Arbitration is a key non-litigation commercial mechanism for the resolution of disputes, and the quality and credibility of its awards depend largely on the competency of the arbitrators. However, the selection and ev...Arbitration is a key non-litigation commercial mechanism for the resolution of disputes, and the quality and credibility of its awards depend largely on the competency of the arbitrators. However, the selection and evaluation systems for arbitrators in China have long faced challenges such as the vague criteria for competency and an unclear professionalization path for arbitrators. To address these issues, this study is grounded in the context of actual Chinese arbitration practice and based on the competency iceberg model. Through a methodological approach encompassing literature reviews, behavioral event interviews, expert revisions, and questionnaire surveys, a Chinese Arbitrator Competency Scale was developed and validated in this study. Examination of the findings indicated that the scale needed to consist of five dimensions—communication and coordination, cognitive skills, ethical conduct, work motivation, and personality traits—and possess a total of 28 specific indicators. Confirmatory analysis of the factors demonstrates a good fit for the five-dimensional model, with each of the dimensions exhibiting high reliability and validity. This scale is innovative in integrating the competency elements with Chinese characteristics, such as commercial acumen, crosscultural mediation skills, and adaptability to the local rule of law. This research not only enriches the competency theory in regard to the field of human resource management but also provides a scientific framework of standards and measurement tools for the selection, training, and evaluation of arbitrators. It thus has significant practical value for enhancing the professionalism and international competitiveness of China's arbitration system.展开更多
The promotion of rural revitalization within the ecological conservation areas(“ECAs”) requires a careful balance between ecological protection and economic development and should be guided by the principle of ecolo...The promotion of rural revitalization within the ecological conservation areas(“ECAs”) requires a careful balance between ecological protection and economic development and should be guided by the principle of ecological priority. The cultivation of rural “Local Specialty Products”(“LSPs”) under a green-development framework aligns with the functional positioning of these areas, drives the revitalization of rural industries, and constitutes a fundamental strategy for addressing the unique challenges they face. Although ECAs possess inherent advantages in terms of developing LSPs, they are also confronted by multiple constraints. Accordingly, we propose development objectives that emphasize(a) driving rural industrial prosperity,(b) enhancing the appeal of agricultural heritage, and(c) ensuring inclusive prosperity in the farming communities. In selecting pathways for growth, priority should be given to improving the quality of products, fostering distinctiveness of the technologies, nurturing cultural identities, and upholding the principle of common prosperity. From a policy standpoint, the development of rural LSPs should be recognized as a key lever for advancing the comprehensiveness of rural revitalization in the ECAs. We recommend a set of supportive measures—namely, reinforcing the guidance for spatial planning, integrating the consolidation of factor inputs, and ensuring the robustness of organizational guarantees—to facilitate the high-quality development of LSPs in these areas.展开更多
Asia‐Pacific’s fast‐developing countries and regions(FDCs)—South Korea,Taiwan Province of China,Singapore,Malaysia,and Thailand—demonstrate the most successful economic development models.The government represent...Asia‐Pacific’s fast‐developing countries and regions(FDCs)—South Korea,Taiwan Province of China,Singapore,Malaysia,and Thailand—demonstrate the most successful economic development models.The government represents the primary guarantee of FDCs’economic and social construction.Public and foreign investments and government policies to stimulate local and foreign businesses play a decisive role in the development of technological innovations in these FDCs.In these countries,basic research is increasing through the development of knowledge‐based industries,the role of research institutes,the applied research undertaken,and the value of educational institutions.Close cooperation between science and industry led to a change in the structure and nature of the economy,which has become increasingly dependent on new knowledge and ideas.展开更多
The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established b...The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established by the World Health Organization(WHO). Reform in China has demonstrated the unwavering confidence and utmost determination of the Chinese government and the Chinese transplantation community. The year 2015 marked a historic turning point when voluntary donations from Chinese citizens became the sole legitimate source for organ transplantation. Since 2015, China has gradually established and refined the “Chinese Mode” and “China System” for organ donation and transplantation, fulfilling its political pledge of reform, and has garnered international recognition, and fostered a social culture which promotes organ donation. This article reviewed the history of reform on organ donation and transplantation in China, presented a new pattern of establishment of organ donation system in the new era of the country, and the direction of advances in the future.展开更多
