm is an extension of the first,and it incorporates a partitioning clustering technique and flexible node architecture to further improve the search performance.Through the use of various synthetic and real-world datasets,the experimental results demonstrated that our algorithms improved the index construction performance by up to three orders of magnitude and the search performance by up to 20.3 times over the previous algorithm.展开更多
文摘本文阐述了应用FastMap算法研究类风湿病通路基因在1号染色体上的连锁特性的方法和结果。结果发现,在FGF Signaling in Rheumatoid Arthritis通路中,CTSB、PRKC、ACAT2和MAPK1出现了相似的连锁特性。在IFN Signaling in Rheumatoid Arthritis通路中,IL15、HLA-DR和HLA-DQA1出现了相似的连锁特性。在IL10 Signaling in Rheumatoid Arthritis通路中,HLA-DR和TGFB1,CXCR4和CD86出现了相似的连锁特性。该结果说明同一通路中的基因存在相似的连锁特性,这些基因可能具有潜在的相似功能。
基金the National Research Foundation of Korea(NRF,www.nrf.re.kr)grant funded by the Korean government(MSIT,www.msit.go.kr)(No.2018R1A2B6009188)(received by W.-K.Loh).
文摘Many database applications currently deal with objects in a metric space.Examples of such objects include unstructured multimedia objects and points of interest(POIs)in a road network.The M-tree is a dynamic index structure that facilitates an efficient search for objects in a metric space.Studies have been conducted on the bulk loading of large datasets in an M-tree.However,because previous algorithms involve excessive distance computations and disk accesses,they perform poorly in terms of their index construction and search capability.This study proposes two efficient M-tree bulk loading algorithms.Our algorithms minimize the number of distance computations and disk accesses using FastMap and a space-filling curve,thereby significantly improving the index construction and search performance.Our second algorithm is an extension of the first,and it incorporates a partitioning clustering technique and flexible node architecture to further improve the search performance.Through the use of various synthetic and real-world datasets,the experimental results demonstrated that our algorithms improved the index construction performance by up to three orders of magnitude and the search performance by up to 20.3 times over the previous algorithm.
