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利用CRISPR/Cas9技术构建FARS2基因定点突变的大鼠模型 被引量:1
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作者 李晨浩 车凤玉 +4 位作者 王国霞 杨行 李辉 张勇 杨颖 《神经解剖学杂志》 CAS CSCD 北大核心 2018年第6期737-741,共5页
目的:利用CRISPR/Cas9技术构建FARS2基因特定位点突变的大鼠模型。方法:根据FARS2基因序列,设计FARS2基因特异性的单链向导RNA(sgRNA)引物序列并克隆入pU57-T7-GDNA载体。利用T7RNA聚合酶体外转录sgRNA和Cas9mRNA。将体外转录的sgRNA/Ca... 目的:利用CRISPR/Cas9技术构建FARS2基因特定位点突变的大鼠模型。方法:根据FARS2基因序列,设计FARS2基因特异性的单链向导RNA(sgRNA)引物序列并克隆入pU57-T7-GDNA载体。利用T7RNA聚合酶体外转录sgRNA和Cas9mRNA。将体外转录的sgRNA/Cas9mRNA显微注射入SD大鼠受精卵,通过PCR和基因测序对FARS2基因特定位点突变进行检测和鉴定。繁育FARS2基因敲除大鼠并分析后代突变情况。结果:基因测序证实成功构建表达sgRNA载体,成功将sgRNA和Cas9mRNA直接注射入大鼠受精卵。基因测序鉴定获得5只F0代初建鼠。DNA测序结果证实5号大鼠(ID#5)发生了gac>tac突变,该突变并可遗传至子代大鼠。结论:利用CRISPR/Cas9技术成功制备FARS2基因定点突变的大鼠模型,为进一步研究FARS2的功能奠定了基础。 展开更多
关键词 CRISPR/Cas9 fars2 sgRNA 遗传性痉挛性截瘫 基因敲除大鼠
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Sedimentary Environments and Correlative Sequence Stratigraphy of Upper Cretaceous—Paleogene Succession in Shiraz Area, Fars, SW IRAN 被引量:2
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作者 Mirzaee Mahmoodabadi Reza 《Open Journal of Geology》 2014年第1期1-17,共17页
Sequence stratigraphic evidences have been used in this research to investigate the stratigraphic correlation of cretaceous paleogene succession in Shiraz area, Fars, SW Iran. For this purpose, 4 stratigraphic section... Sequence stratigraphic evidences have been used in this research to investigate the stratigraphic correlation of cretaceous paleogene succession in Shiraz area, Fars, SW Iran. For this purpose, 4 stratigraphic sections have been chosen and provided. According to petrographic study and field evidences, 4 depositional sequences were identified including the Tarbur, Sachun and Jahrum formations in the east and the Gurpi, Pabadeh and Asmari formations in the west of study area. After identifying the boundaries and systems tract facies, it has been found that the mentioned formations have been deposited among the continuous/discontinuous boundaries in an equivalent manner. In this case, the purple shale (between the Gurpi and Pabdeh formations) could be considered equivalent to the upper part of the Sachun formation. From the point of Paleogeography, the plat-form sedimentary environment covered almost the whole area during the Oligo-Miocene age, so that the Asmari formation would have been deposited, which is marked by sharp contact as disconformity on Jahrum formation in the east of the basin and with continuous contact (C.C) on the Pabdeh formation in the west and southwest. 展开更多
关键词 Iran fars SHIRAZ Sedimentary Environment Sequence STRATIGRAPHY Cretaceous-Tertiary Boundary
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Does prospective permutation scan statistics work well with cutaneous leishmaniais as a high-frequency or malaria as a low-frequency infection in Fars province, Iran?