Energy poverty in developing countries is a critical issue characterized by the lack of access to modern energy services,such as electricity and clean cooking facilities,as marked in SDG 7.This study explores the corr...Energy poverty in developing countries is a critical issue characterized by the lack of access to modern energy services,such as electricity and clean cooking facilities,as marked in SDG 7.This study explores the correlations between energy poverty,energy intensity,resource abundance,and income inequality,as these factors have been theorized to play important roles in influencing energy poverty in developing countries.By observing that the dataset is heterogeneous across the countries and over the time frame,we use the Method of Moments Quantile Regression(MMQR)to analyze our developing countries’data from 2000 to 2019.Our findings indicate that energy intensity is a significant factor influencing energy poverty,suggesting that higher energy consumption relative to the sample countries can exacerbate this issue.Additionally,we observe that income inequality within the sample countries is a critical determinant of energy poverty levels,highlighting the dynamics between economic disparity and access to energy resources.Interestingly,our study reveals that resource abundance acts as a blessing rather than a curse in terms of energy poverty,implying that countries rich in natural resources may have better opportunities to combat energy deprivation.Finally,we emphasize the vital role of financial markets in addressing energy poverty on a global scale,suggesting that robust financial systems can facilitate investments and innovations aimed at improving energy access for vulnerable populations.The results from the robustness analysis support the empirical results obtained from the main estimation.The empirical findings of the present study advance important comprehensions for policymakers to adopt energy policies that address the complex challenges of energy poverty and promote inclusive energy access.展开更多
River ethics,a significant advancement inspired by Chinese President XI Jinping's ecological civilization thought,embodies the philosophical essence of river governance and represents a legacy of innovation by gen...River ethics,a significant advancement inspired by Chinese President XI Jinping's ecological civilization thought,embodies the philosophical essence of river governance and represents a legacy of innovation by generations of water resources professionals.Rooted in river ecology,it offers a framework for advancing modern water governance systems and capabilities.This paper examines eight dimensions of river ethics to provide actionable recommendations:enhancing knowledge systems on water,rivers,and lakes;addressing critical challenges in water governance to strengthen the foundational role of water authorities in ensuring water security,resource management,ecological sustainability and environmental protection;optimizing water project planning to mitigate ecological impacts;ensuring high standards in the lifecycle management of water projects;refining water diversion strategies for precise scheduling;utilizing ecosystem complexity for river and lake restoration;implementing tiered management of water-related disasters;and driving reforms to modernize water governance systems and mechanisms.展开更多
Foreign-funded overseas industrial parks(OIPs)are crucial for attracting foreign investment and promoting globalization in developing countries.However,large-scale land acquisition for these parks generates conflicts ...Foreign-funded overseas industrial parks(OIPs)are crucial for attracting foreign investment and promoting globalization in developing countries.However,large-scale land acquisition for these parks generates conflicts between developers and local stakeholders,increasing development costs.A qualitative multicase study was conducted in this study to analyze the land transaction trajectories of China's OIPs.Four OIPs were selected to reveal the underlying mechanisms from the perspectives of institutional arrangements,governance mechanisms,and enterprise heterogeneity.The findings indicate that in host countries with insufficient institutional development,local governments are more inclined to directly engage in OIP land acquisition.High-level intergovernmental mechanisms facilitate land acquisition processes,although their efficacy depends largely on administrative power allocation across parks in host countries.The results also indicate that enterprise characteristics significantly influence land acquisition,where microscale private enterprises lacking political connections often employ low-cost,bottom-up strategies by leveraging international experience.In summary,policy-makers in developing countries should prioritize enhancing OIP governance to mitigate transaction costs,promote diversified land supply,and optimize land allocation.By depicting China's OIP land acquisition processes,this study deepens the academic understanding of OIP governance in developing countries and related international land transactions,offering practical OIP management insights for governments in both host and parent countries.展开更多
We do so much to prepare our children for the future,but are we doing enough to prepare the future for our children?To do so we must seek sustainability.Sustainability is a new way of thinking about an age-old concern...We do so much to prepare our children for the future,but are we doing enough to prepare the future for our children?To do so we must seek sustainability.Sustainability is a new way of thinking about an age-old concern:ensuring that our children and grandchildren inherit a tomorrow that is at least as good as today,preferably better.We want to make sure that the way we live our lives is sustainable that can continue and keep improving for long time.And since buildings produce half of all greenhouse gases and account for one-sixth of the world's freshwater withdrawals,one-quarter of its wood harvest and two fifths of its material and energy flows.By several estimates,we will double the size of the built environment over the next twenty to forty years.Therefore,there is a critical and immediate need to shift thinking on how the built environment is designed.To reduce environmental impact,protect public health and improve environmental equity and justice,we must change principles for building practice.Designers in general and architects in particular should play a high-profile leadership role in this transformation.展开更多
Building Information Modelling(BIM)technology can solve construction issues from multiple perspectives,including technical and managerial.While existing research has primarily focused on BIM’s benefits and framework ...Building Information Modelling(BIM)technology can solve construction issues from multiple perspectives,including technical and managerial.While existing research has primarily focused on BIM’s benefits and framework development,few studies discussed whether BIM can be successfully applied in developing countries.This paper examines the current status and key obstacles hindering BIM adoption in developing countries,analyzing their underlying causes.Notably,the study reveals that high BIM awareness does not directly lead to high BIM usage.The findings aim to provide theoretical support for enhancing the BIM environment and increasing implementation feasibility in developing countries.Additionally,the research identifies critical barriers for governments to address in promoting BIM adoption,offering a foundation for policy formulation.展开更多
Cardiolipins(CLs),the mitochondria-specific class of phospholipids,are crucial to energy metabolism,cristae structure,and cell apoptosis.CLs present significant challenges in lipidomics analysis due to their structura...Cardiolipins(CLs),the mitochondria-specific class of phospholipids,are crucial to energy metabolism,cristae structure,and cell apoptosis.CLs present significant challenges in lipidomics analysis due to their structural diversity with up to four fatty acyl side chains.In this study,we developed CLAN(Cardio Lipin ANalysis),a comprehensive computational pipeline designed to improve the accuracy and coverage of cardiolipin identification.CLAN integrates three innovative modules:A cardiolipin identification module that utilizes specific fragmentation rules for precise characterization of CLs and their acyl side chains;a false positives detection module that employs retention time(RT)criteria to reduce false positives;and a prediction module that constructs regression models to identify CLs lacking authentic MS/MS spectra.CLAN achieved better identification accuracy and the highest recall rate for potential CL identification compared to the existing lipid identification tools.Furthermore,we applied CLAN program to an intermittent fasting mouse model,delineating tissue-specific CL alterations across 10 tissues.Every-other-day fasting(EODF)can partially counteract the disruption of the CL atlas across multiple tissues caused by high-fat-high-sugar diet feeding,providing novel insights into mitochondrial lipid metabolism under dietary interventions.Taken together,this work not only advances CL identification methodology but also underscores CLAN's potential in comprehensive analysis of CL atlas in the EODF animal model.CLAN is freely accessible on Git Hub.展开更多
The oxytocin receptor(OXTR)has garnered increasing attention for its role in regulating both mature behaviors and brain development.It has been established that OXTR mediates a range of effects that are regionspecifc ...The oxytocin receptor(OXTR)has garnered increasing attention for its role in regulating both mature behaviors and brain development.It has been established that OXTR mediates a range of effects that are regionspecifc or period-specifc.However,the current studies of OXTR expression patterns in mice only provide limited help due to limitations in resolution.Therefore,our objective was to generate a comprehensive,high-resolution spatiotemporal expression map of Oxtr mRNA across the entire developing mouse brain.We applied RNAscope in situ hybridization to investigate the spatiotemporal expression pattern of Oxtr in the brains of male mice at six distinct postnatal developmental stages(P7,P14,P21,P28,P42,P56).We provide detailed descriptions of Oxtr expression patterns in key brain regions,including the cortex,basal forebrain,hippocampus,and amygdaloid complex,with a focus on the precise localization of Oxtr+cells and the variance of expression between diferent neurons.Furthermore,we identifed some neuronal populations with high Oxtr expression levels that have been little studied,including glutamatergic neurons in the ventral dentate gyrus,Vgat+Oxtr+cells in the basal forebrain,and GABAergic neurons in layers 4/5 of the cortex.Our study provides a novel perspective for understanding the distribution of Oxtr and encourages further investigations into its functions.展开更多