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作者 Abbas Rezaianzadeh Marjan Zare +3 位作者 Hamidreza Tabatabaee Mohsen Ali-Akbarpour Hossain Faramarzi Mostafa Ebrahimi 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2018年第10期478-484,共7页
Objective: To determine whether permutation scan statistics was more efficient in finding prospective spatial-temporal outbreaks for cutaneous leishmaniasis(CL) or for malaria in Fars province, Iran in 2016. Methods: ... Objective: To determine whether permutation scan statistics was more efficient in finding prospective spatial-temporal outbreaks for cutaneous leishmaniasis(CL) or for malaria in Fars province, Iran in 2016. Methods: Using time-series data including 29 177 CL cases recorded during 2010-2015 and 357 malaria cases recorded during 2010-2015, CL and malaria cases were predicted in 2016. Predicted cases were used to verify if they followed uniform distribution over time and space using space-time analysis. To testify the uniformity of distributions, permutation scan statistics was applied prospectively to detect statistically significant and non-significant outbreaks. Finally, the findings were compared to determine whether permutation scan statistics worked better for CL or for malaria in the area. Prospective permutation scan modeling was performed using SatScan software. Results: A total of 5 359 CL and 23 malaria cases were predicted in 2016 using time-series models. Applied timeseries models were well-fitted regarding auto correlation function, partial auto correlation function sample/model, and residual analysis criteria(Pv was set to 0.1). The results indicated two significant prospective spatial-temporal outbreaks for CL(P<0.5) including Most Likely Clusters, and one non-significant outbreak for malaria(P>0.5) in the area. Conclusions: Both CL and malaria follow a space-time trend in the area, but prospective permutation scan modeling works better for detecting CL spatial-temporal outbreaks. It is not far away from expectation since clusters are defined as accumulation of cases in specified times and places. Although this method seems to work better with finding the outbreaks of a high-frequency disease; i.e., CL, it is able to find non-significant outbreaks. This is clinically important for both high-and low-frequency infections; i.e., CL and malaria. 展开更多
关键词 CUTANEOUS leishmaniais MALARIA PROSPECTIVE PERMUTATION scan statistics fars PROVINCE Iran
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Determining endemic values of cutaneous leishmaniasis in Iranian Fars province by retrospectively detected clusters and receiver operating characteristic curve analysis
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作者 Marjan Zare Abbas Rezaianzadeh +3 位作者 Hamidreza Tabatabaee Hossain Faramarzi Mohsen Aliakbarpour Mostafa Ebrahimi 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2019年第9期359-364,共6页
Objective: To determine the endemic values of cutaneous leishmaniasis in different cities of Fars province, Iran. Methods: Totally, 29 201 cases registered from 2010 to 2015 in Iranian Fars province were selected, and... Objective: To determine the endemic values of cutaneous leishmaniasis in different cities of Fars province, Iran. Methods: Totally, 29 201 cases registered from 2010 to 2015 in Iranian Fars province were selected, and the endemic values of cutaneous leishmaniasis were determined by retrospective clusters derived from spatiotemporal permutation modeling on a time-series design. The accuracy of the values was assessed using receiver operating characteristic(ROC) curve. SPSS version 22, Arc GIS, and ITSM 2002 software tools were used for analysis. Results: Nine statistically significant retrospective clusters(P<0.05) resulted in finding seven significant and accurate endemic values(P<0.1). These valid endemic scores were generalized to the other 18 cities based on 6 different climates in the province. Conclusions: Retrospectively detected clusters with the help of ROC curve analysis could help determine cutaneous leishmaniasis endemic values which are essential for future prediction and prevention policies in the area. 展开更多
关键词 Cutaneous LEISHMANIASIS Retrospective CLUSTERS Receiver operating characteristic curve ENDEMIC VALUES fars PROVINCE
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Application of Statistical Methods to Biomarkers for Geochemical Evaluation and Genetic Type Determination of Gas Condensates in the Persian Gulf and Coastal Fars,Southern Iran
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作者 Mohammad Javad SEIDY Mohammad Hossein SABERI 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2022年第4期1246-1256,共11页
In a comprehensive geochemical study,the genetic relationships among 14 samples of gas condensates from the Persian Gulf were investigated for the purpose of evaluating the respective source rocks in terms of both age... In a comprehensive geochemical study,the genetic relationships among 14 samples of gas condensates from the Persian Gulf were investigated for the purpose of evaluating the respective source rocks in terms of both age and sedimentary paleoenvironment.Chemometric analysis was used for categorization and determination of a certitude range to determine the genetic type of the condensate families in the studied basin.The samples were collected from Late Permian-Triassic reservoirs(Dalan and Kangan formations)located in 6 gasfields(gas condensate)hosting some of Iran’s most important gas/gas condensate reserves.Obtained by gas chromatography-mass spectrometry(GC-MS),a total of 16 biomarker parameters(10 maturity-related parameters and 6 sedimentary environment-related parameters)were used to evaluate the samples in terms of thermal maturity(and hence their positions in the maturity chart),the sedimentary environment of the source rock and the lithology.Application of Hierarchical Clustering Analysis(HCA)and Principal Component Analysis(PCA)to the collected data led to the categorization of the samples into three main genetic groups,Ⅰ-Ⅲ.GroupsⅠandⅢwere found to be located in the east and the west of the Persian Gulf,respectively,while GroupⅡwas developed between the two other groups. 展开更多
关键词 gas condensate satistical methods genetic linkage thermal maturation Persian Gulf Coastal fars
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Evaluation of Hydrocarbon Potential in the Jahrom Area, Interior Fars, Zagros
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作者 Mehdi Hosseinpour Zahra Maleki Mohsen Aleali 《Open Journal of Geology》 2017年第3期429-442,共14页
The study area is located in the Fars area (Interior Fars sub-basin). This area, which is part of the Zagros fold-thrust belt, is located in Zagros simple folded sub zone. It is known as one of the most important regi... The study area is located in the Fars area (Interior Fars sub-basin). This area, which is part of the Zagros fold-thrust belt, is located in Zagros simple folded sub zone. It is known as one of the most important regions in the world Gas rich. In this area, anticlinal folds are a different orientation of such as the North Western-South Eastern, East-West and North Eastern-South Western. The Karbasi and Khaftar anticlines are case study anticlines in the interior Fars sub-basin (Fassa area). The anticlines in the Fars