The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regul...The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.展开更多
This study aims to understand the behavior of the Bugis community in developing vernacular house models in the coastal areas of South Sulawesi Province,along with the factors influencing this behavior,such as knowledg...This study aims to understand the behavior of the Bugis community in developing vernacular house models in the coastal areas of South Sulawesi Province,along with the factors influencing this behavior,such as knowledge,motivation,attitude,locus of control,commitment,concern,and income level.Bugis vernacular houses reflect local wisdom that is adapted to environmental,socio-cultural conditions,and the challenges of modernization.This correlational research was conducted in the regencies of Pangkajene and Kepulauan,Barru,and Bone,with a sample of 300 household heads.The variables analyzed include knowledge,motivation,attitude,locus of control,commitment,concern,and income level.Data were collected through knowledge tests and questionnaires and were analyzed using simple and multiple regression tech-niques.The results show that the Bugis community’s behavior in developing vernacular houses is moderate.Individually,motivation,locus of control,commitment,and concern significantly influence behavior,while knowledge,attitude,and income do not have a significant impact.However,collectively,all independent variables(knowledge,motivation,attitude,locus of control,commitment,concern,and income)affect the behavior of the Bugis community in developing vernacular houses in coastal areas.This study provides valuable insights into the environmental and social adaptations of the Bugis coastal community,as well as efforts to preserve culture through the sustainable development of vernacular houses.展开更多
基金Research on Problems and Countermeasures in Building the Capacity of the Grassroots International Chambers of Commerce in the Context of High-Quality Development (W2024H03841)a key research project of the China Council for the Promotion of International Trade in 2025。
文摘Arbitration is a key non-litigation commercial mechanism for the resolution of disputes, and the quality and credibility of its awards depend largely on the competency of the arbitrators. However, the selection and evaluation systems for arbitrators in China have long faced challenges such as the vague criteria for competency and an unclear professionalization path for arbitrators. To address these issues, this study is grounded in the context of actual Chinese arbitration practice and based on the competency iceberg model. Through a methodological approach encompassing literature reviews, behavioral event interviews, expert revisions, and questionnaire surveys, a Chinese Arbitrator Competency Scale was developed and validated in this study. Examination of the findings indicated that the scale needed to consist of five dimensions—communication and coordination, cognitive skills, ethical conduct, work motivation, and personality traits—and possess a total of 28 specific indicators. Confirmatory analysis of the factors demonstrates a good fit for the five-dimensional model, with each of the dimensions exhibiting high reliability and validity. This scale is innovative in integrating the competency elements with Chinese characteristics, such as commercial acumen, crosscultural mediation skills, and adaptability to the local rule of law. This research not only enriches the competency theory in regard to the field of human resource management but also provides a scientific framework of standards and measurement tools for the selection, training, and evaluation of arbitrators. It thus has significant practical value for enhancing the professionalism and international competitiveness of China's arbitration system.
基金a phased research outcome report of the Major Innovation Project of the Chinese Academy of Social Sciences,“Research on Major Issues in Improving the Mechanisms and Institutions for Integrated Urban-Rural Development”(Project No. 2024YZD008)。
文摘The promotion of rural revitalization within the ecological conservation areas(“ECAs”) requires a careful balance between ecological protection and economic development and should be guided by the principle of ecological priority. The cultivation of rural “Local Specialty Products”(“LSPs”) under a green-development framework aligns with the functional positioning of these areas, drives the revitalization of rural industries, and constitutes a fundamental strategy for addressing the unique challenges they face. Although ECAs possess inherent advantages in terms of developing LSPs, they are also confronted by multiple constraints. Accordingly, we propose development objectives that emphasize(a) driving rural industrial prosperity,(b) enhancing the appeal of agricultural heritage, and(c) ensuring inclusive prosperity in the farming communities. In selecting pathways for growth, priority should be given to improving the quality of products, fostering distinctiveness of the technologies, nurturing cultural identities, and upholding the principle of common prosperity. From a policy standpoint, the development of rural LSPs should be recognized as a key lever for advancing the comprehensiveness of rural revitalization in the ECAs. We recommend a set of supportive measures—namely, reinforcing the guidance for spatial planning, integrating the consolidation of factor inputs, and ensuring the robustness of organizational guarantees—to facilitate the high-quality development of LSPs in these areas.