region, which are located in the Zagros fold-thrust belt, are valuable because they possess several hydrocarbons. The main aim of this paper is evaluation of hydrocarbon potential in the Jahrom area (Interior Fars) based on interpretation of the Isopach maps and well data. This paper presents part of the results of a regional study of the Coastal Fars area in the Zagros Simply folded belt, based on original fieldwork, satellite images, structural sections, geological maps and well data. In order to investigate of periods Nezamabad fault activity, Isopach maps of the study area has been prepared based on well drilling data and the thickness of the drilled formations. In this study utilizes the thickness of the drilled formations in the study area, for each sedimentary unit was carried out to prepare Isopach maps. The Isopach map prepared based on GIS software method and exploration well data. The Nezamabad fault has been lacked of activity at the deposition time of the Dalan, Kangan, Dashtak, Fahliyan, Gadvan, Dariyan, Kazhdomi, Sarvak, Gurpi and Pabdeh formations within the Khaftar and Karbasi anticline area. Accordingly, changes in basin floor, at the time of sedimentation these formations has not been affected by the Nezamabad fault. Probably the Nezamabad fault has been activated during deposition of the Surmeh, Hith, Laffan and Ilam formations and in this area paleo-basin has been controlled by this fault. In other words, it seems that, activity of the Nezamabad fault in this area have been limited to Jurassic and Cretaceous periods (Coniacian and Senomanian). This can means that in this periods time, the Nezamabad fault have been active sedimentation along with tectonic processes and activities affected on thickness of the Surmeh, Hith, Laffan and Ilam formations. Finally, it seems that the Nezamabad Fault activity has been affected on the source rock, reservoir rock and cap rock and then controlled distributing of hydrocarbon System of the study area in the Khaftar and Karbasi as anticlinal oil traps. 展开更多
关键词 HYDROCARBON POTENTIAL Jahrom Area Nezamabad FAULT INTERIOR fars ZAGROS
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指纹自动识别系统(FARS)简介
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作者 阎振宇 《刑事技术》 1990年第5期49-,共1页
指纹自动识别系统(FARS)是公安部重点指令性课题,由公安部第二研究所承担并完成。FARS为自动与半自动(MFRS)相结合的系统,采用公安部第二研究所独创的指纹'特征图'识别方法。'特征图'以指纹细节特征作为原始数据,系统... 指纹自动识别系统(FARS)是公安部重点指令性课题,由公安部第二研究所承担并完成。FARS为自动与半自动(MFRS)相结合的系统,采用公安部第二研究所独创的指纹'特征图'识别方法。'特征图'以指纹细节特征作为原始数据,系统通过摄像。 展开更多
关键词 fars 指纹细节特征 特征图 识别方法 图像处理 特征点 侦察破案 证据作用 模块化结构设计 自动抽取
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大豆FAR1/FHY3基因家族鉴定与表达分析 被引量:1
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作者 唐晓飞 薛永国 +6 位作者 曹旦 孙建强 刘琦 朱梓菲 栾晓燕 王秀君 刘鑫磊 《大豆科学》 北大核心 2025年第2期40-52,共13页
FAR1/FHY3转录因子家族是光敏色素A(phyA)介导的远红光信号传导的重要因子,在植物生长发育、光信号转导、植物激素反应和抗逆性中发挥重要作用。为了探究大豆FAR1/FHY3基因家族的进化和功能,本研究采用生物信息学方法对大豆中的FAR1/FHY... FAR1/FHY3转录因子家族是光敏色素A(phyA)介导的远红光信号传导的重要因子,在植物生长发育、光信号转导、植物激素反应和抗逆性中发挥重要作用。为了探究大豆FAR1/FHY3基因家族的进化和功能,本研究采用生物信息学方法对大豆中的FAR1/FHY3基因进行全基因组鉴定,对该基因家族的编码蛋白特征、系统发育关系、基因结构、染色体位置、启动子顺式元件以及基因表达模式进行分析。结果表明:在大豆中共鉴定出72个FAR1/FHY3成员,分布在19条染色体上。系统发育分析将其与拟南芥和玉米的FRS蛋白分为5个亚组,保守蛋白质基序和基因结构分析说明蛋白质之间存在进化关系。共线性分析鉴定表明,共有24对基因存在共线性关系。对启动子中的顺式作用元件以及大豆FAR1/FHY3在不同胁迫处理下的表达谱的分析表明,FAR1/FHY3可能在逆境胁迫反应中具有潜在作用。对低温胁迫下表达量差异显著的6个家族成员(A.Glyma.09G012900;B.Glyma.11g088700;C.Glyma.12g052000;D.Glyma.13g211200;E.Glyma.15g125400;F.Glyma.20G156100)进行qRT-PCR分析表明,其表达情况与转录组分析的结果一致。本研究结果可为进一步解析大豆FAR1/FHY3在大豆生长发育及胁迫应答中的功能奠定理论基础。 展开更多
关键词 大豆 FAR1/FHY3 基因家族 表达模式
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一例FARS2基因变异所致联合氧化磷酸化缺陷14型患儿的遗传学分析
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作者 马健 张洪伟 +4 位作者 律玉强 高敏 王东 盖中涛 刘毅 《中华医学遗传学杂志》 CAS CSCD 2022年第12期1393-1397,共5页
目的:探讨一例表现为无诱因惊厥发作、生长发育迟缓、血乳酸值升高的2月龄患儿的遗传学病因。方法:应用二代测序技术对患儿进行全外显子组和线粒体环基因测序,用Sanger测序对候选致病变异进行验证,依据美国医学遗传学及基因组学学会相... 目的:探讨一例表现为无诱因惊厥发作、生长发育迟缓、血乳酸值升高的2月龄患儿的遗传学病因。方法:应用二代测序技术对患儿进行全外显子组和线粒体环基因测序,用Sanger测序对候选致病变异进行验证,依据美国医学遗传学及基因组学学会相关指南进行致病性分析。检索PubMed、万方数据库和中国知网数据库中FARS2变异所致的联合氧化磷酸化缺乏症14型(COXPD14)的病例报道,总结其临床特征及基因变异谱。结果:全外显子组测序提示患儿携带FARS2基因c.925G>A(p.G309S)和c.405C>A(p.H135Q)复合杂合变异;Sanger测序证实这两个变异分别遗传自母亲和父亲。其中c.925G>A为HGMD数据库已收录的致病变异,c.405C>A预测为疑似致病变异。检索文献另发现30例COXPD14患者,其FARS2变异类型包括错义变异、剪接变异、读码框内碱基缺失和编码区微缺失。结论:COXPD14临床表现以发育迟缓(96%)、癫痫发作(97%)和乳酸升高(96%)最为经典。FARS2基因c.925G>A(p.G309S)和c.405C>A(p.H135Q)复合杂合变异是本例患儿的发病原因。 展开更多
关键词 联合氧化磷酸化缺乏症14型 fars2基因 全外显子组测序
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运用FARS模型对语篇修辞结构的实证分析
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作者 尤丽萍 《雪莲》 2015年第6X期119-121,共3页
本文简要介绍"语篇关系结构分析框架理论"(the Framework for the Analysis of the Relational Structure of Texts,FARS)的7种修辞结构关系类型,并运用该模型对2段语篇进行分析。比较了两段语篇修辞关系运用的特点,发现语篇... 本文简要介绍"语篇关系结构分析框架理论"(the Framework for the Analysis of the Relational Structure of Texts,FARS)的7种修辞结构关系类型,并运用该模型对2段语篇进行分析。比较了两段语篇修辞关系运用的特点,发现语篇一修辞手法运用灵活多样;而语篇二中部分修辞关系重复出现,过度使用某些直观形式标记。 展开更多
关键词 fars模型 修辞结构 关系
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桑小头木虱FAR基因家族鉴定及其功能预测分析
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作者 林雅婷 郝阳洋 +3 位作者 韦红显 耿涛 王树昌 卢芙萍 《热带作物学报》 北大核心 2025年第6期1502-1513,共12页
桑小头木虱(PaurocephalasauteriEnderlein)是热带亚热带桑树重要害虫,主要为害桑树顶芽和嫩叶,导致叶片卷曲,难以展开,同时可分泌蜡质,诱发煤烟病,导致桑叶产量和质量显著下降;为害小苗,可致其全株死亡,严重威胁热带蚕桑产业的多元化... 桑小头木虱(PaurocephalasauteriEnderlein)是热带亚热带桑树重要害虫,主要为害桑树顶芽和嫩叶,导致叶片卷曲,难以展开,同时可分泌蜡质,诱发煤烟病,导致桑叶产量和质量显著下降;为害小苗,可致其全株死亡,严重威胁热带蚕桑产业的多元化发展。脂酰辅酶A还原酶(FAR)存在于各种生物体内,参与脂肪酸衍生物的生物合成,进而参与繁殖、两性信息识别与交流、蜡质合成等多项生命活动过程。本研究共筛选到23个桑小头木虱FAR基因,蛋白分析表明,其中大多数为碱性蛋白,具有亲水性;亚细胞定位预测发现,17个FAR蛋白定位于细胞质,1个定位于线粒体,1个定位于细胞核,4个定位于质膜,说明PsmFAR基因发挥功能的主要场所是细胞质。结合其他已知昆虫FAR基因的功能,以及桑小头木虱若虫、雌成虫、雄成虫体内及不同部位FAR基因的表达分析发现,桑小头木虱FAR基因可能参与发育、繁殖、蜡质合成、体表角质层合成、信息素合成及解毒等多个生物学功能,除7个基因可能仅参与蜡质合成功能外,其余16个基因可能参与多个生物学功能,涉及繁殖的有16个(69.56%),涉及蜡质合成的亦有16个(69.56%),与其体表角质层合成相关的有12个(52.17%),与发育相关的有9个(39.13%),与解毒相关的有5个(21.74%),与信息素合成相关的有4个(17.39%)。本研究在转录组测序分析的基础上对桑小头木虱FAR基因家族进行鉴定、序列组成及表达分析,探究FAR基因在桑小头木虱生命活动中的功能,为其高效防控技术和针对性药剂的研发和应用提供理论依据。后续功能的进一步验证将为以FAR基因为靶标的精准防控药剂的研发提供依据。 展开更多
关键词 桑小头木虱 FAR基因家族 亚细胞定位 基因表达 功能预测分析
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结直肠癌患者术前外周血FAR、PLR及CEA与术后临床及病理分期的相关性研究
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作者 尹喜花 牛锦源 +2 位作者 姚学英 王超 高福洋 《中国科技期刊数据库 医药》 2025年第2期053-058,共6页
探讨结直肠癌(Colorectal cancer,CRC)患者术前纤维蛋白原与白蛋白比值(Fibrinogen/albumin ratio,FAR)、血小板计数与淋巴细胞比值(Platelet/lymphocyte ratio,PLR)、CEA与术后临床及和病理分期的相关性。方法 回顾性采集2017年1月-202... 探讨结直肠癌(Colorectal cancer,CRC)患者术前纤维蛋白原与白蛋白比值(Fibrinogen/albumin ratio,FAR)、血小板计数与淋巴细胞比值(Platelet/lymphocyte ratio,PLR)、CEA与术后临床及和病理分期的相关性。方法 回顾性采集2017年1月-2024年5月我院收治并经手术治疗,术后病理明确诊断为CRC的患者资料,共201例,收集他们的姓名、性别、年龄、术前血液学指标(白蛋白、纤维蛋白原、血小板计数、淋巴细胞绝对值、血清CEA、术后病理分期、肿瘤位置等,分析CRC患者术前FAR、PLR、CEA与术后临床及病理分期的相关性。结果 年龄、性别与CRC患者分期无相关性(P>0.05);FAR、PLR以及CEA均与CRC患者的临床分期有相关性,P值分别为0.045、0.019、<0.001;PLR水平与病理T分期相关(P=0.046);FAR水平与病理T和M分期相关P值分别为0.008、0.023。结论 CRC患者术前FAR、PLR及CEA水平与CRC的发生、发展密切相关。 展开更多
关键词 结直肠癌 FAR PLR 病理分期 CEA
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PAgT、FAR和D-D联合检测对妇科恶性肿瘤术后发生下肢深静脉血栓形成的临床评估价值
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作者 姜显亭 谢翠华 《医学理论与实践》 2025年第6期1017-1019,共3页