文摘Asia‐Pacific’s fast‐developing countries and regions(FDCs)—South Korea,Taiwan Province of China,Singapore,Malaysia,and Thailand—demonstrate the most successful economic development models.The government represents the primary guarantee of FDCs’economic and social construction.Public and foreign investments and government policies to stimulate local and foreign businesses play a decisive role in the development of technological innovations in these FDCs.In these countries,basic research is increasing through the development of knowledge‐based industries,the role of research institutes,the applied research undertaken,and the value of educational institutions.Close cooperation between science and industry led to a change in the structure and nature of the economy,which has become increasingly dependent on new knowledge and ideas.
文摘The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established by the World Health Organization(WHO). Reform in China has demonstrated the unwavering confidence and utmost determination of the Chinese government and the Chinese transplantation community. The year 2015 marked a historic turning point when voluntary donations from Chinese citizens became the sole legitimate source for organ transplantation. Since 2015, China has gradually established and refined the “Chinese Mode” and “China System” for organ donation and transplantation, fulfilling its political pledge of reform, and has garnered international recognition, and fostered a social culture which promotes organ donation. This article reviewed the history of reform on organ donation and transplantation in China, presented a new pattern of establishment of organ donation system in the new era of the country, and the direction of advances in the future.
文摘Energy poverty in developing countries is a critical issue characterized by the lack of access to modern energy services,such as electricity and clean cooking facilities,as marked in SDG 7.This study explores the correlations between energy poverty,energy intensity,resource abundance,and income inequality,as these factors have been theorized to play important roles in influencing energy poverty in developing countries.By observing that the dataset is heterogeneous across the countries and over the time frame,we use the Method of Moments Quantile Regression(MMQR)to analyze our developing countries’data from 2000 to 2019.Our findings indicate that energy intensity is a significant factor influencing energy poverty,suggesting that higher energy consumption relative to the sample countries can exacerbate this issue.Additionally,we observe that income inequality within the sample countries is a critical determinant of energy poverty levels,highlighting the dynamics between economic disparity and access to energy resources.Interestingly,our study reveals that resource abundance acts as a blessing rather than a curse in terms of energy poverty,implying that countries rich in natural resources may have better opportunities to combat energy deprivation.Finally,we emphasize the vital role of financial markets in addressing energy poverty on a global scale,suggesting that robust financial systems can facilitate investments and innovations aimed at improving energy access for vulnerable populations.The results from the robustness analysis support the empirical results obtained from the main estimation.The empirical findings of the present study advance important comprehensions for policymakers to adopt energy policies that address the complex challenges of energy poverty and promote inclusive energy access.
基金Three Gorges Follow-up Work Fund,Grant/Award Number:WE0161A042024National Key Research Program of China,Grant/Award Number:2024YFC3210900。
文摘River ethics,a significant advancement inspired by Chinese President XI Jinping's ecological civilization thought,embodies the philosophical essence of river governance and represents a legacy of innovation by generations of water resources professionals.Rooted in river ecology,it offers a framework for advancing modern water governance systems and capabilities.This paper examines eight dimensions of river ethics to provide actionable recommendations:enhancing knowledge systems on water,rivers,and lakes;addressing critical challenges in water governance to strengthen the foundational role of water authorities in ensuring water security,resource management,ecological sustainability and environmental protection;optimizing water project planning to mitigate ecological impacts;ensuring high standards in the lifecycle management of water projects;refining water diversion strategies for precise scheduling;utilizing ecosystem complexity for river and lake restoration;implementing tiered management of water-related disasters;and driving reforms to modernize water governance systems and mechanisms.