目的:探讨血小板聚集率(PAgT)、纤维蛋白原(FIB)与白蛋白(ALB)比值(FAR)和D-二聚体(D-D)水平联合检测对妇科恶性肿瘤术后发生下肢深静脉血栓形成(LDVT)的评估价值。方法:将2022年1月—2024年3月行手术治疗的妇科恶性肿瘤患者140例作为... 目的:探讨血小板聚集率(PAgT)、纤维蛋白原(FIB)与白蛋白(ALB)比值(FAR)和D-二聚体(D-D)水平联合检测对妇科恶性肿瘤术后发生下肢深静脉血栓形成(LDVT)的评估价值。方法:将2022年1月—2024年3月行手术治疗的妇科恶性肿瘤患者140例作为研究对象,根据术后5d内是否发生LDVT分为非LDVT组(n=117)和LDVT组(n=23),根据治疗1周的转归情况分为预后良好亚组(n=17)和预后不良亚组(n=6);分别检测和比较各组的PAgT、FAR和D-D水平,Pearson分析各变量之间的相关性,绘制ROC分析单独和联合检测PAgT、FAR和D-D水平对发生LDVT的评估效能。结果:LEDVT组的PAgT、FAR和D-D水平均显著高于非LEDVT组(P<0.05);预后不良亚组的PAgT、FAR和D-D水平均高于预后良好亚组(P<0.05)。Pearson分析显示,PAgT、FAR和D-D水平与Caprini评分呈正相关,与PT和R水平呈负相关(P<0.01)。ROC曲线显示,PAgT、FAR和D-D水平联合检测评估妇科恶性肿瘤术后发生LDVT的AUC、敏感度和特异度均高于任一单项检测的效能(P<0.01)。结论:PAgT、FAR和D-D水平联合检测对妇科恶性肿瘤患者术后发生LDVT的诊断和评估价值较高。 展开更多
关键词 PAGT FAR D-D 妇科恶性肿瘤 下肢深静脉血栓形成 评估价值
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纤维蛋白原与白蛋白、前白蛋白比值对结直肠癌的诊断价值
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作者 于艳艳 孟雪勤 王扬 《医学检验与临床》 2025年第4期25-29,共5页
目的:探讨纤维蛋白原与白蛋白的比值(FAR)和纤维蛋白原与前白蛋白的比值(FPR)对结直肠癌的诊断价值。方法:选取2020年1月-2023年9月于我院行结直肠癌手术治疗的患者106例(结直肠癌组),同时期于我院住院治疗的结直肠良性疾病患者118例(... 目的:探讨纤维蛋白原与白蛋白的比值(FAR)和纤维蛋白原与前白蛋白的比值(FPR)对结直肠癌的诊断价值。方法:选取2020年1月-2023年9月于我院行结直肠癌手术治疗的患者106例(结直肠癌组),同时期于我院住院治疗的结直肠良性疾病患者118例(结直肠良性疾病组)和肠镜检查未见明显异常的健康人群110例(健康对照组),运用统计学方法比较三组患者的FAR、FPR、NLR、CEA、CA19-9水平差异,比较检验结直肠癌组内FPR、FAR水平与其临床病理特征的相关性。用ROC曲线评价FAR、FPR、NLR、CEA、CA19-9对结直肠癌的诊断效能及其对结直肠癌与结直肠良性病变之间的鉴别诊断效能。结果:与结直肠良性疾病组患者和健康对照组的患者相比,结直肠癌组患者的术前NLR、FPR、FAR、CEA、CA19-9均显著升高(P<0.05);结直肠良性疾病组的FPR较健康对照组明显升高(P<0.05);FAR、NLR、CEA、CA19-9在两组间比较差异无统计学意义(P>0.05)。随着结直肠癌分化程度降低、肿瘤直径增大,浸润深度的加深以及临床分期的增加,结直癌患者的FPR、FAR的中位数显著升高,与肿瘤的发生位置无关。ROC曲线分析结果显示,FPR对结直肠癌的诊断效能显著高于其他检验指标(P<0.05)。结论:FPR对结直肠癌有较高的诊断效能,对结直肠癌早期筛查或者诊断具有较高的参考价值。 展开更多
关键词 结直肠癌 FAR FPR 诊断价值
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寻常型天疱疮合并感染患者实验室相关指标分析
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作者 赵世祺 苗青 张肖晗 《皮肤性病诊疗学杂志》 2025年第4期256-262,共7页
目的分析寻常型天疱疮(PV)患者实验室相关指标与PV合并感染的相关性,以辅助临床判断病情,预防感染的发生。方法收集155例PV住院患者的临床资料及实验室检查结果,包括白细胞计数(WBC)、中性粒细胞计数(NEU)、淋巴细胞计数(LYM)、血小板计... 目的分析寻常型天疱疮(PV)患者实验室相关指标与PV合并感染的相关性,以辅助临床判断病情,预防感染的发生。方法收集155例PV住院患者的临床资料及实验室检查结果,包括白细胞计数(WBC)、中性粒细胞计数(NEU)、淋巴细胞计数(LYM)、血小板计数(PLT),以及C反应蛋白(CRP)、纤维蛋白原(FIB)、白蛋白(ALB)、球蛋白(GLB)、免疫球蛋白E(IgE)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、补体C3、补体C4、抗Dsg1抗体、抗Dsg3抗体水平,比较合并感染者(感染组)与未合并感染者(非感染组)之间实验室指标的差异,采用ROC曲线比较中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、C反应蛋白与血清白蛋白比值(CAR)、纤维蛋白原与血清白蛋白比值(FAR)和单一参数(包括NEU、LYM、PLT、CRP、ALB、FIB)对判断PV合并感染的价值。结果与非感染组比较,感染组血清中的抗Dsg1抗体、抗Dsg3抗体、CRP、FIB水平升高,PLT增加,NLR、PLR、CAR、FAR升高,LYM、ALB降低,差异均有统计学意义(均P<0.05)。ROC曲线分析显示NLR、PLR、CAR、FAR的AUC值均大于相应的单一参数。结论抗Dsg1和Dsg3抗体水平、NLR、PLR、CAR、FAR可辅助判断PV合并感染。 展开更多
关键词 寻常型天疱疮 感染 NLR PLR CAR FAR CD4^(+)T细胞 抗Dsg抗体
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基于功能对等理论的《封神第一部:朝歌风云》字幕英译
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作者 李若凡 冯瑞贞 《英语广场(学术研究)》 2025年第10期47-51,共5页
本研究选取《封神第一部:朝歌风云》中英字幕文本为研究语料,探讨功能对等理论在字幕翻译中的具体应用,同时采用FAR模型对字幕翻译质量进行评估,将功能对等理论与字幕翻译质量评估模型相结合,深入探讨功能对等理论在电影字幕翻译中的适... 本研究选取《封神第一部:朝歌风云》中英字幕文本为研究语料,探讨功能对等理论在字幕翻译中的具体应用,同时采用FAR模型对字幕翻译质量进行评估,将功能对等理论与字幕翻译质量评估模型相结合,深入探讨功能对等理论在电影字幕翻译中的适用性和效果,旨在为提升国产电影字幕翻译的质量和效率提供借鉴,从而促进中国文化在国际市场上的广泛传播与交流。 展开更多
关键词 功能对等理论 电影字幕翻译 《封神第一部:朝歌风云》 FAR模型
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血清SII、TyG、FAR与急性心肌梗死患者冠脉病变严重程度的相关性研究综述
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作者 高院 高燕 《临床医学进展》 2025年第2期1744-1753,共10页
心血管疾病(cardiovascular disease, CVD)是全球发病率和死亡率的主要原因,严重威胁着全球人类的健康。CVD包含疾病有多种其中急性心肌梗死(AMI)是最常见严重危害中老年人群健康的心血管疾病之一,血清甘油三酯葡萄糖指数(triglyceride-... 心血管疾病(cardiovascular disease, CVD)是全球发病率和死亡率的主要原因,严重威胁着全球人类的健康。CVD包含疾病有多种其中急性心肌梗死(AMI)是最常见严重危害中老年人群健康的心血管疾病之一,血清甘油三酯葡萄糖指数(triglyceride-glucose index, TyG指数)是胰岛素抵抗(insulin resistance, IR)的一种新型替代指标,为条件受限地区临床决策提供有力依据。有研究指出TyG指数不仅可预测CVD、2型糖尿病的发生发展,还可评估代谢性疾病发生。SII对冠心病患者介入治疗后发生不良心血管事件的预测价值优于传统危险。FAR在预测主要心血管不良事件尤其是合并DM方面比单独用FIB和Alb有更高敏感性和特异性。本文旨在阐述TyG指数与FIB/Alb比值(FAR)、SII在AMI患者中冠脉病变严重程度的发生发展关系,以便更好地了解TyG指数、FIB/Alb比值(FAR)、SII在AMI中的应用价值。Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide and poses a serious threat to human health worldwide. CVD includes a variety of diseases, among which acute myocardial infarction (AMI) is one of the most common cardiovascular diseases that seriously harm the health of middle-aged and elderly people. Serum triglyceride-glucose index (TyG index) is a novel proxy for insulin resistance (IR), which provides a strong basis for clinical decision-making in restricted areas. Some studies have pointed out that TyG index can not only predict the occurrence and development of CVD and type 2 diabetes, but also evaluate the occurrence of metabolic diseases. The predictive value of SII for adverse cardiovascular events in patients with coronary heart disease after interventional therapy is better than that of traditional risk. FAR has higher sensitivity and specificity than FIB and Alb alone in predicting major cardiovascular adverse events, especially with DM. This paper aims to describe the relationship between TyG index, FIB/Alb ratio (FAR) and SII in the severity of coronary lesions in patients with AMI, so as to better understand the application value of TyG index, FIB/Alb ratio (FAR) and SII in AMI. 展开更多
关键词 心血管疾病 急性心肌梗死 冠状动脉事件注册评分 血清甘油三酯葡萄糖指数 全身免疫炎症指数 FIB/Alb比值(FAR)
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FAR 25附录C结冰气象探测数据处理方法
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作者 张文强 陈奕屹 +3 位作者 雷国强 王光雨 支亚非 毛雪瑞 《北京航空航天大学学报》 北大核心 2025年第10期3324-3336,共13页
结冰会破坏飞机的气动外形,导致升力下降阻力增加,飞机的操纵性和稳定性下降,严重影响飞行安全。考虑到FAR 25附录C的使用有一定的地区和季节的局限性,同时更多更复杂的结冰环境的发现需要对附录C进行不断地修订,因此,总结和探索气象探... 结冰会破坏飞机的气动外形,导致升力下降阻力增加,飞机的操纵性和稳定性下降,严重影响飞行安全。考虑到FAR 25附录C的使用有一定的地区和季节的局限性,同时更多更复杂的结冰环境的发现需要对附录C进行不断地修订,因此,总结和探索气象探测的数据处理方法能够对编制和改进中国的结冰适航审定规章提供指导。介绍附录C的编制背景,总结传统结冰气象探测仪器的测量原理及数据处理方法,重点解释了如何将测量到的气象数据转化为可供查询的包线图;从结冰数据库建立、提升仪器测量精度、无人机防冰3方面给出当前面临的挑战与未来发展趋势,从而为气象探测技术的发展和未来发展方向提供科学的指导。 展开更多
关键词 FAR25附录C 结冰 气象探测 数据处理 防除冰
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Analysis and identification of the hidden relationships between effective factors in the mortality rate caused by road accidents: A case study of Fars Province, Iran
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作者 Saeed Lotfi Ali Reza Honarvar Saeid Gholamzadeh 《Chinese Journal of Traumatology》 CAS CSCD 2019年第4期233-239,共7页
Purpose: An analysis and identification of the hidden relationships between effective factors in the mortality rate caused by road accidents in Fars Province of Iran to prevent and reduce traffic accidents in the futu... Purpose: An analysis and identification of the hidden relationships between effective factors in the mortality rate caused by road accidents in Fars Province of Iran to prevent and reduce traffic accidents in the future. Methods: This cross-sectional study was conducted to integrate all the pervious researches performed on mortality rate of road traffic accidents in Fars Province from March 21,2013 to March 20,2017. In order to reveal the relationships between the factors affecting mortality rates of road traffic accidents, the data regarding road traffic accidents extracted from resources such as Legal Medicine Organization, Traffic Police, Accident & Emergency Department, as well as Department of Roads and Urban Development of Fars Province, then cleaned and the applicable attributes embedded in the data all aggregated for further analysis. It should be noted that the data not related to Fars Province were deleted, the data analyzed, converted and the aggregation between various attributes identified. The aggregation between these different attributes as well as the FP-growth algorithm and two indexes of support and confidence calculated and interesting and effective rules extracted. In the end, several accident-p「ovoking factors, the degree of consecutive and interdepende nee of each one in road accide nts identified and in traduced. The statistical analysis was conducted by using Rapid Miner software. Results: Of the 6216 people dead due to road traffic accidents, 4865 (79.02%) were male and 1292 (20.98%) were female, 59 of them have no clear gender. The largest portion of people died of road traffic accidents belonged to married and self-employed men who collided with motorcycles in autumn. Moreover, young individuals (aged 19-40 years) w让h secondary educational level who died of accidents in summer at 12:00 a.m. and then 5:00 p.m. in outer city main roads of Kazerun-Shiraz, then Darab- Shiraz, Fasa-Darab and in within-city main streets had the highest mortality rates. Among women, the middle-aged group (aged 41-65 years) followed by young-aged group (aged 19-40 years) with elementary educational level and then illiterate accounted for the highest mortality rate of road traffic accidents. The automobiles involved in accidents included Pride, Peugeot 405, Peykan pickup, Sama nd, Peugeot Pars, other vehicles and motorcycles. Conclusion: The high mortality rate of illiterate and low-literate in various age groups indicates that educational level plays a crucial role as a factor in road accidents, requiring related organizations such as Traffic Police and Ministry of Education to take necessary measures and policies. 展开更多
关键词 ROAD TRAFFIC accidents MORTALITY Vehicle fars PROVINCE Iran
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Terahertz active multi-channel vortices with parity symmetry breaking and near/far field multiplexing based on a dielectric-liquid crystal-plasmonic metadevice
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作者 Yiming Wang Fei Fan +3 位作者 Huijun Zhao Yunyun Ji Jing Liu Shengjiang Chang 《Opto-Electronic Advances》 2025年第5期48-58,共11页
Vortex beams carrying orbital angular momentum(OAM)are of great significance for high-capacity communication and super-resolution imaging.However,there is a huge gap between the free-space vortices(FVs)and plasmonic v... Vortex beams carrying orbital angular momentum(OAM)are of great significance for high-capacity communication and super-resolution imaging.However,there is a huge gap between the free-space vortices(FVs)and plasmonic vortices(PVs)on chips,and active manipulation as well as multiplexing in more channels have become a pressing demand.In this work,we demonstrate a terahertz(THz)cascaded metadevice composed of a helical plasmonic metasurface,a liquid crystal(LC)layer,and a helical dielectric metasurface.By spin-orbital angular momentum coupling and photon state superposition,PVs and FVs are generated with mode purity of over 85%on average.Due to the inversion asymmetric design of the helical metasurfaces,the parity symmetry breaking of OAM is realized(the topological charge numbers no longer occur in positive and negative pairs,but all are positive),generating 6 independent channels associated with the decoupled spin states and the near-/far-field positions.Moreover,by the LC integration,dynamic mode switching and energy distribution can be realized,finally obtaining up to 12 modes with a modulation ratio of above 70%.This active tuning and multi-channel multiplexing metadevice establishes a bridge connection between the PVs and FVs,exhibiting promising applications in THz communication,intelligent perception,and information processing. 展开更多
关键词 TERAHERTZ optical vortex plasmonic metasurface near/far field MULTI-CHANNEL liquid crystal
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