基金Philosophy and Social Science Planning Projects in Yunnan Province,No.QN202428China Postdoctoral Science Foundation,No.2024M752918。
文摘Foreign-funded overseas industrial parks(OIPs)are crucial for attracting foreign investment and promoting globalization in developing countries.However,large-scale land acquisition for these parks generates conflicts between developers and local stakeholders,increasing development costs.A qualitative multicase study was conducted in this study to analyze the land transaction trajectories of China's OIPs.Four OIPs were selected to reveal the underlying mechanisms from the perspectives of institutional arrangements,governance mechanisms,and enterprise heterogeneity.The findings indicate that in host countries with insufficient institutional development,local governments are more inclined to directly engage in OIP land acquisition.High-level intergovernmental mechanisms facilitate land acquisition processes,although their efficacy depends largely on administrative power allocation across parks in host countries.The results also indicate that enterprise characteristics significantly influence land acquisition,where microscale private enterprises lacking political connections often employ low-cost,bottom-up strategies by leveraging international experience.In summary,policy-makers in developing countries should prioritize enhancing OIP governance to mitigate transaction costs,promote diversified land supply,and optimize land allocation.By depicting China's OIP land acquisition processes,this study deepens the academic understanding of OIP governance in developing countries and related international land transactions,offering practical OIP management insights for governments in both host and parent countries.
文摘We do so much to prepare our children for the future,but are we doing enough to prepare the future for our children?To do so we must seek sustainability.Sustainability is a new way of thinking about an age-old concern:ensuring that our children and grandchildren inherit a tomorrow that is at least as good as today,preferably better.We want to make sure that the way we live our lives is sustainable that can continue and keep improving for long time.And since buildings produce half of all greenhouse gases and account for one-sixth of the world's freshwater withdrawals,one-quarter of its wood harvest and two fifths of its material and energy flows.By several estimates,we will double the size of the built environment over the next twenty to forty years.Therefore,there is a critical and immediate need to shift thinking on how the built environment is designed.To reduce environmental impact,protect public health and improve environmental equity and justice,we must change principles for building practice.Designers in general and architects in particular should play a high-profile leadership role in this transformation.
文摘Building Information Modelling(BIM)technology can solve construction issues from multiple perspectives,including technical and managerial.While existing research has primarily focused on BIM’s benefits and framework development,few studies discussed whether BIM can be successfully applied in developing countries.This paper examines the current status and key obstacles hindering BIM adoption in developing countries,analyzing their underlying causes.Notably,the study reveals that high BIM awareness does not directly lead to high BIM usage.The findings aim to provide theoretical support for enhancing the BIM environment and increasing implementation feasibility in developing countries.Additionally,the research identifies critical barriers for governments to address in promoting BIM adoption,offering a foundation for policy formulation.
基金supported by grants from the National Key Research and Development Program of China(No.2022YFE0205800)the National Natural Science Foundation of China(No.21974114)+5 种基金Major Science and Technology Special Project of Fujian Province(No.2022YZ036012)the Fundamental Research Funds for the Central Universities(No.20720220003)Project“111”sponsored by the State Bureau of Foreign Experts and Ministry of Education of China(No.BP0618017)to S.-H.LinNatural Science Foundation of Fujian Province of China(No.2022J01330)Natural Science Foundation of Xiamen City of China(No.3502Z20227208)the China Scholarship Council(No.202308350047)to J.Zeng。
文摘Cardiolipins(CLs),the mitochondria-specific class of phospholipids,are crucial to energy metabolism,cristae structure,and cell apoptosis.CLs present significant challenges in lipidomics analysis due to their structural diversity with up to four fatty acyl side chains.In this study,we developed CLAN(Cardio Lipin ANalysis),a comprehensive computational pipeline designed to improve the accuracy and coverage of cardiolipin identification.CLAN integrates three innovative modules:A cardiolipin identification module that utilizes specific fragmentation rules for precise characterization of CLs and their acyl side chains;a false positives detection module that employs retention time(RT)criteria to reduce false positives;and a prediction module that constructs regression models to identify CLs lacking authentic MS/MS spectra.CLAN achieved better identification accuracy and the highest recall rate for potential CL identification compared to the existing lipid identification tools.Furthermore,we applied CLAN program to an intermittent fasting mouse model,delineating tissue-specific CL alterations across 10 tissues.Every-other-day fasting(EODF)can partially counteract the disruption of the CL atlas across multiple tissues caused by high-fat-high-sugar diet feeding,providing novel insights into mitochondrial lipid metabolism under dietary interventions.Taken together,this work not only advances CL identification methodology but also underscores CLAN's potential in comprehensive analysis of CL atlas in the EODF animal model.CLAN is freely accessible on Git Hub.
基金supported by the National Science Fund for Distinguished Young Scholars(32325025)the STI2030-Major Projects(2021ZD0202500)+2 种基金the National Key Research and Development Program of China(2021YFA1101801)the National Natural Science Foundation of China(32171148,and 31770929)the Beijing Municipal Science and Technology Commission(Z181100001518001 and Z161100000216154).
文摘The oxytocin receptor(OXTR)has garnered increasing attention for its role in regulating both mature behaviors and brain development.It has been established that OXTR mediates a range of effects that are regionspecifc or period-specifc.However,the current studies of OXTR expression patterns in mice only provide limited help due to limitations in resolution.Therefore,our objective was to generate a comprehensive,high-resolution spatiotemporal expression map of Oxtr mRNA across the entire developing mouse brain.We applied RNAscope in situ hybridization to investigate the spatiotemporal expression pattern of Oxtr in the brains of male mice at six distinct postnatal developmental stages(P7,P14,P21,P28,P42,P56).We provide detailed descriptions of Oxtr expression patterns in key brain regions,including the cortex,basal forebrain,hippocampus,and amygdaloid complex,with a focus on the precise localization of Oxtr+cells and the variance of expression between diferent neurons.Furthermore,we identifed some neuronal populations with high Oxtr expression levels that have been little studied,including glutamatergic neurons in the ventral dentate gyrus,Vgat+Oxtr+cells in the basal forebrain,and GABAergic neurons in layers 4/5 of the cortex.Our study provides a novel perspective for understanding the distribution of Oxtr and encourages further investigations into its functions.
基金supported by grants from Simons Foundation (SFARI 479754),CIHR (PJT-180565)the Scottish Rite Charitable Foundation of Canada (to YL)funding from the Canada Research Chairs program。
文摘The mechanistic target of rapamycin(m TOR) is a serine/threonine kinase that plays a pivotal role in cellular growth, proliferation, survival, and metabolism. In the central nervous system(CNS), the mTOR pathway regulates diverse aspects of neural development and function. Genetic mutations within the m TOR pathway lead to severe neurodevelopmental disorders, collectively known as “mTORopathies”(Crino, 2020). Dysfunctions of m TOR, including both its hyperactivation and hypoactivation, have also been implicated in a wide spectrum of other neurodevelopmental and neurodegenerative conditions, highlighting its importance in CNS health.
基金The cost of this research comes from a grant from the government of the Republic of Indonesia,through the Ministry of Education and Culture,Research and Technology with contract number:1225/UN36.11/LP2M/2024。
文摘This study aims to understand the behavior of the Bugis community in developing vernacular house models in the coastal areas of South Sulawesi Province,along with the factors influencing this behavior,such as knowledge,motivation,attitude,locus of control,commitment,concern,and income level.Bugis vernacular houses reflect local wisdom that is adapted to environmental,socio-cultural conditions,and the challenges of modernization.This correlational research was conducted in the regencies of Pangkajene and Kepulauan,Barru,and Bone,with a sample of 300 household heads.The variables analyzed include knowledge,motivation,attitude,locus of control,commitment,concern,and income level.Data were collected through knowledge tests and questionnaires and were analyzed using simple and multiple regression tech-niques.The results show that the Bugis community’s behavior in developing vernacular houses is moderate.Individually,motivation,locus of control,commitment,and concern significantly influence behavior,while knowledge,attitude,and income do not have a significant impact.However,collectively,all independent variables(knowledge,motivation,attitude,locus of control,commitment,concern,and income)affect the behavior of the Bugis community in developing vernacular houses in coastal areas.This study provides valuable insights into the environmental and social adaptations of the Bugis coastal community,as well as efforts to preserve culture through the sustainable development of vernacular houses.
